XanthiCouroucliMDFAAP

PubMed

• Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1.
  Rachel Stading, Lauren Swanson, Guobin Xia, Weiwu Jiang, Lihua Wang
  Free Radical Biology & Medicine. 2024-02-01
• 7 citations
  Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells.
  Rebecca Burke, Chun Chu, Guodong Zhou, Vasanta Putluri, Nagireddy Putluri
  Oxidative Medicine and Cellular Longevity. 2021-10-15
• 15 citations
  The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury
  Rachel Stading, Xanthi I. Couroucli, Krithika Lingappan, Bhagavatula Moorthy
  Expert Opinion on Drug Metabolism & Toxicology. 2021-02-01

Journal Articles

• Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD)  
  Maturu P, Wei-Liang Y, Androutsopoulos VP, Jiang W, Wang L, Tsatsakis AM, Couroucli XI., Food Chem Toxicol., 1/1/2018
• Beta-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice  
  Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI, Toxicol Appl Pharmacol, 1/1/2018
• Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway  
  Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K, Am J Physiol Lung Cell Mol Physiol., 1/1/2017
• Vitamin A deficiency in adolescents: rare or underdiagnosed?  
  Couroucli X, Lancet, 1/1/2016
• Should we still use vitamin A to prevent bronchopulmonary dysplasia?  
  Couroucli XI, Placencia JL, Cates LA, Suresh GK, J Perinatol., 1/1/2016
• Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury  
  Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B, Biochem Biophys Res Commun, 1/1/2016
• Sex-specific Differences in Hyperoxic Lung Injury in mice: Role of Cytochrome P450 (CYP) 1A  
  Lingappan, K, Jiang, W., Wang, L., Couroucli, X., and Moorthy, B, Toxicology, 1/1/2015
• Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury  
  Wang L, Lingappan K, Jiang W, Couroucli XI, Welty S.E., Shivanna B, Barrios R, Wang G, M. Khan F Gonzalez FJ, Roberts LJ, and Moorthy B, Free Radic Biol Med, 1/1/2015
• Functional Deficiency of Aryl Hydrocarbon Receptor Augments Oxygen Toxicity-Induced AlveolarSimplification in Newborn Mice  
  Shivanna B, Zhang W, Jiang W, Welty SE, Couroucli XI, Wang L, Moorthy B., Toxicol Appl Pharmacol, 1/1/2013
• Sex-specific Differences in Hyperoxic Lung Injury in Mice: Implications for Acute and Chronic Lung Disease in Humans  
  Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B., Toxicol. Appl. Pharmacol, 1/1/2013
• Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibility to hyperoxic lung injury of transgenic mice exp...  
  Jiang W*, Couroucli XI*, Wang L, Barrios R, Moorthy B., Biochem Biophys Res Commun, 1/1/2011
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  Couroucli XI, Liang YH, Jiang W, Wang L, Barrios R, Yang P, Moorthy B., Toxicol Appl Pharmacol, 1/1/2011
• Disruption of the gene for cyp1a2, which is primarily expressed in liver, leads to differential regulation of hepatic and pulmonary mouse cyp1a1 expression, and augmen...  
  Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, Moorthy B, J. Pharmacol Exp Ther, 1/1/2010
• Mice lacking the Cytochrome P450(CYP)1A2 gene display increased levels of F2-isoprostanes, oxidative DNA adducts, and hyperoxic lung injury in vivo  
  Moorthy B, Wang L, Couroucli XI, Zhou GD, Jiang W, Proceedings of the 16th International Conference on Cytochromes P450. Medimond S.r.l. International Proceedings, 1/1/2008
• Attenuation of oxygen-induced lung maturation in rats by retinoic acid: Possible role of cytochrome P4501A enzymes  
  Couroucli XI, Wei YH, Jiang W, Barrios R, and Moorthy B., J Pharmacol Exp Ther, 1/1/2006
• Differential modulation of hyperoxic lung injury in mice deficient in the genes for CYP1A1, CYP1A2 or CYP2E1  
  Moorthy B, Wang L, Muthiah K, Couroucli X, and Jiang W, Proceedings of the 14th International Conference on Cytochromes P450: Biochemistry, Biophysics, and Bioinformatics Medimond S.r.l. International Proceedings, 1/1/2005
• Attenuation of hyperoxic lung injury by the cytochrome P4501A1 inducer, beta-naphthoflavone  
  Sinha A, Muthiah K, Jiang W, Couroucli XI, Barrios R, and Moorthy B., Toxicol Sci, 1/1/2005
• Disruption of the Ah receptor alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochrome P4501A expression, and exacerbates hy...  
  Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, Yu L, Avery SE, and Moorthy B., J Pharmacol Exp Ther, 1/1/2004
• Detection of Microorganisms in the Tracheal Aspirates of Preterm Infants by Polymerase Chain Reaction: Association of Congenital Adenovirus Infection with Bronchopulmo...  
  Couroucli XI, Welty SE, Ramsay P, Wearden ME, Fuentes FJ, Jacobs TN, Towbin JA, and Bowles NE., Pediatr Res, 1/1/2000
• Differential concentration-dependent effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro  
  Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K, Biochem Biophys Res Commun., 1/2./2014
• Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression  
  Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B, PLoS One., 1/8./2014
• Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal beta-napthoflavone (BNF) administration: Imp...  
  Maturu P1, Wei-Liang Y1, Jiang W1, Wang L1, Lingappan K1, Barrios R, Liang Y1, Moorthy B1, Couroucli XI, Toxicol Sci., 1/1./2017
• Mice deficient in the gene for cytochrome P450 (CYP) 1A1 are more susceptible than wild type to hyperoxic lung injury: evidence for protective role of CYP1A1 against o...  
  Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts JL, Moorthy B, Toxicol. Sci., 1/3./2014
• Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene  
  Thakur V, Wei Liang Y-H, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI, Toxicol Lett, 1/19/2014
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Abstracts/Posters

• Differential time-dependent effects of hyperoxia on gene expression profiling in lungs of newborn rats: Implications for bronchopulmonary dysplasia (BPD).
  Xanthi Couroucli, Yanhong Wei Liang, Weiwu Jiang, Krithika Lingappan, Bhagavatula Moorthy and Cristian Coarfa, Annual Pediatric Academic Societies Conference, Toronto, Canada, 1/1/2018
• Quercetin attenuates hyperoxic lung Injury in newborn mice: Implications for Bronchopulmonary Dysplasia (BPD).
  Couroucli, X, Paramahamsa Maturu, Yanhong Wei-Liang, Weiwu Jiang, Moorthy B., Annual Pediatric Academic Societies Conference, San Francisco, CA, 1/1/2017
• Differential Susceptibility of Cytochrome P450 (CYP)1a1/1a2 Double Knockout and Cyp1a1/1a2/1b1 triple knockout Mice to Hyperoxic Lung Injury in vivo.
  Moorthy B, Wang L, Veith A, Couroucli X, Lingappan K, Jiang W, Annual Pediatric Academic Societies Conference, Baltimore, MD, 1/1/2016
• Attenuation of hyperoxic lung injury in newborn wild type and cytochrome P450 (Cyp)1a1- null mice by the CYP1A inducer, beta-napthoflavone (BNF): Implications for bron...
  Couroucli XI, Wei-Liang Y, Wang L, Jiang W, Lingappan K, Moorthy B., Annual Pediatric Academic Societies Conference, Baltimore, MD, 1/1/2016
• Oral Prenatal Administration of the Cytochrome P450 (CYP)1A/1B Inducer, Beta-Napthoflavone (BNF), Attenuates Hyperoxic Lung Injury in Newborn Mice: Implications for Br...
  Couroucli XI, Liang YW, Lingappan K, Veith,A, Moorthy B., 55th Annual Society of Toxicology Meeting, New Orleans, LA, 1/1/2016
• Attenuation of Hyperoxic Lung Injury in Cyp1b1 Mice.
  Veith A.C., Bou Aram B, Jiang W, Wang L, Chu C, Couroucli XI, Moorthy B., 55th Annual Society of Toxicology Meeting, New Orleans, LA, 1/1/2016
• Role of Cytochrome P450(CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and the Proteome.
  Lingappan K, Maity S, Weiwu J, Wang L, Couroucli X, Coarfa C, and Moorthy B., 55th Annual Society of Toxicology Meeting, New Orleans, LA, 1/1/2016
• Molecular Regulation of Cytochrome P450 1A1 Induction by Hyperoxia in Human Pulmonary Cells
  Basu SK, Chun C, Maturu P, Kalikkot Thekkeveedu R, Jiang W, Couroucli XI, Moorthy B., Annual Pediatric Academic Societies Conference, San Diego, CA, 1/1/2015
• Cytochrome P450 (Cyp)1A1-Null, CYP1A2-null, and CYP1A1/1A2-Double Null Mice Display Differential Susceptibilities to Hyperoxic Lung injury In Vivo: Role of Oxidative D...
  Moorthy B, Wang L, Couroucli XI, Lingappan K, Zhou G, Jiang W, Annual Pediatric Academic Societies Conference, San Diego, CA, 1/1/2015
• Attenuation of Hyperoxic Lung Injury and Alveolar Simplification in Newborn Wild Type and Cytochrome P450 (Cyp)1a1-/- Mice by the CYP1A Inducer, Beta-Napthoflavone (BN...
  Couroucli XI, Liang YW, Wang L, Jiang W, Lingappan K, Moorthy B., Annual Pediatric Academic Societies Conference, San Diego, CA, 1/1/2015
• Attenuation of Hyperoxic Lung Injury in Cyp1b1-/- Mice.
  Veith AC, Aram BB, Jiang W, Wang L, Chu C, Couroucli X, Moorthy B, 54th Annual Society of Toxicology Meeting, San Diego, CA, 1/1/2015
• Cyp1a1-null, Cyp1a2-null, and Cyp1a1/1a2-double null mice display differential susceptibilities to hyperoxic lung injury: Role of oxidative stress.
  Moorthy B, Wang L, Couroucli XI, Lingappan K, Zhou G, Jiang W., 54th Annual Society of Toxicology Meeting, San Diego, CA, 1/1/2015
• Vitamin A (VA) prevents oxygen-induced retinopathy (OIR) in newborn rats via transcriptional regulation of VEGF-A and HIF-1alpha (HIF-1a)
  Couroucli XI, Maturu P, Liang YW, Jiang W, and Moorthy B, 54th Annual Society of Toxicology Meeting, San Diego, CA, 1/1/2015
• Conditional Deletion of Liver Cytochrome P450 Reductase (CPR) Gene in Mice Leads To Increased Susceptibility To Hyperoxic Lung Injury In Vivo.
  Moorthy B, Lihua Wang, Couroucli X, Lingappan K, Jiang W, Annual Pediatric Academic Societies Conference, Vancouver, Canada, 1/1/2014
• Molecular Mechanisms of Induction of Human Cytochrome P4501A1 Gene by Hyperoxia in H441 Lung Cells.
  Basu SK, Chu C, Couroucli XI, Weiwu J, Moorthy B., Annual Pediatric Academic Societies Conference, Vancouver, Canada, 1/1/2014
• Increased Susceptibility To Hyperoxic Lung Injury, Alveolar Simplification, and Capillary Distraction in Newborn Rats Exposed To Prenatal Benzo[a]pyrene: Protective Ro...
  Couroucli X, Thakur VS, Liang YW, Lingappan K, Wang L, Jiang W, Moorthy B., Annual Pediatric Academic Societies Conference, Vancouver, Canada, 1/1/2014
• Concentration-Dependent Effects of Caffeine on Cell Viability, Oxidative Stress and Cell Cycle in an In Vitro Model of Pulmonary Oxygen Toxicity
  Lingappan K, Tiwari KK, Chu C, Couroucli X, Moorthy B, Annual Pediatric Academic Societies Conference, Vancouver, Canada, 1/1/2014
• Increased susceptibility of mice lacking the gene for cytochrome P450 (CYP)1A1 to hyperoxic lung injury in vivo.
  Moorthy B, Lingappan K, Wang L, Couroucli XI, and Jiang W., 53rd Annual Society of Toxicology Meeting, Phoenix, AZ, 1/1/2014
• Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene.
  Couroucli X, Thakur VS, Liang YW, Jiang W, Wang L, and Moorthy B., 53rd Annual Society of Toxicology Meeting, Phoenix, AZ, 1/1/2014
• Transcriptomic changes in a murine hyperoxic lung injury model and analysis of sex-specific changes.
  Lingappan K, Jiang W, Wang L, Couroucli X, and Moorthy B., 53rd Annual Society of Toxicology Meeting, Phoenix, AZ, 1/1/2014
• Prevention of oxygen-induced experimental retinopathy in the newborn rat model by the cytochrome P4501 inducer, beta-naphthoflavone (beta-NF)
  Couroucli X, Liang Y, Thakur VS, Wang L, Chevez-Barrios P, Frishman L, Moorthy B, ARVO/ISOCB Conference, Oxford, UK, 1/1/2013
• Postnatal Administration of the Cytochrome P450 (CYP)1A Inducer, beta-naphthoflavone (BNF), Attenuates Hyperoxic Lung Injury in Newborn Wild Type and Cyp1a2-Null Mice:...
  Couroucli X, Liang Y, Wang L, Chu C., Society of Toxicology Meeting, San Francisco, CA, 1/1/2012
• Attenuation of hyperoxic lung injury in newborn mice by beta-naphthoflavone (BNF)
  Couroucli X, Liang Y, Jiang W, Moorthy B, 48th Congress of European Societies of Toxicology, Stockholm, Sweden, 1/1/2012
• Persistent Induction of CYP1A1 by 3-methylcholanthrene: Role of CYP1A2
  Moorthy B, Jiang W, Wang L, Couroucli X., 48th Congress of European Societies of Toxicology, Stockholm, Sweden, 1/1/2012
• Attenuation of Oxygen-Mediated Lung Injury in Newborn Wild Type and Cytochrome P450 (CYP)1A2-Deficient Mice by the CYP1A Inducer, beta-Napthoflavone (BNF): Implication...
  Couroucli X, Liang Y, Wang L, Jiang W, Moorthy B, Pediatric Academic Societies Annual Meeting, Boston, MA, 1/1/2012
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Lectures

• Increased Susceptibility To Hyperoxic Lung Injury, Alveolar Simplification and Capillary Destruction in Newborn Rats Exposed To Prenatal Benzo[a]pyrene: Protective Rol... 
  Universit� Paris Descartes, Paris, France - 1/1/2014
• Prevention of retinopathy of prematurity by BNF (beta naphthoflavone) in the newborn rat model. 
  John Radcliffe Hospital, Oxford, UK - 1/1/2013
• Attenuation of Oxygen-Mediated Lung Injury in Newborn Wild Type and Cytochrome P450 (CYP)1A2-Deficient Mice by the CYP1A Inducer, beta-Napthoflavone (BNF): Implication... 
  Boston, MA - 1/1/2012
• Prevention of retinal vaso-obliteration in oxygen induced retinopathy by flavonoids in the newborn rat. 
  Sydney, Australia - 1/1/2011
• Protection of retinal vessels from hyperoxic injury by beta-naphthoflavone (BNF) in newborn rats. 
  Washington, D.C. - 1/1/2011
• Attenuation of Hyperoxic Lung Injury in Newborn Wild Type and Cytochrome P450 (CYP) 1A2-Null Mice Exposed Prenatally to the CYP1A Inducer, b-Naphthoflavone 
  University of Paris, Paris, France - 1/1/2010
• Prevention of Oxygen-Induced Retinopathy by High Doses of Vitamin A in the Newborn Rat 
  Berlin, Germany - 1/1/2010
• Prevention of oxygen induced retinopathy by high doses of vitamin A in the newborn rat. 
  Berlin, Germany - 1/1/2010
• Prevention of experimental retinopathy of prematurity by vitamin A 
  Texas Children's Hospital - 1/1/2009
• Prevention of Experimental Retinopathy of Prematurity in the Newborn Rat by Retinoids 
  Bali, Indonesia - 1/1/2009
• Attenuation of hyperoxic lung injury by the cytochrome P450 (CYP)1A inducer beta-naphthoflavone (BNF) in neonatal wild type and CYP1A2-null mice. 
  Tokyo, Japan - 1/1/2009
• Prevention of experimental retinopathy of prematurity in the newborn rat by retinoids. 
  Bali, Indonesia - 1/1/2009
• Attenuation of hyperoxic lung injury in newborn wild type and cytochrome P450 (CYP)1a2-null mice exposed prenatally to the CYP1A inducer, betanaphthoflavone (BNF). 
  Baltimore, MD - 1/1/2009
• Prevention of oxygen-induced retinopathy in a newborn rat model by the flavonoid, beta-naphthoflavone 
  Hong Kong, China - 1/1/2008
• Prevention of oxygen induced retinopathy in the newborn rat by retinoids. 
  Texas Children's Hospital - 1/1/2008
• Alleviation of hyperoxic lung injury in neonatal wild type and cytochrome P450 (Cyp)1a2-null mice by the CYP1A inducer. 
  Honolulu, HI - 1/1/2008
• Prevention of Experimental Retinopathy of Prematurity by Vitamin A in the Newborn Rat Model 
  Rome, Italy - 1/1/2008
• Prevention of experimental retinopathy of prematurity by vitamin A in the newborn rat model. 
  Rome, Italy - 1/1/2008
• Attenuation of hyperoxia-induced retinopathies and abnormal neovascularization in the newborn rat by retinoic acid 
  Il Ciocco, Barga, Italy, 2006; Vienna, Austria, 2007 - 1/1/2007
• The Cytochrome P450(CYP)1A inducer beta-naphthoflavone (BNF) protects wild type neonatal mice and rescues CYP1A2-null mice from hyperoxic lung injury in vivo. 
  San Francisco, CA - 1/1/2007
• Attenuation of retinopathy of prematurity by retinoic acid 
  Department of Pediatrics, Baylor College of Medicine - 1/1/2006
• Attenuation of Hyperoxia-induced retinopathies and abnormal neovascularization in the newborn rat by retinoic acid. 
  Fort Lauderdale, FL - 1/1/2006
• Attenuation of Oxygen Induced Retinopathies by Retinoic Acid in Newborn Rats 
  Tuscany, Italy - 1/1/2006
• Regulation of cytochrome P4501A enzymes by hyperoxia and inhaled nitric oxide. 
  Baylor College of Medicine - 1/1/2005
• Alleviation of oxygen-induced lung injury in the newborn rat by retinoic acid (RA). 
  San Francisco, CA - 1/1/2000
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