StevenKyleGrinspoonMD

Endocrinology • Boston, MA

Diabetes, Lipid Metabolism

Professor of Medicine, Massachusetts General Hospital

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Office
55 Fruit St
Bul 457b
Boston, MA 02114
Phone+1 617-726-7948

Fax+1 617-724-8998

Summary

Dr. Steven Grinspoon, MD is an endocrinologist in Boston, Massachusetts. He is currently licensed to practice medicine in Massachusetts and New York. He is affiliated with Massachusetts General Hospital and is a Professor of Medicine at Massachusetts General Hospital.

Education & Training

Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 1993 - 1995
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1988 - 1992
University of Rochester School of Medicine and DentistryClass of 1988

Certifications & Licensure

MA State Medical License 1992 - 2026
NY State Medical License 1989 - 1992

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2003

Clinical Trials

AIDS Wasting in Women: Anabolic Effects of Testosterone Start of enrollment: 1998 Sep 01
Completed
Phase 2
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities
Completed
Not Applicable
Physiologic Growth Hormone Effects in HIV Lipodystrophy Start of enrollment: 2004 Jan 01
Completed
Not Applicable
Study of Lifestyle Modification in HIV Lipodystrophy Start of enrollment: 2003 Jun 01
Completed
Not Applicable
TH9507 in Patients With HIV-Associated Lipodystrophy Start of enrollment: 2005 Jun 01
Completed
Phase 3
Lifestyle Modification and Metformin Use in the Treatment of HIV Start of enrollment: 2006 Dec 01
Completed
Not Applicable
Study of TNF-Antagonism in Metabolic Syndrome Start of enrollment: 2004 Apr 01
Completed
Not Applicable
Study of TNF-Antagonism in the Metabolic Syndrome (II) Start of enrollment: 2006 Dec 01
Completed
Not Applicable
Subclinical Atherosclerosis in HIV-infected Patients Start of enrollment: 2006 Jun 01
Completed
HIV and Cardiovascular Risk Start of enrollment: 2007 Apr 01
Completed
Prevalence and Cardiovascular Effects of Growth Hormone Deficiency in Abdominal Obesity Start of enrollment: 2007 Nov 01
Completed
TH9507 Extension Study in Patients With HIV-Associated Lipodystrophy Start of enrollment: 2007 Aug 01
Completed
Phase 3
Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are Obese Start of enrollment: 2008 Jul 01
Completed
Phase 2
Effects of Short-term Growth Hormone in HIV-infected Patients Start of enrollment: 2009 Feb 01
Completed
Not Applicable
Effect of Short Term Growth Hormone Releasing Hormone in Healthy Men Start of enrollment: 2009 Feb 01
Completed
Not Applicable
Statin Therapy to Improve Atherosclerosis in HIV Patients Start of enrollment: 2009 Sep 01
Completed
Not Applicable
HIV Fat Redistribution and the Evaluation of Brown Fat Start of enrollment: 2010 Mar 01
Completed
Secondary Analysis of Gut Hormones and Inflammatory Cytokines in Fasting Subjects Start of enrollment: 2002 Nov 01
Completed
Not Applicable
Effects of Growth Hormone Releasing Hormone in HIV Start of enrollment: 2010 Dec 01
Completed
Not Applicable
Eplerenone in HIV Associated Abdominal Fat Accumulation Start of enrollment: 2012 Jan 01
Completed
Not Applicable
Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV Start of enrollment: 2012 Jan 01
Completed
Monitoring and Modifying Atherosclerosis in Psoriasis Patients Study Start of enrollment: 2012 Feb 01
Terminated
Long-term Observational Study in HIV Subjects Exposed to EGRIFTA® Start of enrollment: 2013 Feb 01
Terminated
Abdominal Obesity, Cardiovascular Inflammation, and Effects of Growth Hormone Releasing Hormone Analogue Start of enrollment: 2014 Jan 01
Withdrawn
Not Applicable
Effects of Newly-Initiated QUAD Therapy on Aortic/Coronary Inflammation in ART-Naïve Infected Patients Start of enrollment: 2012 Dec 01
Completed
Tesamorelin Effects on Liver Fat and Histology in HIV Start of enrollment: 2015 Jul 01
Completed
Not Applicable
Use of 99mTc Tilmanocept for Imaging Arterial Inflammation Start of enrollment: 2015 Sep 01
Completed
Application of IV 99mTc-tilmanocept for Imaging of Macrophage-specific Inflammation Start of enrollment: 2018 May 03
Completed
Growth Hormone Dynamics and Cardiac Steatosis in HIV Start of enrollment: 2019 Jan 30
Completed
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Publications & Presentations

PubMed

1 citations
Proteinuria and albuminuria among a global primary cardiovascular disease prevention cohort of people with HIV.
Edgar T Overton, Amy Kantor, Kathleen V Fitch, Mosepele Mosepele, Judith A Aberg
AIDS. 2025-01-01
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial.
Márton Kolossváry, Samuel R Schnittman, Markella V Zanni, Kathleen V Fitch, Carl J Fichtenbaum
JAMA Cardiology. 2024-12-11
What have we learned from the REPRIEVE trial and where do we go from here?
Steven K Grinspoon, Michael T Lu, Markella V Zanni, Marissa R Diggs, Sarah M Chu
HIV Medicine. 2024-12-01

Press Mentions

Analysis Reveals an Additional Mechanism Behind Statin Therapy's Heart-Related Benefits in People with HIVDecember 11th, 2024
Metabolic Risk Contributes to Diabetes Onset in People with HIVOctober 25th, 2024
Mass General Investigators Identify Metabolic Risk Factors for New-Onset Diabetes Among People with HIV Using Data from Large, Global TrialOctober 8th, 2024
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Grant Support

Training Program In Nutrition And MetabolismEunice Kennedy Shriver National Institute Of Child Health &Human Development2012
Strategies To Improve CAD Risk In HIV DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2012
Aldosterone Effects And Targeted Inhibition On Metabolic Indices In Hiv-InfectionNational Institute Of Diabetes And Digestive And Kidney Diseases2011
Inflammatory Mechanisms And Treatment Strategies For Atherosclerosis In HIVNational Heart, Lung, And Blood Institute2009–2011
Metabolic, And Cardiovascular Effects Of GHRH In HIV Infected PatientsNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Initiative To Decrease Cardiovascular Risk And Increase Quality Of CareNational Center For Research Resources2009–2010
Consequences And Treatment Of Growth Hormone Deficiency In The Metabolic SyndromeNational Heart, Lung, And Blood Institute2007–2010
Metabolic Syndrome, Lifestyle Modification And Resistance Training In HIV DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2010
Training Program In Nutrition And MetabolismEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009
Strategies For The Treatment Of HIV Associated Metabolic SyndromeNational Center For Research Resources2008
Prevalence And Metabolic Consequences Of Relative Growth Hormone Deficiency InNational Center For Research Resources2008
Clinical Trial: Use Of Th9507 In HIV Infected Individuals With Excess AbdominalNational Center For Research Resources2008
Clinical Trial: 2mg Dose Of Th9507, A Growth Hormone Releasing Factor Analog InNational Center For Research Resources2008
Assessment Of Cardiovascular Risk In HIV PatientsNational Center For Research Resources2008
Assessing The Safety And Efficacy Of A 2mg Dose Of Th9507, A Growth Hormone ReleNational Center For Research Resources2008
Subclinical Atherosclerosis In HIV Infected MenNational Center For Research Resources2007–2008
Subclinical Altherosclerosis In HIV Infected MenNational Center For Research Resources2007–2008
Metabolic Effects Of Switching Kaletra To Boosted ReyatazNational Center For Research Resources2007–2008
Effects Of Tnf-Alpha Antagonism In Patients With The Metabolic SyndromeNational Center For Research Resources2007–2008
A Multicenter, Doubleblind, Randomized, Placebo-Controlled Study Assessing TheNational Center For Research Resources2007–2008
Long Term Effects Of Testosterone In Hiv-Infected WomenNational Center For Research Resources2005–2008
Long-Term Physiologic Effects Of GH In HIV LipodystrophyNational Center For Research Resources2004–2008
Use Of Th9507 In HIV Infected Individuals With Excess Abdominal FatNational Center For Research Resources2006–2007
The Effects Of Nucleoside Reverse Transcriptase Inhibitors (NRTI) On MitochondNational Center For Research Resources2006–2007
Effects Of A Lifestyle Modification Program (REACH) In Patients With HIV AndNational Center For Research Resources2005–2007
Endocrine Function, Metabolism, And Body Composition In WomenNational Center For Research Resources2004–2007
Effects Of Lsm In HIV And Metabolic SyndromeNational Center For Research Resources2004–2007
Physiologic Growth Hormone Effects In HIV LipodystrophyNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2007
Androgen Effects In Hiv-Infected WomenNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2007
Androgen Effects And Insulin Resistance In HIV DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2007
A Multicenter, Doubleblind, Rancomized, Placebo-Controlled Study Assessing TheNational Center For Research Resources2006
The Effect Of Tnf-Alpha Antagonism In Patients With Metabolic SyndromeNational Center For Research Resources2005–2006
Mechanisms And Clinical Effects Of Adrenal Androgen Shunting In HIV DiseaseNational Center For Research Resources2005–2006
Mechanisms And Clinical Affects Of Adrenal Androgen Shunting In HIVNational Center For Research Resources2005–2006
Exercise Effects In Hiv-Infected WomenNational Center For Research Resources2004–2006
Endocrine Function, Metabolism, &Body Composition In Women W/Aids LipodystrophyNational Center For Research Resources2004–2006
Effects Of Recombinant Human Leptin Administration On Neuroendocrine FunctionNational Center For Research Resources2005
Human Leptin Administration On Neuroendocrine Function During Fastin In HumansNational Center For Research Resources2004–2005
Assessment Of The Mechanisms Affecting Growth Hormone In HIV LipodystrophyNational Center For Research Resources2004–2005
The Use Of GHRH In The AIDS Lipodystrophy SyndromeNational Center For Research Resources2004
The Effects Of Metformin And Exercise In The HIV Lipodystrophy SyndromeNational Center For Research Resources2004
The Effects Of Menopause On Bone Density In Hiv-Infected WomenNational Center For Research Resources2004
The Effects Of Menopause On Bone Density In Hiv-InfectedNational Center For Research Resources2004
Randomized, Double-Blind, Placebo-Controlled Study OfNational Center For Research Resources2004
Effects Of Recombinant Human Leptin Administration On NNational Center For Research Resources2004
Effects Of A Lifestyle Modification Program (REACH) InNational Center For Research Resources2004
A Randomized, Double-Blind, Placebo-Controlled Study Of Rosiglitazone In HIVNational Center For Research Resources2004
Mechanisms And Strategies For Insulin Resistance In AIDSNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2004
Growth Hormone Dynamics In AIDS LipodystrophyNational Center For Research Resources2000–2002
AIDS Wasting In Women--Testosterone Anabolic EffectsNational Center For Research Resources2000–2002
AIDS Wasting In Women--Anabolic Effects Of Testosterone Treatment StudyNational Center For Research Resources1999–2002
AIDS Wasting In Women--Anabolic Effects Of TestosteroneNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2002
Combination Exercise PLUS Testosterone In Eugonadal Men With AIDS WastingNational Center For Research Resources1998–2002
Gonadal Physiology And Somatotroph Function In AIDSNational Center For Research Resources1996–2002
RH IGF-1 &Estrogen On Bone Density In Anorexia NervosaNational Center For Research Resources2000
Metformin On Insulin Resistance In HIV Infected PatientsNational Center For Research Resources2000
GH Dynamics In Patients With AIDS LipodystrophyNational Center For Research Resources2000
Physiologic Effects Of IGF-1 In Anorexia NervosaNational Center For Research Resources1999
Ortho Tri-Cyclen And Biomarkers Of Bone Metabolism In Hypothalamic AmenorrheaNational Center For Research Resources1999
Ortho TRI Cyclen On Biochem Markers Of Bone Metab In Hypothalamic AmenorrheaNational Center For Research Resources1999
Effects Of Anorexia Nervosa On Bone Metabolism In Female AdolescentsNational Center For Research Resources1999
Anorexia Nervosa In Bone Metabolism Of Female AdolescentsNational Center For Research Resources1999
AIDS Wasting In Women--Anabolic Effects Of TestosteroneNational Center For Research Resources1999
Effects Of Rhigf-1 And Estrogen On Bone Density In Anorexia NervosaNational Center For Research Resources1998–1999
Double-Blind, Placebo-Contr, RAND Pilot (TMTDS) In Androgen Deficient WomenNational Center For Research Resources1997–1999
Physiologic Effects Of IGF-1 In Anorexia Nervosa And Normal VolunteersNational Center For Research Resources1997
Growth Hormone/Testosterone Effects AIDS Wasting--Cross Section, WomenNational Center For Research Resources1996–1997
Gonadal Physiology And Somatotroph Function In AIDSNational Institute Of Diabetes And Digestive And Kidney Diseases1995