WilliamTyorMD

PubMed

• 26 citations
  Interferon-α Induces Neurotoxicity Through Activation of the Type I Receptor and the GluN2A Subunit of the NMDA Receptor
  Cari F. Kessing, William R. Tyor
  Journal of Interferon & Cytokine Research. 2015-04-03
• 372 citations
  Oral simvastatin treatment in relapsing-remitting multiple sclerosis.
  Timothy Vollmer, L. Lyndon Key, Valerie Durkalski, William R. Tyor, John R. Corboy
  Lancet. 2004-05-15
• 15 citations
  Linked CSF reduction of phosphorylated tau and IL-8 in HIV associated neurocognitive disorder
  Tugba Ozturk, Alexander L. Kollhoff, Albert M. Anderson, J. Christina Howell, David W. Loring
  Scientific Reports. 2019-06-19

Journal Articles

• The recombinant vaccinia virus gene product, B18R, neutralizes interferon alpha and alleviates histopathological complications in an HIV encephalitis mouse model  
  Fritz-French C, Shawahna R, Ward JE, Maroun LE, Tyor WR, J Interferon and Cytokine Res, 1/1/2014
• Combined antiretroviral therapy reduces brain viral load and pathological features of HIV encephalitis in a mouse model  
  Koneru R, Olive MF, Tyor WR, J Neurovirol, 1/1/2013
• Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders  
  Tyor WR, Fritz-French C, Nath A, J Neurovirol, 1/1/2013
• Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause in...  
  Rao Vasudev R, Ujjwal Neogi, Joshua S Talboom, Ligia Padilla, Mustafizur Rahman, Cari Fritz-French, Sandra Gonzalez-Ramirez, Anjali Verma, Charles Wood, Ruth M Ruprech..., Retrovirology, 1/1/2013
• Interferon-alpha neurotoxicity  
  Fritz-French C, Tyor WR, Cytokine and Growth Factor Rev, 1/1/2012
• Morphine Exposure During HIV Encephalitis in SCID Mice  
  Tyor WR, Hwang HE, Fritz-French C, Neurochem Res, 1/1/2012
• Regulation of Th1/Th17 cytokine and IDO gene expression by inhibition of calpain in PBMCs from MS patients  
  Smith AW, Doonan BP, Tyor WR, Abou-Fayssal N, Haque A, Banik NL, J Neuroimmunol, 1/1/2011
• Interferon Alpha Causes Neuronal Dysfunction in Encephalitis  
  Sas A, Bimonte-Nelson H, Smothers CT, Woodward J, Tyor W, J Neurosci, 1/1/2009
• Reduced leukocyte chemotaxis and chemokine induction by a subtype C HIV isolate in vitro correlates with reduction in neuropathology and cognitive dysfunction in SCID ...  
  Rao V, Sas A, Eugenin E, Siddappa N, Bimonte-Nelson H, Berman J, Ranga U, Tyor WR, Prasad VR, J Neurosci, 1/1/2008
• Chronic cocaine exposure in a SCID mouse model of HIV encephalitis  
  Griffin WC, Middaugh LD, Tyor WR, Brain Research, 1/1/2007
• Increased Calpain Correlates with Th1 Cytokine Profile from MS Patients  
  Imam S, Guyton MK, Haque A, Vandenbark A, Tyor WR, Ray SK, Banik NL, J. Neuroimmunol, 1/1/2007
• The use of statins in multiple sclerosis  
  Tyor WR, Inderjit Singh, Timothy Vollmer, Lyndon Key, John Corboy, Silva Markovic-Plese, Jana Preningerova, Valerie Durkalski, Marco Rizzo, International J Multiple Sclerosis Care, 1/1/2006
• The pathogenesis of HIV-associated dementia: Recent advances using a SCID mouse model of HIV encephalitis  
  Cook J, Tyor WR, Einstein J Biol Med, 1/1/2006
• Impact of Opiate-HIV-1 interactions on neuronal signaling  
  Hauser KF, El-Hage N, Buch S, Nath A, Tyor WR, Bruce-Keller AJ, Knapp PE, J Neuroimmune Pharm, 1/1/2006
• Commentary: Infections and MS  
  Tyor W, International J MS Care, 1/1/2006
• Molecular targets of opiate drug abuse in NeuroAIDS  
  Hauser KF, El-Hage N, Berger JR, Tyor WR, Nath A, Bruce-Keller AJ, Knapp PE, Neurotoxicity Res, 1/1/2005
• Upregulation of Calpain Correlated with Increased Neurodegeneration in Acute Experimental Allergic Encephalomyelitis  
  Guyton M.K., Wingrave J.M., Yallapragada A.V., Wilford Gloria G., Sribnick Eric A., Matzelle D.D., Tyor W.R., Ray Swapan K., Banik Naren, J Neurosci Res, 1/1/2005
• Highly active antiretroviral therapy of HIV-encephalitis in immunodeficient mice  
  Cook J, Dasgupta S, Terry E, Gorry P, Wesselingh S, Middaugh L, and Tyor W, Ann Neuro, 1/1/2005
• The SCID mouse model of HIV encephalitis: Deficits in cognitive function  
  Griffin WC, Cook JE, Middaugh L, Tyor WR, J NeuroVirol, 1/1/2004
• Treatment of spinal cord injury in the rat with Transforming Growth Factor-beta 1  
  Tyor WR, Avgeropoulos N, Ohlandt G, Hogan EL, J Neurol Sci, 1/1/2002
• Recombinant interferon-alpha-induced chorea and frontal sub-cortical dementia (Letter to the Editor)  
  Zhang R, Tyor WR, Neurology, 1/1/2002
• A randomized, comparative study of interferon beta dose in MS: the EVIDENCE trial  
  H Panitch, MD, D Goodin, MD, PK Coyle, MD, P O'Connor, MD, B Weinshenker, MD, for the EVIDENCE (EVidence of Interferon Dose-response: European North American Comparati..., Neurology, 1/1/2002
• Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration  
  Shields DC, Avgeropoulos NG, Banik NL, Tyor WR, Neurochem Research, 1/1/2000
• Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis  
  Jacobs LD, Beck RW, Simon JH, et.al., N. Eng. J. Med., 1/1/2000
• Do drugs of abuse alter the onset and course of HIV-associated dementia complex?  
  Tyor WR, Middaugh LD, J Leukocyte Biol, 1/1/1999
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Books/Book Chapters

• Handbook of Clinical Neurology 
  Chapter: Mumps and Rubella. 
  Page 591 - 600Tyor W, Harrison TEditors: Tselis A and Booss J.Elsevier2013
• Viral Infections of the Human Nervous System 
  Chapter: T. Human Immunodeficiency Virus Infection/AIDS. 
  Page 145 - 181Rumbaugh J, Harrison T, Tyor WREditors: Jackson A.Springer Basel2012
• Handbook of Neurochemistry and Molecular Neurobiology 
  Chapter: Pathogenesis and treatment of HIV-associated dementia: Recent studies in a SCID mouse model. 
  Page 471 - 489Tyor WREditors: Banik N.Springer-Verlag Berlin Heidelberg2009
• NORD Guide to Rare Disorders 
  Chapter: Selected Encephalitides. 
  Page 284 - 285Kaliszky Z, Tyor WRLippincott Williams & Wilkins, Philadelphia, PA2003
• Drug Therapy Pocket 
  Chapter: Neurology. 
  Carter T, Kaliszky Z, Pritchard P, Tyor W and Walker AEditors: Philipp Boerm, M.D..Borm Bruckmeier Publishing LLC, Hermosa Beach, CA2003
• Expert Rev Neurotherapeutics 
  Chapter: Therapeutic Options in Neurosarcoidosis. 
  Kaliszky Z, Walker A, Tyor WR2002
• Current Treatment Options in Neurology 
  Chapter: Neurosarcoidosis. 
  Walker A, Tyor W2001
• Current Opinion in Neurology 
  Chapter: Update on Viral Encephalitis. 
  Page 369 - 374Hinson V, Tyor WREditors: Frackowiak R, editor; Young A, deputy editor, Irani D, section editor.Lippincott, Williams & Wilkins2001
• Practical Neuro-immunology 
  Chapter: Fundamentals of Immunology. 
  Page 3 - 33Tyor WREditors: Rolak LA, Harati Y.Butterworth Heinemann1997
• Neurological and Neuropsychiatric 
  Chapter: Nontransgenic Murine Animal Model Systems for the HIV-associated Cognitive Motor Complex. 
  Page 168 - 178Persidsky Y, Tyor WREditors: Gendelman HE, Lipton S, Epstein L, Swindells S.Chapman & Hall Publishers1997
• Office Practice of Neurology 
  Chapter: Acute disseminated encephalomyelitis. 
  Page 357 - 359Tyor WREditors: Samuels MH, Feske S, Mesalamm, Pessin MS, Preston DC, Rolak LA, Spierings ELH, Sudarsky LR, Wen P.Churchill-Livingstone, Inc.1996
• Cytokines and the CNS: Development, Defense and Disease 
  Chapter: Cytokines and Disease: HIV-Associated Dementia. 
  Page 287 - 307Wesselingh SL, Tyor WR, Griffin DEEditors: Benveniste T, Ransohoff R.CRC Press1996
• HIV, AIDS and the Brain 
  Chapter: Cytokine expression and pathogenesis in AIDS brain. 
  Page 203 - 222Vitkovic L, da Cunha A, Tyor WREditors: Price RW, Berry SW.Raven Press1994
• Current Therapy in Neurological Diseases 
  Chapter: Post-infectious encephalomyelitis and transverse myelitis. 
  Page 155 - 157Tyor WREditors: Johnson RT, Griffin JW.Mosby-Yearbook Publishers1993
• Neurotropic Viruses and Immunity 
  Chapter: Immune Responses and the Central Nervous System. 
  Page 15 - 39Tyor WR, Johnson RTEditors: Spector S, Bendinelli M, Friedman H.Plenum Publishing1992
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Abstracts/Posters

• MRI and CSF Analysis of Cognitive Impairment in Multiple Sclerosis.
  Ganesh G, Tyor W, Saindane A, Wandler E, Lava N, Drane D, Hu W, Consortium of MS Centers Meeting, Dallas, TX, 1/1/2014
• The Effects of a Novel Interferon Inhibitor in a Model of HIV Encephalitis.
  Tyor WR, Kessing C, Shawahna R, Ward JE, Maroun LE, American Academy of Neurology Meeting, Philadelphia, PA, 1/1/2014
• A Novel Interferon-alpha Inhibitor Reduces Histopathological Complications in a Mouse Model of HIV Encephalitis.
  Fritz-French C, Shawahna R, Ward JE, Maroun LE, Tyor WR, The 5th FIP Pharmaceutical Sciences World Congress, Melbourne, Australia, 1/1/2014
• HIV-1 gp120 and Tat are determinants of intra-clade, regional differences in the neurovirulence of Clade C isolates.
  Rao VR, Neogi U, Talboom J, Eugenin E, Prasadarao N, Bimonte-Nelson H, Tyor W, Prasad VR, International Society for Neurovirology Meeting, Washington, DC, 1/1/2013
• Interferon-alpha is toxic to neurons in vitro.
  Fritz-French C, Zhang L, Bassell G, Tyor WR, International Society for Neurovirology Meeting, Washington, DC, 1/1/2013
• Interferon-alpha is toxic to neurons in vitro.
  Fritz-French C, Zhang L, Bassell G, Tyor WR, American Association of Immunologists Annual Meeting, Honolulu, HI, 1/1/2013
• Clade C HIV-1 isolates from Southern Africa bear a unique genetic signature in Tat and display a higher frequency of dicysteine motif containing variants that cause in...
  Rao VR, Neogi U, Talboom J, Padilla L, Rahman M, Eugenin E, Fritz-French C, Gonzalez S, Prasadarao N, Wood C, Ruprecht R, Ranga U, Azim T, Joska J, Shet A, Bimonte-Nel..., Cold Spring Harbor, 1/1/2013
• HIV associated dementia as a surrogate human model for Down Syndrome Cognitive difficulties.
  Maroun LE, Jagadeesh A, Gutman LB, Ward JE, Tyor WR, Conference on Cognition in Down Syndrome, Washington, DC, 1/1/2013
• CSF Interferon Alpha Levels Inversely Correlate with Processing and Motor Speed in HIV-infected Subjects with Cognitive Complaints with and without HAND.
  Anderson AM, Loring DW, Lennox JL, Patel N, Fritz-French C, Sethi N, Rosen J, Koneru R, and Tyor WR, Conference on Retroviruses and Opportunistic Infections, Atlanta, GA, 1/1/2013
• In vitro Studies of Interferon-alpha Neurotoxicity.
  Fritz-French C, Zhang L, Bassell G, Tyor WR, American Association of Immunologists, Boston, MA, 1/1/2012
• In vitro Studies of Interferon-alpha Neurotoxicity.
  William Tyor, Cari Fritz-French, Kristy Welshhans, Lynn Zhang, Andrew Sas, Gary Bassell, American Academy of Neurology Meeting, New Orleans, LA, 1/1/2012
• An Optimal Thrombin Concentration Preserves Dendritic Branching in Cortical Neuron Cultures.
  Woodbury A, Maddi M, Fidler J, Fritz-French C, Tyor WR, Garcia PS, American Society of Anesthesiologists Annual Meeting, Washington, DC, 1/1/2011
• Mechanisms underlying clade-specific differences in HIV associated neuropathogenesis.
  Vasudev R. Rao, Ligia Padilla, Cari Fritz-French Heather Bimonte-Nelson, William R. Tyor and Vinayaka R. Prasad, Cold Spring Harbor Laboratory Meeting on Retroviruses, Cold Spring Harbor, NY, 1/1/2011
• HIV-1 Tat Increases Hydrogen Peroxide and 5-Lipoxygenase in Pulmonary Artery Endothelial Cells.
  K.M. Porter, Cari Fritz-French, William Tyor, and Roy L. Sutliff, Experimental Biology Research Conference, Washington, DC, 1/1/2011
• SCID Mice with HIV Encephalitis Treated with B18, a Novel Interferon-alpha Blocker.
  W Tyor, Hee Young Hwang, Cari Fritz-French, Jennifer Ward, Leonard Maroun, American Academy of Neurology Meeting, Honolulu, HI, 1/1/2011
• Treatment of mice with HIV encephalitis with a novel interferon-alpha blocker.
  Tyor WR, Fritz-French C, Hwang HY, Padilla L, Koneru R, Ward, J, Dettenhofer M, Maroun L, American Neurological Association Meeting, San Francisco, CA, 1/1/2010
• Treatment of mice with HIV encephalitis with a novel interferon-alpha blocker.
  Tyor WR, Fritz-French C, Hwang HY, Padilla L, Koneru R, Ward, J, Dettenhofer M, Maroun L, American Academy of Neurology Meeting, Toronto, Canada, 1/1/2010
• Cerebellar dysfunction and neurocognitive impairment in multiple sclerosis.
  Lee-Wilk T, Kane R, Wallin M, Finkelstein J, Bever C, Maloni H, McCarthy M, Tyor W, Levin M, Hershey L, Royal W, American Neurological Association Meeting, Baltimore, MD, 1/1/2009
• Opiate interactions in SCID mice with HIV encephalitis.
  WR Tyor, Sas A , Jones R, Xu R, Knapp P, Hauser K, American Academy of Neurology, Seattle, WA, 1/1/2009
• Cerebellar dysfunction is associated with neurocognitive impairment in multiple sclerosis patients.
  Lee-Wilk T, Royal W, Wallin M, Finklestein J, Bever C, Maloni H, McCarthy M, Tyor W, Levin M, Hershey L, Kane R, Consortium of MS Centers Meeting, Atlanta, GA, 1/1/2009
• Concurrent diagnosis of multiple sclerosis and HIV infection in US military veterans.
  Vargas DL, Culpepper J, Berger J, McCarthy M, Tyor W, Levin M, Bever C, Royal W, American Neurological Association Meeting, Baltimore, MD, 1/1/2009
• Morphine interactions with HIV encephalitis in SCID mice.
  WR Tyor, Jones R, Hauser K, Sas A, American Neurological Association, Salt Lake City, UT, 1/1/2008
• CD454RA+ T Helper Cell Percentages Correlate with Measures Related to Cognitive Function in Patients with Multiple Sclerosis (MS).
  Royal W, Wallin M, Kane R, Maloni HW, Culpeper WJ, McCarthy M, Tyor WR, Mia Y, Ford D, Bever C, American Academy of Neurology, Chicago, IL, 1/1/2008
• Neutralizing antibody treatment against interferon-alpha in SCID mice with HIV encephalitis and interferon-alpha neurotoxicity.
  Tyor WR, Bimonte-Nelson H, Smothers C, Woodward J, Sas A, American Academy of Neurology, Chicago, IL, 1/1/2008
• Neutralizing antibody to interferon-alpha treatment in SCID mice with HIV encephalitis.
  Tyor WR, Sas A, Bimonte-Nelson H, International Society for NeuroVirology, San Diego, CA, 1/1/2007
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Lectures

• Invited Speaker: "Brief overview of MS and studies at the Emory/Atlanta VAMC MS Center." 
  1/1/2014
• Invited Speaker: "HIV Associated Neurocognitive Disorders." 
  University of Florida School of Medicine, Department of Neurology - 1/1/2014
• Invited Speaker: "Relapsing remitting MS: Focus on newer agents." 
  Las Vegas, NV - 1/1/2012
• Invited Speaker: "New and emerging immunotherapies for multiple sclerosis: oral agents." 
  Las Vegas, NV - 1/1/2012
• Visiting Professor/Grand Rounds: "HIV associated neurocognitive disorders." 
  North Shore LIJ Health System, Department of Neurology, Great Neck, NY - 1/1/2012
• Invited Speaker: "MS treatment issues: Relapsing disease-Interferons and glatiramer acetate." 
  Orlando, FL - 1/1/2011
• Invited Speaker: "Treating Multiple Sclerosis: What are the current and future therapies?" 
  Charleston, SC - 1/1/2011
• Invited Speaker: "Current and future treatment of multiple sclerosis." 
  Atlanta, GA - 1/1/2010
• Invited Speaker: "Safety Issue When Using Monoclonal Antibodies and Emerging Therapies in MS." 
  Atlanta, GA - 1/1/2010
• Invited Speaker: "Taking Care of MS Patients" 
  Charleston, SC - 1/1/2010
• Invited Speaker: "Update on MS Disease Modifying Therapies." 
  Charleston, SC - 1/1/2010
• Invited Speaker: "Cladribine." 
  Baltimore, MD - 1/1/2010
• Visiting Professor/Grand Rounds: "The potential role of interferon-alpha in HIV associated neurocognitive disorders." 
  Johns Hopkins University School of Medicine Department of Neurology, Baltimore, MD - 1/1/2010
• Invited Speaker: "Multiple Sclerosis Research." 
  Destin, FL - 1/1/2009
• Invited Speaker: "MS Models of Care." 
  Baltimore, MD - 1/1/2008
• Invited Speaker: "Cocaine administration in SCID mice with HIV encephalitis." 
  Charlotte, SC - 1/1/2008
• Visiting Professor: "Interferon-alpha: A potentially treatable cause of cognitive dysfunction in HIV-associated dementia." 
  Emory University School of Medicine Department of Neurology - 1/26/2007
• Invited Speaker: "Immunomodulating monoclonal antibodies should be used in MS patients: Con." 
  Baltimore, MD - 1/10/2007
• Invited Speaker: "Advances in MS Research: Tysabri and Beyond." 
  Atlanta, GA - 1/7/2007
• Invited Speaker: "Fatigue and MS." 
  Charlotte, NC - 1/1/2007
• Invited Speaker: "Newest potential treatments for MS." 
  Charlotte, NC - 1/28/2006
• Invited Speaker: "Fatigue and MS" 
  Charlotte, NC - 1/28/2006
• Invited Speaker: "Clade B and C infections in the SCID mouse model of NeuroAIDS." 
  Curitiba, Brazil - 1/21/2006
• Invited Speaker: "MS associated viruses: Who's next ?" 
  Baltimore, MD - 1/18/2006
• Invited Speaker: "Multiple Sclerosis: Advanced therapies." 
  Orangeburg Regional Medical Center - 1/17/2005
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Other

• Degenerative Brain Diseases Caused by "Slow" Viruses and UnConventional Agents (PRIONS). 
  Goust JM, Tyor WR, "Infection and Immunity" Course Syllabus (Gabriel Virella. M.D., Ph.D., editor)
  Medical University of South Carolina, Charleston - 1/1/2003