Yvette I Sheline MD MS

Geriatric Psychiatry

McLure Endowed Professor, Department of Psychiatry and Radiology University of Pennsylvania and Director, Center for Neuromodulation in Depression and Stress (CNDS), University of Pennsylvania

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3700 Hamilton WalkRichards D307Philadelphia, PA 19104
Phone+1 215-573-0082

Education & Training

Beth Israel Deaconess Medical CenterResidency, Psychiatry, 1980 - 1983
Boston University School of MedicineClass of 1979

Certifications & Licensure

CA State Medical License 1983 - Present
PA State Medical License 2013 - 2026
MO State Medical License 1991 - 2014
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Treatment Outcome of Vascular Depression Start of enrollment: 2001 Apr 01
Completed
fMRI Studies of Emotional Brain Circuitry in People With Major Depression Start of enrollment: 2001 Jul 01
Completed
Not Applicable
fMRI Study of Treatment Changes in Major Depression Start of enrollment: 2009 Feb 01
Completed
Not Applicable
Escitalopram Effects on CSF Amyloid Beta Start of enrollment: 2014 Jun 01
Completed
Phase 4
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT Start of enrollment: 2017 Jun 05
COMPLETED
NA
Study to Evaluate the Effect of CT1812 Treatment on Amyloid Beta Oligomer Displacement Into CSF in Subjects With Mild to Moderate Alzheimer's Disease Start of enrollment: 2018 May 30
Completed
Phase 1
Compressed Intermittent Theta Burst Stimulation Start of enrollment: 2020 Feb 20
ACTIVE_NOT_RECRUITING
NA
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Publications & Presentations

PubMed

Suicide characteristics in patients with marked treatment-resistant major depressive disorder: A RECOVER trial report.
Victoria C de Leon, Rebecca M Allen, João Quevedo, Patricio Riva-Posse, Scott T Aaronson
Journal of Affective Disorders. 2025-04-01
Neuroimaging changes in major depression with brief computer-assisted cognitive behavioral therapy compared to waitlist.
Yvette I Sheline, Michael E Thase, Elizabeth A Hembree, Nicholas L Balderston, Frederick J Nitchie
Molecular Psychiatry. 2025-03-11
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.
Zachary P Rosenthal, Joseph B Majeski, Ala Somarowthu, Davin K Quinn, Britta E Lindquist
Biorxiv. 2025-02-21

Journal Articles

Network Changes Associated with Transdiagnostic Depressive Symptom Improvement Following Cognitive Behavioral Therapy in MDD and PTSD
Yvette Sheline, MD, Nature

Press Mentions

World’s First Anti-Depression Nasal Spray Receives FDA ApprovalFebruary 3rd, 2025
Top Mental Health Research Achievements of 2024 from BBRFJanuary 7th, 2025
Accelerated Intermittent Theta-Burst Stimulation Aids Treatment-Resistant Bipolar DepressionJuly 25th, 2024
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Grant Support

HCP-2.0: Ascertaining Network Mechanisms and Analytics of Emotional Dysfunction (HARMONY)UNIVERSITY OF PENNSYLVANIA2023–2028
HCP-2.0: Ascertaining Network Mechanisms and Analytics of Emotional Dysfunction (HARMONY)UNIVERSITY OF PENNSYLVANIA2023–2028
3/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)UNIVERSITY OF PENNSYLVANIA2022–2027
3/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)UNIVERSITY OF PENNSYLVANIA2022–2027
Reducing neural perseveration through closed loop real time fMRI neurofeedback to alleviate depressive symptomsUNIVERSITY OF PENNSYLVANIA2021–2025
FMRI Studies Of Emotional Circuitry In DepressionNational Institute Of Mental Health2003–2012
Citalopram Decreases Amyloid-B Synthesis In Human CSFNational Institute On Aging2011
Neuroimaging In Depression Treatment StudiesNational Institute Of Mental Health2007–2011
Abnormality Of Emotional Circuitry As A Biomarker In PTSDNational Institute Of Mental Health2009–2010
Vascular Depression: Longitudinal FollowupNational Institute Of Mental Health2007–2010
PET Amyloid Plaque Imaging In LATE Life DepressionNational Center For Research Resources2007
PET Amyloid Plaque Imaging In LATE Life DepressionNational Institute Of Mental Health2006–2007
Treatment Outcome Of Vascular DepressionNational Center For Research Resources2004–2006
Neuroimaging In Depression Treatment StudiesNational Center For Research Resources2002–2006
Treatment Outcome Of Vascular DepressionNational Institute Of Mental Health2001–2005
Age Related Hippocampal Atrophy In Recurrent Major Depressive DisorderNational Center For Research Resources1998–2002
5-HT2A Binding Differences In LATE Life DepressionsNational Institute Of Mental Health1997–2001
Age-Related Hippocampal Volume Loss In Recurrent MDDNational Institute Of Mental Health1997–2000
Age Related Hippocampal Volume Loss In Recurrent MDDNational Institute Of Mental Health1996
Neurochemical Markers--Brain Blood Flow In Depression And Bipolar IllnessNational Center For Research Resources1996