WilliamEGrizzleMDPh.D.

PubMed

• 105 citations
  Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma). Light and electron microscopic study confirming the origin of the neoplasm.
  Guillermo A. Herrera, H Pinto de Moraes, William E. Grizzle, S G Han
  Digestive Diseases and Sciences. 1984-03-01
• 1369 citations
  Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
  Katherine A Hoadley, Christina Yau, Toshinori Hinoue, Denise M. Wolf, Alexander J. Lazar
  Cell. 2018-04-05
• 432 citations
  Modern age pathology of pulmonary arterial hypertension.
  Elvira Stacher, Brian B. Graham, James M. Hunt, Aneta Gandjeva, Steve D. Groshong
  American Journal of Respiratory and Critical Care Medicine. 2012-08-01

Journal Articles

• Optoacoustic Imaging Identifies Ovarian Cancer Using a Microenvironment Targeted Theranostic Wormhole Mesoporous Silica Nanoparticle  
  Peter J Frederick, William E Grizzle, Phillip Chuong, Akiko Chiba, ScienceDirect
• Wide-line NMR Study of Molecular Motion in Me3[SiNSiMe3]2.  
  Levy II H, Grizzle WE, J Chem Physics 1966; 45:1954-61
• Inhibitory and Facilitory Hypothalamic Areas Mediating ACTH Release in the Cat.  
  Grizzle WE, Dallman MF, Schramm LP, Gann DS, Endocrinology 1974; 95(5):1450-61
• Hypothalamic Cells in the Area Mediating ACTH Release Respond Right Atrial Stretch.  
  Grizzle WE, Johnson RN, Schramm LP, Gann DS, Am J Physiol 1975; 228(4)1039-45
• Inhibitory and Facilitory Areas of the Rostral Pons Mediating ACTH Release in the Cat.  
  Ward DG, Grizzle WE, Gann DS, Endocrinology 1976; 99(5):1220-28
• Organization of the Hypothalamus for Control of Adrenocorticotropin in the Cat.  
  Maran JW, Carlson DE, Grizzle WE, Ward DG, Gann DS, Endocrinology 1978;103(3):957-70
• Membranous Nephropathy in a Renal Allograft. Its Occurrence With Previous Anti-Glomerular Basement Membrane Disease.  
  Grizzle WE, Johnson KH, Arch Pathol Lab Med 198l; l05(2):7l-75
• Radiology rounds: Fever of Unknown Origin in a 48-Year Old Man Seven Years After Mesocaval Shunt.  
  Rubin KE, Grizzle WE, Ala J Med Sci 1982;19(3):289-95
• Functional Carotid Paragangliomas: Biochemical, Ultrastructural and Histochemical Correlation with Clinical Symptoms.  
  Crowell W, Grizzle WE, Siegel AL, Arch Pathol Lab Med 1982;l06(12):599-603
• An Extra-adrenal Pheochromocytoma Mimicking Lymph Node Metastasis from a Cervical Cancer.  
  Phillips J, Orr JW, Grizzle W, Hatch KD, Gynecol Oncol 1982;13(3):416-22
• Squamous Cell Carcinoma Metastatic to the Placenta and Ovary.  
  Orr JW, Grizzle WE, Huddleston JF, Obstet Gynecol 1982;59(6 Suppl):8lS-83S
• Clinical Significance and Partial Biochemical Characterization of Lactate Dehydrogenase Isoenzyme 6.  
  Ketchum CH, Robinson CA, Hall LM, Grizzle WE, Maclaren NK, Riley WJ, Trost C, Clin Chem 1984;30(1):46-49
• Malignant Small Bowel Neoplasm of Enteric Plexus Derivation (Plexosarcoma) Light and Electron Microscopic Study Confirming the Origin of the Neoplasm.  
  Herrera GA, De Moraes HP, Grizzle WE, Han SG, Dig Dis Sci 1984;29(3):275-84
• Aldosterone Blocks Adrenal Compensatory Hypertrophy in the Rat.  
  Grizzle WE, Dunlap NE, Am J Physiol 1984;246(4 Pt 1):E306-10
• Golden Syrian Hamsters: A New Experimental Model for Adrenal Compensatory Hypertrophy.  
  Dunlap NE, Grizzle WE, Endocrinology 1984;114(5):1490-95
• Corticotropin Production by Tumors of the Autonomic Nervous System.  
  Grizzle WE, Tolbert L, Pittman CS, Siegel AL, Aldrete JS, Arch Pathol Lab Med 1984;108(7):545-50
• Abnormal Lactate Dehydrogenase Isoenzyme Pattern in a Critically Ill Patient.  
  Robinson Jr CA, Ketchum CH, Grizzle WE, Hall LM, Alexander CB, South Med J 1984;77(7):921-23
• LD-6 Isoenzyme and Lactat-Independent Dehydrogenase Differ.  
  Ketchum CH, Robinson Jr CA, Hall LM, Grizzle WE, Clin Chem 1984;30(7):1269-71
• Resistencia a La Insulina, Acanthosis Nigricans Y Escleredema Diabeticorum.  
  Pino JA, Gaitan E, Grizzle WE, Acta Medica Colombiana 1984;9:341-45
• Glucagon Producing Islet Cell Tumors.  
  Herrera GA, Garceau PA, Grizzle WE, Am Soc Clin Pathol Check Sample 1984 AP84-ll
• Cushing's syndrome: Screening Methods in Hospitalized Patients.  
  Dunlap NE, Grizzle WE, Siegel AL, Arch Pathol Lab Med 1985;109(3):222-229
• Plasmacytoid T-cell Lymphoma Associated with Chronic Myeloproliferative Disorder.  
  Prasthofer EF, Prchal JT, Grizzle WE, Grossi CE, Am J Surg Pathol 1985;9(5):380-87
• A Commercially Available Assay Kit for Determining Aldosterone Concentration in Non-Extracted Rat Serum.  
  Grizzle WE, Dunlap NE, Stabler TV, Lab Anim Sci 1985;35(4):387-91
• Pheochromocytomas.  
  Grizzle WE, Clin Chem News 1985;11(12):6-7
• Non-Resolving Cushing's Syndrome Secondary to Depot Methylprednisolone Verified by High-Performance Liquid Chromatography.  
  Stabler TV, Grizzle WE, Howell WH, South Med J 1985;78(9):1143-44
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Books/Book Chapters

• Theory and Practice of Histological Techniques. 
  Chapter: Fixation of Tissues 
  Page 53 - 74Grizzle WE, Fredenburgh J, Myers RBEditors: J. Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United KingdomEdition 6,
• Prospects for Chemoprevention of Colorectal Neoplasia – Emerging Role of Anti Inflammatory Drugs. 
  Chapter: New NSAID targets and derivatives for colorectal cancer prevention 
  Tinsley, H.N., Grizzle, W.E., Abadi, A.H., Keeton, A.B., Zhu, B., Xi, Y., and Piazza, G.A
• Emerging Concepts of Tumor Exosomes-mediated Cell-cell Communication. 
  Chapter: The effects of exosomes and related vesicles on cancer development, progression and dissemination 
  Zhang HG, Grizzle WEEditors: HG Zhang.Springer Science
• Molecular Genetic Pathology. 
  Chapter: Current issues affecting biorepositories 
  Grizzle WEEditors: L Cheng, D. Zhang.Springer Science+Business Media
• Translational Pathology of Early Cancer. 
  Chapter: Development and progression of colorectal neoplasia 
  Page 235 - 265Manne U, Shanmugam C, Katkoori VR, Grizzle WEEditors: S Srivastava, WE Grizzle.IOS Press BV, Amsterdam, The Netherlands
• Translational Pathology of Early Cancer. 
  Chapter: Biomarkers and the genetics of early neoplastic lesions 
  Page 41 - 64Srivastava S, Grizzle WEEditors: S Srivastava, WE Grizzle.IOS Press BV, Amsterdam, The Netherlands
• Translational Pathology of Early Cancer. 
  Chapter: The biology of incipient, pre-invasive or intraepithelial neoplasia 
  Page 21 - 39Grizzle WE, Srivastava S, Manne UEditors: S Srivastava, WE Grizzle.IOS Press BV, Amsterdam, The Netherlands
• Translational Pathology of Early Cancer. 
  Chapter: Issues in collecting, processing and storing human tissues and associated information to support biomedical research 
  Page 531 - 549Grizzle WE, Bell WC, Sexton KCEditors: S Srivastava, WE Grizzle.IOS Press BV, Amsterdam, The Netherlands
• Translational Pathology of Early Cancer. 
  Chapter: Translational Pathology of Neoplasia 
  Page 7 - 20Grizzle WE, Srivastava S, Manne UEditors: S Srivastava, WE Grizzle.IOS Press, BV, Amsterdam, The Netherlands
• Translational Pathology of Early Cancer. 
  Grizzle WEEditors: Srivastava S., Grizzle WE.IOS Press, BV, Amsterdam, The Netherlands
• Molecular Diagnostics. 
  Chapter: General Considerations Concerning Safety in Biomedical Research Laboratories 
  Page 563 - 572Grizzle WE, Bell WC, Fredenburgh JEditors: Patrinos GP and Ansorg W.Edition 2,
• Appendices to Theory and Practice of Histologic Techniques. 
  Page 673 - 694Grizzle WE, Fredenburgh JL, Myers RBEditors: J Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United Kingdom
• Theory and Practice of Histological Techniques. 
  Chapter: The Dispersed Neuroendocrine System, Cytoplasmic Granules, Other Organelles 
  Page 238 - 307Grizzle WE, Bancroft JEditors: J. Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United KingdomEdition 6,
• Theory and Practice of Histological Techniques. 
  Chapter: Proteins and Nucleic Acids 
  Page 217 - 231Fredenburgh JL, Bancroft J, Grizzle WE, and Myers RBEditors: J. Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United Kingdom
• Theory and Practice of Histological Techniques. 
  Chapter: Carbohydrates 
  Page 161 - 186Myers RB, Fredenburgh JL, Grizzle WEEditors: J. Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United Kingdom
• Theory and Practice of Histological Techniques. 
  Chapter: The Gross Room 
  Page 75 - 82Billings, PE and Grizzle, WEEditors: J. Bancroft, M. Gamble.Churchill Livingstone, Edinburgh, United KingdomEdition 6,
• Hypothalamic control of adrenocorticotropic hormone (ACTH) [Ph.D. Dissertation]. 
  Grizzle WEThe Johns Hopkins University
• Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas: Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma. 
  Chapter: Role of immunohistochemical expression of Lewis Y antigen in ovarian carcinoma 
  Page 465 - 471Chhieng DC, Rodriguez-Burford C, Grizzle WEEditors: Hayat MA.Edition 4,
• Molecular Diagnostics. 
  Chapter: Use of mass spectrographic methods to identify disease processes 
  Page 211 - 222Grizzle WE, Semmes OJ, Bigbee WL, Malik G, Miller E, Manne B, Oelschalger DK, Zhu L, Manne UEditors: G. Patrinos, W. Ansorg.
• Molecular Diagnostics. 
  Chapter: Safety in biomedical and other laboratories 
  Page 421 - 428Grizzle WE, Bell W, Fredenburgh JEditors: G. Patrinos, W. Ansorg.
• Cancer Chemoprevention Volume 2. 
  Chapter: Progress in the Development of Effective Chemoprevention Agents for Cervical Neoplasia 
  Page 467 - 438Alvarez RD, Grizzle WE, Weiss HL, Grubbs CJ, Oza AEditors: Kelloff, Hawk, Sigman.Humana Press Inc, Totowa, NJ
• Clinical Approaches to the Discovering and Testing New Breast Cancer Prevention Drugs. 
  Chapter: Strategies for Cancer Chemoprevention 
  Page 213 - 237Fabian CJ, Kimler BF, Mayo MS, Grizzle WE, Masood S, Ursin GEditors: Kelloff, Hawk, Sigman.Humana Press Inc, Totowa, NJ
• Year Book of Surgery. 
  Chapter: Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2 and p53 
  Page 305 - 307Beenken SW, Grizzle WE, Crowe DR, et alEditors: Copeland EM III.Mosby Yearbook, St. Louis, MO
• Molecular Pathology of Early Cancer. 
  Chapter: Development of a Facility to Supply Human Tissues to Aid in Medical Research 
  Page 371 - 383Grizzle WE and Sexton KCEditors: S. Srivastava, D. E. Henson and A. Gazdar.IOS Press, Van Diemenstratt, Amsterdam, Netherlands
• Molecular Pathology of Early Cancer. 
  Chapter: Molecular and Histopathologic Changes in the Development of Colorectal Neoplasia 
  Page 135 - 170Grizzle WE, Shibata D, Manne U, Myers RB, Frost AREditors: S. Srivastava, D. E. Henson and A. Gazdar.IOS Press, Van Diemenstratt, Amsterdam, Netherlands
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Abstracts/Posters

• Biomarkers in Prostate Cancer.
  Grizzle WE, Bostwick DG, Burke H, Tawfik OW, McGregor D, Cohn J, Lieberman R, AACR 96th Annual Meeting, Education Book 2005: 196-204
• Best practices and challenges in collecting and processing human tissues to support biomedical research.
  Grizzle WE, Bell W, Sexton KC, AACR 96th Annual Meeting, Education Book 2005: 305-310
• Localized hypothalamic area related to neural control of ACTH.
  Grizzle WE, Johnson RN, Schramm LP, Gann DS, Fed Proc 1973;32:295
• Hypothalamic areas associated with neural control of ACTH.
  Grizzle WE, Dallman MF, Schramm LP, Gann DS, Physiologist 1973;l6:330
• Hypothalamic control of ACTH release after hemodynamic changes.
  Grizzle WE, Dallman MF, Schramm LP, Gann DS, Abstracts of Short Communications, IV International Congress of the International Society of Psychon
• Medication of the release of ACTH by the medial-dorsal hypothalamus (MDH).
  Grizzle WE, Schramm LP, Gann DS, Proceedings of the Society for Neurosciences 1974, p. 238
• Inhibitory and facilitory areas of the rostral pons mediating ACTH release in the cat.
  Ward DG, Grizzle WE, Gann DS, Endocrinology [Suppl] 1976;97:309
• Hypothalamic organization for control of ACTH in the cat.
  Maran JW, Carlson DE, Grizzle WE, Ward DG, Gann DS, Endocrinology [Suppl] 1977;l00:57
• Identification of functional neoplasms of the autonomic nervous system.
  Siegel AL, Grizzle WE, Stabler TV, Clin Chem 1982;28:l636
• Extra-adrenal pargangliomas: Biochemical, ultrastructural and histochemical analysis.
  Grizzle WE, Siegel AL, Endocrinology [Suppl] 1982;110-119
• Urinary free cortisol as screening method of choice for Cushing's syndrome.
  Dunlap NE, Grizzle WE, American College of Physicians, 1983 Annual Session. Hosp Pract 1983:18(6):37-43
• The golden hamster: A new experimental model of compensatory adrenal hypertrophy.
  Dunlap NE, Grizzle WE, Endocrinology [Suppl] 1983;112:332
• Aldosterone blocks compensatory adrenal hypertrophy in the rat.
  Grizzle WE, Dunlap NE, Endocrinology [Suppl] 1983;112:321
• Islet cell hyperplasia as a cause of hypoglycemia in adult patients.
  Grizzle WE, Bell DS, Diabetes [Suppl] 1983;32:116A
• LD isoenzyme VI: Clinical properties.
  Robinson CA, Ketchum CH, Hall LM, Grizzle WE, Clin Chem 1983;29:1168
• Effect of aldosterone on adrenal compensatory hypertrophy in the rat.
  Dunlap NE, Grizzle WE, Seventh International Congress of Endocrinology. Princeton: Exerpta Medica. 1984, p.542
• Antagonists to aldosterone block its effect on adrenal compensatory hypertrophy in the rat.
  Grizzle WE, Dunlap NE, Seventh International Congress of Endocrinology. Princeton: Excerpt Medica. 1984, p.781
• Adrenomedullary responses of patients with khypopituitarism to insulin induced hypoglycemia.
  Garg A, Grizzle WE, Stabler TV, Boots LR, Boshell BR, Kansal PC, Endocrinology [Suppl] 1985;116:169
• Evaluation of functional endocrine tumors with emphasis on tumors of the autonomic nervous system.
  Grizzle WE, Stabler TV, Siegel AL, South Med J [Suppl] 1985;79:41
• Alteration of the electrophorectic mobility of human brain type creatine kinase (CK-BB) activity.
  Chastain SL, Ketchum C, Grizzle WE, Clin Chem 1986;32:ll29
• An unusually small adrenal cortical carcinoma.
  Gandour MJ, Grizzle WE, South Med Assoc, 80th Annual Scientific Assembly, Atlanta, GA
• Dietary menhaden oil modulates bleomycin-induced pulmonary fibrosis.
  Kennedy JI, Chandler DB, Fulmer JD, Grizzle WE, Wert MB, Markfield Symposium on Interstitial Lung Disease, Chicago, IL
• Characterization of the effect of aldosterone on adrenal compensatory growth in hamsters.
  Ingram JT, Grizzle WE, J Cellular Biochemistry [Suppl] 1987;llA:130
• Changes in intestinal size and weight in the streptozotocin (STZ) - diabetic rat.
  Pillion DJ, Atchison JA, Jenkins R, Stockard CR, Clements RS, Grizzle WE, Diabetes [Suppl] 1987;36:125A
• Efficiency of insulin administered into the large intestine.
  Atchison JA, Grizzle WE, Pillion DJ, Diabetes [Suppl] 1987;36:125A
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Lectures

• Issues in the collection, processing and banking of human tissue specimens – the importance of bias in collections. 
  Isber 2005 Annual Meeting, Seattle, WA
• Scientific Session: AIDS in 1990 - A look at the predictions. 
  Alabama Society for Histotechnology
• Growth Factors and Protooncogenes - Identification and Importance in Diagnostic Histopathology. 
  National Society for Histotechnology, Annual Meeting
• Theoretical Concepts of Silver Stains. 
  National Society for Histotechnology, Annual Meeting
• Histological Silver Stains - Theory and Application. 
  National Society for Histotechnology, Annual Meeting, 1992, 1994
• Quality Control of Special Stains: Involvement of External Organizations - Biological Stain Commission and College of American Pathologists. 
  Florida Society for Histotechnology, Regional Meeting
• Factors Affecting Immunostaining from Fixation to Antigen Retrieval. 
  2nd Annual Advanced Immunohistochemistry Seminar, Birmingham, AL
• It's All in the Silver Family. 
  Alabama Society for Histotechnology, Regional Meeting, Mobile, AL
• Molecular Phenotypes of Neoplastic Lesions from Diagnosis to Molecular Targeting. 
  UAB Comprehensive Cancer Center Seminar Series
• Prostate Cancer from Prostatic Intraepithelial Neoplasia to Androgen Independence. 
  Seminar University of Texas, Southwestern Medical Center, Dallas, TX
• The Relationship of Early Breast Neoplasia in Animals and Man. 
  Breast Spore Exploratory Workshop. Santa Fe, New Mexico
• Androgen Regulation of Prostate Cancer. 
  Northwestern University Department of Pathology, Kansas City, KS
• The Early Detection, Diagnosis and Staging of Colorectal Neoplasia Using Molecular Markers and/or Protein-Fingerprints as Identified by SELDI-TOF-MS. 
  International Academy of Pathology Meeting, Washington, DC
• Use of biomarkers in early detection, diagnosis, prognosis, and surrogate endpoints, applications to GI and pancreatic cancers. 
  12th Spore Investigators’ Workshop, Baltimore, MD
• Prognostic factors in colorectal cancer vary with race. 
  MSM/TU/UAC Cancer Center Partnership’s 3rd Summer Institute in Birmingham, AL
• AIDS Precautions. 
  Alabama Society for Histotechnology
• The Cooperative Human Tissue Network as an example of prospective tissue collections. 
  Isber 2005 Annual Meeting, Seattle, WA
• Tissue specimen resources of the Early Detection Research Network. 
  Isber 2005 Annual Meeting, Seattle, WA
• The development of informatics and databases to support tissue/environmental repositories. 
  Isber 2005 Annual Meeting, Seattle, WA
• Interaction of Clinical Laboratories in Research. 
  Alabama Pathology and Laboratory Professionals Meeting
• Strategies to Address Next Generation of Challenges for Biobanking. 
  World Wide Biobank Summit III, Stockholm, Sweden
• Translational Research Seminar Series. 
  University of Alabama at Birmingham, Birmingham, AL
• New approaches in the study of DCIS/LCIS. 
  Presented at the Inter-SPORE meeting, Boston, MA
• Bias in Tissue Collection, Processing and Storage. 
  University of Michigan
• Even a blind pig can sometimes find a mushroom or accidental discoveries are made by observations followed by careful searches. 
  National Society for Histotechnology Annual Meeting, Birmingham, AL
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Other

• Fixation: Impact of Histopathology from Hematoxylin and Eosin Stains to Immunostaining (Part I). 
  Fredenburgh J and Grizzle WE, American Society of Clinical Pathologists Teleconference - Continuing Education
• Fixation: Impact of Histopathology from Hematoxylin and Eosin Stains to Immunostaining (Part II). 
  Fredenburgh J and Grizzle WE, American Society of Clinical Pathologists Teleconference - Continuing Education
• Overview: It's All in the (Silver) Family. 
  Grizzle WE, J Histotechnology (Guest Editorial) 1996;19(3):179
• President’s Report of the Biological Stain Commission Annual Meeting June 6-7, 2003, Rochester, New York. 
  Grizzle WE, Biotech Histochem 2003; 78(3-4)141-144
• Erratum. 
  Li L, Hsu HC, Grizzle WE, Stockard CR, Ho KJ, Lott P, Yang PA, Zhang HG, Mountz JD, Scand J Immunol 2003; 58(1):118
• Inaugural Issue for ISBER and CPT. 
  Hanner R, Mifflin TE, Grizzle WE, Cell Preservation Technology (Editorial) 2005;3(1):3-4
• Report of the Public Responsibility in Medicine and Research. 
  et al Grizzle WE, et al, The PRIM&R Human Tissue/Specimen Banking Working Group
• Section II Tools for Investigators, IRBs and Repository Managers. 
  et al, Grizzle WE, et al, The PRIM&R Tissue Working Group Report, Section II
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