StevenYChangMDPhD

Critical Care Medicine

Clinical Professor of Medicine, MICU Director, David Geffen School of Medicine at UCLA, Ronald-Reagan UCLA Medical Center

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Office
10833 LeConte Avenue, 37-131 CHS
Los Angeles, CA 90095
Phone+1 310-825-5316

Fax+1 310-825-5316

Summary

Dr. Steven Chang is a Pulmonary & Critical Care physician specializing in critical care medicine based in Los Angeles, CA. He completed his residency in Internal Medicine at Columbia-Presybyterian Medical Center in NYC, fellowship in Pulmonary Disease and Critical Care Medicine at the University of Chicago and has extensive experience in managing conditions in ICUs such as pneumonia, respiratory failure, sepsis, and shock. Dr. Chang is currently a Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA, and has been full-time faculty at institutions such as Rutgers New Jersey Medical School and New York University School of Medicine. He has contributed to numerous publications on vaccine effectiveness and critical care medicine, and participated in numerous clinical trials related to sepsis, ARDS, and therapies affecting host response in COVID-19. Throughout his career, he has been recognized for his teaching, having been nominated for awards such as the inpatient teaching award at UCLA and the Golden Apple Teaching Award at Rutgers-NJMS.

Education & Training

University of ChicagoFellowship, Pulmonary Disease and Critical Care Medicine, 2002
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1996 - 1999
New York Presbyterian Hospital (Columbia Campus)Internship, Internal Medicine, 1996 - 1997
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1996
University of ChicagoPhD, Pharmacological & Physiological Sciences, 1992 - 1995
Miami UniversityB.A., Zoology, Magna Cum Laude, 1985 - 1989

Certifications & Licensure

CA State Medical License 2013 - 2025
NJ State Medical License 2006 - 2015
IL State Medical License 1999 - 2008
NY State Medical License 1997 - 2006
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Nominated for inpatient teaching award David Geffen School of Medicine at UCLA, Department of Medicine, 2021-2022
Nominated for Golden Apple Teaching Award Rutgers-NJMS, 2008, 2011-2013
Faculty Teaching Award North Shore University Hospital, Department of Medicine, 2004
Faculty Teaching Award North Shore University Hospital, Division of Pulmonary & Critical Care Medicine, 2004
Harry Ginsburg Memorial Award University of Chicago, 1995
Phi Beta Kappa 1989
University Honors Miami University, 1989
Herbert Ray Brauchla Scholar Leader Miami University, 1988
National Merit Scholar 1985
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Clinical Trials

Reevaluation Of Systemic Early Neuromuscular Blockade Start of enrollment: 2016 Jan 04
Completed
Phase 3
Severe ARDS: Generating Evidence Start of enrollment: 2016 Oct 01
Completed
Vitamin D to Improve Outcomes by Leveraging Early Treatment Start of enrollment: 2017 Apr 27
Completed
Phase 3
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis Start of enrollment: 2018 Mar 07
Completed
Phase 3
Vitamin C, Thiamine, and Steroids in Sepsis Start of enrollment: 2018 Aug 22
Completed
Phase 3
Novel Experimental COVID-19 Therapies Affecting Host Response Start of enrollment: 2021 Jul 15
COMPLETED
PHASE2, PHASE3
Roles: Contact
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Publications & Presentations

PubMed

1 citations
Assessment and mitigation of bias in influenza and COVID-19 vaccine effectiveness analyses - IVY Network, September 1, 2022-March 30, 2023.
Nathaniel M Lewis, Elizabeth J Harker, Aleda Leis, Yuwei Zhu, H Keipp Talbot
Vaccine. 2025-01-01
Benefit of early oseltamivir therapy for adults hospitalized with influenza A: an observational study.
Nathaniel M Lewis, Elizabeth J Harker, Lauren B Grant, Yuwei Zhu, Carlos G Grijalva
Clinical Infectious Diseases. 2024-11-28
6 citations
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
Lorraine B Ware, D Clark Files, Alpha Fowler, Michael S Aboodi, Neil R Aggarwal
JAMA. 2024-08-06

Journal Articles

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19
Matthew W Semler, Lindsay M Leither, Derek C Angus, Roy G Brower, Steven Y Chang, John C Eppensteiner, Michael R Filbin, Adit A Ginde, Michelle N Gong, Douglas L Hayde..., JAMA
Protocols and hospital mortality in critically ill patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study (USCIITG-CIOS)
Sevransky, J.E., W. Checkley, P. Herrera, B.W. Pickering, J. Barr, S.M.Brown, S.Y. Chang, D. Chong, D. Kaufman, R.D. Fremont, T.D. Girard, J. Hoag, S.B. Johnson, M.P. ..., Critical Care Medicine, 1/24/2015
Structure, process and annual ICU mortality across 69 centers: United Sates Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Checkley, W., G.S. Martin, S. Brown, S.Y. Chang, O. Dabbagh, R.D. Fremont, T.D. Girard, M.D. Howell, S. Johnson, J. O’Brien, P.K. Park, S. Pastores, N.T. Patil, A.P. P..., Critical Care Medicine, 1/1/2014
Contemporary Ventilator Management in Patients with and at risk of ALI/ARDS
Chang, S.Y., O. Dabbagh, O. Gajic, A. Patrawalla, M-C Elie, D. Talmor,A. Malhotra, A. Adesanya, H.L. Anderson III, J.M. Blum, P.K. Park, and M.N. Gong on behalf of the..., Respiratory Care, 1/1/2013
Protocols in the management of critical illness
Chang, S.Y., J. Sevransky, G.S. Martin, Critical Care, 1/1/2012
Early identification of patients at risk of acute lung injury: Evaluation of Lung Injury Prediction Score in a Multicenter Cohort Study
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Regional ICU Care: The future is now
Chang, S.Y., S.L. Merwin, J.F. Fein, A.M. Fein, Journal of Intensive Care Medicine, 1/1/2010
Critical Illness in the Obese Patient
Chang, S.Y., J.P. Kress, and J.B. Hall, Current Respiratory Medicine Reviews, 1/1/2008
Critical Care Organization
Chang, S.Y., A.S. Multz, and J.B. Hall, Critical Care Clinics, 1/1/2005
Mechanisms of CFTR regulation by Syntaxin 1A and PKA
Chang, S.Y., A. Di, A.P. Naren, H.C. Palfrey, K.L. Kirk and D.J. Nelson, Journal of Cell Science, 1/1/2002
CFTR chloride channels are regulated by a SNAP 23/Syntaxin 1A complex
Cormet-Boyaka, E., A. Di, S.Y. Chang, A.P. Naren, A. Tousson, D.J. Nelson, and K.L. Kirk, Proceedings of the National Academy of Sciences, 1/1/2002
Modal behavior of the mu1 Na+ channel and effects of coexpression of the beta1-subunit
Chang, S.Y., J. Satin, and H.A. Fozzard, Biophysical Journal, 1/1/1996
Co-expression of beta1 cardiac Na channel alpha subunits in oocytes decreases lidocaine block
Makielski, J.C., J.T. Limberis, S.Y. Chang, Z. Fan, and J.W. Kyle, Molecular Pharmacology, 1/1/1996
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Books/Book Chapters

Pulmonary Examination and Board Review
Chapter: HIV and the Lung
Arredondo, A, R. Huynh, and S.Y. ChangMcGraw-Hill, New York, NY2015
Clinical Management of Pulmonary Arterial Hypertension
Chapter: Pulmonary Hypertension in the ICU
Chang, S.Y.Editors: J. Klinger, A. Talwar, A. Fein.Professional Communications Inc2015
Manual of Critical Care
Chapter: The Systemic Inflammatory Response Syndrome and Septic Shock
Chang, S.Y., J. Edelson, and A.M. FeinEditors: S. Raoof.McGraw-Hill2009
Just the Facts: Critical Care
Chapter: Echocardiography in the critically ill patient
Chang, S.Y.Editors: J.B. Hall & G.A. Schmidt.McGraw-Hill, New York, NY2007
Irwin and Rippe’s Intensive Care Medicine
Chapter: Defining and measuring patient safety in the critical care unit
Fein, A.M., S.Y. Chang, D. Ost, J.E. Heffner, and S.L. MerwinEditors: R.S.S. Irwin & J.M. Rippe.Lippincott Williams & WilliamsEdition 6th,2007
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Abstracts/Posters

Improving mechanical ventilator bundle compliance: A quality improvement project
Albores, J., and S. Chang, American Journal of Respiratory and Critical Care Medicine, 1/1/2015
Association between clinical protocols and hospital mortality in critically ill patients: United States Critical Illness and Injury Trials Group-Critical Illness Outco...
Sevransky, J.E., W. Checkley, P.E. Morris, B.W. Pickering, J.B. Hoag, S. Shahul, M.P. Kerlin, M. Putman, N. Patil, J. Guzman, S.M. Brown, S. Pastores, R. Fremont, L. R..., American Journal of Respiratory and Critical Care Medicine, 1/1/2014
Critical Illness Outcomes Study: An Observational Cohort of Critically Ill Patients
Sevransky, J.E., W. Checkley, T.D. Girard, S.M. Pastores, S. Shahul, A. Martinez, S. Brown, N. Patil, T. O’Keffe, B. Pickering, J. Liebler, P. Park, J. , S. Chang, J. ..., American Journal of Respiratory and Critical Care Medicine, 1/1/2012
Organizational structure of 27 intensive care units in the United States: 10 Critical Illness Outcomes Study (CIOS)
Checkly, W., G.S. Martin, S. Brown, S.Y. Chang, O. Dabbagh, R. Fremont, T.D. Girard, M. Howell, S. Johnson, J. O’Brien, P.K. Park, S. Pastores, N. Patil, A. Pietropaol..., American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Early cumulative fluid balance and development of acute lung injury
Park, P., N.O. Birkmeyer, N. Gentile, S.Y. Chang, O. Dabbagh., O. Gajic, American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers and clinical outcomes among patients at risk for Acute Lung Injury
Watkins, T., L.B. Lemos-Filho, O. Dabbagh, S.Y. Chang, P.K. Park, M.N. Gong, American Journal of Respiratory and Critical Care Medicine, 1/1/2011
Frequency and outcome of acute lung injury in hospitalized patients at risk: a multicenter cohort study
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2010
Towards prevention of acute lung injury: identification of patients at risk at the time of hospital admission
Gajic, O., O. Dabbagh, P.K. Park, A. Adesanya, S.Y. Chang, P. Hou, H. Anderson III, J.J. Hoth, M. Mikkelsen, N.T. Gentile, M.N. Gong, E. Bajwa, D. Talmor, on behalf of..., American Journal of Respiratory and Critical Care Medicine, 1/1/2010
ALI/ARDS in Emergency Surgery: The U.S. Critical Illness and Injury Trials Group (USCIITG) Lung Injury Prevention Study Cohort
Park, P., S. Chang, O. Gajic, O. Dabbagh, A Adesanya, J. Hoth, H. Anderson, on behalf of the U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Stud..., American Association for the Surgery in Trauma conference, 1/1/2010
Interpretation of PFTs
Chang, S.Y., Rutgers-NJMS – Medical Housestaff, 1/1/-1
Pathophysiology of Sepsis
Chang, S.Y., NYU School of Medicine – 2nd Year Medical Students, 1/1/2005
Pulmonary Manifestations of Rheumatologic Disease
Chang, S.Y., NYU School of Medicine – CME Course, 1/1/2005
Management of ALI/ARDS
Chang, S.Y., NYU School of Medicine – Medical Housestaff, 1/1/2005
Etiology of prolonged mechanical ventilation in tertiary setting
Quinones, A., R. Ali-Permell, R. Russo, S. Chang, E. Hussain, M. Nelson, A. Fein., Chest, 1/1/2003
Regulation of ICFTR by Syntaxin 1A occurs predominantly via direct protein-protein interactions
Di, A. S.Y. Chang, A.P. Naren, K.L. Kirk, and D. Nelson, Biophysical Journal, 1/1/2001
Disruption of direct Syntaxin 1A-CFTR interaction results in increased channel activity in human airway epithelia
Chang, S.Y., A. Di, A.P. Naren, K.L. Kirk, and D.J. Nelson, American Journal of Respiratory and Critical Care Medicine, 1/1/2001
A putative interaction between HCLC-3 and CFTR
Huang, P., A. Di, M.A. Kaetzel, K. Kirk, S. Chang, X.D. Johnson, and D.J. Nelson, Biophysical Journal, 1/1/2000
CFTR cooperatively interacts with SNAP-23 and Syntaxin 1A
Cormet-Boyaka, E., S. Chang, A. Di, A.P. Naren, D.J. Nelson, and K.L. Kirk, Pediatric Pulmonology, 1/1/2000
Na channel beta1 association with cardiac Na channel alpha subunits demonstrated by lidocaine block
Makielski, J.C., J.T. Limberis, S.Y. Chang, Z. Fan, and J.W. Kyle, Biophysical Journal, 1/1/1995
Beta1-subunit expressed with adult rat skeletal muscle Na channel alpha-subunit restores a native-like fast gating mode
Chang, S., J. Satin, J. Kyle and H. Fozzard, Biophysical Journal, 1/1/1995
Rat brain beta1 Na channel subunit interacts with rat brain IIa, skeletal muscle (gamma1), and rat heart (RH1) alpha-subunits
Kyle, J.W., S.Y. Chang, J. Satin, J.M. Fang, H.A. Fozzard, and R.B. Rogart, Biophysical Journal, 1/1/1993
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Lectures

Pulmonary & Critical Care Core Lecture Series
1/1/2013
The Acute Respiratory Distress Syndrome
Queens, NY - 1/1/2013
Severe Sepsis and Septic Shock in 2007
1/1/2007
Critical Care – Critical Care Core Lecture Series
1/1/2005
Innovations in diagnosis and treatment of pulmonary embolism
San Diego, CA - 1/1/2005
Right ventricular dysfunction in critical illness
Orlando, FL - 1/1/2004
Critical Care Lectures Series for Fellows
1/1/-2
Housestaff Lectures Series – Topics in Critical Care
1/1/-3
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