StephenDNimerMD

PubMed

• 190 citations
  PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
  Gang Huang, Pu Zhang, Hideyo Hirai, Shannon Elf, Xiaomei Yan
  Nature Genetics. 2008-01-01
• 1297 citations
  Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
  Bruce D. Cheson, Peter L. Greenberg, John M. Bennett, Bob Löwenberg, Pierre W. Wijermans
  Blood. 2006-07-15
• 83 citations
  Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape
  Fan Liu, Lan Wang, Fabiana Perna, Stephen D. Nimer
  Nature Reviews. Cancer. 2016-06-01

Journal Articles

• Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia  
  Shih AH, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, Antony-Debre I, Viale A, Socci N, Sun Y, Robertson A, Cavatore M, de Stanchina E, Hricik T, Rapaport F, Wood..., Cancer Cell, 1/13/2015
• Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS  
  List AF, Bennett JM, Sekeres MA, Skikne B, Fu T, Shammo JM, Nimer SD, Knight RD, Giagounidis A, Leukemia, 1/1/2015
• A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species  
  Zong H, Gozman A, Caldas-Lopes E, Taldone T, Sturgill E, Brennan S, Ochiana SO, Gomes-DaGama EM, Sen S, Rodina A, Koren J 3rd, Becker MW, Rudin CM, Melnick A, Levine R..., Cell Reports, 1/1/2015
• Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice  
  Zhao Z, Chen L, Dawlaty MM, Pan F, Weeks O, Zhou Y, Cao Z, Shi H, Wang J, Lin L, Chen S, Yuan W, Qin Z, Ni H, Nimer SD, Yang FC, Jaenisch R, Jin P, Xu M, Cell Reports, 1/1/2015
• PRMT5 is essential for sustaining adult hematopoietic stem and progenitor cells  
  Liu F, Cheng G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L, Nimer SD, Journal of Clinical Investigation, 1/1/2015
• Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression  
  Wang L, Man N, Sun XJ, Tan Y, Cao M, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R and Nimer S, Blood, 1/1/2015
• Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis  
  Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M, Okuda T., Br J Haematol, 1/1/2015
• The Polycomb group protein L3MBTL1 represses a SMAD5-mediated transcriptional program in human pluripotent stem cells  
  Perna F, Vu L, Themeli M, Kriks S, Hoya-Arias R, Khanin R, Hricik T, Mansilla-Soto J, Papapetrou EP, Levine R, Studer L, Sadelain M, Nimer SD, Stem Cell Reports, 1/1/2015
• Functional dissection of hemizygous chromosomal deletions with human induced pluripotent stem cell models of myelodysplastic syndromes  
  Kotini AG, Chang C, Boussaad I, Delrow JJ, Dolezal EK, Nagulapally A, Perna F, Fishbein GA, Klimek VM, Hawkins DR, Huangfu D, Murry CE, Graubert T, Nimer SD, Papapetro..., Nature Biotechnology, 1/1/2015
• PARP inhibitors: a treatment option for AML?  
  Wang L, Hamard PJ, Nimer SD, Nature Medicine, 1/1/2015
• The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis  
  Sun XJ, Man N, Tan Y, Nimer SD, Wang L, Front Oncol, 1/1/2015
• DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia  
  Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X,..., Cell Rep., 1/1/2014
• Down-regulation of RUNX1/CBFß by MLL fusion proteins enhances HSC self-renewal  
  Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W Jull..., Blood, 1/1/2014
• PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex  
  Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD, Cell Reports, 1/1/2013
• Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death  
  Altman JK, Rademaker A, Cull E, Weitner B, Ofran Y, Rosenblat T, Haidau A, Park J, Ram S, Orsini Jr. J, Sandhu S, Catchatourian R, Trifilio S, Adel N, Frankfurt O, Ste..., Leuk Res, 1/1/2013
• Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates trans...  
  Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, ..., J Biol Chem, 1/1/2013
• Histone-modifying enzymes: their roles in the pathogenesis of acute leukemia and their therapeutic potential  
  Vu LP, Luciani L, Nimer SD, Int J Hematol, 1/1/2013
• MEF promotes stemness in the pathogenesis of gliomas  
  Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, DeAngelis LM, Nimer SD, Holland EC, Squatrito M, Cell Stem Cell, 1/1/2012
• An Inv(16)(p133q243)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia  
  Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mul..., Cancer Cell, 1/1/2012
• Loss of p53 accelerates the complication of myelodysplastic syndrome (MDS) in a NUP98-HOXD13 driven mouse model  
  Xu H, Menendez S, Schlegelberger B, Bae N, Aplan PD, Gohring G, Deblasio TR, Nimer SD, Blood, 1/1/2012
• ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene expression  
  Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, Melnick A, Nimer SD,..., Cancer Cell, 1/1/2012
• The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy Induces Apoptosis of p53 Mutated Multiple Myeloma Cells  
  Landau HJ, McNeely SC, Nair JS, Comenzo RL, Asai T, Friedman H, Jhanwar SC, Nimer SD, Schwartz GK, Mol Cancer Ther, 1/1/2012
• PRMT1 interacts with AML1- ETO to promote its transcriptional activation and progenitor cell proliferative potential  
  Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR 3rd, Zhang DE, Blood, 1/1/2012
• Normalization of pre-ASCT, FDG-PET imaging with second-line, non-cross-resistant, chemotherapy programs improves event-free survival in patients with Hodgkin lymphoma  
  Moskowitz CH, Matasar MJ, Zelenetz AD, Nimer SD, GerecitanoJ, Hamlin P, Horowitz S, Moskowitz AJ, Noy A, Palomba L, Perales MA, Portlock C, Straus D, Maragulia JC, Sch..., Blood, 1/1/2012
• Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia  
  Klimek VM, Dolezal EK, Smith L, Soff G, Nimer SD, Leukemia Research, 1/1/2011
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Books/Book Chapters

• Myelodysplastic Syndromes 
  Chapter: MDS Stem Cell Biology. 
  Page 73 - 84Greenblatt SM, H. Joachim Deeg, Nimer SDSpringerEdition 2nd,2013
• Cancer Rehabilitation: Principles and Practice 
  Chapter: Evaluation and Treatment of Leukemia and Myelodysplasia. 
  Page 253 - 266Landau H & Nimer SDEditors: Michael D. Stubblefield and Michael W. O'Dell.2009
• Myelodysplastic Syndromes: State of the Art 
  Chapter: Molecular and Genetic Abnormalities in MDS. 
  Page 37 - 56Nimer SDE-Hellstrom-Lindberg2008
• Clinical Malignant Hematology 
  Chapter: Treatment Approach to Early Myelodysplastic Syndromes. 
  Klimek V, Nimer SEditors: Sekeres MA, Kalaycio ME, Bolwell BJ.McGraw - Hill, New York2007
• Transcription Factors: Normal and Malignant Development of Blood Cells 
  Chapter: t(8;21) AML and the AML1/ETO fusion gene: From clinical syndrome to paradigm for the molecular basis of acute leukemia. 
  Page 409 - 424Frank RC, Nimer SDEditors: Ravid K, Licht J.John Wiley & Sons2001
• Developmental Biology of Hematopoiesis 
  Chapter: Transcription Factors Active in Megakaryocyte Development. 
  Page 443 - 449Nimer SDEditors: Zon LI.Oxford University Press2001
• Current Controversies in Bone Marrow/Stem Cell Transplantation 
  Chapter: Autologous Transplantation for Hodgkin's Disease: Who Benefits? 
  Page 137 - 145Moskowitz CH, Nimer SDEditors: Bolwell BJ.Humana Press2000
• Molecular Biology in Cancer Medicine 
  Chapter: Transcription Factors and Malignancy. 
  Page 147 - 159Frank RC, Nimer SDEditors: Kurzrock R, Talpaz M.Martin Dunitz Publ., LondonEdition 2nd,1999
• Molecular Biology of Hematopoiesis 
  Chapter: IL3BP1, a transcription factor with dual function. 
  Page 397 - 402Zhang W, Look AT, Inaba T, Nimer SDEditors: Abraham NG.Plenum Press, NY1996
• Conn's Current Therapy 
  Chapter: Aplastic Anemia. 
  Page 333 - 336Nimer, SD, Childs BHEditors: Rakel R.W.B. Saunders Co.1996
• USMLE Step 1 Review: The Study Guide 
  Chapter: Hematopoietic and Lymphoreticular Systems. 
  Page 295 - 308Nimer SD, Pavlick ACEditors: Goldberg, JS.Sage Publications, Thousand Oaks, CA1996
• The Year Book of Oncology 
  Chapter: Selective depletion of CD8+ cells for prevention of graft-versus-host disease after bone marrow transplantation. 
  Page 474 - 476Nimer SD, Giorgi J, Gajewski JL, Ku N, Schiller GJ, Lee K, Territo M, Ho, W, Feig S, Selch M, Isacescu V, Reichert TA, Champlin REEditors: Simone, JV.Mosby, Inc., St. Louis, MO1995
• Blood: Principles and Practice of Hematology 
  Chapter: Molecular, cell and clinical biology of the phagocyte. 
  Page 513 - 541Nimer SD, Golde DWEditors: Handin RI, Lux SE, Stossel TP.J.B. Lippincott Co1995
• Molecular Biology in Clinical Oncology and Hematology 
  Chapter: Transcription Factors and Malignancy. 
  Page 113 - 128Nimer SDEditors: Kurzrock R, Talpaz M.Martin Dunitz Publ., London1995
• Ontogeny of Hematopoiesis. Aplastic Anemia 
  Chapter: The role of cytokines in the pathogenesis and treatment of aplastic anemia and myelodysplastic syndromes. 
  Page 353 - 359Nimer SDEditors: Gluckman E, Coulombel L.John Libbey Eurotext Ltd, Paris1995
• The Instant Exam Review for the USMLE Step 3 
  Chapter: "Hematology and Oncology" 
  Page 97 - 114Nimer SD, Pavlick AEditors: Goldberg, JS.Appleton and Lange, Norwalk, CT1994
• Pathology of the Bone Marrow 
  Chapter: Bone marrow structure and function. 
  Page 1 - 31Naeim F, Nimer SIgaku Shoin, NY1992
• Manual of Clinical Laboratory Immunology 
  Chapter: Hematopoietic growth factors. 
  Page 244 - 247Nimer SDEditors: Rose NR, de Macario EC, Fahey JL, Friedman H, Renn GM.American Society for Microbiology, Washington, DCEdition 4th,1992
• Bone Marrow Transplantation 
  Chapter: . Therapeutic use of hematopoietic growth factors in bone marrow transplantation. 
  Page 141 - 164Nimer SD, Champlin REEditors: Champlin RE.Kluwer Academic Publishers, Norwell, MA1990
• Proceedings of the American Red Cross Annual Symposium on Hematopoietic Growth Factors in Transfusion Medicine 
  Chapter: Human granulocyte-macrophage colony-stimulating factor (GM-CSF): regulation of expression. 
  Page 27 - 41Gasson JC, Fraser JK, Nimer SDEditors: Spivak J, Drohan W, Dooley D.Alan R. Liss, NY1990
• Early Human Retroviruses. UCLA Symposia on Molecular and Cellular Biology 
  Chapter: The effects of tax and rex protein of HTLV-I and -II on viral and cellular gene regulation. 
  Page 33 - 47Black AC, Nimer SD, Chen ISY, Rosenblatt JDEditors: Groopman J, Chen ISY, Essex M, Weiss R.Alan R. Liss, NY1990
• The Year in Immunology, 1986-87 
  Chapter: Expression and target cell specificity of human granulocyte-macrophage colony-stimulating factor. 
  Page 6084 - 6088Nimer SD, Gasson JC, DiPersio JFEditors: Cruse JM, Lewis RE.Karger, Basel, Switzerland1988
• Recent Advances in Leukemia and Lymphoma, UCLA Symposia on Molecular and Cellular Biology 
  Chapter: Identification of regulatory sequences in the 5' flanking region of the human GM-CSF gene. 
  Page 229 - 238Nimer SD, Gasson JCEditors: Gale RP, Golde DW.Alan R. Liss, Inc., NY1987
• Platelets: Recent Advances in Basic Research and Clinical Aspects 
  Chapter: The effect of certain alkyl-substituted analogues of nitrofurantoin upon platelet aggregation. 
  Page 324 - 328Rossi EC, Nimer S, Louis GEditors: Ulutin ON.Excerpta Medica/American Elsevier, Amsterdam1975
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Abstracts/Posters

• EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression
  Stephen Nimer, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Precision Hematology in Myelodysplastic Syndromes 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• "What are the treatment options?" 
  Sylvester Comprehensice Cancer Center, Miami, FL - 1/28/2015
• "Myelodysplastic Syndromes" 
  Cartagena, Colombia - 1/22/2015
• "Targeting histone modifying enzymes in the treatment of acute leukemia" 
  Miami, FL - 1/19/2015
• "Using targeted therapy to overcome the heterogeneity of acute leukemia" 
  HI - 1/17/2015
• "Key Updates for 2015" 
  Miami - 1/7/2015
• "Program Overview and Objectives" 
  Orlando, FL - 1/4/2015
• "Epigenetic Focused Therapies for Acute Leukemia" 
  Tampa - 1/2/2015
• "Histone Modifying Enzymes" 
  Boston, MA - 1/28/2014
• "Role of arginine methyltransferases in hematological malignancies" 
  Miami, FL - 1/14/2014
• "The role of arginine methyltransferases in normal and malignant hematopoiesis" 
  Cincinnati Children's Hospital Medical Center, Cincinnati, OH - 1/6/2014
• "Therapeutic and prognostic role of epigenetic abnormalities in MDS" 
  San-Francisco, CA - 1/4/2014
• "Gene Expression in MDS and AML" 
  New York, NY - 1/20/2013
• "Epigenetics and Stem Cells" 
  Asheville, NC - 1/18/2013
• "Role of protein arginine methylation in regulating cancer" 
  Il Ciocco, Barga (Lucca), Italy - 1/18/2013
• "The Role of Arginine Methyltransferases in Hematologic Malignancies" 
  Florence, Italy - 1/14/2013
• "Contemporary Stem Cell Transplants and Current Research" 
  Rome, Italy - 1/10/2013
• "Targeting Histone Modifying Enzymes to Treat Hematologic Malignancies" 
  McArdle Laboratory for Cancer Research, University of Wisconsin-Madison - 1/9/2013
• "Treatment of High Risk MDS Patients" 
  Berlin, Germany - 1/7/2013
• "PRMT5 and normal/malignant hematopoiesis" 
  Saxton River, VT - 1/4/2013
• "Oncogenic transcription factors and leukemogenesis" 
  Gainesville, FL - 1/4/2013
• "Stem Cell Science-Cancer" 
  West Palm Beach, FL - 1/6/2012
• "NCCN Guidelines" 
  Madrid, Spain - 1/1/2012
• "Targeting Epigenetic Modifiers in AML" 
  Philadelphia, PA - 1/1/2012
• "Leukemogenic Properties of Histone Modifying Enzymes" 
  University of Toronto, MaRS Center Auditorium, Toronto, ON, Canada - 1/1/2012
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Other

• MDS: A Stem Cell Disorder- But What Exactly is Wrong with the Primitive Hematopoietic Cells in This Disease? 
  Nimer SD, Hematology Am Soc Hematol Educ Program
  1/1/2008