WendyAnneWellsMD

PubMed

• 20 citations
  Validation of novel optical imaging technologies: the pathologists' view.
  Wendy A. Wells, Peter E. Barker, Calum MacAulay, Marco Novelli, Richard M. Levenson
  Journal of Biomedical Optics. 2007-09-01
• 34 citations
  Scatter Spectroscopic Imaging Distinguishes between Breast Pathologies in Tissues Relevant to Surgical Margin Assessment
  Ashley M. Laughney, Venkataramanan Krishnaswamy, Elizabeth J. Rizzo, Mary C. Schwab, Richard J. Barth
  Clinical Cancer Research. 2012-11-15
• 107 citations
  CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies.
  William W. Feng, Owen M. Wilkins, Scott Bang, Matthew Ung, Jiaqi Li
  Cell Reports. 2019-12-10

Journal Articles

• Micro-computed tomography of whole breast conserving surgery specimens enables rapid assessment of solid tumor proximity to positive and negative margins  
  WA, Paulsen KD, Pogue BW, Breast Cancer Research and Treatment, 1/1/2018
• Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue  
  McClatchy III DM, Rizzo E, Wells WA, Black CC, Paulsen KD, Kanick S, Pogue BW, J. Biomed. Opt., 1/1/2018
• Wide-field quantitative imaging of intrinsic scatter bio-markers using sub-diffusive structured light  
  McClatchy DM, Rizzo EJ, Wells WA, Hwang J, Paulsen KD, Pogue BW, Kanick SC, Biomedical Optics, 1/1/2016
• Tumor angiogenesis change estimation by diffuse optical spectroscopic tomography; can a correlation predict neo-adjuvant chemotherapy response in women with invasive b...  
  Pakalniskis MG, Wells WA, Schwab MC, Froehlich HM, Jiang S, Li Z, Tosteson TD, Poplack SP, Kaufman PA, Pogue BW, Paulsen KD, Radiology, 1/1/2011
• Fluorescence-based co-detection with protein markers reveals distinct cellular compartments for altered microRNA expression in solid tumors  
  Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia J, Kauppinen S, Wells WA, Korc M, Clinical Cancer Research, 1/16/2010
• Automated classification of breast pathology using local measures of broadband reflectance  
  Laughney AM, Krishnaswamy V, Garcia-Allende B, Conde OM, Wells WA, Paulsen KD, Pogue BW, Journal of Biomedical Optics, 1/1/2010
• Image guided Near Infrared Spectroscopy of Breast Tissue In-vivo using Boundary Element Method  
  Srinivasan S, Carpenter CM, Ghadyani HR, Taka SJ, Kaufman PA, DiFlorio-Alexander RM, Wells WA, Pogue BW, Paulsen KD, Journal of Biomedical Optics, 1/1/2010
• A Validation Study of a New Molecular Diagnostic Assay: The Dartmouth-Hitchcock Medical Center Experience with the GeneSearch� BLN Assay in Breast Sentinel Lymph Nodes  
  Tafe LJ, Schwab MC, Lefferts JA, Wells WA, Tsongalis GJ, Experimental and Molecular Pathology, 1/1/2010
• A prospective, multi-institutional study of adjuvant radiation therapy after resection of malignant phyllodes tumors  
  Barth RJ, Wells WA, Mitchell SE, Cole BF, Ann Oncol Surgery, 1/1/2009
• Evaluating tumor response to neoadjuvant chemotherapy with Diffuse Optical Spectroscopic Imaging: Case study of tumor Region of Interest changes  
  Jiang S, Pogue BW, Carpenter CM, Poplack SP, Wells WA, Kogel CA, Forero J, Muffly LS, Schwartz GN, Paulsen KD, Kaufman PK, Radiology, 1/1/2009
• Phase Contrast Microscopy analysis of breast tissue: Differences in benign versus malignant epithelium and stroma  
  Wells WA, Wang X, Daghlian CP, Paulsen KD, Pogue BW, Analytical and Quantitative Cytology and Histology, 1/1/2009
• Altered microRNA expression confined to specific epithelial cell subpopulations in breast cancer  
  Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells WA, Kauppinen S, Cole CN, Cancer Research, 1/15/2007
• Developments in Quantitative Oxygen-Saturation Imaging of Breast Tissue in-vivo using Multispectral Near-Infrared Tomography  
  Srinivasan S, Pogue BW, Carpenter C, Jiang S, Wells WA, Poplack SP, Kaufman PA, Paulsen, KD, Antioxidants and Redox Signaling, 1/1/2007
• Outcome of hyperfractionated radiotherapy in chemotherapy resistant non-Hodgkin's lymphoma  
  Martens C, Hodgson DC, Wells WA, Sun A, Bezjak A, Pintilie M, Crump M, Gospodarowicz MK, Tsang R, Int J Radiat Oncol Biol Phys, 1/1/2006
• Estimation of Sub-Cellular Particle Size Histograms with Electron Microscopy for Prediction of Optical Scattering in Breast Tissue  
  Bartek M, Wang X, Wells WA, Paulsen KD, Pogue BW, Journal of Biomedical Optics, 1/1/2006
• Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography  
  Wang X, Pogue BW, Jiang S, Dehghani H, Song X, Srinivasan S, Brooksby BA, Paulsen KD, Kogel C, Poplack SP, Wells WA, Journal of Biomedical Optics, 1/1/2006
• BRCA1 and BRCA2 mutation screening using SmartCycler II high-resolution melt curve analysis  
  Dufresne SD, Belloni DR, Wells WA, Tsongalis GJ, Archives of Pathology & Laboratory Medicine, 1/1/2006
• Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo  
  Wang X, Pogue BW, Jiang S, Song X, Paulsen KD, Kogel C, Poplack SP, Wells WA, Journal of Biomedical Optics, 1/1/2005
• Utilization of Mammography in NH  
  Carney PA, GoodrichME, Weiss JE, MacKenzie T, Poplack SP, Wells WA, Titus-Ernstoff L, Cancer, 1/1/2005
• Near-infrared Characterization of Breast Tumors in vivo using Spectrally-constrained Reconstruction  
  Srinivasan S, Pogue BW, Brooksby B, Jiang S, Dehghani H, Kogel C, Wells WA, Poplack SP, Paulsen KD, Technology in Cancer Research and Treatment, 1/1/2005
• Allel-specific loss of heterozygosity at the DAL-1/41B (EPB41L3) tumor-suppressor gene locus in the absence of mutation  
  Kittiniyom K, Mastronardi M, Roemer M, Wells WA, Greenberg ER, Titus-Ernstoff L, Newsham IF, Genes, Chromosomes & Cancer, 1/1/2004
• Likelihood of additional work-up among women undergoing routine screening mammography: the impact of age, breast density and hormone therapy use  
  Carney PA, Kasales CJ, Tosteson ANA, Weiss JE , Goodrich ME, Poplack, SP, Wells WA, Titus-Ernstoff L, Preventive Medicine, 1/1/2004
• Electromagnetic Breast Imaging Average tissue property values in women with negative clinical findings  
  Poplack SP, Paulsen KD, Hartov A, Meaney PM, Pogue BW, Tosteson TD, Grove MR, Soho SK, Wells WA, Radiology, 1/1/2004
• Leiomyosarcoma of the Popliteal Vein  
  Killoran TP, Wells WA, Barth R, Goodwin, D, Skeletal Radiology, 1/1/2003
• Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS)  
  North WG, Wells WA, Fay MJ, Mathew RS, Donnelly EM, Memoli VA, Endocrine Pathology, 1/1/2003
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Books/Book Chapters

• Alternative Breast Imaging; Four Model-based Approaches 
  Chapter: Four Alternative Breast Imaging Modalities 
  Page 1 - 24Poplack SP, Wells WA, Paulsen KDEditors: Paulsen KD, Meaney PM, Gilman LC.Springer Science, Inc.Edition 1st,2005
• Ductal Carcinoma in situ (DCIS) of the Breast 
  Chapter: The Diagnostic Reproducibility of Ductal Carcinoma in Situ 
  Page 264 - 271Wells WAEditors: Melvin J. Silverstein, MD.Lippincott Williams & WilkinsEdition 2nd,2002
• Clinical Laboratory Automation, Robotics and Knowledge Optimization. The Wiley-Interscience Series on Laboratory Automation 
  Chapter: Image Analysis 
  Wells WA, Memoli VAEditors: Gerald J. Kost.John Wiley & Sons, Inc.1996
• Year Book of Obstetrics and Gynecology 
  Chapter: Placental Hypoechoic-Anechoic Areas and Infarction: Sonograghic-Pathological Correlation. 
  Harris RD, Simpson WA, Marin-Padilla M, Stys S, Crow HCMosby Year Book Inc.1991
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Abstracts/Posters

• "Characterizing Thrombus Age and Molecular Organization Using Magnetic Nanoparticle Spectroscopy."
  Weaver JB, Khurshid H, Shi Y, Berwin BL, Schartz DA, Friedman BJ, Wells WA, Eskey CJ, Med Phys, American Association of Physicists in Medicine Annual Meeting, Nashville, TN, 1/29/2018
• Dartmouth-Hitchcock Weight and Wellness Center: how biospecimens support research into the biological changes related to and predictors of weight-loss.
  Gilbert-Diamond D, McClure AC, Rothstein RI, Aaron Weintraub A, Diane Sette D, Gallagher TL, Hughes EG, Tsongalis GJ, Wells WA, Batsis JA, Obesity Society Annual Meeting, Nashville, TN, 1/11/2018
• Spatial and Spectral Analysis of in-Situ Tumor-Normal Interfaces in Freshly Resected Lumpectomy Slices using Multispectral Structured Light Imaging.
  David Mcclatchy D, Benjamin Maloney B, Elizabeth Rizzo E, Paulsen K, Wells WA, Pogue B, Optical Society (OSA), Biophotonics Congress: Biomedical Optics, Hollywood, FL, 1/3/2018
• Analysis of Next Generation Sequencing results for pathogenic gene mutations.
  Mahmood S, He J, Abreu FB, Deharvengt S, Peterson JD, Steinmetz H, Wells WA, Tsongalis GJ, Northern New England Clinical Oncology Society (NNECOS), 2017 Annual Meeting, Stowe, VT, 1/27/2017
• A patient-specific 3-D printed form accurately transfers supine MRI derived tumor localization information to guide breast conserving surgery.
  Barth RJ, Krishnaswamy V, Wells WA, Angeles C, Rizzo, E, Rooney T, Marotti J, Black, CB, Paulsen KD, American Society of Breast Surgeons Annual Meeting, Las Vegas, NV, 1/26/2017
• Evaluation of a 170 gene NGS panel for the detection of RNA and DNA based variants in FFPE solid tumor samples.
  De Abre FB, Petersen JD, Deharvengt SJ, Tafe LJ, Wells WA, Tsongalis GJ, J Molec Diagn, Association of Molecular Pathology Annual Meeting (AMP), Salt Lake City, UT, 1/16/2017
• "Wide-field quantitative imaging of intrinsic scatter bio-markers using sub-diffusive structured light."
  McClatchy III, DM, Rizzo EJ, Wells WA, �Hwang JC, Paulsen KD, Pogue BW, Kanick SC, Proc. OSA Biomed 2016, 1/25/2016
• Approach to Management Using Evidence Based Medicine: Proliferative Breast Lesions Among Reduction Mammoplasty Specimens.
  Akintayo R, Rosenkranz A, Wells WA, Ridgway E, Plastic Surgery The Meeting, Los Angeles, CA, 1/23/2016
• Evaluation of the Pillar NGS SLIMampTM Lung and Colon Hot Spots Panel.
  Peterson JD, de Abreu FB, Wang Z, Wells WA, Tsongalis GJ, Association of Molecular Pathology Annual Meeting (AMP), Charlotte, NC, 1/10/2016
• Validation of EGFR Fragment Analysis by PerkinElmer LabChip GX Touch 24.
  Gallagher TL, de Abreu FB, Wells WA, Tsongalis GJ, Association of Molecular Pathology Annual Meeting (AMP), Charlotte, NC, 1/10/2016
• Validation of the FusionPlexTM Solid Tumor Panel in routine clinical practice.
  De Abreu FB, Peterson JD, Deharvengt SJ, Tafe LJ, Wells WA, Tsongalis GJ, Association of Molecular Pathology Annual Meeting (AMP), Charlotte, NC, 1/10/2016
• Molecular Test Utilization Improvements at Dartmouth-Hitchcock Medical Center.
  Shajani-Yi, Z; Cervinski MA, Palko Dinulos MB, SE, Wells WA, Tsongalis GJ, Association of Molecular Pathology Annual Meeting (AMP), Charlotte, NC, 1/10/2016
• Evaluation of the CLC Biomedical Genomics Workbench (BMGW) Platform for Targeted Clinical NGS Data Analysis.
  Peterson, JD, Amos CI, de Abreu FB, Wells WA, Tsongalis GJ, Association of Molecular Pathology Annual Meeting (AMP), Charlotte, NC, 1/10/2016
• Broken promise of liquid biopsy: plasma DNA does not accurately reflect tumor DNA in metastatic breast cancer.
  Chamberlin MD, Shee K, Varn FS, Bean JR, Marotti JD, Wells WA, Trask HW, Hamilton JS, West RJ, Kaufman PA, Schwartz GN, Gemery JM, McNulty NJ, Tsapakos MJ, Barth RJ, A..., San Antonio Breast Consortium Symposium Meeting, San Antonio, TX, 1/6/2016
• Expression of Spot-14 and lipoprotein lipase in matched samples of primary and metastatic breast cancer tumor tissue.
  Bhatt A, Lupien LE, Wells WA, Kinlaw WB, Chamberlin MD, Breast Cancer Symposium (ASCO), San Francisco, CA, 1/25/2015
• Somatic Mutation Profiling Using a 50 Gene Cancer Panel: The Dartmouth Experience.
  De Abreu FB, Peterson JD, Amos CI, Wells WA, Tsongalis GJ, Northern New England Clinical Oncology Society annual Meeting, Portland, ME, 1/23/2015
• Somatic Gene Mutation Analysis of Triple Negative Breast Cancers.
  Dillon J, Mockus S, Patterson S, Ananda G, Mitchell T, Spotlow V, York E, Palisoul S, Wells WA, Tsongalis GJ, Marotti JD, J Molec Diagn, Association for Molecular Pathology (AMP) Annual Meeting, Austin, TX, 1/5/2015
• "High Spatial Frequency Structured Light Imaging for Intraoperative Breast Tumor Margin Assessment."
  McClatchy III DM, Krishnaswamy V, Kanick SC, Elliott JT, Barth, Jr. RJ, Wells WA, Paulsen KD, and Pogue, BW, Proc. SPIE, 1/1/2015
• Stromal expression of microRNA-21 identified high risk group in triple negative breast cancer.
  MacKenzie TA, Schwartz GR, Hostetter G, Winn M, Graveel M, Wells WA, Sempere LF, American Association for Cancer Research (AACR), Special Conferences: Cancer Susceptibility and Cancer Susceptibility Syndromes, San Diego, CA, 1/29/2014
• Clinical Genotyping of Somatic Mutations in Glioma.
  Maloku E, Tafe LJ, Peterson JD, de Abreu F, Hickey WF, Ronan LK, Fadul CE, Wells WA, Amos CI, Association for Molecular Pathology (AMP) Annual Meeting, Gaylord National Resort & Convention Center, National Harbor, MD, 1/12/2014
• Evaluation of Whole-Genome Amplification for Next-Generation Sequencing Using the Illumina TruSeq Amplicon Cancer Panel.
  Allen S, Peterson JD, Wells WA, de Abreu F, Association for Molecular Pathology (AMP) Annual Meeting, Gaylord National Resort & Convention Center, National Harbor, MD, 1/12/2014
• Somatic Mutation Analysis in Melanoma Using Targeted Next Generation Sequencing.
  Association for Molecular Pathology (AMP) Annual Meeting, Gaylord National Resort & Convention Center, National Harbor, MD, 1/12/2014
• Implementing Lean Methods to Improve the HER2 Fluorescence In-Situ Hybridization Process in the Diagnostic Molecular Pathology Laboratory.
  Steinmetz HB, Perry OM, Wells WA, Tafe LJ, The Journal of Molecular Diagnostics, Association for Molecular Pathology (AMP) Annual Meeting, Gaylord National Resort & Convention Center, National Harbor, MD, 1/12/2014
• MRI-Detected Benign Papillary and Sclerosing Lesions of the Breast: Microvessel Analysis with Radiologic Correlation.
  Bond JS, DeFlorio-Alexander RM, Memoli VA, Wells WA, Poplack SP, Marotti JD, United States and Canadian Academy of Pathology's Annual Meeting (USCAP), San Diego, CA, 1/1/2014
• Structured Light Scatteroscopy of Intraoperative Breast Lumpectomy Specimens: Imaging through Blood and Ink.
  McClatchy III DM, Krishnaswamy V, Elliott JT, Barth, Jr. RJ, Wells WA, Paulsen KD, Pogue BW, Proc. OSA Biomed, 1/1/2014
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Lectures

• "The Hospital Autopsy: Why patients, their families or their providers should be asking for one." 
  Dartmouth College, Hanover, NH - 1/1/2018
• "Efficiency Transformations in the Clinical Laboratories at DHMC: Our LEAN-Six Sigma experience." 
  DHMC, Lebanon, NH - 1/1/2018
• "Breast Margin Assessment by Ex Vivo Microscopy: the Crucial Role of the Pathologist in Validation" 
  San Francisco, CA - 1/20/2017
• "The Business Plan for Introducing Ex-vivo microscopy into a Pathology Department" 
  Washington, DC - 1/8/2017
• "The Hospital Autopsy - functions, barriers and outcomes." 
  Lebanon, NH - 1/1/2017
• "Justifying the Introduction of Emerging Technologies into a Pathology Department: How to Develop a Business Plan" 
  San Diego, CA - 1/12/2016
• "Improving Efficiency in an Academic Pathology Department in the USA: The Dartmouth experience." 
  1/3/2016
• "Quantitative Pathology" 
  Gaithersburg Campus, MD - 1/26/2014
• "Establishing a Biobanking Operational Plan that Affordably Accounts for Multiple Data Sources, End Users, and Service Providers" 
  Seaport World Trade Center, Boston, MA - 1/18/2012
• "How NIR imaging predicts the expression of endoglin (CD105) positive angiogenesis during neo-adjuvant chemotherapy treatment for breast cancer." 
  Burlington, VT - 1/28/2009
• "Validating Translational Breast Imaging Modalities - the pathologist's perspective." 
  Burlington, VT - 1/1/2009
• "Network collaborations for pathology-imaging correlations - genomic correlates in with NIR-imaging in neoadjuvant chemotherapy patients." 
  Newport Beach, CA - 1/29/2007
• "Breast Cancer sentinel lymphadenectomy standard-of-care and the DHMC experience." 
  Los Angeles, CA - 1/7/2007
• "Breast core biopsies: a practical guide to radiologic correlation, pathologic interpretation and clinical recommendations" 
  DHMC, Lebanon, NH - 1/1/2007
• "Tissue morphology and novel imaging correlates - the pathologist's perspective." 
  Fort Lauderdale, FL - 1/19/2006
• "Breast Cancer Diagnosis, Prognosis and Translational Research: A Multidisciplinary Approach which includes Pathologist Assistants" 
  DHMC, Lebanon, NH - 1/1/2006
• "Defining the Clinical Role of Optical Methods in Breast Cancer Detection" 
  San Jose, CA - 1/19/2005
• "Pathology Validation of Optical Signals in early Cancer Detection" 
  University of Maryland, Adelphi, MD - 1/6/2005
• "Breast Cancer Diagnosis, Prognosis and Translational Research: a Multidisciplinary Approach between Clinicians, Scientists, Epidemiologists and Engineers." 
  DHMC, Lebanon, NH - 1/1/2005
• "Alternative Breast Cancer Imaging: Novel Non-Invasive Techniques for Early Detection" 
  CA - 1/1/2005
• "The issues of pathology reproducibility in validating correlates for near-infrared imaging." 
  Rockville, MD - 1/1/2004
• "Network collaborations for pathology-imaging correlations - validation, standardization and reproducibility." 
  Newport Beach, CA - 1/1/2004
• "Pathology correlates for near-infrared imaging in breast." 
  Rockville, MD - 1/1/2004
• "The Role and Process of the Hospital Autopsy." 
  DHMC, Hanover, NH - 1/1/2002
• "From Biopsy to Diagnosis - the Pathologist's Role." 
  Hanover, NH - 1/1/2001
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Other

• "Justify Introducing an Emerging Technology into a Pathology Department that does not yet have a Reimbursement Code." 
  Simpson WA, CAP Webinar (IVM/EVM Subcommittee of CAP)
  1/23/2018
• "Breast Margin Assessment in Ex Vivo Microscopy: the Crucial Role of the Pathologist in Validation" 
  Simpson WA, CAP Webinar (IVM/EVM Subcommittee of CAP)
  1/27/2016
• "The Business Plan to Justify Introducing an Emerging Technology into a Pathology Department that does not yet have a Reimbursement Code." 
  Simpson WA, CAP Webinar (IVM/EVM Subcommittee of CAP)
  1/18/2016
• Wide-field quantitative imaging of intrinsic scatter bio-markers using sub-diffusive structured light. 
  McClatchy DM, Rizzo EJ, Wells WA, Hwang J, Paulsen KD, Pogue BW, Kanick SC, OSA (Optical Society of America) Optical Society of America
  https://doi.org/10.1364/CANCER.2016.JM4A.7
  1/1/2016
• "The Final word." 
  Wells WA, Grand Rounds Essay, Dartmouth Medicine (Winter Edition), p. 24
  1/1/2003
• Creating a Business Plan for Emerging Technologies. 
  Wells WA, Webcasts, College of American Pathologists
  https://soundcloud.com/pathologists/want-to-bring-an-emerging-technology-into-your-lab-write-a-business-plan
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