Dr. Bekaii-Saab is on Doximity
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Office
5881 E. Mayo Boulevard
Phoenix, AZ 85050
Summary
- Tanios Bekaii-Saab is a Professor of Medicine at the Mayo Clinic College of Medicine and Science, Leader of the Gastrointestinal Cancer Program at the Mayo Clinic Cancer Center, Chair Medical Oncology and Hematology in at the Mayo Clinic in Phoenix, Arizona, USA. He is also the consortium chair for the ACCRU research Network. Dr. Bekaii-Saab earned his medical degree from the American University of Beirut and completed a residency in internal medicine at Indiana University. He then completed fellowships in clinical pharmacology/experimental therapeutics and oncology at Tufts University/New England Medical Center in Boston.
Dr. Bekaii-Saab, MD, conducts clinical/translational research focused on developing anticancer agents for patients with gastrointestinal cancers. Dr. Bekaii-Saab collaborates with various scientists and industry partners to design and execute innovative clinical trials, including many first-in-human studies. Bekaii-Saab’s research includes a focus on the incorporation of agents that target the multiple facets of cancer, including genetic drivers, as well as the microenvironment and the immune milieu. His work includes 2 recent discoveries as coinventor of a molecule that targets cancer-related cachexia (AR-42) and an anti–PD-1 vaccine. His research has led to the launch of a number of phase II and III clinical trials, including a recent trial with a cancer stem cell inhibitor (napabucasin) in pancreatic cancer, the development of an FGFR inhibitor in bile duct cancers, and a contribution to the pivotal study that led to the regulatory approval of nanoliposomal irinotecan for treating pancreatic cancer.
Dr. Bekaii-Saab has authored or co-authored more than 500 peer reviewed publications, abstracts, and book chapters, including papers in Lancet Oncology, Journal of Clinical Oncology, JAMA, Journal of the National Cancer Institute, Annals of Oncology, and Clinical Cancer Research.
Education & Training
- Tufts Medical CenterFellowship, Hematology and Medical Oncology, 1999 - 2002
- Indiana University School of MedicineResidency, Internal Medicine, 1996 - 1999
- American University of Beirut Faculty of MedicineClass of 1996
- McGill UniversityB.S., Neuro Biology, With Great Distinction, 1990 - 1992
- American University of BeirutNo Degree, Dean's Honor List, 1987 - 1989
Certifications & Licensure
- AZ State Medical License 2015 - 2025
- OH State Medical License 2002 - 2017
- American Board of Internal Medicine Medical Oncology
Awards, Honors, & Recognition
- High Performing Physician 2013
- Best Doctor Best Doctors in America, 2013
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
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Clinical Trials
- Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer Start of enrollment: 2005 Oct 01
- 3-AP and Radiation Therapy in Treating Patients With Stage III Pancreatic Cancer That Cannot Be Removed By Surgery Start of enrollment: 2006 Dec 20
- 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma Start of enrollment: 2006 Jun 01
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Publications & Presentations
PubMed
- 10 citationsEfficacy of Immune Checkpoint Inhibition and Cytotoxic Chemotherapy in Mismatch Repair-Deficient and Microsatellite Instability-High Pancreatic Cancer: Mayo Clinic Exp...Tucker Coston, Aakash Desai, Hani Babiker, Mohamad Bassam Sonbol, Sakti Chakrabarti
JCO Precision Oncology. 2023-08-01 - 171 citationsInfigratinib (BGJ398) in previously treated patients with advanced or metastatic cholangiocarcinoma with FGFR2 fusions or rearrangements: mature results from a multice...Milind Javle, Sameek Roychowdhury, Robin Kate Kelley, Saeed Sadeghi, Teresa Macarulla
The Lancet. Gastroenterology & Hepatology. 2021-10-01 - 13 citationsFrontline therapy for advanced hepatocellular carcinoma: an update.Mehmet Akce, Bassel F El-Rayes, Tanios S Bekaii-Saab
Therapeutic Advances in Gastroenterology. 2022-01-01
Journal Articles
- Comparison of Universal Genetic Testing vs Guideline-Directed Targeted Testing for Patients with Hereditary Cancer SyndromeScott Okuno, Luke Mountjoy, Cameron S Thorpe, Edward D Esplin, Robert L Nussbaum, Alan H Bryce, Tanios S Bekaii-Saab, Aleksandar Sekulic, JAMA Oncology
- Systemic Therapy and Sequencing Options in Advanced Hepatocellular CarcinomaMohamad Bassam Sonbol, Amit Mahipal, Zhaohui Jin, Kabir Mody, Mitesh J Borad, Daniel H Ahn, Tanios Bekaii-Saab, JAMA Oncology
- Processes of Care in the Multidisciplinary Treatment of Gastric Cancer: Results of a RAND/UCLA Expert PanelBrar SS, Mahar AL, Helyer LK, Swallow C, Law C, Paszat L, Seevaratnam R, Cardoso R, McLeod R, Dixon M, Yohanathan L, Lourenco LG, Bocicariu A, Bekaii-Saab T, JAMA Surg, 11/13/2013
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Lectures
- Phase III study of first-line (1L) pemigatinib (PEM) versus gemcitabine (GEM) plus cisplatin (CIS) for cholangiocarcinoma (CCA) with FGFR2 fusions or rearrangements.ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/24/2020
- Biomarker-Based Basket Trials: A New Model for Biliary Cancer Drug DevelopmentASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/24/2020
- Phase 1b/2 trial of cancer stemness inhibitor napabucasin (NAPA) + nab-paclitaxel (nPTX) and gemcitabine (Gem) in metastatic pancreatic adenocarcinoma (mPDAC).2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
Authored Content
- The POLO Trial Is Great, but Probably Not Practice-ChangingJune 2019
- The POLO Trial Is Great, but Probably Not Practice-ChangingJune 2019
Press Mentions
- Colon Cancer: Lowering Ammonia Levels Increases Tumor Treatment ResponseFebruary 8th, 2023
- ReDOS: Regorafenib Dose-Escalation Strategy in Refractory Advanced Colorectal CancerJuly 11th, 2019
- Dr. Bekaii-Saab on the APACT Trial in Pancreatic CancerOctober 3rd, 2019
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Professional Memberships
- Member
Other Languages
- French, Arabic
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