TimLekicMDPhD

PubMed

• 106 citations
  Isoflurane Posttreatment Reduces Neonatal Hypoxic–Ischemic Brain Injury in Rats by the Sphingosine-1-Phosphate/Phosphatidylinositol-3-Kinase/Akt Pathway
  Yilin Zhou, Tim Lekic, Nancy Fathali, Robert P. Ostrowski, Robert D. Martin
  Stroke. 2010-07-01
• 55 citations
  Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia
  Nancy Fathali, Robert P. Ostrowski, Yu Hasegawa, Tim Lekic, Jiping Tang
  Translational Stroke Research. 2013-04-01
• 62 citations
  Minocycline Improves Functional Outcomes, Memory Deficits, and Histopathology after Endovascular Perforation-Induced Subarachnoid Hemorrhage in Rats
  Prativa Sherchan, Tim Lekic, Hidenori Suzuki, Yu Hasegawa, William B. Rolland
  Journal of Neurotrauma. 2011-12-09

Journal Articles

• Crotalus Atrox Venom Preconditioning Increases Plasma Fibrinogen and Reduces Perioperative Hemorrhage in a Rat Model of Surgical Brain Injury  
  Tim Lekic, Richard Applegate, Brian S Bull, Ronak Raval, Nature
• Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury  
  Kim CH, McBride DW, Raval R, Sherchan P, Hay KL, Gren EC, Kelln W, Lekic T, Hayes WK, Bull BS, Applegate R, Tang J, Zhang JH, Sci Rep, 1/19/2017
• Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury  
  Kim CH, McBride DW, Sherchan P, Person CE, Gren EC, Kelln W, Lekic T, Hayes WK, Tang J, Zhang JH, Neurobiol Dis, 1/9/2017
• Fingolimod Confers Neuroprotection through Activation of Rac1 after Experimental Germinal Matrix Hemorrhage in Rat Pups  
  Rolland WB, Krafft PR, Lekic T, Klebe D, LeGrand J, Weldon AJ, Xu L, Zhang JH, J Neurochem, 1/5/2017
• composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats  
  McBride DW, Nowrangi D, Kaur H, Wu G, Huang L, Lekic T, Tang J, Zhang JH, J Cereb Blood Flow Metab, 1/1/2017
• alpha7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage  
  Krafft PR, McBride D, Rolland WB, Lekic T, Flores JJ, Zhang JH, Biomed Res Int, 1/1/2017
• Aligning animal models of clinical germinal matrix hemorrhage, from basic correlation to therapeutic approach  
  Lekic T, Klebe DW, Pichon P, Brankov K, Sultan S, McBride DW, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, Curr Drug Targets, 1/14/2016
• Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia  
  Dixon B, Malaguit J, Casel D, Doycheva D, Tang J, Zhang JH, Lekic T, Acta Neurochir Suppl, 1/1/2016
• Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups  
  Klebe D, Flores JJ, McBride DW, Krafft PR, Rolland WB, Lekic T, Zhang JH, J Cereb Blood Flow Metab, 1/1/2016
• Exsanguination Postconditioning of ICH (EPIC-H) Using the Lancet for Brain Bleed in Rodents, Preliminary Study  
  Lekic T, Zhang JH, Acta Neurochir, 1/1/2016
• Remote Ischemic Postconditioning (RIPC) After GMH in Rodents  
  Lekic T, Klebe D, Flores J, Peters R, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Brain Volume Determination in Subarachnoid Hemorrhage Using Rats  
  Lekic T, Hardy M, Fujii M, McBride DW, Zhang JH, Acta Neurochir, 1/1/2016
• Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats  
  McBride DW, Jacob C, Doycheva D, Dixon BJ, Malaguit J, Lekic T, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage  
  Lekic T, Flores J, Klebe D, Doycheva D, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• PPARgamma-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats  
  Flores JJ, Klebe D, Rolland WB, Lekic T, Krafft PR, Zhang JH, Neurobiol Dis, 1/1/2016
• Intranasal Osteopontin for Rodent Germinal Matrix Hemorrhage  
  Malaguit J, Casel D, Dixon B, Doycheva D, Tang J, Zhang JH, Lekic T, Acta Neurochir, 1/1/2016
• PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage  
  Lekic T, Krafft PR, Klebe D, Flores J, Rolland WB, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats  
  Lekic T, Krafft PR, Klebe D, Rolland WB, Flores J, Tang J, Zhang JH, Acta Neurochir, 1/1/2016
• Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network  
  Lekic T, Klebe D, Poblete R, Krafft PR, Rolland WB, Tang J, Zhang JH, Curr Med Chem, 1/1/2015
• Imatinib preserves blood-brain barrier integrity following experimental subarachnoid hemorrhage in rats  
  Zhan Y, Krafft PR, Lekic T, Ma Q, Souvenir R, Zhang JH, Tang J, J Neurosci Res, 1/1/2015
• Inhibition of transforming growth factor-Beta attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage  
  Manaenko A, Lekic T, Barnhart M, Hartman R, Zhang JH, Stroke, 1/1/2014
• Small molecule inhibitors in the treatment of cerebral ischemia  
  Flores JJ, Zhang Y, Klebe DW, Lekic T, Fu W, Zhang JH, Expert Opin. Pharmacother., 1/1/2014
• Splenic Immune Cells In Experimental Neonatal Hypoxia-Ischemia  
  Fathali N, Ostrowski RP, Hasegawa Y, Lekic T, Tang J, Zhang JH, Transl. Stroke Res., 1/1/2013
• Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage  
  Rolland WB, Lekic T, Krafft PR, Hasegawa Y, Altay O, Hartman R, Ostrowski R, Manaenko A, Tang J, Zhang JH, Exp. Neurol., 1/1/2013
• Pontine hemorrhage Response  
  Lekic T, Rolland W, Krafft PR, Suzuki H, Tang J, Zhang JH, Kamper JE, Hartman RE, J. Neurosurg., 1/1/2013
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Other

• Experimental models of brain hemorrhage using clostridial collagenase (Dissertation)