SudarshanRajagopalMDPhD

Adult Congenital Heart Disease

Assistant Professor in Medicine, Division of Cardiology, Co-Director, Pulmonary Vascular Disease Center, Duke University Medical Center

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I take care of patients with pulmonary hypertension (PH). I also research signaling pathways that are altered in the development of PH in rodent models of the disease. PH covers a wide spectrum of diseases, from the rare pulmonary arterial hypertension (prevalence of 15 in one million) to complications of more common heart and lung disease. PH typically leads to complications through its effects on the heart, leading to heart failure. At the Duke Pulmonary Vascular Disease Center, we see a number of patients with PH and offer all available therapies, including continuous intravenous infusion, inhaled therapies, and surgical options.

Duke Medicine Profiles: Sudarshan Rajagopal, MD, PhD

Get to know Duke Medicine's cardiologists at https://www.dukehealth.org/find-doctors-physicians/sudarshan-rajagopal-md-phd

Duke University HospitalFellowship, Cardiovascular Disease, 2008 - 2013
Duke University HospitalResidency, Internal Medicine, 2006 - 2008
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 2006
University of ChicagoPh.D., Biochemistry and Molecular Biology, 2006
The College, The University of ChicagoB.S., Chemistry, with General and Departmental Honors, 1994 - 1998

Chair’s Award Department of Medicine, Duke University Medical Center, 2013
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Joseph C. Greenfield, Jr., MD Scholar in Cardiology Division of Cardiology, Duke University Medical Cente, 2012
ACCF/Herman K. Gold Young Investigator Award in Molecular and Cellular Cardiology American College of Cardiology, 2011
Finalist Northwestern Cardiovascular Young Investigator’s Forum, 2010
Future Leaders in CV Medical Research Award Schering-Plough, 2009
Barton F. Haynes Resident Research Award Department of Medicine, Duke University, 2008
Departmental Award for Outstanding Performance in the General Field of Biochemistry and Molecular Biology The University of Chicago, 2004
Best Poster Prize Science at Interface Symposium of the Institute for Biophysical Dynamics, The University of Chicago, 2004
Student Research Achievement Award Biophysical Society, 2004
Medical Scientist Training Program The Pritzker School of Medicine, The University of Chicago, 1998
Richter Fund for Undergraduate Research The University of Chicago, 1997
National Merit Scholar 1994
Fellow (FACC) American College of Cardiology
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Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI Start of enrollment: 2018 Mar 29
Completed
Phase 2
Pulmonary Hypertension SOLAR Start of enrollment: 2023 Nov 08
Recruiting
Phase 2

PubMed

31 citations
Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic Sensor
Raymond L. Benza, Mark Doyle, David Lasorda, Kishan S. Parikh, Priscilla Correa-Jaque
Chest. 2019-12-01
35 citations
Pulmonary Hypertension Subtypes and Mortality in CKD.
Daniel L. Edmonston, Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis M. Abraham
American Journal of Kidney Diseases. 2020-05-01
71 citations
Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI
Ziyi Wang, Scott H. Robertson, Jennifer M Wang, Mu He, Rohan S. Virgincar
Medical Physics. 2017-06-01

Journal Articles

A Protocol for Quantifying Cardiogenic Oscillations in Dynamic 129Xe Gas Exchange Spectroscopy: The Effects of Idiopathic Pulmonary Fibrosis
Sudarshan Rajagopal, Craig Rackley, Joseph G Mammarappallil, H Page McAdams, NMR in Biomedicine

Abstracts/Posters

Beta-arrestins regulate signaling by the type II bone morphogenetic protein receptor in pulmonary arterial hypertension.
Rajagopal S, Duke Cardiovascular Symposium, Durham, NC., 5/24/2010
Beta-arrestins regulate signaling by bone morphogenetic protein receptor 2 in pulmonary arterial hypertension.
Rajagopal S, American Society for Clinical Investigation Annual Meeting, Chicago, IL., 4/23/2010
Total Chemical Synthesis of a Minimal Isoform of a Potassium Channel Regulatory Subunit.
Rajagopal S, American Society for Clinical Investigation, Chicago, IL., 5/1/2006
Visualizing Chromophore Conformation in the Photocycle of Photoactive Yellow Protein.
Rajagopal S, Science at Interface Symposium, Institute for Biophysical Dynamics, The University of Chicago, Chica, 6/1/2004
A Structural Pathway for Signal Transduction in the E46Q Mutant of Photoactive Yellow Protein.
Rajagopal S, Gordon Conference on Photosensory Biology, Ventura, California, 2003; Biophysical Society Annual M, 2/1/2004
Crystal Structure of a Photoactive Yellow Protein from a Sensor Histidine Kinase: Conformational Variability and Signal Transduction.
Rajagopal S, Gordon Conference on Photosensory Biology, Barga, Italy., 6/1/2001
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Lectures

Beta-arrestins Regulate Signaling by Type II Bone Morphogenetic Protein Receptor in Pulmonary Arterial Hypertension.
American College of Cardiology, New Orleans, LA. - 4/3/2011
G proteins, Beta Arrestins and the Role of Hypoxia in Adrenergic Signaling.
17th International Hypoxia Symposium, Lake Louise, Canada. - 2/17/2011
Beta-arrestin- but not G protein-mediated Signaling by the "Decoy" Receptor CXCR7.
Columbia University Division of Preventive Medicine and Nutrition Seminar Series. - 10/14/2009
Chemical Kinetic Mechanisms for Photoactive Yellow Protein from TimeResolved Laue Crystallography.
Vrije Universitaet Amsterdam. - 2/1/2004
A Structural Pathway for Signal Transduction in the E46Q Mutant of Photoactive Yellow Protein.
The University of Chicago Molecular Biosciences Retreat, Lake Geneva, WI. - 1/1/2003
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