ThomasEScammellMD

PubMed

• Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder: a pooled post hoc analysis of two randomized phase 3 clinical studies.
  Tobias Di Marco, Ina Djonlagic, Yves Dauvilliers, Kolia Sadeghi, David Little
  Sleep. 2024-11-08
• What is cataplexy?
  Margaret S Blattner, Thomas E Scammell
  Sleep. 2024-11-08
• Impaired cognition in narcolepsy: clinical and neurobiological perspectives.
  Christopher A Cano, Brian T Harel, Thomas E Scammell
  Sleep. 2024-09-09

Journal Articles

• Damage to histaminergic tuberomammillary neurons and other hypothalamic nuclei with traumatic brain injury  
  Annals of Neurology, 1/1/2015
• Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord  
  J Physiol, 1/1/2014
• Optogenetic mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal  
  J Neurosci, 1/1/2014
• SCOPRISM: A new algorithm for automatic sleep scoring in mice  
  J. Neurosci Methods, 1/1/2014
• Challenges in diagnosing narcolepsy without cataplexy: a consensus statement  
  Sleep, 1/1/2014
• Narcolepsy as an adverse event following immunization: Case definition and guidelines for data collection, analysis and presentation  
  Vaccine, 1/1/2013
• Amygdala lesions reduce cataplexy in orexin KO mice  
  J Neurosci, 1/1/2013
• Role of the medial prefrontal cortex in cataplexy  
  J Neurosci, 1/1/2013
• Increase of histaminergic tuberomammillary neurons in narcolepsy  
  Annals of Neurology, 1/1/2013
• Emerging Therapeutics in Sleep  
  Annals of Neurology, 1/1/2013
• Control of arousal by the orexin neurons  
  Current Opinion in Neurobiology, 1/1/2013
• Neural circuitry engaged by prostaglandins during the sickness syndrome  
  Nature Neuroscience, 1/1/2012
• Narcolepsy: neural mechanisms of sleepiness and cataplexy  
  Journal of Neuroscience, 1/1/2012
• Inter-hemispheric oscillations in human sleep  
  PLoS One, 1/1/2012
• Seasonal Factors and the Onset of Narcolepsy  
  Journal Watch Neurology, 1/1/2011
• Sodium oxybate is an effective and safe treatment for narcolepsy  
  Sleep Med, 1/1/2009
• Parkinson's disease, sleepiness and hypocretin/orexin  
  Brain, 1/1/2008
• The neurobiology of sleep  
  Neurology Journal Watch, 1/1/2007
• The International Classification of Sleep Disorders  
  American Academy of Sleep Medicine, 1/1/2006
• REM sleep behavior disorder in narcolepsy  
  Neurology Journal Watch, 1/1/2006
• Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome")  
  Mov Disord, 1/1/2004
• Behavioral state instability in orexin knockout mice  
  Sleep and Biological Rhythms, 1/1/2004
• Hypocretin deficiency and HLA in narcolepsy  
  Neurology Journal Watch, 1/1/2003
• What is narcolepsy?  
  Neurology Journal Watch, 1/1/2003
• Modafinil: a novel stimulant for the treatment of narcolepsy  
  Exp Opin Invest Drugs, 1/1/1998
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Books/Book Chapters

• Diagnosis and neurobiology of narcolepsy 
  Chapter: Diagnosis and neurobiology of narcolepsy 
  Editors: Rose B, Sanders M, Benca R, Wilson K.UpToDate: Wolters Kluwer2014
• Diagnosis and neurobiology of narcolepsy 
  Chapter: Treatment of narcolepsy 
  Editors: Sanders M, Benca R, Wilson K.UpToDate: Wolters Kluwer2014
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Chapter: The neural basis of sleepiness in narcoleptic mice 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Chapter: Serotonin and narcolepsy 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Case Book of Sleep Medicine 
  Chapter: Idiopathic hypersomnia with long sleep time 
  Editors: Winkelman, JW, Henderson, JH, Kotagal, S, Lee-Chiong, TL, Lichstein, KL, Murray, BJ, Schenck, CH.American Academy of Sleep Medicine, Westchester, IL2008
• Narcolepsy and Hypersomnia 
  Chapter: Modafinil: mechanisms of action 
  Editors: Bassetti, C, Mignot, E, Billiard, M.Informa Healthcare, NY2007
• Sleep Disorders and Neurologic Disease 
  Chapter: Secondary narcolepsy 
  Page 117 - 134Editors: Culebras, A.Informa Healthcare, NYEdition 2nd,2007
• Narcolepsy and Hypersomnia 
  Chapter: Treatment guidelines 
  Editors: Bassetti, C, Billiard, M, Mignot, E.Informa Healthcare, NY2007
• The Orexin/Hypocretin System: It's Physiology and Pathophysiology 
  Chapter: Orexin and the hypothalamic control of sleep and waking 
  Editors: Nishino, S, Sakurai, T.Humana Press, Totowa, NJ2006
• Principles of Molecular Medicine 
  Chapter: Narcolepsy and other neurological sleep disorders 
  Page 1153 - 1159Editors: Runge, MS, Paterson, C.Humana Press, Totowa, NJ2006
• Insomnia: Principles and Management 
  Chapter: Hypothalamic pathways and neurotransmitters underlying sleep wake regulation 
  Editors: Szuba, M, Dinges, D, Kloss,.Cambridge University Press, Cambridge, MA2003
• Handbook of Behavioral State Control 
  Chapter: Hypothalamic regulation of sleep 
  Editors: Lydic, R, Baghdoyan, HA.CRC Press, NY1998
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Abstracts/Posters

• GABA and glutamatergic projections from the basal forebrain to the MCH neurons
  Sleep, 1/1/2013
• Neural circuitry of cataplexy: projection targets of GABA cells subpopulations in the central amygdala
  Sleep, 1/1/2013
• Basal forebrain efferents to the orexin neurons
  Sleep, 1/1/2013

Lectures

• Interaction of Orexin and Histamine Systems 
  Tallinn, Estonia - 1/1/2014
• Year in Review: Narcolepsy 
  Minneapolis, MN - 1/1/2014
• Neurobiology of Cataplexy 
  Minneapolis, MN - 1/1/2014
• Treatment of Narcolepsy 
  Minneapolis, MN - 1/1/2014
• Narcolepsy: Neurobiology and Neuropathology 
  University of Pennsylvania, Philadelphia, PA - 1/1/2014
• Rodent Models for Understanding Narcolepsy 
  Children's Hospital Boston - 1/1/2012
• Narcolepsy: Neurobiology of sleepiness and cataplexy 
  1/1/2012
• Rodent Models for Understanding Sleep 
  Children's Hospital Boston - 1/1/2012
• Narcolepsy: Clinical Features, Diagnosis, and Pathophysiology 
  Boston, MA - 1/1/2012
• Molecular Dissection of Narcolepsy Signs and Symptoms 
  Boston, MA - 1/1/2012
• Afferent and Efferent Control of the Orexin System 
  Kyoto, Japan - 1/1/2011
• Neurobiology of Orexin Antagonists 
  Kyoto, Japan - 1/1/2011
• New insights into the causes of sleepiness and cataplexy 
  University of Zurich, Zurich, Switzerland - 1/1/2011
• Remaining Mysteries: Etiology & Genetics 
  Budapest, Hungary - 1/1/2011
• Regulation of Wakefulness and Sleep by Orexin/Hypocretin 
  Stanford University, Stanford, CA - 1/1/2011
• Neurobiology of Narcolepsy 
  Center for Brain Science, Harvard College - 1/1/2010
• What sleepy mice can teach us about sleepy people 
  1/1/2010
• Narcolepsy: What sleepy mice can teach us about sleepy people 
  Seattle, WA - 1/1/2009
• The Neural Basis of Sleepiness in Narcoleptic Mice 
  Ascona, Switzerland - 1/1/2009
• Orexins and the Neural Control of Sleep and Wakefulness 
  Basel, Switzerland - 1/1/2009
• Orexin receptor-2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice 
  Osaka, Japan - 1/1/2009
• Hypothalamic Control of Sleep and Circadian Rhythms 
  Leiden University Medical Center, Leiden, Netherlands - 1/1/2008
• Orexin 
  etherlands Institute for Neuroscience, Amsterdam, Netherlands - 1/1/2008
• Neural Mechanisms Controlling Sleep and Wakefulness 
  Buonas, Switzerland - 1/1/2008
• The Neurobiology of Narcolepsy 
  Harvard Medical School - 1/1/2008
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Other

• Narcolepsy 
  Harvard Medical School
  1/1/2014
• Commentary on narcolepsy and orexin 
  The Boston Globe
  1/1/2009
• The Sleepy Student 
  Human Nervous System and Behavior course
  1/1/2009
• The regulation of sleep & circadian rhythm 
  Monograph, National Sleep Foundation
  1/1/2004
• Narcolepsy and Other Causes of Sleepiness 
  American College of Physicians
  1/1/2003
• Living without sleep 
  The Connection, NPR
  1/1/2002
• Commentary on modafinil 
  Good Morning America
  1/1/2001
• Treatment of narcolepsy 
  Scammell TE
  http://www.uptodate.com/contents/treatment-of-narcolepsy
  UpToDate, Wolters Kluwer Health - 2013-01-21
• Clinical features and diagnosis of narcolepsy 
  Scammell TE
  http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-narcolepsy
  UpToDate, Wolters Kluwer Health - 2013-03-15
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