WilliamCKnowlerMD

Family Medicine • Phoenix, AZ

Preventive Medicine

Section Chief, Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch

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Office
1550 E Indian School Rd
Phoenix, AZ 85014
Phone+1 602-200-5206

Education & Training

Tufts Medical CenterInternship, Internal Medicine, 1973 - 1974
Harvard Medical SchoolClass of 1973

Certifications & Licensure

MA State Medical License 1974 - 2023
American Board of Preventive Medicine General Preventive Medicine

Clinical Trials

Diabetes Prevention Program Outcomes Study Start of enrollment: 2002 Sep 01
Active, not recruiting
Phase 3
The Family Investigation of Nephropathy and Diabetes Study Start of enrollment: 1999 Oct 01
Completed
Prospective Studies of the Natural History of Diabetes Mellitus and Its Complications in the Gila River Indian Community Start of enrollment: 1976 Sep 03
Completed
Family Investigation of Nephropathy and Diabetes (F.I.N.D.) Start of enrollment: 2001 Mar 07
Recruiting
Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix Start of enrollment: 2013 Mar 28
Completed
Phase 3
Vitamin D and Type 2 Diabetes (Phoenix Site) Start of enrollment: 2013 Nov 01
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Publications & Presentations

PubMed

Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes.
Liana K Billings, Kathleen A Jablonski, Qing Pan, Jose C Florez, Paul W Franks
Diabetes. 2024-08-01
Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians.
Robert C Williams, Robert L Hanson, Bjoern Peters, Kendall Kearns, William C Knowler
Diabetes. 2024-06-01
1 citations
Within and post-trial effects of an intensive lifestyle intervention on kidney disease in adults with overweight or obesity and type 2 diabetes mellitus: a secondary a...
William C Knowler, Haiying Chen, Judy L Bahnson, Steven E Kahn, Cora E Lewis
BMJ Open Diabetes Research & Care. 2024-05-30

Journal Articles

Genetic Ancestry Markers and Difference in A1c Between African-American and White in the Diabetes Prevention Program
Steven Kahn, William C Knowler, Kieren J Mather, Jose C Florez, The Journal of Clinical Endocrinology and Metabolism

Lectures

Common Genetic Variation in Glucokinase (GCK) Is Associated with Rates of Carbohydrate Oxidation, Energy Expenditure, and Type 2 Diabetes
Phoenix, AZ - 6/14/2014
Variants in the Promoter of STAM2 Are Associated with Type 2 Diabetes in Pima Indians
Phoenix, AZ - 6/16/2014
Comparison of Regression and Ratio Indices for Weight or Waist Circumference Adjusted for Height as Predictors of Diabetes
Phoenix, AZ - 6/15/2014

Press Mentions

Poster AbstractsNovember 4th, 2020
The Vitamin D and Type 2 Diabetes StudyJune 9th, 2019
F.D.A. Panel Votes to Restrict AvandiaJuly 14th, 2010
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Grant Support

Morphometric Studies Of Diabetic NephropathyNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2011
Methods Of Assessing Physical ActivityNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Macrovascular And Other Complications Of Type 2 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Heatlh Services Research And PolicyNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Genetic Epidemiology Of Non-Renal Diabetic ComplicationsNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Genetic Epidemiology Of Diabetic NephropathyNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Genetic Epidemiology Of Diabetes And ObesityNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Genetic Epidemiologic Methods For Study Of Diabetes And Related TraitsNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Epidemiology Of Type 2 Diabetes Mellitus In AdultsNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Epidemiology Of Type 2 Diabetes In Children And AdolescentsNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Epidemiology Of Diabetic RetinopathyNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Epidemiology And Physiology Of Diabetic NephropathyNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
Macrovascular And Other Complications Of Type 2 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Genetic Epidemiology Of Non-Renal Diabetic ComplicationsNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Genetic Epidemiology Of Diabetic NephropathyNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Genetic Epidemiology Of Diabetes And ObesityNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Genetic Epidemiologic Methods For Study Of Diabetes And Related TraitsNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Epidemiology Of Type 2 Diabetes Mellitus In AdultsNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Epidemiology Of Type 2 Diabetes In Children And AdolescentsNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Epidemiology Of Diabetic RetinopathyNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Epidemiology And Physiology Of Diabetic NephropathyNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2008
Gila River Indian Community Mortality StudyNational Institute Of Diabetes And Digestive And Kidney Diseases2006
Look Ahead: Clinical Trial Of Weight Loss In Type 2 DiabNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2006
Prevention Of Type 2 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2006
Genetics Of Type 2 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2006
Epidemiology Of Complications Of Type 2 Diabetes MellituNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2006
Diabetes Mellitus And Other Chronic Diseases In The GilaNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2006
Complications And Outcome Of Diabetic And Prediabetic PRNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2006
Look Ahead: Clinical Trial Of Weight Loss In NIDDMNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Epidemiology Of Complications Of NIDDMNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Diabetes Mellitus/Chronic Diseases In Gila River IndiansNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Complications/Outcome Of Diabetic /Prediabetic PregnancyNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Gila River Indian Community Autopsy And Mortality StudyNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2005
Native Americans: Diabetes Mellitus/Chronic DiseasesNational Institute Of Diabetes And Digestive And Kidney Diseases2004
Epidemiology: Complications Of Type 2 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2004
Diabetic/ Prediabetic Pregnancy: Complications/OutcomesNational Institute Of Diabetes And Digestive And Kidney Diseases2004
Clinical Trial Of Weight Loss In Type 2 DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases2004
WHO Collaborating Center--Epidemiological &Clinical InvNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Complication /Outcome /Diabetic /Prediabetic PregnanciesNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Prevention Of Non-Insulin Dependent Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2000
Epidemiology Of Complications Of Non-Insulin Dependent DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2000
Complications And Outcome Of Diabetic And Prediabetic PregnanciesNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2000
Genetics Of Non-Insulin Dependent Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases1990–2000
Diabetes Mellitus And Other Chronic Diseases In The Gila River Indian CommunityNational Institute Of Diabetes And Digestive And Kidney Diseases1986–2000
Genetics Of Noninsulin Dependent Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1997
Epidemiology Of Complications Of Noninsulin Dependent DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1997
Epidemiology Of Complications Of Non-Insulin-Dependent DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases1990–1993
Diabetes Mellitus And Other Chronic Diseases In The Gila River Indian CommunityNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985