WilliamMitchellMD

PubMed

• 1 citations
  Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action.
  Angela Corona, David Strayer, Simona Distinto, Gian Luca Daino, Annalaura Paulis
  Antiviral Research. 2023-04-01
• 12 citations
  Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
  David R. Strayer, Diane Young, William M. Mitchell
  Plos One. 2020-10-29
• 112 citations
  Tumor Cell-Free DNA Copy Number Instability Predicts Therapeutic Response to Immunotherapy
  Glen J. Weiss, Julia Beck, Donald P Braun, Kristen Bornemann-Kolatzki, Heather Barilla
  Clinical Cancer Research. 2017-09-01

Journal Articles

• Antibody-dependent Enhancement of SIV Infection In Vitro by Plasma from SIV Infected Rhesus Macaques.  
  Montefiori, D.C., Robinson, W.E., Jr., Hirsch, V.M., Modliszewski, A., Mitchell, W.M., and Johnson, P.R, J. Virol. 64:113-119
• Inactivation of a Common Epitope Responsible for the Induction of Antibody-Dependent Enhancement of the Human Immunodeficiency Virus.  
  Mitchell, W.M., Ding, L., and Gabriel, J, AIDS 12:147-156
• Multiple Sclerosis Associated with Chlamydia pneumoniae Infection of the Central Nervous System.  
  Sriram, S., Mitchell, W.M., and Stratton, C.W, Neurology 50:571-572
• Functional Design of Potential Inhibitors of HIV Binding to CD4+ Target Cells: A Molecular Model of gp120 Predicts Ligand Binding.  
  Gabriel, J.L., and Mitchell, W.M, Drug Design & Discovery 14:103-114
• Induction of Mucosal Anti-HIV Anti¬bodies by Facilitated Transfection of Airway Epithelium with Lipospermine/DNA.  
  Mitchell, W.M., Rosenbloom, S.T., and Gabriel, J, Complexes. Immunotechnology 1:211-219
• Antibodies to the Putative SIV Infection-Enhancing Domain Diminish Beneficial Effects of an SIV gp160 Vaccine in Rhesus Macaques.  
  Mitchell, W.M., Torres, J., Johnson, P.R., Hirsch, V., Yilma, T., Gardner, M.B., and Robinson, Jr., W.E, AIDS 9:27-34
• Long Term Improvements in Patients with Chronic Fatigue Syndrome Treated with Ampligen.  
  Strayer, D.R., Carter, W., Strauss, K.I., Brodsky, I., Suhadolnik, R.J., Ablashi, D., Henry, B., Mitchell, W.M., Bastien, S., and Peterson, D, J. Chronic Fatigue Syn. 1:35
• Evaluation of Monoclonal Antibodies to HIV 1 Envelope by Neutralization and Binding Assays.  
  D’Souza, M.P., Geyer, S.J., Hanson, C.V., Hendry, R.M., Milman, G., and Collaborating Investigators, An International Collaboration AIDS 8:169-181
• Proposed Atomic Structure of a Truncated HIV gp120 Derived by Molecular Modeling: Target CD4 Recognition and Docking Mechanism.  
  Gabriel, J.L., and Mitchell, W.M, Proc. Natl. Acad. Sci. USA 90:4186-4190
• Interferon  Receptor: mRNA Half-life, Receptor Mass and Abundance on A431 Human Epidermoid Carcinoma Cells.  
  Crouse, J.A., and Mitchell, W.M, . J. Interferon Res. 12:23-25
• Two Immunodominant Domains of gp41 Bind Antibodies Which Enhance HIV 1 Infection In Vitro.  
  Robinson, W.E., Jr., Gorny, M.K., Xu, J. Y., Mitchell, W.M., and Zolla-Pazner, S, J. Virol. 65:4169-4176
• Antibodies to the Primary Immunodominant Domain of Human Immunodeficiency Virus Type 1 (HIV 1) Glycoprotein 41 Enhance HIV 1 Infection In Vitro.  
  Robinson, W.E., Jr., Kawamura, T., Lake, D., Masuho, Y., Mitchell, W.M., and Hersh, E.M, J. Virol. 64:5301-5305
• Effective Inactivation of Human Immunodeficiency Virus with Chlorhexidine Antiseptics Containing Detergents and Alcohol.  
  Montefiori, D.C., Robinson, W.E., Jr., Modliszewski, A., and Mitchell, W.M, J. Hosp. Infect. 15:279-282
• Chromosomal proviral sequences of human immunodeficiency virus in multiple thymic cell types in a patient with acquired immunodeficiency syndrome and massive thymic hy...  
  Fisher, R.G., Wilson, G.J., Johnson, J.E., Scott, M.A., and Mitchell, W.M, Ped. Infect. Dis. J. 17:1050-1052
• Complement-mediated, Antibody-dependent Enhancement of HIV 1 Infection Requires CD4 and Complement Receptors.  
  Robinson, W.E., Jr., Montefiori, D.C., and Mitchell, W.M, Virology 175:600-604
• . Phosphorothioate Analogs of 2 5A: Activation/Inhibition of RNase L and Inhibition of HIV 2 Reverse Transcriptate.  
  Suhadolnik, R.J., Lebleu.,B., Pfleiderer, W., Charubala, R., Montefiori, D.C., Mitchell, W.M., Sobol, R.W., Li, S.W., Kariko, K., and Reichenbach, N.L, Nucleosides Nucleotides 8:987-990
• Inhibition of HIV 1 Reverse Transcriptase and Infection In Vitro by Structural and Phosphothioate Stereochemical Analogues of 2',5' Oligoadenylate.  
  Montefiori, D.C., Sobol, R.W., Li, S.W., Reichenbach, N.L., Suhadolnik, R.J., Charubala, R., Pfleiderer, W., Robinson, W.E., Jr., and Mitchell, W.M, Proc. Natl. Acad. Sci. USA 86:7191-7194
• Antibody-independent, Complement-mediated Enhancement of HIV 1 Infection by Mannosidase I and II Inhibitors.  
  Montefiori, D.C., Robinson, W.E., Jr., and Mitchell, W.M, Antiviral Res. 11:137-146
• Antibody-dependent Enhancement of HIV 1 Infection In Vitro by Sera from HIV 1 Infected and Passively-immunized Chimpanezees.  
  Robinson, W.E., Jr., Montefiori, D.C., Mitchell, W.M., Prince, A.M., Alter, H.J., Dreesman, G.R., and Eichberg, J.W, Proc. Natl. Acad. Sci. USA 86:4710-4714
• Complement-mediated, Antibody-dependent Enhancement of Human Immunodeficiency Virus Type 1 (HIV 1) Infection In Vitro Accelerates Viral RNA and Protein Synthesis and I...  
  Robinson, W.E., Jr., Montefiori, D.C., Gillespie, D.H., and Mitchell, W.M, J. Acquired Immune Def. Synd. 2:33-42
• Role of Protein N Glycosylation in Pathogenesis of Human Immunodeficiency Virus Type 1 (HIV 1).  
  Montefiori, D.C., Robinson, W.E., Jr., and Mitchell, W.M, Proc. Natl. Acad. Sci. USA. 85:9248-9252
• In Vitro Evaluation of Mismatched Double-stranded RNA (Ampligen) for Combination Therapy in the Treatment of Acquired Immunodeficiency Syndrome.  
  Montefiori, D.C., Robinson, W.E., and Mitchell, W.M, AIDS Res. Human Retroviruses 5:193-203
• Natural Killer Cell Infection and Inactivation In Vitro by HTLV III/LAV.  
  Robinson, W.E., Mitchell, W.M., Chambers, W.H., Schuffman, S.S., Montefiori, D.C., and Oeltman, T.N, Human Pathol. 19:535-540
• Will Antibody-dependent Enhancement of HIV 1 Iinfection Be a Problem with AIDS Vaccines?  
  Robinson, W.E., Jr., Montefiori, D.C., and Mitchell, W.M, Lancet i:830-831
• Mismatched dsRNA (Ampligen) Induces Protection Against Genomic Variants of the Human Immunodeficiency Virus Type 1 (HIV 1) In a Multiplicity of Target Cells.  
  Montefiori, D.C., Robinson, W.E., and Mitchell, W.M, Antiviral Res. 9:47-56
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Books/Book Chapters

• Methods in Enzymology. 
  Chapter: Clostripain 
  Page 635 - 642Mitchell, W.M., and Harrington, W.FEditors: Lorand, L., and Perlmann, G.E..Academic Press, New York
• Chlamydia pneumoniae and Chronic Diseases. 
  Chapter: Association of Chlamydia pneumoniae with multiple sclerosis: protocol for detection of C. pneumoniae in the CSF and summary of preliminary results. 
  Page 137 - 141Stratton CW, Sriram S, Yao S, Tharp A, Ding L, Bannan JD, Mitchell WMEditors: Líage-Stehr, J.Springer, Berlin
• AIDS 89-90 News and Views on Research and Control. 
  Chapter: Role of Enhancing Antibodies in HIV 1 Vaccine Development Strategies 
  Page 215 - 218Mitchell, W.M., Montefiori, D.C., Robinson, W.E., Jr., Prince, A.M., Dreesman, G.R., and Eichberg, J.WEditors: deThé, G.MEDSi/McGraw-Hill, Paris
• AIDS 89-90 News and Views on Research and Control. 
  Chapter: Role of Protein N-Glycosylation in HIV Pathogenesis and in the Immune Response to HIV Infection 
  Page 157 - 161Montefiori, D.C., Robinson, W.E., Jr., and Mitchell, W.MEditors: deThé, G.MEDSi/McGraw-Hill, Paris
• AIDS 89-90 News and Views on Research and Control. 
  Chapter: Enhancement of HIV 1 Infection In Vitro by HIV 1 Antibody-positive Serum 
  Page 133 - 136Robinson, W.E., Jr., Montefiori, D.C., Mitchell, W.M., and Prince, A.MEditors: deThé, G..MEDSi/McGraw-Hill, Paris
• Methods in Enzymology. 
  Chapter: Objective Antiviral Assay of the Interferons by Computer Assisted Data Collection and Analysis 
  Forti, R.L., Schuffman, S.S., Davies, H.A., and Mitchell, W.MEditors: Pestka, S.Academic Press, New York
• Year Book of Cancer. 
  Chapter: Diseases of the Human Breast 
  Page 199 - 200Halter, S.A., Bradbury, E., amd Mitchell, W.MEditors: Clark, R.L., Cumley, R.W., and Hickey, R.C.Yearbook Medical Publishers, Inc., Chicago
• Enzyme Structure, Part E. in Methods in Enzymology. 
  Chapter: Cleavage at Arginine with Clostripain 
  Page 165 - 174Mitchell, W.MEditors: Hirs, C.H.W., and Timasheff, S.N..Academic Press, New York
• Selective Inhibitors of Viral Function. 
  Chapter: Active Sites of the Animal Viruses: Potential Sites of Specific Chemotherapeutic Attack 
  Page 51 - 80Mitchell, W.MEditors: Carter, W.C.CRC Press, Cleveland, Ohio
• The Enzymes. 
  Chapter: Clostripain 
  Page 699 - 719Mitchell, W.M., and Harrington, W.FEditors: Boyer, P.D..Academic Press, New YorkEdition 3,
• Macromolecules Regulating Growth and Development. 
  Chapter: Hormonal Control of Oviduct Growth and Differentiation 
  Page 53 - 77O'Malley, B.W., Means, A.R., Socher, S.H., Spelsberg, T.C., Chytil, F., Comstock, J.P., and Mitchell, W.MEditors: Elizabeth D. Hay, Thomas J. King and John Papaconstantinou.Academic Press, New York and London
• Genes and Viruses in Multiple Sclerosis. 
  Chapter: Association of multiple sclerosis with Chlamydia pneumoniae: demonstration of the 16S rRNA gene and immunoreactivity of CSF cationic antibodies against C. pneumoniae antigens 
  Page 221 - 229Sriram, S., Stratton, C.W., Yao, S., Bannan, J.D., Mitchell, W.MEditors: Hommes OR, Clanet M, Wekerle H.Elsevier Science, Inc., New York
• Chlamydia pneumoniae and Chronic Diseases. 
  Chapter: Association of Chlamydia pneumoniae with Multiple Sclerosis: Protocol for Detection of C. pneumoniae in the CSF and Summary of Preliminary Results 
  Page 137 - 152Stratton, C.W., Sriram, S., Yao, S., Tharp, A., Ding, L., Bannan, J.D., Mitchell, WEditors: J. L’age-Stehr.Springer, Berlin
• Development and Applications of Vaccines and Gene Therapy in AIDS. 
  Chapter: Functional Studies of Bispecific Antibodies Directed Against HIV 1 and the Fc I Receptor 
  Page 173 - 183Gorny, M.K., Keler, T., Burda, S., Williams, C., Gabriel, J.L., Mitchell, W.M., Deo, Y.M., and Zolla-Pazner, SEditors: G. Giraldo, D. Bolognesi, M. Salvatore, and E. Beth-Giraldo.Ibid, Antibiotics and Chemotherapy 48:173-183, S. Karger, Switzerland
• Protein Folds, A Distance-Based Approach. 
  Chapter: HIV GP120 Docking Interactions and Inhibitor Design Based on an Atomic Structure Derived by Molecular Modeling Using the DREIDING II Force Field 
  Page 294 - 307Gabriel, J.L., and Mitchell, W.MEditors: Bohr, H. and Brunak, S.CRC Press, Boca Raton
• Cinguieme Colloque des Cent Gardes. 
  Chapter: Antibody-dependent Enhancement of HIV and SIV Infection: Domain Marking and Vaccines 
  Page 161 - 167Zolla-Pazner, S., Hersh, E., Mitchell, W.M., and Robinson, W.E
• Vaccines 90: Modern Approaches to New Vaccines Including Prevention of AIDS. 
  Chapter: Generation of Human Monoclonal Antibodies to HIV and Characterization of Their Biological Activities 
  Page 263 - 267Zolla-Pazner, S., Gorny, M.K., Robinson, W.E., Jr., Mitchell, W.M., Weinhold, K., Tyler, D.S., Till, M., Uhr, J.W., and Vitetta, E.SEditors: Lerner, R.A., Ginsberg, H., Chanock, R.M., and Brown, F.Cold-Spring Harbor Laboratory
• Vaccines 89, Modern Approaches to New Vaccines Including Prevention of AIDS. 
  Chapter: Mechanisms for the Failure of Passively Administered Neutralizing Antibodies to Protect Against HIV Challenge in the Chimpanzee Model. 
  Page 195 - 199Prince, A.M., Saunders, A., Pascual, D., Andrus, L., Bianco, C., Robinson, W.E., Jr., Montefiori, D.C., and Mitchell, W.MEditors: Lerner, R.A., Ginsberg, H., Chanock, R.M., and Brown, F.Cold Spring Harbor Laboratory
• Human Mammary Carcinoma. 
  Chapter: Molecular and Morphological Evidence of Type B Retrovirus (Oncornavirus) 
  Page 1 - 11Mitchell, W.M., Halter, S.A., Schuffman, S.S., and Hartmann, W.HSEM, Inc
• Diseases of the Human Breast: Selective Isolation and Exposure of Epithelia and Their Correlative Surface Features and Histopathology. 
  Chapter: III 
  Page 139 - 152Halter, S.A., Bradbury, E., and Mitchell, W.MScanning Electron Microscopy SEM, Inc., AMF O'Hare, IL
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Abstracts/Posters

• The Laboratory Diagnosis of Rheumatoid Arthritis.
  Mitchell, W.M., Robinson, J.P., Sawyer, M., and Najjar, V.A, Southern Med. J. 53:1584
• Physiochemical Properties of Chalaropsis Species, N,O Diacetylmuramidase.
  Mitchell, W.M., and Hash, J.H, Fed. Proc. 27:596
• Clostridiopeptidase B as a Contaminant of Clostridium Histolyticum Collagenase Preparations.
  Mitchell, W.M, S.E. Regional Meeting Amer. Chem. Soc. 22:99
• The Physical Properties of Clostridiopeptidase B.
  Mitchell, W.M, Amer.Soc. Microbiology, Louisville, KY
• Clostridiopeptidase B: Specificity Studies and Its Influence as a Contaminant of Clostridium Histolyticum Collagenase Preparations.
  Mitchell, W.M, Amer. Soc. Microbiology, Louisville, KY
• Correlation of Structure and Lipolytic Activity of Glucagon.
  Mitchell, W.M., and Felts, P.W, Amer. Chem. Soc, New York, NY
• Studies on the Structure-function Relationships of Glucagon.
  Felts, P.W., Ferguson, M.E.C., Hagey, K.A., Stitt, E.S., and Mitchell, W.M, European Assoc. for the Study of Diabetes, Montpellier, France
• Epidermal Growth Factors (EGF): Properties of a High Molecular Weight Species.
  Taylor, J., Cohen, S., and Mitchell, W.M, Fed. Proc. 29:670
• Evidence for Oncogenic Viruses Associated with Murine Endocrine Tumors.
  Mitchell, W.M., Korinek, J., Moses, H.D., and Orth, D.N, Kentucky-Tennessee Society for Micro¬biology, Cookeville, TN
• Murine Leukemia C Type Virus Associated with Functional Murine Carcinomas of Endocrine Origin.
  Mitchell, W.M., Moses, H.D., Orth, D.N., and Korinek, J, Fed. Proc. 30:275
• The Active Site Directed Inactivation of Clostripain by Tosyl-L Lysine Chloromethyl Ketone.
  Porter, W.H., Cunningham, L.W., and Mitchell, W.M, Fed. Proc. 30:762
• Evidence for the Production of C Terminal ACTH Fragments in the Ectopic ACTH Syndrome.
  Orth, D.N., Nicholson, W.E., and Mitchell, W.M, Endocrinology 88:A130
• The Effect of Adenosine-3':5' cyclic Monophosphate (cAMP) on XC Rat Sarcoma Cell Growth and Function.
  Mitchell, W.M., and Korinek, J, Amer. Chem. Soc., 162nd National Meeting, Biol. Abs. 302
• Syncytium Formation Between Cells of Mouse Endocrine Tumor Origin and XC Cells.
  Korinek, J., Moses, H.L., Mitchell, W.M., and Orth, D.N, Amer. J. Path. 62:120
• The Effect of Adenosine-3':5' cyclic Monophosphate (cAMP) on XC Rat Sarcoma Cell Growth and Function.
  Mitchell, W.M., and Korinek, J, Amer. Soc. for Microbiology, Kentucky,Tennessee Section; Bowling Green, KY
• ACTH and ACTH Fragments in Tumors Causing the Ectopic ACTH Syndrome.
  Orth, D.N., Nicholson, W.E., Mitchell, W.M., Island, D.P., and Wilson, D.K, Clin. Res. XX:73
• Extracellular Human Procollagen: A Soluble, Anionic Tropocollagen Precursor.
  Bankowski, E., and Mitchell, W.M, Fed. Proc. 31:3513
• Adenosine-3':5' cyclic Monophosphate (cAMP) Effect on Plasma Membrane and Chromatin of Rat SC Sarcoma Cells.
  Mitchell, W.M., Korinek, J., and Spelberg, T.C, Fed. Proc. 32:610
• Steroid Hormone-induced Messenger RNA is Transcribed from Single Copy DNA.
  Harris, S.E., Mitchell, W.M., Rossen, J., and O'Malley, B.W, The Endocrine Soc, Chicago
• The Physical and Chemical Properties of an Oncornavirus Associated with an Adrenal Carcinoma Cell Line.
  Burnette, W.N., Riggin, C.H., and Mitchell, W.M, Soc. Exptl. Biol. Med., Southeast Regional Meeting
• Comparison of the RNA's from Murine Leukemia Virus and Murine Sarcoma-Leukemia Virus: Differences in Subunit Compositions and the Effects of Virion Age.
  Riggin, C., Bondurant, M., and Mitchell, W.M, Soc. Exptl. Biol. Med., Southeast Regional Meeting
• Physical Properties of the Moloney Murine Leukemia and Sarcoma Virus RNA.
  Riggin, C., Bondurant, M., and Mitchell, W.M, Fed. Proc. 33:1604
• The Physical and Chemical Characteri¬zation of a C type Oncornavirus from a Murine Adrenal Carcinoma Cell Line.
  Burnette, W.N., Riggin, C.H., and Mitchell, W.M, Am. Soc. Microbiol., 74th Ann. Meet. Abst. V85:214
• The Correlation of Plasma Membrane Microvilli and Intracellular Cyclic AMP Content in a Rat Epitheloid Kidney Cell Line.
  Carley, W.W., Moses, H.L., and Mitchell, W.M, Prog. Clin. Biol. Res. 17:261
• Molecular Basis for (p30) gag Murine Oncornavirus Variation,
  Burnette, W.N., and Mitchell, W.M, J. Supramol. Structure 8:258 (Suppl. 2)
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