WadeSmithMD

Neurology • San Francisco, CA

Spinal Disorder, Vascular Neurology

Director, UCSF Neuroscience ICU UCSF Professor of Neurology

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Office
505 Parnassus Ave
San Francisco, CA 94143
Phone+1 415-353-1489

Fax+1 415-353-8705

Education & Training

UC San Francisco1994
University of California (San Francisco)Chief Residency, Neurology, 1992 - 1993
University of California (San Francisco)Residency, Neurology, 1990 - 1992
University of California (San Francisco)Internship, Internal Medicine, 1989 - 1990
University of WashingtonPhD, Neurophysiology, 1982 - 1989
University of Washington School of MedicineClass of 1989
University of WashingtonBS, Electrical Engineering, 1978 - 1982

Certifications & Licensure

CA State Medical License 1991 - 2026
FL State Medical License 2014 - 2016
American Board of Psychiatry and Neurology Neurology
ASNNeurosonology
UCNSNeurocritical Care

Awards, Honors, & Recognition

Most Outstanding Lecture Series of the first year 2007
Excellence in Neurology J. Elliott Royer, 2005
Most Outstanding Lecture University of California Medical Class, 1997
Member Alpha Omega Alpha Honor Medical Society, 1997
Teaching University of California Medical Class, 1996
Clinical Excellence University of California, 1990
Graduate with Honor University of Washington, 1989
Graduated Magna Cum Laude University of Washington, 1982
House Staff Teaching University of California Medical Class, 1992, 1994
Super Doctor SuperDoctors.com
Top MD Consumers Checkbook
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Clinical Trials

Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCI™]) Start of enrollment: 2004 Jan 01
Completed
Not Applicable
Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Start of enrollment: 2007 Jun 01
Completed
Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS) Start of enrollment: 2009 Sep 01
Completed
Not Applicable
Randomized Trial Evaluating Performance of the Trevo Retriever Versus the Merci Retriever in Acute Ischemic Stroke Start of enrollment: 2011 Feb 01
Completed
Not Applicable
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial Start of enrollment: 2012 Apr 01
Completed
Phase 3
Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx Start of enrollment: 2020 Nov 02
Completed
Multi-arm Optimization of Stroke Thrombolysis Start of enrollment: 2019 Oct 15
Active, not recruiting
Phase 3
Roles: Contact
AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke Start of enrollment: 2018 Jan 19
Terminated
Phase 3
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the DAWN Trial.
Raul G Nogueira, Mohamed F Doheim, Ashutosh P Jadhav, Amin Aghaebrahim, Michael R Frankel
Annals of Neurology. 2024-08-01
5 citations
A Survey on Monitoring and Management of Cerebral Vasospasm and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: The Mantra Study.
Edoardo Picetti, Pierre Bouzat, Mary Kay Bader, Giuseppe Citerio, Raimund Helbok
Journal of Neurosurgical Anesthesiology. 2024-07-01
Trends in stroke-related journals: Examination of publication patterns using topic modeling.
Burak Berksu Ozkara, Mert Karabacak, Konstantinos Margetis, Wade Smith, Max Wintermark
Journal of Stroke and Cerebrovascular Diseases. 2024-06-01

Journal Articles

Utilizing Simulated Errors in Radiotherapy Plans to Quantify the Effectiveness of the Physics Plan Review
Wade P Smith, Olga Gopan, Avrey Novak, Minsun Kim, Jing Zeng, Medical Physics
Performance/outcomes Data and Physician Process Challenges for Practical Big Data Efforts in Radiation Oncology
Amy Moreno, Shruti Jolly, Mary Feng, Robert Miller, Joseph Herman, Martha M Matuszak, Clifton D Fuller, Wade Smith, James Hayman, Seungtaek Choi, Torunn I Yock, Peter ..., Medical Physics
Machine Learning and Modeling: Data, Validation, Communication Challenges
Ying Xiao, Wade Smith, Medical Physics
Thrombectomy 6 to 24 Hours After Stroke with a Mismatch Between Deficit and Infarct
Elad I. Levy, Qaisar A. Shah, Jawad F. Kirmani, Parita Bhuva, Cathy A. Sila, Michael G. Abraham, Amin Aghaebrahim, Wade S. Smith, Raul G. Nogueira, Brijesh P. Mehta, P..., The New England Journal of Medicine
PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. Prolyse in Acute Cerebral Thromboe...
del Zoppo, GJ; Higashida, RT; Furlan, AJ; Pessin, MS; Rowley, HA; Gent, M, Stroke (1998) 29:4-11
Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.
Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F, JAMA (1999) 282:2003-11
Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alte...
Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S, JAMA (1999) 282: 2019-26
Clinical stroke trials: guarding against bias.
Goldstein LB, Brott TG, Kothari RU, Smith, WS, Stroke (1999) 30: 1165-1166
Introduction to monitoring in the neurological intensive care unit and its future impact.
Smith WS, Aminoff MJ, Neurologist (2000) 6: 83-97
Improved Paramedic Sensitivity in Identifying Stroke Victims in the Prehospital Setting.
Smith WS, Corry MD, Fazackerley J, Isaacs SM, Prehosp Emerg Care (1999) 3:207- 210
Spinal manipulative therapy is an independent risk factor for vertebral artery dissection.
Smith WS, Johnston SC, Skalabrin EJ, Weaver M, Azari P, Albers GW, Gress DR, Neurology (2003) 60: 1424-1428
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Books/Book Chapters

Higher Brain Function: Recent Explorations of the Brain's Emergent Properties.
Chapter: Noninvasive brain imaging and the study of higher brain function in humans
Smith WS, Fetz EEEditors: Wise SP.Wiley
Cerebral Cortex. Vol. 9
Chapter: Synaptic interactions between cortical neurons
Fetz EE, Toyama K, Smith WSEditors: Jones EG.Wiley
The Neurology of AIDS.
Chapter: Legal and ethical issues in HIV-1 induced dementia
Smith WSEditors: Gendelman HE, Lipton S, Epstein L and Swindells S.Chapman & Hall
Cardiology Looseleaf.
Chapter: Ischemic Stroke
Smith WSEditors: Parmley WW & Chatterjee K.Lippincott-Raven
Neurobase.
Chapter: Neurocardiogenic Syncope
Smith WSEditors: Gilman.Arbor
Neurobase.
Chapter: Syncope
Smith WSEditors: Gilman.Arbor
Hospital Medicine.
Chapter: Cerebrovascular Disease: Strokes and TIAs
Smith WSEditors: Wachter RM, Goldman L and Hollander H.Williams & Wilkins
Harrison’s Principles of Internal Medicine.
Chapter: Cerebrovascular Diseases
Smith WS, Easton D, Hauser SLEditors: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL and Jameson JL.Edition 15,
Principles of Internal Medicine.
Chapter: Cerebrovascular Diseases
Smith WS, Johnston, SCJ, Easton DEditors: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL and Jameson JL.Edition 16,
Hospital Medicine.
Chapter: Cerebrovascular Disease: Strokes and TIAs
Smith WSEditors: Wachter RM, Goldman L and Hollander H.Edition 2,
Harrison’s Principles of Internal Medicine
Chapter: Cerebrovascular Diseases
Smith WS, English JD, Johnston, SCJEditors: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL and Jameson JL.Edition 17,
Handbook of Clinical Neurology. Vol 93
Chapter: Cardio-embolic Stroke
English JD, Smith WSEditors: Aminoff MJ, Boller F and Swaab DF.
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Lectures

Acute Ischemic Stroke Board Review.
Neurocritical Care Society
Ethics Consultation and Capacity.
UCSF Department of Psychiatry, Grand Rounds
Update on Neurocritical Care.
AAN Fall Conference, Las Vegas
ENLS.
Hawaii Neurological Society
Teaching the Teacher.
AAN, Honolulu Hawaii
Update on Stroke.
Recent Advances in Neurology, SF
Cardiovascular complications of brain injury.
60th Annual Cerebrovascular Surgeons Meeting, SF, CA
Large vessel stroke.
Johns Hopkins Neurology Grand Rounds
Evidence Basis for IA treatment of Stroke.
International Stroke Conference, San Antonio, TX
ICU stroke management.
Society of Critical Care Medicine, Miami
ICU management of acute stroke.
Clinical Neuroscience Practice, Eugene
Status of Endovascular Stroke Therapy.
American Stroke Association
Stroke Circle: Endovascular Treatment.
Stroke Circle-National Stroke Association
Mechanical Embolectomy for Acute Stroke.
Society of Vascular Interventional Neurology
Mechnaical Management of Acute Intracranial Ischemia; Neuriprotection; Current Status and Perspective in Acute Stroke; Future Trials in Acute Stroke.
Asia Pacific Conference Against Stroke, Manila, Philippines
10 Major Advances in Stroke; Endovascular Stroke Therapy.
University of Utah Regional Stroke Conference
Neuroprotection Strategies.
Western State Stroke Consortium
How to Write a Research Proposal.
Neurocritical Care Society
Stroke Treatment and Prevention.
Idaho Neurological Society
ICU Management of the Endovascular Patient
Society Neuroanesthesia and Critical Care
CTA, CTP; Endovascular Stroke Therapy.
University of Texas Southwestern
Comprehensive Stroke Centers.
ANIM Meeting, Mannheim Germany
Stroke Review.
Neurocritical Care Society, Montreal QB
Endovascular Stroke Therapy.
Multiple Locations, 2007, 2008, 2009
Endovascular Stroke Treatment.
Multiple Locations, 2009
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Other

Ischemic Stroke.
Smith, WS, Current Opinion in Critical Care (1998) 4(2):89-93
Cervical Arterial Dissection: Causes and treatment.
Smith WS, Stroke Rounds (2003) 1: 2
http://www.strokerounds.org
Pathophysiology of Focal Cerebral Ischemia: A Therapeutic Perspective.
Smith WS, J Vasc Interv Radiol (2004) 15:S3-12
Patent foramen ovale, other interatrial septal anomalies, and neurological disease.
English JD, Smith WS, Stroke Rounds (2004) 2:3
http://www.strokerounds.org
Anticoagulation in stroke management: beyond anecdotal experience.
Yu W, Smith WS, Stroke Rounds (2004) 2:4
http://www.strokerounds.org
Migraine and Ischemic Stroke.
Neill TA, Smith WS, Stroke Rounds (2004) 2:9
http://www.strokerounds.org
Predicting long-term outcomes for ischemic stroke based on admission variables.
Flint AC, Smith WS, Stroke Rounds (2004) 2:10
http://www.strokerounds.org
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Press Mentions

MindRhythm Raises $5 Million to Solve the Triage Problem in StrokeAugust 24th, 2021
First Patient Enrolled in MindRhythm Trial to Assess LVO Stroke Diagnostic DeviceApril 29th, 2021
Medicare Data Reveal $564 Million Wasted on Chiropractors and Osteopathic ManipulationFebruary 12th, 2018
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