Vincent W.WYangMDPhD

PubMed

• Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis.
  Soma Kobayashi, Christopher Sullivan, Agnieszka B Bialkowska, Joel H Saltz, Vincent W Yang
  Scientific Reports. 2023-09-01
• 4 citations
  Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration.
  Emilia J Orzechowska-Licari, Agnieszka B Bialkowska, Vincent W Yang
  Cellular and Molecular Gastroenterology and Hepatology. 2023-01-01
• 1 citations
  Intestinal Epithelial Regeneration in Response to Ionizing Irradiation.
  Emilia J Orzechowska-Licari, Joseph F LaComb, Michael Giarrizzo, Vincent W Yang, Agnieszka B Bialkowska
  Journal of Visualized Experiments. 2022-07-27

Journal Articles

• Kruppel-like factor 6 regulates mitochondrial function in the kidney  
  Mallipattu, S.K., Horne, S.J., D'Agati, V., Narla, G., Liu, R., Dickman, K., Chen, E.Y., Ma'ayan, A., Bialkowska, A.B., Ghaleb, A.M., Nandan, M.O., Jain, M.K., Daehn, ..., Journal of Clinical Investigation, 1/1/2014
• Intestinal stem cell (Lgr5)-specific deletion of Kruppel-like factor 5 in mice results in acute loss of proliferation and chronic depletion of stem cells  
  M.O. Nandan, A.M. Ghaleb, A.B. Bialkowska, V.W. Yang, Gastroenterology, 1/1/2014
• Kruppel-like factor 4 is a radio-protective factor of the intestine following gamma radiation-induced gut injury in mice  
  D. Talmasov, A.M. Ghaleb, B. Yu, M.O. Nandan, V.W. Yang, Gastroenterology, 1/1/2013
• Kruppel-like factor 4 is necessary and sufficient for re-establishing genetic stability in mouse embryonic fibroblasts null for Klf4  
  E.A. El-Karim, A.M. Ghaleb, E.G. Hagos, V.W. Yang, Gastroenterology, 1/1/2013
• Ultrahigh-throughput screening strategies for identification of small-molecule compounds that target the colon cancer oncogene Kruppel-like factor 5  
  A. B. Bialkowska, M. Crisp, T.D. Bannister, Y. He, S. Chowdhury, S. Schurer, P. Chase, T. Spicer, F. Madoux, P. Hodder, D. Zaharevitz, V.W. Yang, Gastroenterology, 1/1/2013
• Intestine-specific deletion of Kruppel-like factor 5 results in an epithelial regenerative phenotype  
  M.O. Nandan, K. Yu, A. Bialkowska, B. McConnell, V.W. Yang, Gastroenterology, 1/1/2012
• Helicobacter pylori promotes expression of a mediator of carcinogenesis, Kruppel-like factor 5, in vitro and in vivo  
  T. Khizanishvili, J.M. Noto, M.B. Piazuelo, A.G. Delgado, V.W. Yang, P. Correa and R.M. Peek Jr, Gastroenterology, 1/1/2012
• A novel microtubule-modulating noscapinoid triggers apoptosis by inducing multipolarity via centrosome amplification and declustering  
  Karna, P., Rida, P.C.G., Pannu, V., Gupta, K.K., Dalton, W.B., Joshi, H., Yang, V.W., Zhou, J., and Aneja, R., Cell Death & Differentiation, 1/1/2011
• Regulator of mediator of DNA damage checkpoint 1 (MDC1) during mitosis  
  B. Yu, W.B. Dalton, and V.W. Yang, Proc. Amer. Assoc. Cancer Res., 1/1/2011
• Intestine-specific expression of K-RasG12D from the endogenous K-Ras locus leads to a hyperproliferative phenotype and spontaneous polyposis  
  M.O. Nandan, A.M. Ghaleb and V.W. Yang, Gastroenterology, 1/1/2011
• Intestine-specific deletion of the Kruppel-like factor 4 (KLF4) gene protects mice from dextran sulfate sodium (DSS)-induced colitis  
  A.M. Ghaleb, B.B. McConnell and V.W. Yang, Gastroenterology, 1/1/2011
• The E3 ubiquitin ligase, SMAD ubiquitination regulatory factor 2 (SMURF2), negatively regulates the pro-proliferative Kruppel-like factor 5 (KLF5)  
  J.X. Du and V.W. Yang, Gastroenterology, 1/1/2011
• Kruppel-like factor 5 is a key factor for maintenance of crypt architecture and barrier function in the mouse intestine  
  B.B. McConnell, S.S. Kim, A.M. Ghaleb, N. Takeda, I. Manabe, A. Nusrat, R. Nagai and V.W. Yang, Gastroenterology, 1/1/2011
• MMP-9 modulates colitis associated cancer through Notch-1-mediated p53 activation  
  P. Garg, S. Jeppsson, G. Dalmasso, A. Ghaleb, N.R. Patel, B.B. McConnell, V.W. Yang, A.T. Gewirtz, D. Merlin, S.V. Sitaraman, Gastroenterology, 1/1/2011
• p53 prevents structural chromosome instability after mitotic arrest in human cells  
  Dalton, W.B. and Yang, V.W., Oncogene, 1/1/2010
• Identification of small molecule inhibitors of Kruppel-like factor 5 (KLF5) through ultra-high-throughput screening  
  M. Crisp, P. Chase, A.B. Bialkowska, S. Schuerer, W. Roush, V.W. Yang, and P. Hodder, Society of Biomolecular Sciences, 1/1/2010
• Kruppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined APC and KRAS mutations  
  M.O. Nandan, A.M. Ghaleb, B.B. McConnell, and V. W. Yang, Gastroenterology, 1/1/2010
• Intestine-specific deletion of the mouse Kruppel-like factor 4 gene results in altered homeostasis of intestinal epithelial cells  
  A.M. Ghaleb, B.B. McConnell, J. P. Katz, K.H. Kaestner, and V.W. Yang, Gastroenterology, 1/1/2010
• Aberrant intestinal crypt morphology and cell positioning in mice with intestine-specific deletion of the Kruppel-like factor 5 gene  
  B.B. McConnell, S. S. Kim, R. Nagai, and V.W. Yang, Gastroenterology, 1/1/2010
• Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable  
  Hagos, E.G., Ghaleb, A.M., Dalton, W.B., Bialkowska, A.B., and Yang, V.W., Oncogene, 1/1/2009
• The new mimicker of pancreatic cancer: sarcoidosis  
  J. Naik, D. Dressler and V.W. Yang, Journal of General Internal Medicine, 1/1/2009
• Haploinsufficiency of Kruppel-like factor 5 (KLF5) reduces intestinal adenoma KRasV12G/ApcMin/+ mice  
  M.O. Nandan, A. M. Ghaleb, B.B. McConnell, and V. W. Yang, Gastroenterology, 1/1/2009
• The absence of LPA2 attenuates tumor formation in both an animal model of colitis-associated cancer and ApcMin/+ mice  
  S. Lin, A.M. Ghaleb, H. Shim, V.W. Yang, J. Chun, and C.C. Yun, Gastroenterology, 1/1/2009
• Haploinsufficiency of Kruppel-like factor 5 (Klf5) sensitizes mice to dextran sodium sulfate (DSS)-induced colitis  
  B.B. McConnell, V.L. Kolachala, S.V. Sitaraman, and V. W. Yang, Gastroenterology, 1/1/2009
• Prostaglandin levels in the gastric mucosa of patients with stress and without stress-a preliminary study  
  C.S. Marin, J. Qin, Q. Zhou, X. Wang, V.W. Yang and Q. Cai, Gastroenterology, 1/1/2008
• Join now to see all

Books/Book Chapters

• Mechanisms of Intestinal Tumorigenesis. 
  A.B. Bialkowska and V.W. Yang (Eds)Editors: A.B. Bialkowska and V.W. Yang.Springer Publishing2014
• Physiology of the Gastrointestinal. 
  Chapter: The Cell Cycle. 
  Page 451 - 472Yang, V.W.Editors: L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said and J. Wood.Academic Press, Oxford, Great BritainEdition 5th,2012
• Essentials of Gastroenterology. 
  Chapter: Colorectal Neoplasms. 
  Page 132 - 146Azrak, M.F. and Yang, V.W.Editors: L. Friedman and S. Sitaraman.John Wiley & Sons, Ltd.2012
• Biology of Kruppel-Like Factors. 
  Chapter: Kruppel-Like Factors in Cancers. 
  Page 205 - 219Yang, V.W.Editors: R. Nagai, S.L. Friedman, and M. Kasuga.Springer2009
• Lange Outline Review for the USMLE Step 1. 
  Chapter: The Gastrointestinal System. 
  Page 77 - 101Yang, V. W. and Wehbi, M.AEditors: J.S. Goldberg.McGraw-Hill, New York, NYEdition 2nd,2006
• Current Colorectal Cancer Reports. 
  Chapter: Molecular Biology Section 
  Yang VW (Section Ed)Editors: Yang VW (Section Ed).2006
• Appleton & Lange Outline Review for the USMLE Step 1. 
  Chapter: The Gastrointestinal System. 
  Page 89 - 122Yang, V. W.Editors: J.S. Goldberg.McGraw-Hill, New York, NYEdition 4th,2004
• The Principles and Practice of Medicine. 
  Chapter: Malaborsption. 
  Yang, V.W. and Bayless, T.M.Editors: Benz, Hellmann, Ladenson, Petty, Thomas, and Traill.Appleton & Lange, Stamford, CTEdition 24th,2001
• Molecular Basis of Medicine. 
  Chapter: Arachidonic Acid Metabolism and Inflammatory Bowel Disease. 
  Yang, V.W.Editors: A.M. Feldman and C.V. Dang.Mosby Year Book Inc., St. Louis, MO1993
• Molecular Basis of Medicine. 
  Chapter: Molecular Biology of Hepatitis B Virus and Hepatocellular Carcinoma. 
  Yang, V.W. and Diehl, A.M.Editors: M. Feldman and C.V. Dang.Mosby Year Book Inc., St. Louis, MO1993
• Join now to see all

Abstracts/Posters

• Intestine-specific deletion of Klf4 renders mice susceptible to inflammation-associated tumorigenesis and increases colonic adenoma incidence in ApcMin/+ mice.
  A.M. Ghaleb, V.W. Yang, Gastroenterology, 1/1/2014
• Kruppel-like factor 5 modulates intestinal epithelial barrier function by regulating components of the tight junction in vitro.
  Y. Liu, A.B. Bialkowska, V.W. Yang, Gastroenterology, 1/1/2014
• Amelioration of dextran sodium sulfate-induced colitis in mice by genetic deletion of Klf4 in the intestinal epithelium or by oral delivery of nanoparticles loaded wit...
  A.M. Ghaleb, H. Laroui, P. Rakhya, D. Merlin, V.W. Yang, Gastroenterology, 1/1/2013
• A colon cancer-derived mutant of Kruppel-like factor 5 inhibits its degradation by glycogen synthase kinase 3Beta and the E3 ubiquitin ligase FBW7.
  A.B. Bialkowska, Y. Liu, M.O. Nandan , V.W. Yang, Gastroenterology, 1/1/2013
• Deletion of the Kruppel-like factor 4 gene in colonic epithelium protects mice from dextran sulfate sodium (DSS)-induced colitis.
  A.M. Ghaleb, H. Larou, D. Merlin, V.W. Yang, Gastroenterology, 1/1/2012
• MMP-9 mediates colitis-associated cancer in mice through Notch-1 via p53 activation.
  P. Garg, S. Jeppsson, V.W. Yang, A.T. Gewirtz, D. Merlin and S.V. Sitaraman, Inflammatory Bowel Diseases, 1/1/2012
• Identification of small-molecule compounds that inhibit the pro-proliferative transcription factor Kruppel-like factor 5 (KLF5) in colorectal cancer cells by cell-base...
  A.B. Bialkowska, C. Tian and V.W. Yang, Gastroenterology, 1/1/2011
• Clinical predictors of positive radionucleotide imaging in patients with lower gastrointestinal bleed.
  C. Tian, F. Azrak, E. Shehada and V.W. Yang, Gastroenterology, 1/1/2011
• MMP-9 functions as a tumor suppressor in colitis-associated cancer through its effects on cell cycle.
  P. Garg, A.B. Bialkowska, S. Jeppsson, V.W. Yang, A.T. Gewirtz, D. Merlin, and S. V. Sitaraman, Gastroenterology, 1/1/2010
• High-throughput screening (HTS) of a 290,000-small molecule compound library for inhibitors of the gene encoding the pro-proliferative human Kruppel-like factor 5 (KLF5).
  A.B. Bialkowska, M. Crisp, S. Schuerer, B.A. Mercer, P. Hodder, W.R. Roush and V.W. Yang, Gastroenterology, 1/1/2010
• Chemoprevention of familial adenomatous polyposis by EM011 in the ApcMin/+ mouse model.
  S. Li, A.M. Ghaleb, J. He, U. Bughani, A.B. Bialkowska, V.W. Yang, and H.C. Joshi, Proc. Amer. Assoc. Cancer Res., 1/1/2010
• Induction of Kruppel-like factor 5 by lipopolysaccharide in intestinal epithelial cells is mediated by mitogen-activated protein kinase and phosphoinositide 3-kinase p...
  S.K. Ngwenya, A. Bialkowska, and V.W. Yang, Gastroenterology, 1/1/2008
• SUMOylation enhances nuclear localization of Kruppel-like factor 5.
  J.X. Du and V.W. Yang, Gastroenterology, 1/1/2008
• Identification of novel small molecules that inhibit the pro-proliferative Kruppel-like factor 5 by high-throughput screening.
  A. Bialkowska, Y. Du, H. Fu, and V.W. Yang, Gastroenterology, 1/1/2008
• Pre-procedural group education significantly improves screening colonoscopy compliance rate in a predominantly African American inner city population.
  H. Olejeme, A. Smith, and V.W. Yang, Gastroenterology, 1/1/2007
• Induction of Kruppel-like factor 5 expression by lysophosphatidic acids.
  H. Zhang, R. Rusovici, A. Bialkowska, S. Chanchevalap, J. P. Katz, H. Shim, and V.W. Yang, and C. C. Yun, Gastroenterology, 1/1/2007
• Kruppel-like factor 5 interacts with and enhances the activity of Beta-catenin in vitro.
  A. Bialkowska, B.B. McConnell, C.R. Williams, M.O. Nandan, and V.W. Yang, Gastroenterology, 1/1/2007
• Noscapine-induced apoptosis in human colon cancer cells is p53-dependent.
  R. Aneja, A. Ghaleb, V.W. Yang, and H. Joshi, Proc. Amer. Assoc. Cancer Res., 1/1/2006
• The rate of polyp recurrence in patients undergoing colonoscopy in a U.S. metropolitan teaching hospital.
  M.A. Wehbi, J.W. Nam, C.G. NeSmith, D.M Pham, and V.W. Yang, Gastroenterology, 1/1/2006
• The utilization of colonoscopy as a screening method for colorectal cancer in two U. S. metropolitan teaching hospitals.
  M.A. Wehbi, J.W. Nam, C.G. NeSmith, D.M. Pham, and V.W. Yang, Gastroenterology, 1/1/2006
• Kruppel-like factor 4 (KLF4) prevents entry into mitosis following DNA damage by suppressing cyclin B1 gene expression.
  H.S. Yoon and V.W. Yang, Gastroenterology, 1/1/2004
• The cell cycle checkpoint function of Kruppel-like factor 4 as revealed by transcriptional profiling.
  E.M. Whitney and V.W. Yang, Gastroenterology, 1/1/2004
• Wnt 11 signaling induces proliferation and transformation of intestinal epithelial cells IEC6 and is mediated by a protein kinase C-dependent mechanism.
  L. Ouko, L.H.Gu, T.R. Ziegler, and V.W. Yang, Gastroenterology, 1/1/2003
• Screening colonoscopy as a tool for the detection of advanced neoplasia of the colon in two metropolitan university hospitals with different demographics.
  M.A. Wehbi, J. W. Nam, M. Shapiro, and V.W. Yang, Gastroenterology, 1/1/2003
• Comparison of the expression levels of the genes encoding Kruppel-like factor 4 (KLF4), Kruppel-like factor 5 (KLF5), and p21WAF1/Cip1 in matched normal and cancerous ...
  W. Zhao, I. M. Hisamuddin, and V. W. Yang, Gastroenterology, 1/1/2003
• Join now to see all

Lectures

• The Career Journey of a Physician Scientist and Department Chair. 
  Stony Brook, NY - 1/1/2014
• GI Cancer Program. 
  Stony Brook, NY - 1/1/2014
• Department of Medicine, Cancer Center, and Beyond. 
  Stony Brook, NY - 1/1/2014
• My Career Journey as a Physician Scientist and Department Chair. 
  San Diego, CA - 1/1/2014
• Universal Screening for Lynch Syndrome. 
  Stony Brook, NY - 1/1/2014
• Population-Based Screening for Lynch Syndrome. 
  Stony Brook, NY - 1/1/2014
• Intestinal Stem Cells: Dynamics and Regulation. 
  Stony Brook, NY - 1/1/2014
• High-Throughput Screening Approach to Targeted Therapeutic Discovery in Colorectal Cancer. 
  Baltimore, MD - 1/1/2014
• Population-Based Screening and Cascade Testing for Lynch Syndrome. 
  Baltimore, MD - 1/1/2014
• Population-Based Screening and Cascade Testing for Lynch Syndrome: Are We There Yet? 
  Multiple Presentations, 2011, 2012, 2013 - 1/1/2013
• The Role of Kruppel-Like Factors in Intestinal Epithelial Biology and Pathobiology. 
  Cleveland, OH - 1/1/2013
• A Career Journey of a Physician Scientist. 
  Stony Brook, NY - 1/1/2012
• DNA: A Key to Your Health or a Lock on Your Destiny? 
  Stony Brook, NY - 1/1/2012
• The Career Journey of a Physician Scientist. 
  Stony Brook, NY - 1/1/2012
• The Biology and Pathobiology of Kruppel-Like Factors in Intestinal Epithelium. 
  Boston, MA, 2011; Stony Brook, NY, 2011, 2012 - 1/1/2012
• Publishing Manuscripts: The Path from Ideas to Publication. 
  San Diego, CA - 1/1/2012
• Vision for a Department of Medicine at Stony Brook University. 
  Boston, MA - 1/1/2012
• Kruppel-Like Factors (KLFs) and Intestinal Tumorigenesis. 
  Stony Brook, NY - 1/1/2012
• The Role of Kruppel-Like Factors in Intestinal Tumorigenesis. 
  Hong Kong, China, 2009; Snowmass, CO, 2012 - 1/1/2012
• The Approach to Targeted Therapy Discovery: High Throughput Screening. 
  Washington, DC - 1/1/2011
• High Throughput Screening Approach to Targeted Therapeutic Discovery in Colorectal Cancer. 
  Stony Brook, NY - 1/1/2011
• The Best of AGA at DDW on GI Oncology. 
  Stockholm, Sweden - 1/1/2011
• Vision for a Successful Department of Medicine. 
  Stony Brook, NY - 1/1/2011
• Kruppel-Like Factors and Intestinal Tumorigenesis. 
  Beijing, China, 2007; Taipei, Taiwan, Republic of China, 2008; Little Rock, AR, 2011 - 1/1/2011
• Update on Colorectal Cancer 2010 U. S. A. 
  New Orleans, LA - 1/1/2010
• Join now to see all

Other

• KLF4 (Kruppel-like factor 4 (gut)). 
  Ghaleb, A.M. and Yang, V.W., Atlas of Genetics and Cytogenetics in Oncology and Haematology
  http://atlasgeneticsoncology.org//Genes/KLF4ID44316ch9q31.html
  1/1/2008
• Acute Gastritis. 
  Wehbi, M., Snyder, R.H., Sarver, G., Obideen, K., and Yang, V.W., eMedicine
  http://www.emedicine.com/med/topic850.htm
  1/1/2006
• Familial Adenomatous Polyposis. 
  Wehbi, M.., Carethers, J.M., and Yang, V.W., eMedicine
  http://www.emedicine.com/med/topic769.htm
  1/1/2006
• Gastroesophageal Reflux Disease (GERD) FAQs. 
  Hale, K.L. and Yang, V.W., eMedicine Consumer Health
  http://www.emedicinehealth.com/articles/43158-1.asp
  1/1/2005
• Heartburn FAQs. 
  Hale, K.L. and Yang, V.W., eMedicine Consumer Health
  http://www.emedicinehealth.com/articles/43179-1.asp
  1/1/2005
• Celiac Sprue. 
  Wehbi, M.A., Yang, V.W. and Rutherford, E., eMedicine Consumer Health
  http://www.emedicinehealth.com/Articles/52913-1.asp
  1/1/2005
• Understanding Gastroesophageal Reflux Disease and its Dental Manifestations. 
  Yang, V.W. and Wehbi, M. A., Academy of Dental Therapeutics and Stomatology
  http://www.ineedce.com/PDF%20files/ADTS.AcidReflux.pdf
  1/1/2005
• Reflux Disease (GERD). 
  Simic, P.J., and Yang, V.W., eMedicine Consumer Health
  http://www.emedicinehealth.com/articles/10685-1.asp
  1/1/2004
• Heartburn. 
  Patel, Y., Jerrard, D., and Yang, V.W., eMedicine Consumer Health
  http://www.emedicinehealth.com/articles/5984-1.asp
  1/1/2004
• Malabsorption. 
  Yang, V.W., eMedicine Journal
  http://www.emedicine.com/med/index.shtml
  1/1/2001
• Celiac Sprue 
  Yang, V.W., eMedicine Journal
  http://www.emedicine.com/med/index.shtml
  1/1/2001
• Transcription and processing of type 2 adenoviral sequence in nuclei isolated from productively infected HeLa cells. 
  Yang, V.W.
  1/1/1980
• ML264: An Antitumor Agent that Potently and Selectively Inhibits Kruppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progress... 
  Bialkowska, A., Crisp, M., Madoux, F., Spicer, T., Knapinska, A., Mercer, B., Bannister, T.D., He, Y., Chowdhury, S., Cameron, M., Yang, V.W., Hodder, P., Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Informatio
  Bethesda, MD
• Join now to see all