UbaldoEmilioMartinez OutschoornMD

PubMed

• 191 citations
  Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment.
  Ubaldo E. Martinez-Outschoorn, Stephanos Pavlides, Anthony Howell, Richard G. Pestell, Herbert B. Tanowitz
  The International Journal of Biochemistry & Cell Biology. 2011-07-01
• 122 citations
  Power surge: supporting cells "fuel" cancer cell mitochondria.
  Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti
  Cell Metabolism. 2012-01-04
• 337 citations
  Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
  Ubaldo E. Martinez-Outschoorn, Casey Trimmer, Zhao Lin, Diana Whitaker-Menezes, Barbara Chiavarina
  Cell Cycle. 2010-09-01

Journal Articles

• A 2-Step Haploidentical Versus A 2-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation  
  Gaballa S, Palmisiano N, Alpdogan O, Carabasi M, Filicko-O'Hara J, Kasner M, Kraft WK, Leiby B, Martinez-Outschoorn U, O'Hara W, Pro B, Rudolph S, Sharma M, Wagner JL,..., Biol Blood Marrow Transplant, 1/25/2015
• Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease  
  Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Oncotarget, 1/22/2015
• Multicompartment metabolism in papillary thyroid cancer  
  Curry JM, Tassone P, Cotzia P, Sprandio J, Luginbuhl A, Cognetti DM, Mollaee M, Domingo-Vidal M, Pribitkin EA, Keane WM, Zhan T, Birbe R, Tuluc M, Martinez-Outschoorn U, Laryngoscope, 1/15/2015
• Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial rich, cancer cells  
  Lamb R, Ozsvari B, Bonuccelli G, Smith DL, Pestell RG, Martinez-Outschoorn UE, Clarke RB, Sotgia F, Lisanti MP, Oncotarget, 1/1/2015
• Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling  
  Lamb R, Bonuccelli G, Ozsvari B, Peiris-Pagès M, Fiorillo M, Smith DL, Bevilacqua G, Mazzanti CM, McDonnell LA, Naccarato AG, Chiu M, Wynne L, Martinez-Outschoorn UE, ..., Oncotarget, 1/1/2015
• Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction  
  Lamb R, Harrison H, Smith DL, Townsend PA, Jackson T, Ozsvari B, Martinez-Outschoorn UE, Pestell RG, Howell A, Lisanti MP, Sotgia F, Oncotarget, 1/1/2015
• Caveolae and signaling in cancer  
  Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Nature Reviews Cancer, 1/1/2015
• Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy  
  Lamb R, Fiorillo M, Chadwick A, Ozsvari B, Reeves KJ, Smith DL, Clarke RB, Howell SJ, Cappello AR, Martinez-Outschoorn UE, Peiris-Pagès M, Sotgia F, Lisanti MP, Oncotarget, 1/1/2015
• Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells  
  De Luca A, Fiorillo M, Peiris-Pagès M, Ozsvari B, Smith DL, Sanchez-Alvarez R, Martinez-Outschoorn UE, Cappello AR, Pezzi V, Lisanti MP, Sotgia F, Oncotarget, 1/1/2015
• Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates  
  Mills TA, Orloff M, Domingo-Vidal M, Cotzia P, Birbe RC, Draganova-Tacheva R, Martinez Cantarin MP, Tuluc M, Martinez-Outschoorn U, Semin Oncol, 1/1/2015
• Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer  
  Johnson JM, Lai SY, Cotzia P, Cognetti D, Luginbuhl A, Pribitkin EA, Zhan T, Mollaee M, Domingo-Vidal M, Chen Y, Campling B, Bar-Ad V, Birbe R, Tuluc M, Martinez Outsc..., Semin Oncol, 1/1/2015
• Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?  
  Peiris-Pages M, Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Cell Metab, 1/1/2015
• A Two-Step Approach to Myeloablative Haploidentical Transplantation: Low Nonrelapse Mortality and High Survival Confirmed in Patients with Earlier Stage Disease  
  Grosso D, Gaballa S, Alpdogan O, Carabasi M, Filicko-O'Hara J, Kasner M, Martinez-Outschoorn U, Wagner JL, O'Hara W, Rudolph S, Chervoneva I, Colombe B, Farley PC, Flo..., Biol Blood Marrow Transplant, 1/23/2014
• Catabolic cancer-associated fibroblasts (CAFs) transfer energy and biomass to anabolic cancer cells, fueling tumor growth  
  Martinez-Outschoorn UE, Lisanti MP, Sotgia F, Semin Cancer Biol, 1/1/2014
• Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer  
  Lisanti MP, Sotgia F, Pestell RG, Howell A, Martinez-Outschoorn UE, Cell Cycle, 1/1/2013
• Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment  
  Salem AF, Al-Zoubi MS, Whitaker-Menezes D, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Galbiati F, Bevilacqua G, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2013
• Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkB target stromal MCT4  
  Martinez-Outschoorn UE, Curry JM, Ko YH, Lin Z, Tuluc M, Cognetti D, Birbe RC, Pribitkin E, Bombonati A, Pestell RG, Howell A, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2013
• Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers  
  Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, Philp NJ, Lin Z, Gandara R, Sneddon S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2012
• Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth  
  Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, Casimiro MC, Aquila S, Ando' S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Oncotarget, 1/1/2012
• Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells  
  Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Salem AF, Tsirigos A, Lamb R, Sneddon S, Hulit J, Howell A, Lisanti MP, Cell Cycle, 1/1/2012
• Creating a tumor-resistant microenvironment: Cell-mediated delivery of TNF-alpha completely prevents breast cancer tumor formation in vivo  
  Al-Zoubi M, Salem AF, Martinez-Outschoorn UE, Whitaker-Menezes D, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Arafat H, Bevilacqua G, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2012
• Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism  
  Ertel A, Tsirigos A, Whitaker-Menezes D, Birbe RC, Pavlides S, Martinez-Outschoorn UE, Pestell RG, Howell A, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2012
• Power Surge: Supporting Cells "Fuel" Cancer Cell Mitochondria  
  Martinez-Outschoorn UE, Sotgia F, Lisanti MP, Cell Metab, 1/1/2012
• Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells  
  Salem AF, Whitaker-Menezes D, Lin Z, Martinez-Outschoorn UE, Tanowitz HB, Al-Zoubi MS, Howell A, Pestell RG, Sotgia F, Lisanti MP, Cell Cycle, 1/1/2012
• Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis  
  Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, Mercier I, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP, Antioxid Redox Signal, 1/1/2012
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Books/Book Chapters

• Case Studies in Hematology and Coagulation. 
  Chapter: Copper deficiency. 
  Martinez Outschoorn U, Caro JASCP Press2012
• Case Studies in Hematology and Coagulation. 
  Chapter: Iron deficiency anemia. 
  Martinez Outschoorn U, Caro JASCP Press2012
• Case Studies in Hematology and Coagulation. 
  Chapter: Post-transplant lymphoproliferative disorder. 
  Flomenberg N, Dulau Florea A, Martinez Outschoorn UASCP Press2012
• Case Studies in Hematology and Coagulation. 
  Chapter: Transferrin deficiency. 
  Martinez Outschoorn U, Caro JASCP Press2012
• Williams Textbook of Hematology. 
  Chapter: Anemia of renal disease (Chapter 36) 
  Martinez Outschoorn U, Caro JMcGraw Hill2010
• Williams Textbook of Hematology. 
  Chapter: Hypersplenism and Hyposplenism (Chapter 55) 
  Martinez Outschoorn U, Caro JMcGraw Hill2010
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Abstracts/Posters

• OPB-111077 in Combination with Decitabine and Venetoclax for the Treatment of Acute Myeloid Leukemia
  Ubaldo Martinez-Outschoorn, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• Metabolic asymmetry in cancer: a microenvironment rethink. 
  OHSU, Portland, OR - 1/8/2015
• Oncometabolites, Mitochondria and Multicompartment Cancer Metabolism 
  Whistler, British Columbia, Canada - 1/18/2014
• Metabolic Compartmentalization in Cancer 
  Doylestown, PA - 1/10/2014
• Tumor Microenvironment in Cancer Metabolism 
  Harvard Medical School, Boston, MA - 1/5/2014
• Multi-compartment Tumor Metabolism 
  Universidad Autonoma Madrid, Madrid, Spain - 1/29/2013
• Role of Oncometabolites in Multi-compartment Tumor Metabolism 
  Hospital Vall d’ Hebron, Barcelona, Spain - 1/25/2013
• Metabolites and Mitochondria in Multicompartment Tumor Metabolism 
  MD Anderson Cancer Center, Houston, TX - 1/11/2013
• The Role of Metabolites in Tumor Metabolic Coupling 
  Children’s Hospital of Philadelphia, Philadelphia, PA - 1/10/2013
• Two Compartment Metabolism 
  Bellinzona, Switzerland - 1/7/2013
• Cancer Stem Cells and Mitochondria: a Metabolic Rethink 
  New York Academy of Sciences, New York, NY - 1/1/2013
• Tumor microenvironment-Integrating Autophagy, Metabolism and Inflammation 
  Boston, MA - 1/16/2012
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