Stephen D. Silberstein MD

Neurology•Philadelphia, PA

Headache

Professor of Neurology; and Director, Jefferson Headache Center, at Thomas Jefferson University

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900 Walnut StPhiladelphia, PA 19107
Phone+1 215-955-2243
Fax+1 215-955-2060

Education & Training

University of Pennsylvania Health SystemResidency, Neurology, 1972 - 1975
University of Pennsylvania Health SystemResidency, Internal Medicine, 1967 - 1969
Perelman School of Medicine at the University of PennsylvaniaClass of 1967

Certifications & Licensure

PA State Medical License 1968 - 2026
MD State Medical License 1971 - 2023
NJ State Medical License 1974 - 2019
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Philadelphia Magazine Castle Connolly, 2004-2014
America's Top Doctors Castle Connolly, 2004-2014
Women's Health Castle Connolly, 2008
Men's Health Castle Connolly, 2007
Super Doctor SuperDoctors.com
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Clinical Trials

An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster Headaches. Start of enrollment: 2003 Jul 01
Completed
Not Applicable
Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache Start of enrollment: 2003 May 01
Completed
Not Applicable
A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity Start of enrollment: 2003 Dec 01
Completed
Not Applicable
A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache Start of enrollment: 2005 Jun 01
Completed
Not Applicable
A Research Study Examining the Use of Olanzapine for the Prevention of Migraine Start of enrollment: 2004 May 01
Terminated
Not Applicable
Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine. Start of enrollment: 2005 Dec 01
Completed
Phase 2
PREMIUM Migraine Trial Start of enrollment: 2006 Jan 01
Completed
Not Applicable
A Research Study To Evaluate If Frovatriptan Is Safe And Effective In Preventing Migraine Headache After Fasting Start of enrollment: 2007 Jul 01
Completed
Not Applicable
NINDS CRC Chronic Migraine Treatment Trial Start of enrollment: 2008 Oct 01
Completed
Phase 3
Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
COMPLETED
Pilot Study to Collect and Evaluate Data on the Use of IV* Ibuprofen in the Treatment of an Acute Migraine Attack Start of enrollment: 2011 Jun 01
Completed
Phase 4
STOPAIN in the Treatment of a Single Migraine Attack Start of enrollment: 2012 May 01
Completed
Not Applicable
Incobotulinum Toxin for the Treatment of Trigeminal Neuralgia Start of enrollment: 2014 Mar 14
Terminated
Phase 2
A Study of Galcanezumab (LY2951742) in Participants With Migraine Headache Start of enrollment: 2014 Jul 07
Completed
Phase 2
A Study of Galcanezumab in Participants With Chronic Cluster Headache Start of enrollment: 2015 Jun 18
Completed
Phase 3
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Publications & Presentations

PubMed

2 citations
Insights from 25 years of onabotulinumtoxinA in migraine - mechanisms and management.
Patricia Pozo-Rosich, Alicia Alpuente, Stephen D Silberstein, Rami Burstein
Nature Reviews. Neurology. 2024-09-01
Clinical factors associated with day-to-day peak pain severity in individuals with chronic migraine: A cohort study using daily prospective diary data.
Marina Vives-Mestres, Amparo Casanova, Stephen D Silberstein, Andrew D Hershey, Serena L Orr
Headache. 2024-09-01
1 citations
Sustained benefits of onabotulinumtoxinA treatment in chronic migraine: An analysis of the pooled Phase 3 REsearch Evaluating Migraine Prophylaxis Therapy (PREEMPT) ra...
Stephen D Silberstein, Hans-Christoph Diener, David W Dodick, Katherine Sommer, Richard B Lipton
Headache. 2024-06-22

Journal Articles

Health Care Resource Utilization and Migraine Disability Along the Migraine Continuum Among Patients Treated for Migraine
Stephen Silberstein, MD, Headache: The Journal of Head and Face Pain

Press Mentions

Can Central Vein Sign Distinguish Multiple Sclerosis from Its Most Common Mimic?March 20th, 2025
What Will Be the Next Big Breakthrough in Migraine Research?May 13th, 2022
Ctrl M HealthJune 24th, 2021
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Stephen D. Silberstein MD

Dr. Silberstein is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Press Mentions

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