Warren S Pear MD PhD
Molecular Genetics, Anatomic Pathology, Clinical Pathology
Professor, Pathology & Laboratory Medicine, Perelman School of Medicine
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800 Spruce St# RsPhiladelphia, PA 19107
Phone+1 215-829-3000
Fax+1 215-829-7564
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Education & Training
MIT & Rockefeller UniversityPost-Doctoral Fellowship, 1991 - 1996
Mass General Brigham/Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1989 - 1991
University of Rochester School of Medicine and DentistryClass of 1989, MD- Karolinska InstitutePhD, Tumor Biology, 1983 - 1987
- Williams CollegeBA, Economics, 1976 - 1980
Certifications & Licensure
PA State Medical License 1996 - 2026
American Board of Pathology Clinical Pathology
Awards, Honors, & Recognition
- Elected Member Association of American Physicians (AAP), 2002
- Elected Member American Society of Clinical Investigation (ASCI)
Publications & Presentations
PubMed
- 4 citationsThe pseudokinase Trib1 regulates the transition of exhausted T cells to a KLRCD8effector state, and its deletion improves checkpoint blockade.Susan E McClory, Oishi Bardhan, Kelly S Rome, Josephine R Giles, Amy E Baxter
Cell Reports. 2023-08-29 - 1 citationsThe pseudokinase Trib1 regulates the transition of exhausted T cells to a KLRCD8effector state and its deletion improves checkpoint blockade.Susan E McClory, Oishi Bardhan, Kelly S Rome, Josephine R Giles, Amy E Baxter
Biorxiv. 2023-02-16 - 5 citationsc-Rel-dependent monocytes are potent immune suppressor cells in cancer.Ting Li, Mayassa J Bou-Dargham, Norman Fultang, Xinyuan Li, Warren S Pear
Journal of Leukocyte Biology. 2022-10-01
Journal Articles
- Downregulating Notch Counteracts KrasG12D-Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative NeoplasmErik A Ranheim, David Yang, Warren S Pear, Lan Zhou, Mignon Loh, Eric Padron, Elliot Stieglitz, Nature
Press Mentions
Systemic Notch Downregulation Promotes KrasG12D‐Induced Myeloproliferative NeoplasmMarch 31st, 2019
Linking Mutations in Notch Gene to Role in B-cell CancersNovember 25th, 2017
Newly Described Type of Immune Cell and T Cells Share Similar Path to MaturityMay 14th, 2013
Grant Support
- Physician Scientist Training Program in Immune DysregulationUNIVERSITY OF PENNSYLVANIA2024–2029
- Physician Scientist Training Program in Immune DysregulationUNIVERSITY OF PENNSYLVANIA2024–2029
- Physician Scientist Training Program in Immune DysregulationUNIVERSITY OF PENNSYLVANIA2024–2029
- Physician Scientist Training Program in Immune DysregulationUNIVERSITY OF PENNSYLVANIA2024–2029
- The c-Rel Checkpoint for Immunosuppression and ImmunotherapyUNIVERSITY OF PENNSYLVANIA2020–2025
- Immunobiology of Normal and Neoplastic LymphocytesUNIVERSITY OF PENNSYLVANIA1975–2025
- The Function Of Tribbles In The Pathogenesis Of AMLNational Cancer Institute2007–2011
- Retroviral Transduction CoreNational Cancer Institute2007–2011
- Oncogenic Notch Signaling: Mouse ModelingNational Cancer Institute2006–2010
- Notch Regulation Of Hematopoetic Cell FatesNational Institute Of Allergy And Infectious Diseases2000–2010
- Pathogenesis Of Chronic Myelogenous LeukemiaNational Cancer Institute1999–2003
- Signals Downstream Of Notch Regulating Lymphoid Cell Fate And FunctionNational Cancer Institute2002
- Notch Signaling In B Cell Development And SurvivalNational Cancer Institute2002
- Core--Retroviral Transduction Of Murine Bone Marrow For In Vivo AnalysisNational Cancer Institute2002
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