ThyagarajanSubramanianMD

PubMed

• 227 citations
  Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates.
  Thomas Wichmann, Hagai Bergman, Philip A. Starr, Thyagarajan Subramanian, Ray L. Watts
  Experimental Brain Research. 1999-04-01
• 240 citations
  A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
  M. Flint Beal, David Oakes, Ira Shoulson, Claire Henchcliffe, Wendy R. Galpern
  JAMA Neurology. 2014-05-01
• 62 citations
  Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.
  DE Kellstein, Richard B. Lipton, R Geetha, K Koronkiewicz, FT Evans
  Cephalalgia. 2000-06-01

Journal Articles

• Type 2 Diabetes Presenting With Persistent Chorea  
  Chalia M, Subramanian T, JAMA Neurol, 1/21/2018
• Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat  
  Anselmi L, Bove C, Coleman FH, Le K, Subramanian MP, Venkiteswaran K, Subramanian T, Travagli RA, Parkinson's Disease, 1/1/2018
• Commentary on - Human Embryonic Retinal Pigment Epithelial (RPE) Cell Transplants for Chronic Refractory Cocaine Addiction  
  Venkiteswaran K, Subramanian T, Sue-Grigson P, Health Care: Current Reviews, 1/1/2016
• Transplantation of Human Retinal Pigment Epithelial Cells in the Nucleus Accumbens of cocaine self-administering rats provides protection from reinstatement  
  Venkiteswaran K, Alexander DN, Puhl MD, Rao A, Piquet AL, Nyland JE,�Subramanian�MP, Iyer P, Boisvert MM, Handly E,�Subramanian�T, Grigson PS, Brain Res Bull, 1/1/2016
• Update on Movement Disorders � five new things in Parkinson�s disease  
  Subramanian, T., Venkiteswaran, K., BMH Medical Journal, 1/1/2015
• Impact of disclosure of individual imaging results in a multi-center Parkinson clinical trial  
  Jennings D, Eberly S, Oakes D, Seibyl J, Marek K, Shoulson I; Parkinson Study Group PRECEPT Investigators(Includes Thyagarajan Subramanian), J Parkinsons Dis, 1/1/2014
• Longitudinal follow-up of SWEDD subjects in the PRECEPT Study Parkinson Study Group (includes T Subramanian)  
  Marek, Kenneth, John Seibyl, Shirley Eberly, David Oakes, Ira Shoulson, Anthony E. Lang, Chris Hyson, and Danna Jennings, Neurology, 1/1/2014
• Quadrature RF coil for in vivo brain MRI of a macaque monkey in a stereotaxic head frame  
  Roopnariane, CA., Ryu, Y-C., Tofighi, M-R, Miller, PA., Oh, S., Wang, J., Park, BS, Ansel, L., Lieu, CA., Subramanian, T., Yang, QX., Collins, CM, Concepts in Magnetic Resonance Part B (Magnetic Resonance Engineering), 1/1/2012
• Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts  
  Marras C, McDermott MP, Marek K, Rochon P, Naglie G, Tanner CM, Rudolph A, Shoulson I, Lang AE; Parkinson Study Group DATATOP and PRECEPT investigators(Includes Subram..., Mov Disord., 1/1/2011
• Serum urate and probability of dopaminergic deficit in early "Parkinson's disease"  
  Schwarzschild MA, Marek K, Eberly S, Oakes D, Shoulson I, Jennings D, Seibyl J, Ascherio A; on behalf of the Parkinson Study Group PRECEPT Investigators (Includes Subr..., Mov Disord., 1/1/2011
• Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease  
  Schwid SR, Bausch J, Oakes D, Schuchter L, Tanner C, Forrest M, Lang AE, Shoulson I; PSG PRECEPT Investigators (Includes Subramanian, T.), Shoulson I, Hyson C, Oakes D..., Mov Disord, 1/1/2010
• Guillain�Barr� syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: A case report and review of the literature  
  Abbi, KKS, Rizvi, SM, Sivik, J, Subramanian, T, Loughran, T, Drabick, JJ., Leukemia Research, 1/1/2010
• Twice-daily, low-dose pramipexole in early Parkinson's disease: A randomized, placebo-controlled trial  
  Kieburtz K; The Parkinson Study Group PramiBID Investigators (Includes Subramanian, T.), Mov Disord, 1/1/2010
• Design and implementation of a quadrature RF volume coil for in-vivo MR brain imaging of rhesus macaque monkey in a stereotaxic head frame  
  Roopnariane CA, Miller PA, Bu Sik Park, Ansel L, Sukhoon Oh, Lieu C, Subramanian T, Tofighi M-R, Collins CM, Microwave Symposium Digest, 1/1/2009
• A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts  
  Marras C, Lang AE, Eberly SW, Oakes D, Fahn S, Schwid SR, Hyson C, Shoulson I, Parkinson Study Group DATATOP and PRECEPT investigators (includes Subramanian T), Mov Disord., 1/1/2009
• A longitudinal program for biomarker development in Parkinson's disease: a feasibility study  
  Ravina B, Tanner C, Dieuliis D, Eberly S, Flagg E, Galpern WR, Fahn S, Goetz CG, Grate S, Kurlan R, Lang AE, Marek K, Kieburtz K, Oakes D, Elliott R, Shoulson I, Parki..., Mov Disord., 1/1/2009
• Serum urate as a predictor of clinical and radiographic progression in Parkinson disease  
  Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A, Parkinson Study Group PRECEPT Investigators (includes Subramanian T), Hyson C,..., Arch Neurol., 1/1/2008
• Long-term treatment with botulinum toxin type A in cervical dystonia has low immunogenicity by mouse protection assay  
  Brin MF, Comella CL, Jankovic J, Lai F, Naumann M, CD-017 BoNTA Study Group (includes Subramanian T), Mov Disord., 1/1/2008
• The Mixed Lineage Kinase Inhibitor CEP-1347 Fails to Delay Disability in Early Parkinson�s Disease  
  The Parkinson Study Group PRECEPT Investigators* (includes Subramanian T), Neurology, 1/1/2007
• Safety of rasagiline in elderly Parkinson�s disease patients  
  Goetz CG, Schwid SR, Eberly SW, Oakes D, Shoulson I, and the Parkinson Study Group TEMPO and PRESTO Investigators (Includes Subramanian, T.), Neurology, 1/1/2006
• Rasagiline-associated motor improvement in PD occurs without worsening of cognitive and behavioral symptoms  
  Elmer L, Schwid S, Eberly S, Goetz C, Fahn S, Kieburtz K, Oakes D, Blindauer K, Salzman P, Oren S, Prisco UL, Stern M, Shoulson I; Parkinson Study Group TEMPO and PRES..., J Neurol Sci, 1/1/2006
• Intrathecal Baclofen (ITB) Management of Spastic Hypertonia Following Stroke: Implications for Function and Quality of Life  
  Ivanhoe, CB, Francisco, GE, McGuire, J, Subramanian, T, Grissom, S, Archives of Physical Medicine and Rehabilitation, 1/1/2006
• Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the deep layers of the superior colliculus/deep mesenc...  
  Zhao, Z, Krishnaney, A, Teng, Q, Garrity-Moses, M, Tanase, D, Liu, JK, Venkiteswaran, K, Subramanian, T, Davis, M, Boulis, NM, Gene Therapy, 1/1/2006
• Pathophysiological basis of treatment strategies for drug-induced dyskinesias in Parkinson�s disease  
  Deogaonkar, MS., Subramanian, T., Brain Research Reviews, 1/1/2005
• Methods of construction of a MRI based 3D tabular database of 3D stereotactic coordinates for individual structures in the basal ganglia of Macaca mulatta  
  Deogaonkar, MS., Heers, M., Mahajan, S., Brummer, M., Subramanian, T., Journal of Neuroscience Methods, 1/1/2005
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Books/Book Chapters

• Imaging of Neurodegenerative Disorders 
  Chapter: Secondary Parkinsonism 
  Thyagarajan Subramanian, Kala Venkiteswaran and Elisabeth LucassenEditors: Sangam Kanekar.Thieme Publishers2015
• Imaging of Neurodegenerative Disorders 
  Chapter: Advances in the treatment of Dementia 
  Madhav Thambisetty, Nestor Galvez-Jimenez, and Thyagarajan SubramanianEditors: Sangam Kanekar.Thieme Publishers2015
• Signal Processing Applications to Electrophysiology of Continuous Dopaminergic Stimulation Therapy in Preclinical Parkinson�s Disease Models 
  Gilmour, TP. (Thesis co-supervised by Jenkins, KW. and Subramanian, T.)PSU Press2012
• THE ROLE OF INTERHEMISPHERIC PATHWAYS IN PARKINSON�S DISEASE AND DRUG-INDUCED DYSKINESIAS 
  Lieu, CA. (Thesis supervisior: Subramanian, T.)PSU Press2011
• Parkinson�s Disease Book 3 
  Chapter: Pathophysiology of Drug-Induced Dyskinesias 
  Lieu, CA., Shivkumar, V., Gilmour, TP., Venkiteswaran, K., Nolt, MJ., Deogaonkar, M., Subramanian, T.InTech Publishers2011
• Atlas of Neonatal Rat Brain 
  Ramachandra, R., Subramanian, T.CRC Press2010
• Movement Disorders: 100 Instructive Cases 
  Chapter: MSA-P presenting as stridor 
  Tousi B., Subramanian, TEditors: Stephen G. Reich.Taylor & Francis, Inc.2008
• Scientific Basis for Treatment of Parkinson's Disease 
  Chapter: Cell transplantation and Gene therapy for the treatment of Parkinson�s disease 
  Subramanian T., Deogaonkar MEditors: Galvez-Jimenez N..Taylor & Francis Medical books, London, UK2005
• Deep Brain Stimulation and Epilepsy 
  Chapter: The Basal ganglia: an overview 
  Subramanian, T.Editors: Hans O Luders.Martin Dunitz Publishers2004
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Abstracts/Posters

• Chronic high exposure to cocaine results in degeneration of VTA dopaminergic neurons
  K. VENKITESWARAN, M. SUBRAMANIAN, T. CAYTON, A. KIM, P. S. GRIGSON, T. SUBRAMANIAN, Society for Neuroscience, San Diego, CA, 1/1/2018
• Deficits in mental rotation test (mrt-a) may be correlated to higher Unified Parkinson's Disease Rating Scale (UPDRS) scores in early onset idiopathic Parkinson’s disease
  B. MULLEN, S. RAVI, M. P. SUBRAMANIAN, K. VENKITESWARAN, T. SUBRAMANIAN, P. ESLINGER, D. WAGNER, Society for Neuroscience, San Diego, CA, 1/1/2018
• Promoting neuroscience awareness among Central Pennsylvania youth leads to career selection in the neurosciences
  K. VENKITESWARAN, S. RAVI, A. R. WHITE, E. BLANKE, E. MADAR, Y. KIM, A. BARBER, T. SUBRAMANIAN, Society for Neuroscience, San Diego, CA, 1/1/2018
• SN hyperechogenicity as seen in transcranial sonography (TCS) is a reliable biomarker for disease progression from StageI to Stage II in early onset Parkinson's diseas...
  S. RAVI, V. SHIVKUMAR, D. DANG, T. GILMOUR, N. HARID, J.-L. WANG, T. SUBRAMANIAN, K. VENKITESWARAN, Society for Neuroscience, San Diego, CA, 1/1/2018
• Optogenetic and chemogenetic induction of unilateral hemiparkinsonism is not associated with the risk of levodopa induced dyskinesias
  K. M. LE, S. CHINNIAH, V. IYER, N. PATEL, C. LIEU, M. PENNOCK, E. HANDLEY, A. ZENEROWITZ, E. DICKEY, S. SAVALIYA, T. SUBRAMANIAN, K. VENKITESWARAN, Society for Neuroscience, San Diego, CA, 1/1/2018
• Hemispheric-specific neuropsychological tests in stage I early-onset Parkinson�s disease (EOPD) as a predictor for disease progression
  K. M. LE, B. MULLEN, K. VENKITESWARAN, M. SUBRAMANIAN, S. RAVI, D. WAGNER, S. SWAMINATHAN, K. ANANTHAKRISHNAN, M. IBRAHIMI, J.-L. WANG, P. ESLINGER, T. SUBRAMANIAN, Society for Neuroscience, Washington, DC, 1/1/2017
• Mechanism of action of retinal pigment epithelial (RPE) grafts reducing drug seeking in high-dose cocaine taking rats after a period of abstinence
  K. VENKITESWARAN, T. CAYTON, S. SINGH, A. PATEL, T. SUBRAMANIAN, P. SUE GRIGSON, Society for Neuroscience, Washington, DC, 1/1/2017
• Optogenetic and chemogenetic inhibition of striatal dopaminergic cell transplants in hemiparkinsonian rats to ameliorate graft-induced dyskinesias
  V. IYER, K. VENKITESWARAN, N. PATEL, S. CHINNIAH, K. LE, C. WHITE, E. HANDLY, A. ZENEROVITZ, A. COCKING, Z. LIU, C. RAMAKRISHNAN, K. DEISSEROTH, T. SUBRAMANIAN, Society for Neuroscience, Washington, DC, 1/1/2017
• DYSTEXTIA, as an initial presentation of Takotsubo cardiomyopathy
  Elangovan, C., Krishnaiah, B., Campoverde, E., Niazi, M., Subramanian, T., 11th Annual Meeting of the Pennsylvania Neurological Society, Bethlehem, PA, 1/22/2016
• Pelvic MRI can be helpful in Supporting Diagnosis of Diabetic Amyotrophy in Correct Clinical Setting
  Niazi, M., Ibrahimi, M., Subramanian, T., 11th Annual Meeting of the Pennsylvania Neurological Society, Bethlehem, PA, 1/22/2016
• Hemichorea associated with conduction aphasia in the setting of a cavernous malformation
  Chalia, M., Krishnaiah, B., Subramanian, T., 11th Annual Meeting of the Pennsylvania Neurological Society, Bethlehem, PA, 1/22/2016
• Novel Observation-Based Criteria for Sleep-Wake Classification in a Preclinical Model of Sleep Disorder (P4. 281)
  Vo, Quynh, Anthony Mell, Vishakh Iyer, Kala Venkiteswaran, Siven Chinniah, Jidong Fang, and Thyagarajan Subramanian, Neurology, 1/1/2016
• Circuit specific optogenetic neuromodulation for Parkinson�s disease
  Neel Patel; Vishakh Iyer; Sandip Savaliya, MD; Kala Venkiteswaran, PhD; Erin Handly; Naila Iqbal; Caitlin White; Zhiwen Liu, PhD; Charu Ramakrishnan; Karl Deisseroth, ..., 84th Annual American Academy of Neurological Surgeons Meeting, Chicago, IL, 1/1/2016
• Preclinical Model of Parkinson�s Disease Using Circuit Specific Optogenetics (P5. 402)
  Patel, Neel, Vishakh Iyer, Kala Venkiteswaran, Erin Handly, Caitlin White, Naila Iqbal, Pooja Sridhar, Thyagarajan Subramanian, Neurology, 1/1/2016
• Utilizing remote blood pressure monitoring in a phase III clinical drug trial for Parkinson�s disease
  J.L. Adams, R.A. Biemiller, K.L. Andrzejewski, S. Sharma, R.L. Rockhill, B.L. Greco, K.C. Hodgeman, P. Singh, S. Khanuja, T. Simuni, K.M. Biglan and Parkinson Study Group, 20th International Congress. Abstract Number: 2082 (Includes T. Subramanian), 1/1/2016
• Utilizing remote blood pressure monitoring in a phase III clinical drug trial for Parkinson�s disease
  J.L. Adams, R.A. Biemiller, K.L. Andrzejewski, S. Sharma, R.L. Rockhill, B.L. Greco, K.C. Hodgeman, P. Singh, S. Khanuja, T. Simuni, K.M. Biglan and Parkinson Study Group, 20th International Congress, 1/1/2016
• Promoting neuroscience awareness in Central Pennsylvania
  K. VENKITESWARAN, Q. VO, Z. NASSRALLAH, S. RAVI, A. BARBER, T. SUBRAMANIAN, Society for Neuroscience, Chicago, IL, 1/1/2015
• Early onset Parkinson's disease (EOPD) progression as monitored by hyperechogenicity of the substantia nigra (SN)
  S. RAVI, K. VENKITESWARAN, V. SHIVKUMAR, N. HARID, T. GILMOUR, C. LIEU, R. SAADI, D. DANG, J.-L. WANG, Q. YANG, T. SUBRAMANIAN, Society for Neuroscience, Chicago, IL, 1/1/2015
• Behavioral effects of partial unilateral optogenetic inhibition of the nigrostriatal pathway, Program 736.18/DD65
  V. IYER, N. PATEL, K. VENKITESWARAN, E. HANDLY, N. IQBAL, C. WHITE, P. SRIDHAR, K. THIAGARAJAN, Z. LIU, C. RAMAKRISHNAN, K. DEISSEROTH, T. SUBRAMANIAN, Society for Neuroscience, Chicago, IL, 1/1/2015
• Immunological response to optogenetic laser stimulation of fetal ventral mesencephalic transplants, Program 736.20/DD67
  R. E. THOMAS, K. VENKITESWARAN, E. HANDLEY, M. DAWSON, C. WHITE, A. HARRIS, A. STULL, C. RAMAKRISHNAN, K. DEISSEROTH, T. SUBRAMANIAN, Society for Neuroscience, Chicago, IL, 1/1/2015
• Hyperechogenicity of Substantia Nigra: A Potential Disease Progression Marker in Early Onset Parkinson�s Disease (EOPD)
  Balaji Krishnaiah, MD; Kala Venkiteswaran, PhD; Vikram Shivkumar, MD; Timothy Gilmour, PhD; Nitish Harid; Robert Saadi; Thyagarajan Subramanian, MBBS, AAN meeting, Philadelphia, PA, 1/26/2014
• Functional optogenetic modulation of striatal transplants in parkinsonian rats
  Thyagarajan Subramanian, Kala Venkiteswaran, Zhiwen Liu, Timothy P Gilmour, Baigang Zgang, Christopher A Lieu, Megan Dawson, Caitlin White, Erin Handly,, Megha P Subr..., Annals of Neurology, 1/1/2014
• Hemispheric-specific functional deficit in the primary olfactory cortex of early state Parkinson�s disease
  Jianli Wang, Thyagarajan Subramanian, Qing X. Yang, Annals of Neurology, 1/1/2014
• Functional selectivity at the dopamine D1 receptor and its role in mediating antiparkinson effects
  Yang Y., Lee S-M., Huang X., Lieu CA., Subramanian T., Murthy V., Mailman RB., Society for Neuroscience, Washington, DC, 1/1/2014
• Optogenetic modulation of striatal fetal ventral mesencephalic dopaminergic transplants in hemiparkinsonian rats
  Subramanian T., Venkiteswaran K., Liu Z., Gilmour TP., Zhang B., Liu CA., Dawson M., White C., Handly E., Subramanian MP., Ramakrishnan C., Deisseroth K., Society for Neuroscience, Washington, DC, 1/1/2014
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Lectures

• Chorea and dyskinesias 
  Penn State College of Medicine - 1/12/2018
• GRAFT-HOST SYNAPTIC CONNECTIVITY CAN BE OPTOGENETICALLY OR CHEMOGENETICALLY INHIBITED TO ELIMINATE GRAFT-INDUCED DYSKINESIAS (GID) WITHOUT LOSING ANTI-PARKINSONIAN BEN... 
  Clearwater Beach, FL - 1/7/2018
• Graft induced dyskinesias (GID) can be eliminated using optogenetic or chemogenetic inhibition of graft-host synapses without losing anti-parkinsonian benefits 
  Port Douglas, QD, Australia - 1/13/2017
• Transplantation of human fetal retinal pigment epithelial cells into the nucleus accumbens of cocaine self-administering rats protects against drug seeking 
  Port Douglas, QD, Australia - 1/13/2017
• Beyond symptomatic management in Parkinson's disease - Is disease modification and restorative therapy imminent? 
  Chennai, India - 1/7/2017
• Data Blitz Presentation - Mechanistic basis of Nucleus Accumbens (NAc) cell transplantation mediated reduction in drug seeking in cocaine self administering rats 
  1/4/2017
• Prediction of multifocal epileptogenic zones using normalized transfer entropy 
  1/1/2017
• In-vivo transcranial ultrasound imaging of induced Substantia Nigra hyperechogenicity using adaptive sparse Third Order Volterra Filter 
  1/1/2017
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  1/1/2017
• Transcranial enhanced Ultrasound Imaging of induced substantia nigra in brain using adaptive Third Order Volterra Filter: In-vivo results 
  1/1/2017
• Can normalized transfer entropy be used as an informational transfer measure of ictal pathophysiology in patients undergoing stereo-EEG for epilepsy surgery 
  Washington, DC - 1/1/2017
• Novel Presynaptic mechanisms for drug induced dyskinesias 
  1/1/2016
• Recent Advances in Movement Disorders Therapeutics 
  Chennai, India - 1/1/2016
• Patient selection for DBS 
  Chennai, India - 1/1/2016
• Musician�s cramp and other related disorders 
  University Park, PA - 1/24/2014
• Movement Disorders Research Update Grand Rounds � Optogenetics, Channels and Neurotoxins 
  1/17/2014
• Interesting Cases � CPC presentations of CJD and DLB 
  1/5/2014
• Parkinson�s disease: special issues for geriatric patients 
  1/16/2012
• Parkinson�s disease 
  1/23/2011
• Interventional Neurology: Procedures for Dystonia, Spasticity, Chorea, Tremor and Parkinson�s Disease 
  Harrisburg, PA - 1/13/2011
• Ayurvedic medicines for Parkinson�s disease: Mucuna pruriens revisited 
  Madras Neurological Institute, Madras Medical College and MGR Medical University, Chennai, India - 1/27/2010
• Bench to bedside: lessons for intraoperative recording in DBS 
  Vancouver, BC, Canada - 1/23/2009
• Basal Ganglia Neurophysiology: why should a clinician know about this? 
  Penn State Milton S. Hershey College of Medicine - 1/20/2009
• Electrophysiology of the basal ganglia: can new treatments come from correcting errors in signal processing? 
  Penn State College of Engineering, University Park - 1/15/2009
• Cell transplantation for PD: eye to the rescue of the brain 
  University of Tubingen, Germany - 1/9/2008
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