WilliamMullerMDPhD

PubMed

• FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration.
  Can Tan, Zhi-Dong Ge, Shreya Kurup, Yaryna Dyakiv, Ting Liu
  Arteriosclerosis, Thrombosis, and Vascular Biology. 2024-09-01
• A physiologic roll for cell surface GlycoRNAs.
  William A Muller
  Journal of Leukocyte Biology. 2024-05-29
• 2 citations
  Mitochondria regulate proliferation in adult cardiac myocytes.
  Gregory B Waypa, Kimberly A Smith, Paul T Mungai, Vincent J Dudley, Kathryn A Helmin
  The Journal of Clinical Investigation. 2024-05-09

Journal Articles

• Targeted recycling of the LBRC precedes adherens junction dissociation during transendothelial migration  
  Gonzalez, AM, BF Cyrus, WA Muller, Am. J. Pathol., 1/1/2016
• A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 (KLC1C) in Leukocyte Transendothelial Migration  
  Cyrus, BF and WA Muller, Am. J. Pathol., 1/1/2016
• Cutting Edge: CD99 is a novel therapeutic target for control of T-cell mediated CNS autoimmune disease  
  Winger, RC, CT Harp, M-Y Chiang, DP Sullivan, RL Watson, EW Weber, JR Podojil, SD Miller, and WA Muller, J. Immunol., 1/1/2016
• 4-D intravital microscopy reveals strain-dependent differences for the roles of PECAM and CD99 in leukocyte diapedesis  
  Sullivan, D., R.L. Watson, and W.A. Muller, Am J Physiol Heart Circ Physiol, 1/1/2016
• Identification of a severe bleeding disorder in humans caused by a mutation in CalDAG-GEFI  
  Muller WA, The Journal of Experimental Medicine, 1/1/2014
• Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice  
  Lishnevsky, M., L.C. Young, S.J. Woods, S.D. Groshong, R.J. Basaraba, J.M. Gilchrist, D.M. Higgins, M. Gonzalez-Juarrero, T.A. Bass, W.A. Muller, and A.R. Schenkel, Experimental and Molecular Pathology, 1/1/2014
• Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99 Efficient large scale purification from periplasmic inclusion bodies in E coli e...  
  Moricoli, D., WA Muller, DC Carbonella, MC Balducci, S Dominici, R Watson, V Fiori, E Weber, M Cianfriglia, K Scotlandi, and M Magnani, Journal of Immunological Methods, 1/1/2014
• Poliovirus receptor (CD155) regulates a step in transendothelial migration between PECAM and CD99  
  Sullivan, DP, MA Seidman, WA Muller, Am. J. Pathol., 1/1/2013
• Mechanisms of Leukocyte Transendothelial Migration  
  Muller WA, Ann. Rev. Pathol. Mech. Dis., 1/1/2011
• HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes  
  Wu J, Z Liu, C Shao, Y Gong, E Hernando, P Lee, M Narita, W Muller, J Liu, JJ Wei, Cancer Res, 1/1/2011
• Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity  
  Privratsky, JR, CM Paddock, O Florey, DK Newman, WA Muller, PJ Newman, J Cell Sci, 1/1/2011
• Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment  
  Mamdouh Z, A Mikhailov, WA Muller, J. Exp. Med., 1/1/2009
• A novel and critical role for tyrosine 663 in PECAM trafficking and transendothelial migration  
  Dasgupta B, E Dufour, Z Mamdouh, WA Muller, J. Immunol., 1/1/2009
• Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages  
  Westhorpe CLV, J Zhou, NL Webster, B Kalionis, SR Lewin, A Jaworowski, WA Muller, SM Crowe, J. Leukoc. Biol., 1/1/2009
• Mechanisms of Transendothelial Migration of Leukocytes  
  Muller WA, Circ. Res., 1/1/2009
• Endothelial Src kinase regulates membrane recycling from the Lateral Border Recycling Compartment (LBRC) during leukocyte transendothelial migration (TEM)  
  Dasgupta B and WA Muller, Eur. J. Immunol., 1/1/2008
• CD99 is essential for leukocyte diapedesis in vivo  
  Dufour EM, A DeRoche, Y Bae, WA Muller, Cell Commun. Adhes., 1/1/2008
• Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the Lateral Border Recycling Compartment  
  Mamdouh Z, GE Kreitzer, WA Muller, J. Exp. Med., 1/1/2008
• Tonsilar NK cells restrict B cell transformation by the Epstein Barr virus via IFNgamma  
  Strowig T, F Brilot, F Arrey, G Bougras, D Thomas, WA Muller, C. Munz, PLOS Pathog, 1/1/2008
• Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms  
  Reinke, E.K., J. Lee, A. Zozulya, J. Karman, W.A. Muller, M. Sandor, and Z. Fabry, J Neuroimmunol, 1/1/2007
• CD99 is a key mediator of the transendothelial migration of neutrophils  
  Lou, O., P. Alcaide, F.W. Luscinskas, and W.A. Muller, J. Immunol., 1/1/2007
• NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion  
  Morandi, B, G Bougras G., WA Muller, G Ferlazzo, C Munz, Eur J Immunol, 1/1/2006
• Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation  
  Han H., J Roberts, O Lou, WA Muller, N Nathan, C Nathan, J Leukoc Biol, 1/1/2006
• Transendothelial migration of monocytes: The underlying molecular mechanisms and consequences of HIV-1 infection  
  Maslin CLV, K Kedzierska, NL Webster, WA Muller, SM Crowe, Current HIV Research, 1/1/2005
• Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection  
  Maslin, C.L., K. Kedzierska, N.L. Webster, W.A. Muller, and S.M. Crowe, Curr HIV Res, 1/1/2005
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Books/Book Chapters

• Williams' Hematology 
  Chapter: "Vascular Function in Hemostasis." 
  Hajjar, KA, AJ Marcus, WA MullerEditors: K Kaushansky, MA Lichtman, E Beutler, TJ Kipps, U Seligsohn, JT Prchal.McGraw-Hill, McGraw-HillEdition 9th,2015
• Current Topics in Membranes 
  Chapter: "How Endothelial Cells Regulate Transendothelial Migration of Leukocytes: Molecules and Mechanisms." 
  Muller WAEditors: Ley, K.Academic Press, Burlington2009
• Methods in Enzymology, Vol. 443 Angiogenesis: In Vitro Systems 
  Chapter: "Assays of Transendothelial Migration in vitro." 
  Page 155 - 176Muller WA and FW LuscinskasEditors: Cheresh, D.2008
• Adhesion Molecules: Function and Inhibition 
  Chapter: "PECAM: Regulating the start of diapedesis." 
  Page 201 - 235Muller WAEditors: K. Ley.Birhhauser Publishing, Basel, Switzerland2007
• Williams' Hematology 
  Chapter: "Vascular Function in Hemostasis" 
  Page 1715 - 1739Hajjar, KA, NL Esmon, AJ Marcus, WA MullerEditors: E Beutler, MA Lichtman, TJ Kipps, U Seligsohn, K Kaushansky, JT Prchal.McGraw-Hill, New YorkEdition 7th,2006
• Cell Migration in Development and Disease 
  Chapter: Transendothelial Migration of Leukocytes. 
  Page 237 - 249Muller WA and AR SchenkelEditors: Wedlich D.Wiley-VCH Verlag, Weinheim, Germany2005
• Wiley Encyclopedia of Molecular Medicine 
  Chapter: CD31 (PECAM-1) 
  Page 588 - 591Muller WAEditors: Creighton, TE.John Wiley & Sons, Inc., New York2002
• Williams' Hematology 
  Chapter: Vascular function in hemostasis. 
  Page 1451 - 1469Hajjar KA, NL Esmon, AJ Marcus, WA MullerEditors: Beutler, et al.McGraw-Hill, New York, NYEdition 6th,2000
• Methods in Molecular Biology, vol. 121: Natural Killer Cell Protocols: Cellular and Molecular Methods 
  Chapter: Assay for the transendothelial migration of human natural killer cells. 
  Page 115 - 123ME Berman and WA MullerEditors: K.S. Campbell and M. Colonna.The Humana Press, Inc., Totowa, NJ1999
• Vascular Adhesion Molecules and Inflammation 
  Chapter: The Role of PECAM-1 in Leukocyte Emigration. 
  Page 125 - 140Muller WAEditors: Pearson, J..Birkhauser Verlag Publishing Ltd., Basel, Switzerland1999
• Inflammation: Basic Principles and Clincal Correlates 
  Chapter: Leukocyte-endothelial cell adhesion molecules in transendothelial migration. 
  Page 585 - 592Muller WAEditors: Gallin, J, R Snyderman, D Fearon, B Haynes, C Nathan.Lippincott Williams & Wilkins, Philadelphia1999
• Leukocyte Typing VI. White Cell Differentiation Antigens 
  Chapter: Transendothelial migration and interstitial migration of monocytes are mediated by separate domains of monocyte CD31. 
  Page 370 - 372Muller WA, T Greene, F LiaoGarland Publishing, Inc., New York1997
• Leukocyte Typing VI. White Cell Differentiation Antigens 
  Chapter: CD31 Workshop Panel Report. 
  Page 362 - 364Muller WAGarland Publishing, Inc., New York1997
• Handbook of Experimental Immunology, v. 2B, Section 3 The Myeloid System 
  Chapter: Assays of transendothelial migration in vitro. 
  Page 1641 - 1646Muller WAEditors: Weir, DM, L.A. Herzenberg, C. Blackwell, L.A. Herzenberg.Blackwell Scientific Publications, Inc., Cambridge, MAEdition 5th,1997
• Leukocyte Recruitment In Inflammatory Disease. Section I. Molecular and Cellular Components 
  Chapter: Transendothelial Migration of Leukocytes. 
  Page 3 - 18Muller WAEditors: G. Peltz.R.G. Landes Company, Austin, TX1996
• Methods in Molecular Biology, v. 27. Biomembrane Protocols: II. Architecture and Function 
  Chapter: Biochemical methods to determine cell surface topography. 
  Page 31 - 42Muller WAEditors: Graham, J. and Higgins, J..The Humana Press, Totowa, NJ1994
• Methods in Molecular Biology, v. 27. Biomembrane Protocols: II. Architecture and Function 
  Chapter: Determination of cell-surface polarity by solid-phase lactoperoxidase iodination. 
  Page 19 - 30Muller WAEditors: Graham, J. and Higgins, J..The Humana Press, Totowa, NJ1994
• Mononuclear Phagocytes. The Proceedings of the Fifth Leiden Meeting on Mononuclear Phagocytes 
  Chapter: PECAM-1: An adhesion molecule at the junctions of endothelial cells. 
  Page 138 - 148Muller WAEditors: van Furth, R., Cohn, Z.A., and Gordon, S..Blackwell Publishers, London1992
• Methods in Enzymology, Vol. 98 Biomembranes Part L. Membrane Biogenesis: Processing and Recycling 
  Chapter: Intracellular iodination of lysosome membrane for studies of membrane composition and recycling. 
  Page 404 - 415Muller WA, RM Steinman, ZA CohnEditors: Fleischer S, Fleischer B.Academic Press, New York1983
• Mononuclear Phagocytes: Functional Aspects 
  Chapter: Membrane flow during endocytosis. 
  Page 595 - 612Muller WA, RM Steinman, ZA CohnEditors: van Furth R, Cohn ZA.Martinus Nijhoff, The Hague1980
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Lectures

• "Leukocyte/endothelial cell signaling during transmigration." 
  Houston, TX - 1/20/2016
• "Endothelial cell regulation of transendothelial migration." 
  Girona, Spain - 1/17/2016
• "Endothelial cell PECAM and CD99 signaling pathways that regulate transendothelial migration." 
  Weill Cornell Medical Center, New York, NY - 1/13/2016
• "How Endothelial Cells Regulate Egress of Leukocytes During Inflammation." 
  Brown University School of Medicine, Providence, RI - 1/11/2016
• "Coordination of endothelial cell membrane movements that promote leukocyte transmigration." 
  Oregon Health & Science University, Portland, OR - 1/7/2016
• "Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration." 
  Boston, MA - 1/28/2015
• "Novel endothelial cell signals that regulate transendothelial migration of leukocytes in vitro and in vivo." 
  Feinberg School of Medicine, Chicago, IL - 1/24/2015
• "How endothelial cell PECAM and CD99 regulate transendothelial migration." 
  University of Wisconsin - 1/20/2015
• "Novel endothelial cell signaling mechanisms that regulate leukocyte transendothelial migration." 
  Keuth, Germany - 1/13/2015
• "New insights into the regulation of transendothelial migration by endothelial cells." 
  Department of Pathology, Brigham and Women's Hospital, Boston, MA - 1/19/2014
• "Novel Endothelial Signaling Pathways that Regulate Transendothelial Migration of Leukocytes." 
  Chicago, IL - 1/15/2014
• "The Lateral Border Recycling Compartment and the Regulation of Transendothelial Migration." 
  Chicago, IL - 1/14/2014
• "Novel mechanisms regulating transendothelial migration." 
  1/8/2014
• "How Endothelial CD99 Signals though Soluble Adenylyl Cyclase to Regulate Transendothelial Migration." 
  Tufts Medical Center, Boston, MA - 1/2/2014
• "Sequential molecular interactions in endothelial cells that regulate transmigration of leukocytes." 
  1/27/2013
• "Sequential Molecular Interactions that Regulate Leukocyte Transendothelial Migration: Studies in vitro and in vivo." 
  1/22/2013
• "How Endothelial Cells Regulate Transmigration of Leukocytes in the Inflammatory Response." 
  Boston, MA - 1/21/2013
• "Regulation of Leukocyte Transmigration by the Endothelial Cell LBRC." 
  1/20/2013
• "How Endothelial Cells Regulate Diapedesis of Leukocytes in Inflammation." 
  Ludwig-Maximilians-Universitat Munchen, School of Medicine, Munich Germany - 1/19/2013
• How endothelial cells regulate leukocyte transmigration. 
  University of Minnesota - 1/16/2012
• Membrane recycling: Still essential after all these years. 
  The Rockefeller University, New York, NY - 1/14/2012
• How the endothelial cell Lateral Border Recycling Compartment Regulates Leukocyte Transmigration 
  Wiesbaden, Germany - 1/2/2012
• How vascular endothelial cells regulate leukocyte influx in inflammation. 
  1/27/2011
• The Endothelial Cell Lateral Border Recycling Compartment Regulates Transendothelial Migration of Leukocytes(and tumor cells?) 
  Arizona State University - 1/20/2011
• Targeted trafficking of membrane from the LBRC controls leukocyte transendothelial migration. 
  1/15/2011
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Other

• Sorting the signals from the signals in the noisy environment of inflammation. 
  Muller WA, Science Signaling
  1/1/2011
• Transmigratory cups: Half-full or half-empty? 
  Muller WA, Nature Immunology, Vol. 9, Online Focus "Outstanding Questions" supplement to focus issue on Leukocy
  http://www.nature.com/ni/focus/trafficking/questions.html
  1/1/2008
• The Membrane Polypeptides of the Vacuolar System: Composition and Recycling 
  Muller WA, Ph.D. Thesis, The Rockefeller University
  1/1/1981
• Isolation and Preliminary Characterization of the DNA of Porphyridium aerugineum. 
  Muller WA, Honors Thesis, Harvard College
  1/1/1975
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