WadeHBerrettiniMDPhD in Pharmacology

Psychiatry • Wynnewood, PA

Addiction, Psychopharmacology

Professor of Psychiatry, Perelman School of Medicine at the University of Pennsylvania

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Office
113 Cherry Lane
Wynnewood, PA 19096
Phone+1 484-432-5836

Fax+1 610-642-2740

Summary

Dr. Wade Berrettini is a psychiatrist and pharmacologist in the Philadelphia area. for the past 25 years he has been a professor of psychiatry at the Perelman School of Medicine, University of Pennsylvania. He received his medical degree from Jefferson Medical College in 1977, and a Phd in pharmacology from Thomas Jefferson University in 1979. He specializes in psychopharmacology of treatment-resistant mood, anxiety and addictive disorders. The author of more than 400 peer-reviewed scientific publications, he has a practice of psychiatry in Wynnewood, PA.

Education & Training

Clinical Center at the National Institutes of HealthFellowship, Psychosomatic Medicine, 1982 - 1983
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Psychiatry, 1977 - 1980
Thomas Jefferson UniversityPh.D, Pharmacology, 1977 - 1979
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1977, MD
Dickinson CollegeBS, Cum Laude, 1969 - 1973

Certifications & Licensure

PA State Medical License 1978 - 2024
MD State Medical License 1980 - 1990
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

National Alliance for Research on Schizophrenia and Depression Distinguished Investigator Award 1999, 2004, 2009
Research Award Caron Foundation, 2009
GlaxoSmithKline Fellowship in Genetics of Disease 2007
Metzger-Conway Fellow Dickinson College, 2006
H. J. Weitbrecht Scientific Award University of Bonn, Bonn, Germany, 2001
Member Scientifi Council of the National Alliance for Research on Schizophrenia and Depression, 2000
Karl E. Rickels Chair of Psychiatry Department of Psychiatry, University of Pennsylvania, 1999
Louis Lurie Memorial Lecture Award University of Cinncinnati College of Medicine, 1999
Simon Gratz Award Jefferson Medical College, Thomas Jefferson University, 1997
Distinguished Alumnus Award Thomas Jefferson University, 1997
Pfizer Visiting Professorship University of Washington Department of Psychiatry, 1996
Selo Prize National Alliance for Research on Schizophrenia and Depression, 1996
National Alliance for Research on Schizophrenia and Depression Established Investigator Award 1992
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Clinical Trials

Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Start of enrollment: 2011 Apr 01
Completed

Publications & Presentations

PubMed

526 citations
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon J. Coombes, Jonathan R. I. Coleman
Nature Genetics. 2021-05-17
1581 citations
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S. Hong Lee, Stephan Ripke, Benjamin M. Neale, Stephen V. Faraone, Shaun Purcell
Nature Genetics. 2013-09-01
474 citations
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Douglas M. Ruderfer, Stephan Ripke, Andrew McQuillin, James Boocock, Eli A. Stahl
Cell. 2018-06-14

Journal Articles

Detecting Significant Genotype–Phenotype Association Rules in Bipolar Disorder: Market Research Meets Complex Genetics
John Kelsoe, Melvin McInnis, James Potash, William Lawson, John Rice, Evaristus Nwulia, William Byerley, Francis J McMahon, John Nurnberger, Wade Berrettini, Cinnamon ..., Springer Open
Platelet monoamine oxidase in chronic schizophrenia.
Berrettini, W.H., Vogel, W.H. and Clouse, R, American Journal of Psychiatry 134:805-806
Decreased platelet monoamine oxidase activity in chronic schizophrenia demonstrated with novel substrates.
Berrettini, W.H., Prozialeck, W. and Vogel, W.H, Archives of General Psychiatry 35:600-605
Arterial blood gases in Pranayama practice.
Pratap, V., Berrettini, W.H. and Smith, C, Perceptual and Motor Skills 46: 171-174
Evidence for an endogenous inhibitor of platelet monoamine oxidase in chronic schizophrenia.
Berrettini, W.H. and Vogel, W.H, American Journal of Psychiatry 135:836-38
Platelet monoamine oxidase in manic-depressive illness: Effect of lithium therapy.
Berrettini, W.H., Vogel, W.H. and Ladman, R.K, Am J Psychiatry 136: 836-38
Human platelet vasopressin receptors.
Berrettini, W.H., Post, R.M., Worthington, E.K. and Casper, J.B, Life Sciences 30:425-432
Platelet vasopressin receptors in bipolar affective illness.
Berrettini, W.H., Nurnberger, J.I., Jr., Worthington, E. K., Simmons-Alling, S. and Gershon, E.S, Psych Research 7:83-86
Plasma and CSF GABA in affective illness.
Berrettini, W.H., Nurnberger, J.I., Jr., Hare, T., Gershon, E.S. and Post, R.M, British Journal of Psychiatry 141:483-488
Platelet 3H-imipramine binding in euthymic bipolar patients.
Berrettini, W.H., Nurnberger, J.I., Jr., Post, R.M. and Gershon, E.S, Psychiatry Research 7:215-219
Platelet GABA-Transaminase in affective illness.
Berrettini, W.H., Umberkoman-Wiita, B., Nurnberger J.I., Jr., Vogel, W.H., Gershon, E.S. and Post, R.M, Psychiatry Research 7:255-260
Kindling and carbamazepine in affective illness.
R.M., Uhde, T.W., Putnam, F.W., Ballenger, J.C. and Berrettini, and W.H, Journal of Nervous and Mental Disease 170:717-731
Reduced plasma and CSF GABA in affective illness: effect of lithium carbonate.
Berrettini, W.H., Nurnberger, J.I., Jr., Hare, T.A., Simmons-Alling, S., Gershon, E.S. and Post, R.M, Biological Psychiatry l8:185-194
Absence of specific binding of several putative neurotransmitters to human fibroblasts.
Berrettini, W.H., Nadi, N.S. and Gershon, E.S, Journal of Receptor Research 3:409-421
Genetic factors in affective illness.
Berrettini, W.H., Goldin, L.R., Nurnberger, J.I., Jr. and Gershon, E.S, Journal of Psychiatric Research 18:329-350
Vasoactive intestinal peptide and bipolar affective illness: evidence for an effect of lithium.
Berrettini, W.H., Nurnberger, J.I., Jr., Hotvedt, P., Simmons-Alling, S. and Gershon, E.S, Journal of Affective Disorders 8:55-59
Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients.
Berrettini, W.H., Nurnberger, J.I., Jr., Linnoila, M., Narrow, W., Scheinin, M., Seppala, T., Simmons-Allings, S. and Gershon, E.S, Biological Psychiatry 20:257-275
CSF substance P immunoreactivity in affective disorders.
Berrettini, W.H., Rubinow, D.R., Nurnberger, J.I., Jr., Simmons-Alling, S., Post, R.M. and Gershon, E.S, Biological Psychiatry 20:965-970
Neuropeptides in human cerebrospinal fluid.
Berrettini, W.H., Nurnberger, J.I., Jr., Gold, P.W., Chretien, M., Chrousos, G.P., Goldin, L.R. and Gershon, E.S, Life Sciences 37:1265-1270
Proopiomelanocortin-related peptides in CSF: a study of manic-depressive disorder.
Berrettini, W.H., Nurnberger, J.I., Jr., Seidah, N.G., Chrousos, G.P., Chan, J.S.D., Gold, P.W., Simmons-Alling, S., Goldin, L.R., Chretien, M. and Gershon, E.S, Psychiatry Research 16:287-302
CSF GABA in euthymic manic-depressive patients and controls.
Berrettini, W.H., Nurnberger, J.I., Jr., Hare, T.A., Simmons-Alling, S. and Gershon, E.S, Biol Psychiatry 21:842-44
Neuropeptide Y immunoreactivity in human cerebrospinal fluid.
Berrettini, W.H., Nurnberger, J.I., Jr. and DiMaggio, D.A, Peptides 7:455-458
Intravenous GABA is anxiogenic in man.
Nurnberger, J.I., Jr., Berrettini, W.H., Simmons-Alling, S., Guroff, J.J. and Gershon, E.S, Psychiatry Research 19:113-117
Different neurotransmitter metabolite concentrations in CSF samples from inpatient and outpatient normal volunteers.
Guthrie, S.K., Berrettini, W.H., Rubinow, D.R., Nurnberger, J.I., Jr., Bartko, J.J. and Linnoila, M, Acta Psychiatrica Scandinavica 73:315-321
Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees.
Detera-Wadleigh, S.D., Berrettini, W.H., Goldin L.R., Boorman, D., Anderson, S. and Gershon, E.S, Nature 325:806-808
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Books/Book Chapters

Neuropsychopharmacology, The Fifth Generation of Progress.
Chapter: Bipolar disorders: review of molecular genetic studies.
Page 1027 - 1038Berrettini WHEditors: KL Davis, D Charney, JT Coyle, C Nemeroff.Lippincott, Philadelphia, PA
Handbook of Psychogenetics.
Chapter: Molecular linkage studies of manic-depressive illness
Page 161 - 167Berrettini WHEditors: K Blum and EP Noble.CRC Press, Boca Raton, FL
61st Symposium on Quantitative Biology.
Chapter: Quantitative trait loci mapping in mouse models of complex behavior.
Page 771 - 778Ferraro TN, BerrettiniWHCold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
Bipolar Disorder: Biological Models and their Clinical Application.
Chapter: Linkage studies of bipolar syndromes.
Page 219 - 233Berrettini WHEditors: LT Young, RT Joffe.Marcel Dekker, Inc, New York, NY
Directions in Psychiatry.
Chapter: Genetic factors in Anorexia Nervosa.
Page 53 - 58Berrettini WHEditors: Frederic Flach.The Hatherleigh Company, New York, NY
Genetic Influences on Neural and Behavioral Functions.
Chapter: The search for susceptibility genes in bipolar disorder.
Page 31 - 47Berrettini WHEditors: Don Pfaff.CRC Press, Boca Raton, FL
Annual Review of Medicine.
Chapter: Genetics of psychiatric disease.
Page 465 - 479Berrettini, WHEditors: CH Coggins.Annual Reviews, Palo Alto, CA
Current Diagnosis and Treatment in Psychiatry.
Chapter: Psychiatric genetics
Page 61 - 79Nurnberger JI, Berrettini WHEditors: Ebert MH, Loosen PT, Nurcombe B.Lange Medical Books, New York, NY
Emery and Rimoin’s Principles and Priactice of Medical Genetics vol. III.
Chapter: Addictive Disorders
Page 2949 - 2974Faroud T, Berrettini WHEditors: DL Rimoin, JM Connor, RE Pyerlitz, BR Korf.Churchill Livingstone, London
The Genetic Basis of Common Disease.
Chapter: The major affective disorders: bipolar, unipolar, and schizoaffective.
Goldin, L.R., Gershon, E.S., Nurnberger, Jr., J.I. and Berrettini, W.HEditors: R.A. King, J.A. Rotter, A.G. Motulsky.University Press, New York, NY
The Neurobiology of Mental Illness.
Chapter: Genetic studies of bipolar disorder.
Page 369 - 379Berrettini WHEditors: D Charney and E Nestler.Oxford University Press, New York, NYEdition 2,
Textbook of Mood Disorders.
Chapter: Genetics of Bipolar and Unipolar Disorders.
Page 235 - 250Berrettini WHEditors: DJ Stein, DJ Kupfer, AF Schatzberg.American Psychiatric Publishing, Boulevard Arlington, VA
Neurobehavioral Genetics.
Chapter: Genetics of Major Affective Disorders
Page 127 - 246Berrettini WHEditors: BC Jones and P Mormede.CRC Press, Boca Raton, FL
Current Diagnosis and Treatment in Psychiatry.
Chapter: Psychiatric Genetics
Page 15 - 34Nurnberger JI and Berrettini WHMcGraw-Hill, New York, NY
The Neurobiology of Mental Illness.
Chapter: Genetics of mood disorders.
Page 360 - 377Lohoff FW and Berrettini WHEditors: D Charney and E Nestler.Oxford University Press, New York, NYEdition 3,
Bipolar Disorder.
Chapter: Genetics of bipolar disorder.
Page 110 - 123Lohoff FW, Berrettini WHEditors: LN Yatham and M. Maj.Wiley-Blackwell, Hoboken, NJ
Psychiatric Genetics.
Nurnberger JI, Jr, and Berrettini WHChapman and Hall, London
Advanced Methods in Psychobiology.
Chapter: Genetic methods in neuropsychiatric disorders.
Page 221 - 235Nurnberger, J.I., Jr., Berrettini, W.H., Goldin, L.R. and Gershon, E.SEditors: J.N. Hingtgen, et al.C.J. Hogrefe, Inc., Toronto
Comprehensive Textbook of Psychiatry. Vol 2
Chapter: Genetic aspects of affective disorder.
Page 228 - 285Gershon, E.S., Nurnberger, J.I., Jr., Berrettini, W.H. and Goldin, L.REditors: H. Kaplan, B. Sadock.Williams and Wilkins, Baltimore, MD
Neurobiology of Mood Disorders.
Chapter: GABA in affective illness.
Page 673 - 685Berrettini, W.H. and Post, R.MEditors: R.M. Post, J.C. Ballenger.Williams and Wilkins, Baltimore, MD
Pathochemical Markers of the Psychoses.
Chapter: Cerebrospinal fluid amine metabolite studies in depression: Research update.
Page 129 - 143Jimerson, D.C. and Berrettini, W.HEditors: H. Beckmann, P. Riederer.Springer-Verlag, Berlin
Proceedings of the IVth World Congress of Biological Psychiatry.
Chapter: CSF GABA in bipolar affective illness.
Page 926 - 928Berrettini, W.H., Nurnberger, J.I., Jr., Hare, T.A. and Gershon, E.SEditors: C. Shagass, et al.Elsevier Pub. Co., Inc., New York, NY
Proceedings of the IVth World Congress of Biological Psychiatry.
Chapter: DNA polymorphisms in schizophrenia and affective disorders.
Page 67 - 79Detera-Wadleigh, S.D., DeLisi, L.E., Berrettini, W.H., Nurnberger, J.I., Jr., Boorman, D.G., Gershon, E.S., Minth, C.D. and Dixon, J.EEditors: C. Shagass, et al.Elsevier Pub. Co. Inc., New York, NY
Proceedings of the IVth World Congress of Biological Psychiatry.
Chapter: The inheritance of mania.
Page 829 - 832Nurnberger, J.I., Jr., Berrettini, W.H. and Gershon, E.SEditors: C. Shagass, et al.Elsevier Pub. Co. Inc., New York, NY
Antidepressants and Receptor Function.
Chapter: Beta-adrenergic receptor function in human adult skin fibroblasts: A study of manic-depressive illness.
Page 30 - 42Berrettini, W.H., Bardakjian, J., Barnett, A.L., Nurnberger, J.I. and Gershon, E.SEditors: R. Porter, et al.John Wiley and Sons, New York, NY
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Abstracts/Posters

Further evidence for an endogenous inhibitor of platelet MAO in chronic schizophrenia.
Vogel, W.H., Berrettini, W.H. and Ladman, R.K, Schizophrenia Bulletin 6:232-234
Platelet MAO in families of chronic schizophrenics.
Berrettini, W.H., Benfield, T.C., Schmidt, A.O., Ladman, R.K. and Vogel, W.H, Schizophrenia Bulletin 6:235-237
Effects of oxygen, pH, and toluene on the activity of platelet MAO obtained from healthy and chronic schizophrenic individuals.
Vogel, W.H., Berrettini, W.H., Weiss, K.J. and Benfield, T.C, Psychopharmacology Bulletin l7:28-31

Press Mentions

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia NervosaDecember 5th, 2018
Genome-Wide Association Study of Seasonal Affective DisorderSeptember 14th, 2018
Yes, You Can Inherit Depression—Here’s What That Means if You're StrugglingMay 16th, 2018
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Grant Support

Genetics Of Nicotine DependenceNational Institute On Drug Abuse2009–2012
MU Opioid Receptor In AddictionNational Institute On Drug Abuse2008–2011
Linkage Disequilibrium Studies Of Morip Genes In Opiod DependenceNational Institute On Drug Abuse2008–2011
Administrative CoreNational Institute On Drug Abuse2008–2011
MU Receptor Interacting Proteins In Opiate DependenceNational Institute On Drug Abuse2007–2011
A Collaborative Genomic Study Of Bipolar DisorderNational Institute Of Mental Health2004–2007
Genetics Of Anorexia NervosaNational Institute Of Mental Health2002–2005
Quantitative Genetics Of Opiate AddictionNational Institute On Drug Abuse2002–2004
A Neuropeptide Gene In Psychiatric IllnessNational Institute Of Mental Health2002–2004
MU Receptor Polymorphisms And Heroin AddictionNational Institute On Drug Abuse2002
Collaborative Genomic Study Of Bipolar DisorderNational Institute Of Mental Health1998–2001
Genetic Study Of Opioid AddictionNational Institute On Drug Abuse1997–2000
Quantitative Genetics Of A RAT Model For AlcoholismNational Institute On Alcohol Abuse And Alcoholism1997–1999
Quantitative Genetics Of Opiate AddictionNational Institute On Drug Abuse1997
Quantitative Genetics Of A RAT Model For AlcoholismNational Institute On Alcohol Abuse And Alcoholism1996–1997
Quantitative Genetics Of Opiate AddictionNational Institute On Drug Abuse1995–1997
Linkage Studies Of Bipolar DiseaseNational Institute Of Mental Health1995–1996

Other Languages

French, Italian