Thomas Owen Crawford MD

PubMed

• Patient-reported assessment of bulbar function in spinal muscular atrophy (SMA): Validation of a self-report scale.
  Maureen A Lefton-Greif, Lisa Belter, Jill Jarecki, Mary Schroth, Yong Zeng
  Journal of Neuromuscular Diseases. 2025-03-20
• 3 citations
  Combined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants.
  Sarah H Berth, Linh Vo, Do Hoon Kwon, Tiffany Grider, Yasmine S Damayanti
  Brain. 2025-02-03
• Prevalence and outcomes of cancer and treatment-associated toxicities for patients with ataxia telangiectasia.
  Aimee Magnarelli, Qi Liu, Fan Wang, Xiao P Peng, Jennifer Wright
  The Journal of Allergy and Clinical Immunology. 2025-02-01

Journal Articles

• High-dose glucocorticoid therapy in the management of seizures in neontatal incontinentia pigmenti: A case report  
  Wolf DS, Golden WC, Hoover-Fong J, Applegate C, Cohen BA, Germain-Lee EL, Goldberg MF, Crawford TO, Gauda EB, J Child Neurol, 1/1/2014
• Susceptibility-weighted imaging in Cockayne syndrome  
  Wagner MW, Poretti A, Wang T, Crawford TO, Huisman TAGM, Bosemani T, J Pediatr, 1/1/2014
• Cerebral abnormalities in adults with ataxia telangiectasia  
  Lin DDM, Barker PB, Lederman HM, Crawford TO, Am J Neuroradiol, 1/1/2014
• Pulmonary function in children and young adults with ataxia-telangiectasia  
  McGrath-Morrow S, Lederman HM, Aherrera AD, Lefton-Greif MA, Crawford TO, Ryan R, Wright J, Collaco JM, Pediatr Pulmonol, 1/1/2014
• SMA-MAP: A plasma protein biomarker panel for spinal muscular atrophy  
  Kobayashi DT, Shi J, Stephen L, Ballard KL, Dewey R, Mapes J, Chung B, McCarthy K, Swoboda KJ, Crawford TO, Li R, Plasterer T, Joyce C and the Biomarkers for SMA Study..., PloS One, 1/1/2013
• Effects of 4-aminopyridine on nystagmus and vestibulo-ocular reflex in ataxia-telangiectasia  
  Shaikh AG, Marti S, Tamutzer AA, Palla A, Crawford TO, Zee DS, Straumann D, J Neurol, 1/1/2013
• SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3’-end formation of histone mRNAs  
  Tisdale S, Lotti, F, Saieva L, Van Meerbeke JP, Crawford TO, Sumner CJ, Mentis GZ, Pellizzoni L, Cell Reports, 1/1/2013
• Spinal muscular atrophy biomarker discovery project: candidate proteins, metabolites, and transcripts  
  Finkel RS, Crawford TO, Kaufmann P, Swoboda KJ, Juhasz P, Li X, Li RH, Trachtenberg F, Tiziano FD, Lomastro R, Paushkin S, Kobayashi DT, Forrest S, Chen KDS, Joyce C, ..., PloS One, 1/1/2012
• Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders  
  Finanger Hedderick ELF, Simmers JL, Soleimani A, Andres-Mateos E, Marx R, Files DC, King L, Crawford TO, Corse AM, Cohn RD, Neurology, 1/1/2011
• Ataxia-telangiectasia: a “disease model” to understand the cerebellar control of vestibular reflexes  
  Shaikh AG, Marti S, Tarnutzer AA, Palla A, Crawford TO, Straumann D, Carey JP, Nguyen KD, Zee DS, J Neurophysiol, 1/1/2011
• Proteomic characterization of cererospinal fluid from ataxia-telangiectasia (A-T) patients using a LC/MS-based label-free protein quantification technology  
  Dzieciatkowska M, Qi G, You J, Bemis KG, Sahm H, Lederman HM, Crawford TO, Gelbert LM, Rothblum-Oviatt C, Wang M, Int J Proteomics, 1/1/2011
• Elevated serum IL-8 in ataxia telangiectasia  
  McGrath-Morrow SA, Collaco JM, Rosquist K, Green D, Crawford TO, Carson KA, Lefton-Greif MA, Zeitlin P, Lederman HM, J Pediatr, 1/1/2010
• Electroconvulsive therapy for pediatric malignant catatonia with cerebellar dysgenesis  
  Wachtel LE, Crawford TO, Dhossche DM, Reti IM, Ped Neurol, 1/1/2010
• Gaze fixation deficits and their implication in ataxia-telangiectasia  
  Shaikh AG, Marti S, Tarnutzer AA, Palla A, Crawford TO, Straumann D, Taylor AM, Zee DS, J Neurol Neurosurg Psychiatry, 1/1/2009
• Emerging treatment options for spinal muscular atrophy  
  Burnett BG, Crawford TO, Sumner CJ, Curr Treat Options in Neurol, 1/1/2009
• Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect  
  Gavrilina TO, McGovern VL, Workman E, Crawford TO, Gogliotti RG, Didonato CJ, Monani UR, Morris GE, Burghes HM, Hum Mol Genet, 1/1/2008
• Perspectives on clinical trials in spinal muscular atrophy  
  Swoboda KJ, Kissel JT, Crawford TO, Bromberg MB, Acsadi G, D'Anjou G, Krosschell KJ, Reyna SP, Schroth MK, Scott CB, Simard LR, J Child Neurol, 1/1/2007
• Consensus statement for standard of care in spinal muscular atrophy  
  Wang CH, Finkel RS, Bertini ES, Schroth M, Simonds A, Wong B, Aioysius A, Morrison L, Main M, Crawford TO, Treja A, J Child Neurol, 1/1/2007
• Extrapyramidal signs in normal pressure hydrocephalus: an objective assessment  
  Mandir AS, Jilfiker J, Thomas G, Minahan RE, Crawford TO, Williams MA, Rigamonti D, Cerebrospinal Fluid Res, 1/1/2007
• Survival probability in ataxia telangiectasia  
  Crawford TO, Skolasky RL, Fernandez R, Rosquist KJ, Lederman HM, Arch Dis Child, 1/1/2006
• Peripheral pathways regulate motoneuron collateral dynamics  
  Redett R, Jari R, Crawford T, Chen Y-G, Rohde C, Brushart TM, J Neurosci, 1/1/2005
• Cellular Fate of Truncated Slow Skeletal Muscle Troponin T Produced by Glu_180 Nonsense Mutation in Amish Nemaline Myopathy  
  Wang X, Huang Q-Q, Breckenridge MT, Chen A, Crawford TO, Morton DJ, Jin J-P, J Biol Chem, 1/1/2004
• Concern about the design of clinical trial for SMA  
  Crawford TO, Neuromuscul Disord, 1/1/2004
• Re: Practice Parameter: Evaluation of the child with global developmental delay  
  Crawford TO, Comi A, Freeman JM, Kossoff EH, Singer H, Vining EPG, Yohay K, Neurology, 1/1/2003
• Proton magnetic resonance spectroscopy in the diagnostic evaluation of suspected mitochondrial diseases  
  Lin DDM, Crawford TO, Barker PB, Am J Neuroradiol, 1/1/2003
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Books/Book Chapters

• Handbook of Pediatric Orthopedics 
  Chapter: Neuromuscular disorders in Pediatric Orthopedics 
  Sponseller PD, Crawford TOEditors: Sponseller PD.Thieme Medical Publishers, New York, NYEdition 2nd,2011
• Spinocerebellar degenerations: the ataxias and spastic paraplegias 
  Chapter: Ataxia Telangiectasia 
  Crawford TO, Shiloh YEditors: Brice A, Pulst S-M.Butterworth Heinemann Elsevier, Philadelphia, PA2007
• Neurodegenerative Diseases: Neurobiology Pathogenesis and therapeutics 
  Chapter: Ataxia Telangiectasia 
  Gatti RA, Crawford TO, Mandir AS, Perlman S, Mount HTJEditors: Beal MF, Lang AE, Ludolph A.Cambridge University Press, Cambridge2005
• Neuromuscular Disorders of Infancy, Childhood and Adolescence: A Clinician’s Approach 
  Chapter: Infant Botulism 
  Crawford TOEditors: Jones HR, De Vivo DC, Darras BT.Butterworth Heinemann, Philadelphia, PA2003
• Clinical Neurophysiology and Neuromuscular Diseases 
  Chapter: The spinal muscular atrophies and other disorders of the anterior horn cell 
  Crawford TO, Jones HREditors: Brown WF, Bolton CF, Aminoff MJ.W.B. Saunders, Co, Philadelphia, PA2002
• Neurology in Clinical Practice 
  Chapter: The Floppy Infant 
  Crawford TOEditors: Bradley WG, Daroff RB, Fenichel GM, Marsden CD.Butterworth-Heinemann, Philadelphia, PA1999
• The Neurology of Aids 
  Chapter: Peripheral neuropathies associated with HIV infection 
  Griffin JH, Crawford TO, McArthur JCEditors: Gendelman HE, Lipton SA, Epstein L, Swindells S.Chapman & Hall, New York, NY1998
• Neurodevelopmental Disabilities in Infancy and Childhood 
  Chapter: Neuromuscular disorders 
  Crawfort TOEditors: Capute AJ, Pasquale PJ.Paul H Brookes Publishing Co, Baltimore, MDEdition 2nd,1996
• Textbook of Pediatric Critical Care 
  Chapter: Respiratory failure and other complications of neuromuscular disease 
  Crawford TOEditors: Holbrook, PR.W.B. Saunders, Co, Philadelphia, PA1993
• Diseases of the Nervous System 
  Chapter: Motor neuron diseases 
  Kuncl RW, Crawford TO, Rothstein JD, Drachman DBEditors: Asbury AK, McKhann GM, McDonald WI.W.B. Saunders Co, Philadelphia, PAEdition 2nd,1991
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Lectures

• What is Static, What is Degenerative and how can we measure each? 
  7/1/2013
• Challenges in Drug Discovery for Ataxia Telangiectasia 
  11/1/2012
• Instrumented and non-instrumented assessments 
  6/1/2012
• Plenary Address: Clinical Science of Ataxia Telangiectasia: Status Quo and Future Directions 
  10/1/2011
• Proof-of-Concept Trial Design and Conduct, Clinical Trial Feasibility and Conduct Issues for SMA 
  10/1/2010
• State of the Art in Biomarker Development in Spinal Muscular Atrophy 
  9/1/2010
• Ataxia Telangiectasia: developmental and degenerative features 
  4/1/2010
• Keynote Address: The Floppy Infant, and one special story 
  4/1/2010
• Spinal muscular atrophy: A ten million, one hundred, ~ ten, ~one, and 0.1 year perspective 
  12/1/2009
• Evaluating the child with muscle weakness 
  10/1/2009
• Assessment of Ataxia Telangiectasia: Clinical Scale Development 
  5/1/2009
• Ataxia Telangiectasia; Spinal Muscular Atrophy; The Genetics of Neuromuscular Disease 
  5/1/2008
• Differential Diagnosis of the Hypotonic Infant Presenting for Muscle Biopsy 
  5/1/2008
• Neurology Goings-On from the Hopkins A-T Clinical Center 
  4/1/2008
• Toxic Neuropathy; What’s Happening in SMA 
  10/1/2007
• Neurologic Problems in Children with Ataxia Telangiectasia 
  4/1/2006
• Neuromuscular Transmission Defects 
  10/1/2005
• Features of Cerebellar and Extrapyramidal Impairment in A-T, and Insights into the Pathogenesis of A-T from Long-term Neurologic Follow Up 
  10/1/2004
• Ataxia Telangiectasia 
  10/1/2004
• The Neurology of Ataxia Telangiectasia 
  2/1/2004
• Insights into pathogenesis from the clinic 
  9/1/2003
• Congenital Cerebellar Abnormalities in Ataxia Telangiectasia 
  5/1/2002
• Spinal Muscular Atrophy 
  9/1/2001
• The Neurologist’s Agenda for Research 
  11/1/2000
• Neuromuscular Diseases of Children 
  10/1/2000
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