TimothyAYapMD

Oncology • Houston, TX

Physician

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Office
1515 Holcombe Blvd
Houston, TX 77030
Phone+1 713-792-6161

Education & Training

Imperial College London School of MedicineClass of 2002

Certifications & Licensure

TX State Medical License 2018 - 2026
OK State Medical License 2020 - 2021

Clinical Trials

IACS-010759 in Advanced Cancers Start of enrollment: 2017 Nov 13
Completed
Phase 1
Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations Start of enrollment: 2019 Nov 21
Active, not recruiting
Phase 1
Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study Start of enrollment: 2020 Jun 30
Active, not recruiting
Phase 1
Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors Start of enrollment: 2020 Mar 17
Active, not recruiting
Phase 1, Phase 2
Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN Start of enrollment: 2020 Jul 17
Active, not recruiting
Phase 1, Phase 2
Study of RP-3500, Camonsertib, in Advanced Solid Tumors Start of enrollment: 2020 Jul 22
Recruiting
Phase 1, Phase 2
Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors. Start of enrollment: 2020 Sep 28
Terminated
Phase 1
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies Start of enrollment: 2020 Nov 12
Recruiting
Phase 1, Phase 2
Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial Start of enrollment: 2020 Dec 01
Recruiting
Phase 1
SAR439459 and Cemiplimab for the Treatment of Advanced or Unresectable Solid Tumors, Strategic Alliance, TACTIC TRIAL Start of enrollment: 2021 Feb 09
Terminated
Phase 1
IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors Start of enrollment: 2021 Sep 09
Recruiting
Phase 1
Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations Start of enrollment: 2022 Sep 27
Active, not recruiting
Phase 2
Roles: Principal Investigator, Contact
Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301) Start of enrollment: 2019 Dec 20
Active, not recruiting
Phase 1
Roles: Principal Investigator
Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors Start of enrollment: 2019 Aug 01
Recruiting
Phase 1
Roles: Principal Investigator, Contact
Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers Start of enrollment: 2024 Jan 30
Recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers.
Christopher L Carroll, Michael G Johnson, Yanbing Ding, Zhijun Kang, R S K Vijayan
Journal of Medicinal Chemistry. 2024-12-04
Synthetic lethal strategies for the development of cancer therapeutics.
Natalie Y L Ngoi, David Gallo, Carlos Torrado, Mirella Nardo, Daniel Durocher
Nature Reviews. Clinical Oncology. 2024-12-03
Oncology Combination Drug Development Strategies for Project Optimus.
Timothy A Yap, Julie Bullock, Susan Chong, Megan K Doyle, Azher Hussain
Clinical Cancer Research. 2024-12-02

Lectures

A first-in-human phase I study of FS118, an anti-LAG-3/PD-L1 bispecific antibody in patients with solid tumors that have progressed on prior PD-1/PD-L1 therapy.
2019 ASCO Annual Meeting - 6/1/2019
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

BridGene Biosciences Announces Dosing of First Patient in Phase 1 Study Evaluating Novel TEAD Inhibitor BGC515 in Advanced Solid TumorsJune 28th, 2024
AACR Annual Meeting 2023: Phase III Immunotherapy Trials Offer Hope for Patients with Lung, Liver, and Biliary Tract CancersMay 4th, 2023
IDEAYA Doses First Patient in Phase L HRD Solid Tumour Therapy TrialApril 19th, 2023
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TimothyAYapMD

Dr. Yap is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

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