Stephen G Waxman MD PhD

PubMed

• Sculpting excitable membranes: voltage-gated ion channel delivery and distribution.
  Sidharth Tyagi, Grant P Higerd-Rusli, Elizabeth J Akin, Stephen G Waxman, Sulayman D Dib-Hajj
  Nature Reviews. Neuroscience. 2025-04-02
• In Vitro Inhibition of Voltage-Dependent Sodium Currents by the Antifungal Drug Amorolfine.
  Mohammad-Reza Ghovanloo, Sidharth Tyagi, Philip R Effraim, Stephen G Waxman
  The Journal of Biological Chemistry. 2025-03-14
• 2 citations
  Voltage-gated sodium channels in excitable cells as drug targets.
  Matthew Alsaloum, Sulayman D Dib-Hajj, Dana A Page, Peter C Ruben, Adrian R Krainer
  Nature Reviews. Drug Discovery. 2025-02-03

Journal Articles

• Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable  
  Dib-Hajj, S.D., Estacion, M., Jarecki, B.W., Tyrrell, T., Fischer, T., Lawden, M., Cummins, T.R., and Waxman, S.G., Molec Pain, 1/1/2008
• Erythromelalgia  
  Abuzetun, J., Hazin, R., Khan, F., Fischer, T.Z., Waxman, S.G., Medlink Neurology, 1/1/2008
• Mutations of the Nav1.7 sodium channel underlie inherited erythromelalgia  
  Dib-Hajj, S.D., Rush, A.M., Cummins, T.R., Waxman, S.G., Drug Discovery Today/Disease Mechanisms, 1/1/2006
• Calmodulin binds to the C-terminus of sodium channels Nav1.4 and Nav1.6 and differentially modulates their functional properties  
  Herzog, R. I., Liu, C., Waxman, S. G., Cummins, T. R., J. Neurosci., 1/1/2003
• Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination  
  Craner, M. J., Lo, A. C., Black, J. A., Waxman, S. G., Brain, 1/1/2003
• GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones  
  Baker, M.D., Chandra, S. Y., Ding, Y., Waxman, S. G., Wood, J. N., J. Physiol. (Lond.), 1/1/2003
• The pentapeptide QYNAD does not block voltage-gated sodium channels  
  Cummins, T.R., Renganathan, M., Stys P.K., Herzog, R.I., Scarfo K., Horn, R., Dib-Hajj, S.D., Waxman, S.G., Neurology, 1/1/2003
• International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels  
  Catterall, W.A., Goldin, A.L., Waxman, S.G., Pharmacol Rev., 1/1/2003
• Channelopathies of the Nervous System  
  Waxman, S. G., 1/1/2001
• GDNF up-regulates expression of functional SNS and NaN sodium channels and their currents in axotomized DRG neurons  
  Cummins, T. R., Black, J. A., Dib-Hajj, S. D., Waxman, S. G., J. Neurosci., 1/1/2000
• Nomenclature of voltage-gated sodium channels  
  Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Netter, Y. B., Tamkun, M. M., Waxman..., Neuron, 1/1/2000
• Editorial: Different strokes in different folks: Unique molecular signatures in cortical and deep brain infarcts  
  Waxman, S.G., Cerebrovascular Disease, 1/1/1997
• Spinal cord repair: progress towards a daunting goal  
  Waxman, S.G. and Kocsis, J.D., The Neuroscientist, 1/1/1997
• Sodium channel mRNA in the B104 neuroblastoma cell line  
  Dib-Hajj, S.D., Hinson, A.W., Black, J.A., and Waxman, S.G., 1/1/1996
• White matter stroke: Autoprotective mechanisms with therapeutic implications  
  Fern, R., Ransom, B.R., and Waxman, S.G., Cerebrovascular Diseases, 1/1/1996
• Ion channels in spinal cord astrocytes in vitro: II. Biophysical and pharmacological analysis of two Na+ current types  
  Sontheimer, H., and Waxman, S. G., J. Neurophysiol., 1/1/1992
• Nonpyramidal motor systems and functional recovery after damage to the central nervous system  
  Waxman, S. G., J. Neurol. Rehab., 1/1/1988
• Dyslexia  
  Shaywitz, B. and Waxman, S. G., New England J. Med., 1/1/1987
• The astrocyte as a component of the node of Ranvier  
  Waxman, S. G., Trends in Neurosciences, 1/1/1986
• A quantitative study of developing axons and glia following altered gliogenesis in rat optic nerve  
  Black, J. A., Waxman, S. G., Ransom, B. R. and Feliciano, M. D., Brain Res., 1/1/1985
• Autoimmune diseases of the nervous system  
  Weinrich, M. and Waxman, S. G., Triangle, 1/1/1984
• Computer simulation of conduction in myelinated and demyelinated axons  
  Wood, S. L. and Waxman, S. G., IEEE Frontiers in Engineering and Health Care, 1/1/1983
• Action potential propagation and conduction velocity - new perspectives and questions  
  Waxman, S. G., Trends in Neuroscience, 1/1/1983
• Regional node-like membrane specializations in non-myelinated axons of rat retinal nerve fiber layer  
  Hildebrand, C. and Waxman, S. G., Brain Research, 1/1/1983
• Conduction in demyelinated nerve fibers: computer simulations of the effects of variation in voltage-sensitive ionic conductances  
  Conduction in demyelinated nerve fibers: computer simulations of the effects of variation in voltage-sensitive ionic conductances, IEEE Frontiers of Engineering in Health Care, 1/1/1982
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Books/Book Chapters

• Pharmacology of Pain 
  Chapter: Sodium channels in Pain Pharmacology 
  Cummins, T.R. and Waxman, S.G.Editors: Beaulieu, P, Lussier, D, Porreca, F, and Dickenson, AH.IASP Press, Seattle, WA2010
• Clinical Neuroanatomy 
  Editors: Waxman, S.G..McGraw-Hill2009
• Multiple Sclerosis 
  Chapter: Neurophysiology of demyelination 
  Page 178 - 191Kocsis, J., Waxman, S.G.Editors: Raine, C.F., McFarland, H.F., Hohlfeld, R..Elsevier2008
• Molecular Neurology 
  Editors: Waxman, S. G..Elsevier Academic Press2007
• Encyclopedia of Pain 
  Chapter: Painful channelopathies 
  Waxman, S.G.Editors: Schmidt, R.F. and Willis, W.D..Springer-Verlag Publications2007
• Progress in Brain Research (Neurotrauma: New Insights into Pathology and Treatment) 
  Chapter: Sodium channel expression and the molecular pathology of pain after SCI 
  Page 195 - 204Hains, B.C., Waxman, S.G.Editors: J. Weber & A.I. Maas.2007
• Textbook of Neural Repair and Rehabilitation 
  Chapter: Dysfunction and recovery in demyelinated and dysmyelinated axons 
  Page 468 - 486Waxman, S.G.Editors: Seltzer, M.E. et al.Cambridge University Press2006
• From Neuroscience to Neurology: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology 
  Editors: Waxman, S. G..Elsevier Academic Press2005
• Multiple Sclerosis as a Neuronal Disease 
  Editors: Waxman, S. G..Elsevier Academic Press2005
• Neuroglia 
  Chapter: Myelin function and saltatory conduction 
  Page 273 - 284Waxman, S. G., Bangalore, L.Editors: B. R. Ransom and H. Kettenmann.Oxford University Press2005
• From Neuroscience to Neurology 
  Chapter: Transcriptional channelopathies of the nervous system: new targets for molecular medicine 
  Page 319 - 338Waxman, S.G.Editors: S.G. Waxman.Elsevier Academic Press2005
• From Neuroscience to Neurology 
  Chapter: New molecular targets for the treatment of neuropathic pain 
  Page 339 - 355Wood, J.N. and Waxman, S.GEditors: S.G. Waxman.Elsevier Academic Press2005
• Creating Coordination in the Cerebellum 
  Chapter: Cerebellar dysfunction in multiple sclerosis: evidence for an acquired channelopathy 
  Page 353 - 366Waxman, S.G.Editors: L.M.R. Nijs-de Langen.Elsevier Pub2005
• Sodium Channels, Pain and Analgesia 
  Chapter: Voltage-gated sodium channels and pain associated with nerve injuries and neuropathie 
  Page 1 - 21Black, J.A., Hains, B.C., Dib-Hajj S.D., Waxman, S.G.Editors: K. Cowan & M. Baker.Birkhausen Verlag Publishers2005
• Myelin Biology and Disorders 
  Chapter: Electrophysiological consequences of myelination and demyelination 
  Page 117 - 141Waxman, S. G., Bangalore, L.Editors: Robert Lazzarini.Academic Press, New York, NY2004
• Myelin Biology and Disorders 
  Chapter: Ischemic white matter injury 
  Page 985 - 1008Stys, P. K., Waxman, S. G.Editors: Robert Lazzarini.Academic Press, New York, NY2004
• Encyclopedia of the Human Genome 
  Chapter: Transcriptional channelopathies of the nervous system 
  Waxman, S. G.2003
• The IUPHAR Compendium of Voltage-Gated Ion Channels 
  Chapter: Nav1.3 
  Page 19 - 21Waxman, S. G.Editors: W. A. Catterall, K. G. Chandy, and G. A. Gutman.2003
• The IUPHAR Compendium of Voltage-Gated Ion Channels 
  Chapter: Nav1.8 
  Page 28 - 29Waxman, S. G.Editors: W. A. Catterall, K. G. Chandy, and G. A. Gutman.2003
• The IUPHAR Compendium of Voltage-Gated Ion Channels 
  Chapter: Nav1.9 
  Waxman, S. G.Editors: W. A. Catterall, K. G. Chandy, and G. A. Gutman.2003
• Subcortical Stroke 
  Chapter: Molecular mechanisms of subcortical versus cortical infarction 
  Page 67 - 84Waxman, S.G.Editors: G. Donnan, B.Norrving. J. Bamford and J. Bogousslavsky.Oxford University PressEdition 2nd ,2002
• Sodium Channels and Neuronal Hyperexcitability 
  Chapter: Diverse functions and dynamic expression of neuronal sodium channels 
  Page 34 - 60Waxman, S. G., Cummins, T. R., Black, J. A., Dib-Hajj, S. D.Editors: J. Goode, ed., S. G. Waxman, Chairman.Novartis Foundation2002
• Mechanisms and Mediators of Neuropathic Pain 
  Chapter: Annika B. Malberg and Sandra R. Chaplan 
  Page 23 - 50Black, J. A., Cummins, T. R., Dib-Hajj, S. D., Waxman, S. G.Editors: Annika B. Malberg and Sandra R. Chaplan.Birkhauser Verlag, Basel/Switzerland2002
• Form and Function in the Brain and Spinal Cord 
  Editors: Waxman, S.G..MIT Press, Cambridge, MA2001
• Handbook of Multiple Sclerosis 
  Chapter: Loss and restoration of impulse conduction in disorders of myelin 
  Page 257 - 289Waxman, S. G.Editors: S. D. Cook.Marcel Dekker Publ.Edition 3rd ,2001
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Other

• SCN9A-Related Inherited Erythromelalgia 
  Hisama FM, Dib-Hajj S.D, Waxman S.G., Gene Reviews [data base online at GeneTests: Medical Genetics Information Resource, Univ. of Washin
  http://www.genetests.org
  1/1/2006