TerenceRFlotteMD
Pediatric Pulmonology • Worcester, MAProfessor, Pediatrics, University Massachusetts Medical School
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Office
55 Lake Ave N
Worcester, MA 01655Phone+1 774-441-8086Fax+1 774-441-8071
Education & Training
Johns Hopkins UniversityFellowship, Pediatric Pulmonology, 1989 - 1992- Johns Hopkins UniversityResidency, Pediatrics, 1986 - 1989
Louisiana State University School of Medicine in New OrleansClass of 1986
Certifications & Licensure
MA State Medical License 2007 - 2026
FL State Medical License 1996 - 2010
MD State Medical License 1987 - 1996
LA State Medical License 1986 - 1991- American Board of Pediatrics Pediatrics
- American Board of Pediatrics Pediatric Pulmonology
Clinical Trials
- Phase I Randomized Study of Adeno-Associated Virus-CFTR Vector in Patients With Cystic Fibrosis Start of enrollment: 1999 Aug 01
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency Start of enrollment: 2004 Mar 01
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency Start of enrollment: 2006 Feb 01
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Publications & Presentations
PubMed
- 40 citationsImmunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Transfer.Motahareh Arjomandnejad, Ishani Dasgupta, Terence R Flotte, Allison M Keeler
Biodrugs. 2023-05-01 - 60 citationsA Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna.Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King
Molecular Therapy. 2020-02-05 - 111 citationsHuman Treg responses allow sustained recombinant adeno-associated virus- mediated transgene expressionChristian Mueller, Jeffrey D. Chulay, Bruce C. Trapnell, Margaret Humphries, Brenna Carey
The Journal of Clinical Investigation. 2013-12-02
Press Mentions
Gene Therapy to Treat Mucopolysaccharidosis IVAOctober 25th, 2024
New Consensus on Assessing Carcinogenic Risks of Gene TherapiesAugust 29th, 2024- Top Story: UMass Chan Launches Translational Institute for Molecular TherapeuticsDecember 27th, 2022
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Grant Support
- Preclinical &Phase I/II Trials Of Aav-Aat VectorsNational Heart, Lung, And Blood Institute2007–2011
- Liver-Directed Gene Therapy For Alpha 1 Antitrypsin (AAT) DeficiencyNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2009
- Expression System With Adeno-Associated Viral VectorsNational Heart, Lung, And Blood Institute2004–2008
- L2762g Eff Of Nutropin AQ For Trmt Of Growth Restriction In Child W CFNational Center For Research Resources2006–2007
- Phase I Trial Of Intramuscular Injection Of A Recombinant Adeno-Associated VirusNational Center For Research Resources2005–2007
- Preclinical &Phase I/II Trials Of Aav-Aat VectorsNational Heart, Lung, And Blood Institute2003–2007
- Establishment Of Ngvl Toxicology LAB: Raav Vectors, Cystic FibrosisNational Center For Research Resources2004–2006
- Recombinant AAV For Correction Of Genetic AbnormalitiesNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2006
- Administrative CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2005
- AAV Vector Delivery To Skeletal Muscle, Platform For Therapeutic Protein DeliveryNational Heart, Lung, And Blood Institute2002–2005
- Molecular Therapies For A1a Liver Disease. Sub: Estab Cell Lines For LAB InvNational Center For Research Resources2004
- Ngvl Toxicology LaboratoryNational Center For Research Resources2001–2004
- Ngvl Toxicology LaboratoryNational Center For Research Resources2003
- Gene Therapy For Liver And Lung DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2002
- Adeno-Associated Virus Vectors For Cystic Fibrosis Gene TherapyNational Heart, Lung, And Blood Institute1996–2002
- AAV Vector Delivery To Skeletal Muscle--Therapeutic Protein Delivery PlatformNational Heart, Lung, And Blood Institute1997–2001
- Phase I Study--Adeno Associated Virus CFTR Gene Vector In Adult Cystic FibrosisNational Center For Research Resources1997–2001
- Effects Of Nicotine Nasal Spray Device On Cardiovascular &PulmonaryNational Center For Research Resources1999–2000
- Effects Of Nicotine Nasal Spray Devices On Pulmonary And Cardiovascular FunctionNational Center For Research Resources1998–1999
- Strategies To Improve AAV CFTR Persistence &ExpressionNational Institute Of Diabetes And Digestive And Kidney Diseases1996–1999
- AAV Vector Delivery To Skeletal Muscle--Therapeutic Protein Delivery PlatformNational Heart, Lung, And Blood Institute1998
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