StevenBremMD

PubMed

• Machine Learning-based Prognostic Subgrouping of Glioblastoma: A Multi-center Study.
  Hamed Akbari, Spyridon Bakas, Chiharu Sako, Anahita Fathi Kazerooni, Javier Villanueva-Meyer
  Neuro-Oncology. 2024-12-12
• 1 citations
  Commentary: Resting State Functional Networks in Gliomas: Validation With Direct Electric Stimulation Using a New Tool for Planning Brain Resections.
  Steven Brem, Michael J Hoch
  Neurosurgery. 2024-12-01
• Distinction of pseudoprogression from true progression in glioblastomas using machine learning based on multiparametric magnetic resonance imaging and O-methylguanine-...
  Virendra Kumar Yadav, Suyash Mohan, Sumeet Agarwal, Laiz Laura de Godoy, Archith Rajan
  Neuro-Oncology Advances. 2024-10-03

Journal Articles

• Three‐Dimensional Echo Planar Spectroscopic Imaging for Differentiation of True Progression from Pseudoprogression in Patients with Glioblastoma  
  Arati Desai, Ronald L Wolf, MacLean Nasrallah, Suyash Mohan, Steven Brem, NMR in Biomedicine
• commentary to Esquenazi Y et al The survival advantage of “supratotal” resection of glioblastoma using selective cortical mapping and subpial technique  
  Brem S, Lee JYK, Lucas TH, O’Rourke DM, Neurosurgery, 1/1/2017
• commentary to Bonney PA et al A simplified method of accurate postprocessing of diffusion tensor imaging for use in brain tumor resections  
  Brem S, Operative Neurosurgery, 1/1/2017
• Pervasive within-mitochondrion single-nucleotide variant heteroplasmy as revealed by single-mitochondrion sequencing  
  Morris J, Na Y-J, Zhu H, Lee J-H, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O’Rourke DM, Wolf JA, Grady MS, Sul J-Y, Kim J, Eberwine J., Cell Reports, 1/1/2017
• commentary to Youngerman BE et al Making milestones: development and implementation of a formal socioeconomic curriculum in a neurosurgical residency training program  
  Brem S, Schuster JM, Neurosurgery, 1/1/2016
• Intraoperative probe-based laser endomicroscopy in surgery and stereotactic biopsy of low-grade and high-grade gliomas: a feasibility study in humans  
  Brem S, Lee J, Sighal S, commentary to Pavlov V et al., Neurosurgery, 1/1/2016
• commentary to Nuño M et al Does 30-day readmission affect long-term outcome among glioblastoma patients?  
  Brem S, Neurosurgery, 1/1/2014
• Recent updates in the treatment of glioblastoma: introduction  
  Mehta M, Brem S, Semin Oncol, 1/1/2014
• Intracranial spread of Merkel cell carcinoma to the cerebellopontine angle  
  Seaman B, Brem S, Fromm A, Staller A, McCardle T, Jain S, J Cutan Med Surg, 1/1/2012
• SSBP2 variants are associated with survival in glioblastoma patients  
  Xiao Y, Decker PA, Rice T, McCoy LS, Smimov I, Patoka JS, Hansen HM, Wiemels JL, Tihan T, Prados MD, Chang SM, Berger MS, Kosel ML, Fridley BL, Lachance DH, O’Neil BP,..., Clin Cancer Res, 1/1/2012
• Tumor-to-tumor metastasis: pathology and neuroimaging considerations  
  Moody P, Murtagh K, Piduru S, Brem S, Murtagh R, Rojiani AM., Int J Clin Exp Pathol, 1/1/2012
• A safety run-in and randomized phase II study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)  
  Nabors LB, Mikkelsen T, Hegi ME, Ye X, Batchelor T, Lesser G, Peereboom D, Rosenfeld M, Olsen J, Brem S, Fisher JD, Grossman SA., Cancer, 1/1/2012
• Phase I trial of vorinostat in combination with bevacizumab and CPT-11 in recurrent glioblastoma  
  Chinnaiyan P, Chowdhary S, Potthast L, Prabhu A, Tsai Y-Y, Sarcar B, Kahali S, Brem S, Yu M, Rojiani A, Murtagh R, Pan E, Neuro-Oncol, 1/1/2012
• commentary to Babu MA et al Device innovation in neurosurgery: controversy, learning, and future directions  
  Brem S, Tran N, Neurosurgery, 1/1/2012
• Bevacizumab for recurrent glioblastoma: a meta-analysis  
  Wong ET, Gautam S, Malchow C, Lun M, Pan E, Brem S, J Natl Compr Cancer Netw, 1/1/2011
• commentary to: Elliott RE et al Local control of newly diagnosed and distally recurrent, low-volume brain metastases with fixed-dose (20 Gy) gamma knife radiosurgery  
  Brem S, Jain S, Neurosurgery, 1/1/2011
• commentary to: Yang X et al 14-3-zeta positive expression is associated with a poor prognosis in patients with glioblastoma  
  Brem S, Jain S, Neurosurgery, 1/1/2011
• Taming glioblastoma by targeting angiogenesis: Three years later  
  Wong ET, Brem S, J Clin Oncol, 1/1/2011
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  Brem S, Neurosurgery, 1/1/2011
• commentary to: Velez AM, Friedman WA Disseminated intravascular coagulation during resection of a meningioma  
  Brem S, Neurosurgery, 1/1/2011
• commentary to: Forster M-T et al Navigated transcranial magnetic stimulation and functional magnetic resonance imaging: Advanced adjuncts in preoperative planning for ...  
  Brem S, Jain S, Neurosurgery, 1/1/2011
• Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer’s disease  
  Paris D, Ganey N, Banasiak M, Laporte V, Patel N, Mullan M, Murphy SF, Yee G-T, Bachmeier C, Ganey C, Beaulieu-Abdelahad D, Mathura VS, Brem S, Mullan M, J Neurosci, 1/1/2010
• commentary to: Sankar T, et al Miniaturized handheld confocal microscopy for neurosurgery: Results in an experimental glioblastoma model  
  Brem S, Neurosurgery, 1/1/2010
• commentary to: Bohman L-E et al Magnetic resonance imaging characteristics of glioblastoma multiforme: Implications for understanding glioma ontogeny  
  Brem S, Jain S, Neurosurgery, 1/1/2010
• commentary to: Schmid S et al Vascular endothelial growth factor: the major factor for tumor neovascularization and edema formation in meningioma patients  
  Brem S, Jain S, Neurosurgery, 1/1/2010
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Books/Book Chapters

• Glioblastoma 
  Editors: Brem S, Abdullah KG.Elsevier, Philadelphia, PA2017
• Cancer Growth and Progression 
  Chapter: Molecular mechanisms of central nervous system metastasis. Mechanisms of Carcinogenesis 
  DeMers NM, Rojiani MV, Brem S, Rojiani AMEditors: Coppola D.Springer Life Sciences, Dordrecht, The Netherlands2012
• Youmans Neurological Surgery 
  Chapter: Angiogenesis and brain tumors: Molecular targets and molecular scalpels. 
  Page 271.0 - 277.0Brem S, Wong EEditors: Winn HR.Elsevier, PhiladelphiaEdition 6th,2011
• Radiosurgery 
  Chapter: Safety and efficacy of fractionated stereotactic radiosurgery in the treatment of skull base tumors: an evidence based approach 
  Page 212.0 - 226.0Jain S, Chinnaiyan P, Sarangasarin S, Smith DO, Vrionis FD, Brem SEditors: McDermott M.Karger, Basel2010
• Textbook of Neurooncology 
  Chapter: Anaplastic astrocytoma. 
  Page 122.0 - 142.0Brem S, Snodgrass S, Booth-Jones, M, Pearlman J, Murtagh R, Vrionis F, Schold SC Jr, Wotoczek-Obadia M, Rojiani A.Editors: Prados MD, Berger MS.Elsevier Saunders, Philadelphia2005
• Youmans Neurological Surgery 
  Chapter: Angiogenesis and brain tumors 
  Page 771.0 - 789.0Brem SEditors: Winn Hr, Dacey RG, Jr., Brem H.Edition Fift,2003
• Growth Factors, Peptides, and Receptors 
  Chapter: Angiosuppressive and antiproliferative actions of suramin: A growth factor antagonist. 
  Page 255.0 - 264.0Takano S, Gately S, Engelhard H, Tsanaclis AMC, Gross JL, Herblin WF, Eidsvoog K, Brem SEditors: Moody TW.Plenum Press, New York1993
• Angiogenesis 
  Chapter: Tumor growth regulation by modulation of basic fibroblast growth factor. 
  Page 421.0 - 427.0Gross JL, Herblin WF, Eidsvoog K, Horlick R, Brem SSEditors: Stein R, Weisz PB, Haudenschild C, Langer R.Birkhauser Verlag, Basel1992
• The Search for New Anti-Cancer Drugs 
  Chapter: Angiosuppression 
  Page 183.0 - 228.0Fan T-P D, Brem SEditors: Waring M J, Ponder B.Cancer Biology Series, Kluwer, Boston1992
• Angiogenesis in Health and Disease 
  Chapter: The development of therapeutic angiosuppression: problems and progress 
  Page 295.0 - 302.0Brem SEditors: Maragoudakis M.NATO-ASI series, Plenum Press, New York1992
• Advances in Neuro-oncology 
  Chapter: Brain tumor angiogenesis 
  Page 89.0 - 102.0Brem H, Tamargo R, Guerin C, Brem S, Brem HEditors: Kornblith PL, Walker MD.Futura, N.Y.1988
• Cardiovascular Disease Molecular and Cellular Mechanisms, Prevention, Treatment 
  Chapter: Neovascularization induced by the cellular component of atherosclerotic plaque. 
  Page 193.0 - 199.0Alpern-Elran H, Hoover G, Kalant N, Brem SEditors: L Gallo.Plenum Press, New York1987
• Pituitary Microadenomas 
  Chapter: Medical treatment of amenorrhea-galactorrhea: implications of growth of pituitary tumors during pregnancy. 
  Page 419.0 - 426.0Brem S, Zervas NTEditors: G. Faglia, M.A. Giovanelli and R.M. MacLeod.Academic Press, London1980
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Abstracts/Posters

• IMCT-15*Pilot study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma
  O’Rourke DM, Desai A, Morrissette JD, Martinez-Lage M, Nasrallah M, Brem S, Maloney E, Shen A, Mohan S, Wang S, Verma G, Lacey S, Melenhorst J, Navenot J-M, Zheng Z, L..., Neuro-Oncology, 1/1/2015
• Finding the zebra in a herd of horses: using diffusion tensor imaging metrics to aid in the diagnosis of hemangiopericytoma—radiologic-pathologic correlation.
  Skolnik AD, Wang S, Learned KO, Gopal PP, Stein J, Brem S, Mohan S, American Society of Neuroradiology, Chicago, 1/1/2015
• Factors associate with increased survival after surgical resection of glioblastoma in octogenarians.
  Abdullah KG, Ramayya A, Thawani JP, Macyszyn L, Martinez-Lage M, O’Rourke DM, Brem S., AANS-CNS Brain Tumor Satellite Meeting, J Neuro-Oncol, Washington, DC, 1/1/2015
• Two-dimensional localized correlated spectroscopy (2D L-COSY) at 7T for detection of 2-hydroxyglutarate in gliomas with IDH mutations.
  Verma G, Mohan S, Nasrallah M, Thomas MA, Desai A, Desiderio L, Poptani H, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
• Chemical Shift Imaging (CSI) for detection of 2-hydroxyglutarate (2HG) in human gliomas at 3T.
  Verma G, Poptani H, Nasrallah M, Thomas A, Brem S, Mohan S, Radiol Soc North Amer (RSNA), Chicago, IL, 1/1/2015
• 2D L-COSY of low-grade gliomas at 7T
  Verma G, Mohan S, Brem S, Thomas MA, Poptani. H., International Society for Magnetic Resonance in Medicine, Milan, Italy, 1/1/2014
• Significant alterations in integrity of distant white matter tracts in patients with left temporal tumors revealed by diffusion tensor imaging
  Larkin E , Lecoeur J, Abdulla KG, Verma R, Macyszyn L, Brem S, Proc Congr Neurol Surg, Boston, MA, 1/1/2014
• On reading white matter fibers.
  Tunc B, Parker WA, Ingalhalikar M, Brem, Macyszyn L, Verma R, Medical Imaging Computing and Computed Assisted Intervention Society –MICCAI, Boston, Massachusetts, 1/1/2014
• Validation and utilization of next generation sequencing in the clinical assessment of gliomas.
  Nasrallah MP, Martinez-Lage M, Fox A, Sukhadia S, Desai A, O’Rourke DM, Brem S, Roth D, Morrissette JJD, Daber RD, American Association of Cancer Research (AACR), Cancer Res, 1/1/2014
• Next generation sequencing and immunohistochemistry for EGFR, p53, and mutant IDHI in high-grade gliomas.
  Emery LA, Motley WW, O’Rourke DM, Brem S, Daber R, Martinez-Lage M, American Association of Neuropathology (AANP), J Neuropathol Exp Neurol, 1/1/2014
• Tractography for neurosurgeons: automating tract extraction and resolving the challenges of edema.
  Macyszyn L, Lecoeur J, Caruyer E, Tunc B, Larkin E, Quattrone F, O’Rourke D, Wolf R, Brem S, Verma R, European Association of Neurological Surgeons, Prague, Czech Republic, 1/1/2014
• Addressing the challenge of edema in fiber tracking. MICCAI 2014 DTI Tractography challenge
  Lecoeur J, Caruyer E, Elliott M, Brem S, Macyszyn L, Verma R., Boston, MA, 1/1/2014
• Automated Pipeline for Quantitative Tract Analysis in Diffusion Tensor Images of Glioma patients: Pre- and post-operative tract evaluation in the presence of edema and...
  Macyszyn L, Lecoeur J, Ingalhalikar M, Davatzikos C, Wolf R, O’Rourke D, Brem S, Verma R, Radiol Soc North Amer (RSNA), 1/1/2013
• DTI-based longitudinal quantitative assessment of white matter tract integrity in glioma patients.
  Macyszyn L, Lecouer J, Ingalhalikar M, Davatzikos C, Wolf R, O’Rourke D, Brem S, Verma R, Proc Congr Neurol Surg, 1/1/2013
• Stereotactic volumetric resection, intracavitary carmustine wafers, and radiation therapy for brain metastases: The Moffitt Cancer Center experience
  Brem S, Sampath R, Yu D, Staller A, Obadia M, Ewend MG, J Clin Oncol, 1/1/2011
• Comparison of MRI based techniques in surgical resection of tumors in the eloquent brain: Maximizing safety and improving outcomes
  Jain S, Brem S, Proc. Amer Assoc. Neurol. Surg., 1/1/2011
• Genetic variation in the voltage-gated chloride channel family members CLCN2 and CLCN3 in relation to glioma risk and outcome.
  Egan KM, Nabors B, Olson JJ, Browning JE, Madden MH, Chen A, Brem S, Brat DJ, Sontheimer H, Tran ND, Thompson RC, Cancer Res, 1/1/2011
• Upregulation of IKBKE promotes glioma cell migration and invasion by phosphorylation of Snail.
  Guo J, Huang Q, Shu S, Kim D, Brem SS, Cheng JQ, Cancer Res, 1/1/2011
• Novel p75NTR targeted compounds that inhibit angiogenesis and invasion of human malignant glioma cells
  Murphy S, Vaghaiwalla T, Wotoczek-Obadia M, Albright R, Mack D, Lawn S, Henderson F, Jung M, Dakshanamurthy S, Brown M, Forsyth PA, Brem S., Neuro-Oncology, 1/1/2011
• Senescence-related genes signature in high grade gliomas.
  Coppola D, Balducci L, Chen D-T, Brem S, Egan K, Dalton W, Yeatman T, Cancer Res, 1/1/2011
• Effects of surgery with BCNU wafer placement on neurocognitive function in patients with one to three brain metastases
  Ewend MG, Meyers CA, Silva E, Booth-Jones M, Jain S, Brem S, J Clin Oncol, 1/1/2011
• The role of p75ntr and TIMP-1 in U251 malignant glioma cells
  Rojiani MV, Brem S, Murphy S, Obadia M, Rojiani AM, Cancer Res, 1/1/2010
• Ibuprofen, an inhibitor of angiogenesis, enhances radiosensitivity and suppresses glioma invasion: Role of p75NTR and VEGF
  Murphy SF, Banasiak M, Yee G-T, Wotoczek-Obadia M, Malafa M, Rojiani MV, Rojiani AM, Tofilon P, Henderson F, Djakiew D, Jung M, Forsyth PA, Senger DL, Brem S, Proc Amer Assoc Cancer Res, 1/1/2010
• A prospective study of surgery plus biodegradable, carmustine wafers for local control and neurocognitive function in 39 patients with 1-3 brain metastases
  Brem S, Meyers CA, Booth-Jones M, Jain S, Ewend MG, J Clin Oncol, 1/1/2010
• Pharmacokinetic analysis and pharmacodynamics evidence of autophagy inhibition in patients with newly diagnosed glioblastoma treated on a phase I trial of hydroxychlor...
  Rosenfeld MR, Grossman SA, Brem S, Mikkelsen T, Wang D, Piao S, Davis LE, O’Dwyer PJ, Amaravadi RK, J Clin Oncol, 1/1/2010
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Lectures

• Advances in the Management of Brain Tumors 
  Ft. Lauderdale - 1/1/2007
• Early detection of brain tumor response to shaped beam radiosurgery using b-value diffusion-weighted MRI in patients with cerebral metastases: A pilot study in 20 pati... 
  Kyoto, Japan - 1/1/2006
• BCNU-Chemotherapeutic Wafers for Local Control of Brain Metastases 
  Taipei, Taiwan - 1/1/2005
• Angiogenesis and Immunotherapy: Scientific Horizons in the Treatment of Brain Tumors 
  Ft. Lauderdale - 1/1/2005
• History of Angiogenesis Research: Tribute to Judah Folkman 
  Boston - 1/1/2003
• Role of the Surgeon in Establishing Brain Tumor Diagnosis 
  Chicago - 1/1/2003
• Current Surgical Management of Brain Metastases 
  Denver - 1/1/2003
• Copper Reduction using Penicillamine for the Treatment of Glioblastoma, Results of a Clinical Trial (NABTT 9704) 
  Quebec City - 1/1/2002
• Treatment of Cerebral Metastasis with Interstitial Radiation Therapy (Glissade(R)) 
  Chicago - 1/1/2002
• Moffitt Cancer Center 
  Leadership Tampa - 1/1/2002
• Image-Guided Surgery 
  Tampa - 1/1/2002
• Angiogenesis as a Target for Brain Tumors 
  University of Minnesota - 1/1/2001
• Angiogenesis and Brain Tumors 
  MD Anderson Hospital, Houston Texas - 1/1/2001
• Innovations in Neurosurgery: 3-D Neuronavigation and Angiogenesis Inhibitors 
  Fort Lauderdale, Florida - 1/1/2001
• Overview of Biological/ Molecular Target/ Models to Evaluate New Angiogenesis Antagonists 
  Tampa - 1/1/1998
• Changing Paradigms in Health Care: Moffitt Management of Brain Tumors 
  Tampa - 1/1/1998
• Update on Brain Tumors 
  Halifax Medical Center, Daytona Beach - 1/1/1998
• Interstitial Chemotherapy for the Treatment of Malignant Brain Tumors 
  Naples, Florida - 1/1/1998
• Advances in the Treatment of Brain Tumors 
  Palm Beach - 1/1/1998
• Current Treatment of Glioblastoma 
  New Orleans - 1/1/1998
• New Approaches to Brain Tumor Therapy 
  Fort Lauderdale - 1/1/1997
• Brain Tumors: Novel Therapeutic Approaches 
  Tulane University School of Medicine, New Orleans - 1/1/1997
• Advances in Brain Tumor Therapy 
  Palm Beach - 1/1/1997
• Brain Tumor Therapy: Scientific Leads, Clinical Progress 
  University of Pennsylvania, Department of Neurosurgery - 1/7./2011
• Diaminoanthraquinone (NSC-63966), a novel angiosuppressant compound, that inhibits protein kinase C and urokinase-type plasminogen activator 
  Cambridge Healthtechurg Institute, Boston - 1/1./1996
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Other

• Studies on the Host Response to a Human Brain Tumor. Honors Thesis 
  Brem S, Harvard Medical School
  1/1/1972
• Electrophysiological Studies of the Thermoregulatory System in Two Invertebrates. Biology Honors Thesis 
  Brem S, Rutgers University
  1/1/1964
• Turning Point: The Race Against Cancer 
  Peter Jennings, Host, ABC News
  1/29/1998