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Office
5323 Harry Hines Boulevard
Dallas, TX 75390Phone+1 214-645-0595Fax+1 214-645-0581
Summary
- Dr. Lee has served as Professor of Internal Medicine and Bioengineering at the University of Texas Southwestern Medical Center at Dallas since 1990. He holds the Meredith Mosle Chair in Liver Diseases in his honor. Dr. Lee graduated from Amherst College and the College of Physicians and Surgeons of Columbia University, AOA, completing his internal medicine residency at the Presbyterian Hospital in New York City. After completing a research fellowship at Kings College Hospital, London, he has served on the faculties of Columbia University, the Medical University of South Carolina and The Ohio State University.
Dr. Lee initially characterized Gc protein as an actin scavenger in acute liver failure and has delineated many of the clinical features of acetaminophen hepatotoxicity. In 1997, he founded the Acute Liver Failure Study Group (ALFSG), a national network to study this orphan disease, funded continuously since then by the National Institutes of Health. In addition, he has served as principal investigator for the NIDDK sponsored HALT-C, DILIN and the Hepatitis B Research Networks. A past Secretary-Treasurer of American Association for the Study of Liver Diseases (AASLD), he has given both the Leon Schiff and the Hyman Zimmerman Memorial Lectures at AASLD Annual Meetings. In November 2014, he was awarded the Distinguished Clinician Educator/Mentor Award from the AASLD, and in 2018 received the Alumni Gold Medal from the College of Physicians and Surgeons for Clinical Excellence.
Education & Training
- New York Presbyterian Hospital (Columbia Campus)Internship, Internal Medicine, 1967 - 1968
- Columbia University Vagelos College of Physicians and SurgeonsClass of 1967
Certifications & Licensure
- NY State Medical License 1970 - Present
- TX State Medical License 1991 - 2026
- OH State Medical License 2010 - 2016
- SC State Medical License 1980 - 1991
- DC State Medical License 1969 - 1971
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Gastroenterology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
- Fellow (FACG) American College of Gastroenterology
Clinical Trials
- Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Start of enrollment: 1998 Jun 01
- Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard Treatment Start of enrollment: 2000 Jun 01
- Hepatitis B Research Network Adult Cohort Study Start of enrollment: 2010 Dec 01
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Publications & Presentations
PubMed
- 193 citationsEmergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.Nicole L. Washington, Karthik Gangavarapu, Mark Zeller, Alexandre Bolze, Elizabeth T. Cirulli
Cell. 2021-05-13 - 1452 citationsResults of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United StatesGeorge Ostapowicz, Robert J. Fontana, Frank V. Schioødt, Anne M. Larson, Timothy J. Davern
Annals of Internal Medicine. 2002-12-17 - 329 citationsViral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infectionYueh Ming Loo, David M. Owen, Kui Li, Andrea K. Erickson, Cynthia L. Johnson
Proceedings of the National Academy of Sciences of the United States of America. 2006-04-11
Journal Articles
- The Revolution in Treatment of Hepatitis CWilliam M Lee, Jordan Mayberry, ScienceDirect
- Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by an Expert Committee to Establish CausalityDaniel R Ganger, Norman Sussman, Charles Chiu, R T Stravitz, Laura James, Nathan Bass, Anne M Larson, Jorge Rakela, William M Lee, Nature
- Viral Surveillance in Serum Samples from Patients with Acute Liver Failure by Metagenomic Next-Generation SequencingWilliam M Lee, Charles Y Chiu, Clinical Infectious Diseases
Press Mentions
- UTSW Research: Female Sex Hormones, Adrenal Hyperplasia, and MoreJuly 2nd, 2024
- Lactulose vs Polyethylene Glycol 3350--Electrolyte Solution for Treatment of Overt Hepatic Encephalopathy: The HELP Randomized Clinical TrialOctober 20th, 2016
Professional Memberships
- Fellow
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