TimothyRBilliarMD

PubMed

• Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway.
  Ting Gong, Qing-De Wang, Patricia A Loughran, Yue-Hua Li, Melanie J Scott
  Military Medical Research. 2024-10-28
• Decoding the multiple functions of ZBP1 in the mechanism of sepsis-induced acute lung injury.
  Ting Gong, Yu Fu, Qingde Wang, Patricia A Loughran, Yuehua Li
  Communications Biology. 2024-10-21
• Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
  Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei
  Cancer Research Communications. 2024-10-01

Journal Articles

• Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury  
  Francis X Guyette, Brian J Eastridge, Raminder Nirula, Gary A Vercruysse, Louis H Alarcon, Clifton W Callaway, Brian S Zuckerbraun, Matthew D Neal, Raquel M Forsythe, ..., JAMA Surgery
• Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults with Type 2 Diabetes  
  Katherine M Reitz, Edith Tzeng, Timothy R Billiar, Brian S Zuckerbraun, Richard L Simmons, Matthew R Rosengart, Matthew D Neal, JAMA Surgery
• PKM2-Dependent Glycolysis Promotes NLRP3 and AIM2 Inflammasome Activation  
  Timothy Billiar, MD, Nature
• Hepatic Dysfunction after Shock: Clinical Parameters and Biological Pathways for Therapeutic Intervention  
  Gill R., Billiar TR, J Organ Dysfunction, 1/1/2009
• Endothelial Specificity of ICAM2, Flt-1, and Tie2 Promoters In Vitro and In Vivo  
  Lei J, Vodovotz Y, Billiar TR, Int J Biolog Biomed Med Sci, 1/1/2008
• Invited Critique: Etomidate use in the critically injured patient is associated with increased risk of adrenal insufficiency  
  Billiar TR, Arch Surg, 1/1/2008
• Session IV: Arginine and pathophysiology II – discussion summary  
  Billiar TR, J Nutr, 1/1/2004
• Carbon monoxide paradoxically protects against hypoxia  
  Zuckerbraun BS, Billiar TR, J Surg Res, 1/1/2003
• Inhaled carbon monoxide abrogates pulmonary hypertension  
  Nadler EP, Zuckerbraun BS, Otterbein LE, Billiar TR, Kanno S, J Surg Res, 1/1/2003
• Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory st...  
  Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran PA, Aulak KS, Stuehr DG, Gibson KF, Billiar TR, Arch Biochem Biophys, 1/1/2001
• Nitric Oxide – Biology and Pathobiology  
  Kibbe MR, Lee PC, Billiar TR, Tzeng E, 1/1/2001
• Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis  
  Seol DW, Li J, Seol MH, Park S, Talanian RV, Billiar TR, Cancer Res, 1/1/2001
• Inducible Nitric Oxide Synthase Attenuates Acute Cardiac Rejection  
  Lee PC, Wang ZL, Mahidhara R, Qian S, Watkins SC, Griffith BP, Billiar TR, Shears LL, Surg Forum, 1/1/2000
• Increased Expression of Vascular Endothelial Growth Factor in Steroid-Treated Murine Wounds  
  Schwentker A, Salyapongse AN, Billiar TR, Surg Forum, 1/1/2000
• The Role of Serine/Threonine and Tyrosine Phosphatases in Mediating Inhibition of Vascular Smooth Muscle Cell Proliferation  
  Kibbe MR, Nie S, Billiar TR, Tzeng E, Surg Forum, 1/1/2000
• Activation of C-JUN N-Terminal Kinase in Mouse Liver during Hemorrhagic Shock  
  McCloskey CA, Billiar TR, Surg Forum, 1/1/2000
• Mice Deficient in eNOS Have Normal Blood Pressure Response to Resuscitation but Increased Early Mortality following Hemorrhagic Shock  
  Schuchert VD, Baust JJ, Gallo DJ, Zenati MS, Peitzman AB, Billiar TR, Harbrecht BG, Surg Forum, 1/1/2000
• Induction of Reperfusion-Independent Early Events in the Inflammatory Cascade of Hemorrhagic Shock  
  Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ, Surg Forum, 1/1/2000
• p53 is protective against nitric oxide-induced apoptosis in vascular smooth muscle cells  
  Kibbe MR, Li J, Nie S, Billiar TR, Tzeng E, Surg Forum, 1/1/1999
• The nitric oxide scavenger NOX reduces intestinal inflammation and organ damage following hemorrhagic shock  
  Hierholzer C, Kalff JC, Menezes JM, Siewert JR, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG, Surg Forum, 1/1/1999
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  Bombeck CA, Ganster RW, Green A, Ou J, Billiar TR, Surg Forum, 1/1/1999
• Nitric oxide mediates growth factor-stimulated angiogenesis  
  Lee PC, Kibbe MR, Stolz DB, Gleixner SL, Watkins SC, Griffith BP, Billiar TR, Shears LL, Surg Forum, 1/1/1999
• Improved transfection efficiency of excisional wounds using poloxamer 407 or targeting adenoviral vectors  
  Salyapongse AN, Bragdon GA, Edington HDJ, Lizonova A, Kovesdi I, Billiar TR, Surg Forum, 1/1/1999
• The involvement of apoptosis in inflammatory liver failure  
  Bombeck CA, Billiar TR, Sepsis, 1/1/1998
• Introduction, from the Guest Editor  
  Billiar TR, Sepsis, 1/1/1998
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Books/Book Chapters

• Schwartz's Principles of Surgery 
  Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock REMcGraw-Hill Companies, New YorkEdition 10th,2014
• Schwartz's Principles of Surgery 
  Brunicardi FC, Brandt ML, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock REMcGraw-Hill Companies, New YorkEdition 9th,2009
• Radicals for Life: The Various Forms of Nitric Oxide 
  Chapter: Cellular non-heme iron modulates apoptosis and caspase 3 activity 
  Page 253 - 268Stoyanovsky DA, Billiar TREditors: van Faassen E, Vanin AF.Elsevier Publishers, Oxford, UK2007
• Schwartz’s Manual of Surgery 
  T Billiar (editor)Editors: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2006
• Schwartz’s Manual of Surgery Self-Assessment and Board Review 
  T Billiar (editor)Editors: Brunicardi FC, Brandt ML, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2006
• Modern Surgical Care: Physiologic Foundations and Clinical Applications 
  Chapter: Hepatic Physiology 
  Page 427 - 441Prince JM, Billiar TREditors: Miller TA.Informa Healthcare USA, Inc, New York, NYEdition 3rd,2006
• Greenfield’s Surgery Scientific Principles & Practice 
  Chapter: Inflammation 
  Page 124 - 163Rosengart MR, Billiar TREditors: Mulholland MW, Lillemoe KD, Doherty GM, Maier RV, Upchurch GR.Lippincott Williams & Wilkins, Philadelphia, PAEdition 4th,2006
• Schwartz's Principles of Surgery 
  T Billiar (editor)Editors: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2005
• Proceedings of the 11th Congress of the European Shock Society 
  Chapter: Initiation of inflammation pathways in hemorrhagic shock 
  Page 1 - 6Prince J, Levy R, Billiar TREditors: Redl H.Medimod, Bologna2005
• Schwartz’s Principles of Surgery 
  Chapter: Shock 
  Page 85 - 108Peitzman AB, Harbrecht BG, Billiar TREditors: Bruncardi FC, Anderson DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE.McGraw-Hill Companies, New York, NYEdition 8th,2005
• Immunobiology of Organ Transplantation 
  Chapter: Nitric oxide, oxygen radicals 
  Page 477 - 487Kanno S, Shears LL, and Billiar TREditors: Wilkes DS, Burlingham WJ.Kluwer2004
• The Trauma Manual 
  Chapter: Shock 
  Page 23 - 27Harbrecht BG, Billiar TREditors: Peitzman AB, Rhodes M, Schwab CW, Yealy DM, Fabian TC.Lippincott Williams & Wilkins, Philadelphia, PA2002
• Nitric Oxide and Inflammation 
  T Billiar (editor)Editors: Salvimini D, Billiar TR, Vodovotz Y.Birkhäuser Verlag Basel, Switzerland2001
• Nitric Oxide and Inflammation 
  Chapter: Nitric oxide in shock: sepsis and hemorrhage 
  McCloskey CA, Billiar TREditors: Sakvemini D, Billiar TR, Vodovotz Y.Birkhauser Verlag Basel, Switzerland2001
• Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes 
  Jaiswal M, LaRusso N, Shapiro R, Billiar TR, Gores G2001
• Surgical Research 
  Chapter: Biology of Nitric Oxide: Measurement, Modulation, and Models 
  Collins JL, Vodovotz Y, Billiar TREditors: Souba WW, Wilmore DW.Academic Press, San Diego, CAEdition 949,2001
• Handbook of Experimental Pharmacology 
  Chapter: Nitric Oxide: A True Inflammatory Mediator 
  Page 493 - 523Zamora R. and Billiar TRMayer-Springer2000
• Multiple Organ Failure Pathophysiology, Prevention and Therapy 
  Chapter: Nitric oxide as a modulator of sepsis: therapeutic possibilities 
  Page 176 - 187Salyapongse AN, Billiar TRSpringer-Verlag, New York, NY2000
• Free Radicals & Inflammation 
  Chapter: Reactive oxygen species, nitric oxide and apoptosis 
  Page 207 - 219Bombeck CA, Li J, Billiar TREditors: Winyard P.G..Birkhauser Publishing Ltd1999
• Encyclopedia of Molecular Biology 
  Chapter: Nitric Oxide 
  Page 1607 - 1615Li J, Billiar TRJohn Wiley & Sons, Inc1999
• Recent Advances in Nitric Oxide Research 
  Chapter: Regulation and Function of Nitric Oxide in the Liver 
  Page 109 - 137Taylor BS, Billiar TR, Geller DASpringer-Verlag, Tokyo, Japan1999
• Molecular Biology of Free Radicals in Human Diseases 
  Chapter: Nitric oxide, altered DNA, and mammalian disease 
  Page 287 - 325Felley-Bosco E, Buzard GS, Billiar TR, Keefer LKEditors: Aruoma OI, Halliwell B.OICA International1998
• The Trauma Manual 
  Chapter: Patterns of blunt injury 
  Page 6 - 11Billiar TR, Peitzman ABEditors: Peitzman AB, Rhodes M, Schwab CW, Yealy DM.Lippincott-Raven Inc, Philadelphia, PA1998
• Methods in Molecular Biology, Vol. 100. Nitric Oxide Protocols 
  Chapter: Cloning and expression of human inducible nitric oxide synthase 
  Page 43 - 49Johnson ML, Shapiro RA, Billiar TREditors: Titheradge MA.Humana Press Inc, Totowa, NJ1997
• Progress in Liver Diseases 
  Chapter: The role of nitric oxide in liver pathophysiology 
  Page 85 - 108Alarcon LH, Taylor BS, Billiar TREditors: Boyer JL, Ockner RK.WB Saunders Co, Philadelphia, PA1997
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Lectures

• The Role of HMGB1 in driving hypoxia-induced inflammasome activation and mitophagy 
  Stockholm, Sweden - 1/30/2014
• Of Men and Mice: An Iterative Strategy to Dissect the Immune Response To Trauma 
  Multiple Locations - 1/20/2014
• Perspective: The Role of Surgeon Scientist 
  Pittsburgh, PA, 2013; Providence, RI, 2014 - 1/18/2014
• Management of Ambulatory Surgery 
  Changsha, China - 1/17/2014
• Circulating Biomarkers Predict Nosocomial Infection After Trauma in Humans 
  Newport, RI - 1/15/2014
• The Tolls of Trauma 
  Multiple Locations - 1/10/2014
• Characterization of the Inflammatory Response to Severe Injury 
  Shanghai, China - 1/10/2014
• Biology and Metabolism of Sepsis 
  Baltimore, MD - 1/1/2014
• An Iterative Strategy to Sudy Complex Human Diseases 
  Shanghai, China - 1/29/2013
• Drivers of the Inflammatory Response following Injury 
  Wuhan, China - 1/28/2013
• Cell-type Selective Roles of HMGB1 in liver 
  Honolulu, HI - 1/25/2013
• The Role of Toll-like Receptors in Sensing Tissue Ischemia 
  Xi’an, China - 1/19/2013
• Sensing tissue damage and ischemia through toll like receptors 
  Seattle, WA - 1/18/2013
• Innate Immune Mechanisms of Sensing Ischemia and Tissue Trauma 
  Taipei, Taiwan - 1/16/2013
• General Surgery Training in the United States 
  Wuhan, China - 1/12/2013
• Regulation of the Immuno-inflammatory Response to Injury 
  Guangzhou, China - 1/2/2013
• Cell Type Specific Roles for TLR4 in Sepsis and Trauma 
  Chicago, IL - 1/30/2012
• Molecular Biology of Hemorrhagic Shock 
  San Francisco, CA - 1/21/2012
• The Role of the Surgeon Scientist 
  Changsha, China - 1/21/2012
• The Role of Danger Associated Molecular Pattern Molecules Toll-Like Receptors 
  Guangzhou, China - 1/15/2012
• DAMPs in Trauma and Sepsis 
  Heidelberg, Germany - 1/10/2012
• Cell Specific TLR4 Response to Injury 
  Miami, FL - 1/9/2012
• Perspectives 
  1/30/2011
• Injury Induced Inflammation 
  Wuhan, China - 1/29/2011
• The Tolls of Trauma: Trauma and Regenerative Medicine Symposium 
  Shanghai, China - 1/27/2011
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