
William Martens Lee MD
Hepatology & Liver Transplantation
Professor, Internal Medicine, Holder of the Meredith Mosle Chair in Liver Diseases, University of Texas Southwestern Medical Center, Southwestern Medical School
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5323 Harry Hines BoulevardDallas, TX 75390
Phone+1 214-645-0595
Fax+1 214-645-0581
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Summary
- Dr. Lee has served as Professor of Internal Medicine and Bioengineering at the University of Texas Southwestern Medical Center at Dallas since 1990. He holds the Meredith Mosle Chair in Liver Diseases in his honor. Dr. Lee graduated from Amherst College and the College of Physicians and Surgeons of Columbia University, AOA, completing his internal medicine residency at the Presbyterian Hospital in New York City. After completing a research fellowship at Kings College Hospital, London, he has served on the faculties of Columbia University, the Medical University of South Carolina and The Ohio State University.
Dr. Lee initially characterized Gc protein as an actin scavenger in acute liver failure and has delineated many of the clinical features of acetaminophen hepatotoxicity. In 1997, he founded the Acute Liver Failure Study Group (ALFSG), a national network to study this orphan disease, funded continuously since then by the National Institutes of Health. In addition, he has served as principal investigator for the NIDDK sponsored HALT-C, DILIN and the Hepatitis B Research Networks. A past Secretary-Treasurer of American Association for the Study of Liver Diseases (AASLD), he has given both the Leon Schiff and the Hyman Zimmerman Memorial Lectures at AASLD Annual Meetings. In November 2014, he was awarded the Distinguished Clinician Educator/Mentor Award from the AASLD, and in 2018 received the Alumni Gold Medal from the College of Physicians and Surgeons for Clinical Excellence.
Education & Training
- New York Presbyterian Hospital (Columbia Campus)Internship, Internal Medicine, 1967 - 1968
- Columbia University Vagelos College of Physicians and SurgeonsClass of 1967
Certifications & Licensure
- NY State Medical License 1970 - Present
- TX State Medical License 1991 - 2026
- OH State Medical License 2010 - 2016
- SC State Medical License 1980 - 1991
- DC State Medical License 1969 - 1971
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Gastroenterology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
- Fellow (FACG) American College of Gastroenterology
Clinical Trials
- Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Start of enrollment: 1998 Jun 01
- Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard Treatment Start of enrollment: 2000 Jun 01
- Hepatitis B Research Network Adult Cohort Study Start of enrollment: 2010 Dec 01
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Publications & Presentations
PubMed
- Association of Acetaminophen (Paracetamol) Use With Severity and Outcomes in Patients With Viral Hepatitis-Associated Acute Liver Failure.William M Lee, Carson Barnard, Jody A Rule, Babak J Orandi, Laura P James
The American Journal of Gastroenterology. 2025-03-01 - Genetic Variants of GBP4: Reduced Risks for Drug-Induced Acute Liver Failure in Non-Finnish European Population.Tsung-Jen Liao, Menghang Xia, Paul Hayashi, Bohun Pan, Guruprasad P Aithal
Liver International. 2025-02-01 - Oral LPCN 1148 improves sarcopenia and hepatic encephalopathy in male patients with cirrhosis: A randomized, placebo-controlled phase 2 trial.Benjamin J Bruno, Joshua C Weavil, Jonathan Ogle, Nachiappan Chidambaram, Elizabeth J Carey
Hepatology. 2025-01-31
Journal Articles
- The Revolution in Treatment of Hepatitis CWilliam M Lee, Jordan Mayberry, ScienceDirect
- Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by an Expert Committee to Establish CausalityDaniel R Ganger, Norman Sussman, Charles Chiu, R T Stravitz, Laura James, Nathan Bass, Anne M Larson, Jorge Rakela, William M Lee, Nature
- Viral Surveillance in Serum Samples from Patients with Acute Liver Failure by Metagenomic Next-Generation SequencingWilliam M Lee, Charles Y Chiu, Clinical Infectious Diseases
Press Mentions
- UTSW Research: Female Sex Hormones, Adrenal Hyperplasia, and MoreJuly 2nd, 2024
- Lactulose vs Polyethylene Glycol 3350--Electrolyte Solution for Treatment of Overt Hepatic Encephalopathy: The HELP Randomized Clinical TrialOctober 20th, 2016
Professional Memberships
- Fellow
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