StephenLeeLessnickMDPhD

PubMed

• DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
  Ariunaa Bayanjargal, Cenny Taslim, Iftekhar A Showpnil, Julia Selich-Anderson, Jesse C Crow
  Biorxiv. 2024-06-07
• 19 citations
  Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's ...
  Steven G DuBois, Mark D Krailo, Julia Glade-Bender, Allen Buxton, Nadia Laack
  Journal of Clinical Oncology. 2023-04-10
• 15 citations
  The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
  Diana Y Lu, Jana M Ellegast, Kenneth N Ross, Clare F Malone, Shan Lin
  Nature Cell Biology. 2023-02-01

Journal Articles

• Author Correction: EWS–FLI1 Increases Transcription to Cause R-loops and Block BRCA1 Repair in Ewing Sarcoma  
  Kimberly Stegmaier, Stephen L Lessnick, Jeffrey A Toretsky, Nature
• Comparison of Clinical Features and Outcomes in Patients with Extraskeletal Versus Skeletal Localized Ewing Sarcoma: A Report from the Children’s Oncology Group  
  Cash, T, McIlvaine, E, Krailo, MD, Lessnick, SL, Lawlor, ER, Laack, N, Sorger, J, Marina, N, Grier, HE, Granowetter, L, Womer, RB, and Dubois SG, Pediatr Blood Cancer, 1/1/2016
• Recent advances in targeted therapy for Ewing sarcoma  
  Pishas, KI and Lessnick, SL, F1000Research, 1/1/2016
• Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop  
  Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, M..., Cancer Genet, 1/1/2016
• Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor  
  Osgood, CL, Maloney, N, Kidd, CG, Segars, L, Gebregiorgis, M, Woldemichael, G, He, M, Sankar, S, Lessnick, SL, Kang, M, Smith, M, Goosen, S, Turner, L, Nuñez, LE, Gonz..., Clin Cancer Res, 1/1/2016
• Impact of Two Different Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology ...  
  Vo, KT, Edwards, JV, Epling, CL, Sinclair, E, Hawkins, DS, Grier, HE, Janeway, KA, Barnette, P, McIlvaine, E, Krailo, MD, Barkauskas, DA, Matthay, KK, Womer, RB, Gorli..., Clin Cancer Res, 1/1/2016
• Tumoral TP53 and/or CDKN2A Alterations are Not Reliable Prognostic Biomarkers in Patients with Localized Ewing Sarcoma: A Report from the Children’s Oncology Group  
  Lerman, DM, Monument, MJ, McIlvaine, E, Liu, X-q, Huang, D, Monovich, L, Beeler, N, Gorlick, RG, Marina, NM, Womer, RB, Bridge, JA, Krailo, MD, Randall, RL, Lessnick, ..., Pediatr Blood Cancer, 1/1/2015
• EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma  
  Fadul, J, Bell, R, Hoffman, LM, Beckerle, MC, Engel, ME, and Lessnick, SL, Genes & Cancer, 1/1/2015
• Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma  
  Chaturvedi, A, Hoffman, LM, Jensen, CC, Lin, Y-C, Grossman, AH, Randall, RL, Lessnick, SL, Welm, AL, and Beckerle, MB, Mol Biol Cell, 1/1/2014
• Targeting Glutathione S-transferase M4 in Ewing sarcoma  
  Zhuo, R, Kosak, KM, Sankar, S, Wiles, ET, Sun, Y, Zhang, J, Ayello, J, Prestwich, GD, Shami, PJ, Cairo, MS, Lessnick, SL, Luo, W, Front Pediatr, 1/1/2014
• Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth  
  Sankar, S, Theisen, ER, Bearss, J, Mulvihill, T, Hoffman, LM, Sorna, V, Beckerle, MC, Sharma, S, and Lessnick, SL, Clin Cancer Res, 1/1/2014
• Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex  
  Kumar, PP, Emechebe U, Smith, R, Moore, B, Yandell, M, Lessnick, SL, and Moon AM, eLife, 1/1/2014
• Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group  
  Monument, MJ, Johnson, KM, McIlvaine, E, Abegglen, L, Watkins, WS, Jorde, LB, Womer, RB, Beeler, N, Monovich, L, Bridge, JA, Schiffman, JD, Krailo, MD, Randall, RL, an..., PLoS ONE, 1/1/2014
• Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma  
  Sankar, S, Bell, R, Stephens, B, Zhuo, R, Sharma, S, Bearss, DJ, and Lessnick, SL, Oncogene, 1/1/2013
• Children’s Oncology Group’s 2013 Blueprint for Research: Bone Tumors  
  Gorlick, R, Janeway, K, Lessnick S., Randall, RL, and Marina, N., on behalf of the COG Bone Tumor Committee, Pediatr Blood Cancer, 1/1/2013
• The second European interdisciplinary Ewing sarcoma research summit - A joint effort to deconstructing the multiple layers of a complex disease  
  Kovar, H, Amatruda, J, Brunet, E, Burdach, S, Cidre-Aranaz, F, de Alava, E, Dirksen, U, van der Ent, W, Grohar, P, Gruenewald, T, Helman, L, Houghton, P, Iljin, K, Kor..., Oncotarget, 1/1/2013
• ZEB2 represses the epithelial phenotype and facilitates metastasis in Ewing sarcoma  
  Wiles, ET, Bell, R, Thomas, D, Beckerle, M, and Lessnick, SL, Genes & Cancer, 1/1/2013
• EWS and RE1-Silencing Transcription Factor inhibit neural phenotype development and oncogenic transformation in Ewing sarcoma  
  Sankar, S, Gomez, NC, Bell, R, Patel, M, Davis, IJ, Lessnick, SL, and Luo, W, Genes & Cancer, 1/1/2013
• Biomarkers in Ewing sarcoma: The promise and challenge of personalized medicine A report from the Children’s Oncology Group  
  Shukla, N, Schiffman, J, Reed, D, Davis IJ, Womer, RB, Lessnick, SL, Lawlor, ER, COG Ewing Sarcoma Biology Committee, Front Oncol, 1/1/2013
• A decade in banking Ewing sarcoma: a report from the Children's Oncology Group  
  Borinstein, SC, Beeler, N, Block, J, Gorlick, R, Grohar, P, Jedlicka, P, Krailo, M, Morris, S, Siegal, GP, Lawlor, E, Lessnick, SL, Front Oncol, 1/1/2013
• The clone wars – revenge of the metastatic rogue state: the sarcoma paradigm  
  Spraker, HL, Price, SL, Chaturvedi, A, Schiffman, JD, Jones, KB, Lessnick, SL, Beckerle, M, Randall, RL, Front Oncol, 1/1/2012
• Microsatellites with macro-influence in Ewing sarcoma  
  Monument, MJ, Johnson, KM, Grossman, AH, Schiffman, JD, Randall, RL, Lessnick, SL, Genes, 1/1/2012
• Microsatellite instability in sarcoma: fact or fiction?  
  Monument, MJ, Lessnick, SL, Schiffman, JD, Randall RL, ISRN Oncology, 1/1/2012
• At-risk populations for osteosarcoma: The syndromes and beyond  
  Calvert, GT, Randall, RL, Jones, KB, Cannon-Albright, L, Lessnick, S, Schiffman, JB, Sarcoma, 1/1/2012
• The First European Interdisciplinary Ewing´s Sarcoma Research Summit  
  Kovar, H, Alonso, J, Aman, P, Aryee, DNT, Ban, J, Burchill, SA, Burdach, S, De Alava, E, Delattre, O, Dirksen, U, Fourtouna, A, Fulda, S, Helman, LJ, Herrero-Martin, D..., Front Oncol, 1/1/2012
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Books/Book Chapters

• Principles and Practice of Pediatric Oncology 
  Chapter: Chapter 33: Ewing Sarcoma. 
  Hawkins, D, Bolling, T, DuBois, S, Hogendoorn, PCW., Jurgens, H, Paulussen, M, Randall, RL, and Lessnick, SLEditors: Pizzo, PA and Poplack DG.Lippincott Williams & Wilkins, Philadelphia, PAEdition 7th,2014
• Oncology of Infancy and Childhood. 
  Chapter: Chapter 61: Ewing's Sarcoma. 
  Dubois, S, Grier, HE, and Lessnick, SLEditors: Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., and Nathan, D.G..Saunders-Elsevier, Philadelphia, PA2013
• WHO Classification of Tumors of Soft Tissue and Bone 
  Chapter: Chapter 19-1: Ewing sarcoma. 
  de Alava, E, Lessnick, SL, and Sorensen, PEditors: Fletcher, C, Hogendorn, P, Mertens, F, and Bridge, J.International Agency for Research on Cancer (IARC), Lyon, FranceEdition 4th,2012
• Principles and Practice of Pediatric Oncology 
  Chapter: Chapter 33: Ewing Sarcoma 
  Hawkins, D, Bolling, T, DuBois, S, Hogendoorn, PCW., Jurgens, H, Paulussen, M, Randall, RL, and Lessnick, SLEditors: Pizzo, PA and Poplack DG.Lippincott Williams & Wilkins, Philadelphia, PAEdition 6th,2011
• Oncology of Infancy and Childhood. 
  Chapter: Chapter 21: Ewing's Sarcoma. 
  Dubois, S, Grier, HE, and Lessnick, SLEditors: Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., and Nathan, D.G..Saunders-Elsevier, Philadelphia, PA2009
• American Society of Clinical Oncology 2007 Educational Book. 
  Chapter: EWS/FLI Biology. 
  Lessnick, SLEditors: Ramaswamy Govindan.2007
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Abstracts/Posters

• Epigenomic profiling reveals global reorganization of the chromatin regulatory network in Ewing sarcoma.
  Saund, R, Lessnick SL, Cell Symposia- Biology and Data Science, Berkeley, CA, 1/1/2016
• EWS/FLI Hijacks Chromatin Regulatory Complexes to Maintain Malignancy in Ewing Sarcoma Cells.
  Theisen ER, Lessnick SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• Defining the mechanisms of sensitivity to HCI-2509: A novel LSD1 inhibitor for the treatment of Ewing sarcoma.
  Pishas, KI, Sharma, S, Lessnick, SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• EWS/FLI regulates transcriptional activation in Ewing sarcoma via length dependent GGAA microsatellites.
  Johnson, KM, Lessnick SL, Connective Tissue Oncology Society annual meeting, Lisbon, Portugal, 1/1/2016
• Bad Influence: EWS/FLI Coopts Chromatin Regulatory Machinery to Enforce Malignancy in Ewing Sarcoma.
  Theisen ER, Lessnick SL, Gordon Research Conference: Chromatin Structure and Function, Les Diablerets, Switzerland, 1/1/2016
• Targeting the Chromatin Regulatory Machiner Hijacked by EWS/FLI in Ewing Sarcoma.
  Theisen ER, Pishas KI, Lessnick SL, Special Conference ON Pediatric Clinical Oncology. CAC2- From Bench to Bedside and Beyond, Cold Spring Harbor, NY, 1/1/2016
• Epigenomic analysis of inhibition of histone demethylase LSD1 reveals novel enhancer elements in Ewing sarcoma cells.
  Saund, R, Smiley, B, Tanner, J., and Lessnick, SL, Chromatin and Epigenetics in Cancer Conference of American Association of Cancer Research, Atlanta, GA, 1/1/2015
• Clinical impact of bone marrow micrometastatic disease burden detected by flow cytometry in patients with Ewing sarcoma.
  Vo, K, Epling, L, Sinclair, E, Hawkins, D, Grier, HE, Janeway, K, Barnette, P, Barkauskas, DA, Matthay, K, Lessnick, SL, Dubois, S, Connective Tissue Oncology Society annual meeting, Salt Lake City, UT, 1/1/2015
• Defining the mechanisms of resistance to LSD1 inhibition.
  Pishas, KI, Sharma, S, Lessnick, SL, Connective Tissue Oncology Society annual meeting, Salt Lake City, UT, 1/1/2015
• Modulating glutathione s-transferase M4 activity for the treatment of Ewing sarcoma.
  Zhuo R, Kosak KM, Sankar S, Wiles ET, Sun Y, Zhang J, Prestwich GD, Shami PJ, Lessnick SL, Cairo MS, and Luo W, American Association of Cancer Research Annual Meeting, San Diego, CA, 1/1/2014
• Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma.
  Theisen E, Sankar S, Bearss J, Mulvihill T, Sorna, V, Sharma S, and Lessnick SL, American Association of Cancer Research Annual Meeting, San Diego, CA, 1/1/2014
• Tumoral TP53 and/or CDKN2A Alterations are Not Reliable Prognostic Biomarkers in Patients with Localized Ewing Sarcoma: A Report from the Children's Oncology Group.
  Lerman, DM, Monument, MJ, McIlvaine, E, Liu, X-q, Huang, D, Monovich, L, Beeler, N, Gorlick, RG, Marina, NM, Womer, RB, Bridge, JA, Krailo, MD, Randall, RL, Lessnick, ..., Connective Tissue Oncology Society annual meeting, Berlin, Germany, 1/1/2014
• Biochemical and clinical assessment of GGAA microsatellite polymorphisms in Ewing sarcoma.
  Monument MJ, Randall RL, Mcilvaine E, Krailo M, and Lessnick SL, Connective Tissue Oncology Society annual meeting, New York, NY, 1/1/2013
• BCL11B is a critical EWS/FLI up-regulated target in Ewing's sarcoma.
  Toomey E, Lui B, Lessnick S, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• Mechanism of transcriptional repression by EWS/FLI in Ewing's sarcoma.
  Sankar S and Lessnick SL, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• Ethnic polymorphisms in the GGAA microsatellite response element of key Ewing's sarcoma EWS/FLI-target genes.
  Monument MJ, Beck R, Watkins WS, Jorde LB, Randall RL, Lessnick SL, American Association of Cancer Research Annual Meeting, Chicago, IL, 1/1/2012
• Antibody detection of translocations (ADOT) in Ewing’s sarcoma.
  Luo W, Milash B, Dalley B, Smith R, Dutrow N, Cairns, B, Lessnick SL, American Association of Cancer Research Annual Meeting, Orlando, FL, 1/1/2011
• Impact of EWS-FLI induced changes in gene expression and cell behavior on metastatic potential.
  Chaturvedi AP, Welm A, Lessnick S, Beckerle M, American Association of Cancer Research Annual Meeting, Orlando, FL, 1/1/2011
• Ewing sarcoma (EWS): How does percent necrosis of the primary tumor, in post chemotherapy surgical specimens, aid in distinguishing treatment failures?
  Million L, Putnam A, Randall L, Coffin C, Lessnick S, Zhou H, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Antibody detection of translocations (ADOT) in Ewing's sarcoma.
  Luo W, Milash B, Dalley B, Smith R, Dutrow N, Cairns S, and Lessnick SL, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Identification of a heritable contribution to sarcoma predisposition.
  Jones KB, Schiffman JD, Kohlmann W, Randall R, Lessnick SL, Cannon-Albright L, Connective Tissue Oncology Society annual meeting, Paris, France, 1/1/2010
• Novel use of molecular inversion probes to interrogate formalin-fixed paraffin-embedded (FFPE) samples of Ewing's sarcoma.
  Druzgal CH, Downie J, Putnam A, Lessnick S, and Schiffman JD, American Society of Pediatric Hematology/Oncology Annual Meeting, Montreal, Quebec, Canada, 1/1/2010
• Mechanistic dissection of EWS-FLI impact on Ewing’s sarcoma cell behavior.
  Chaturvedi A, Lessnick SL, and Beckerle MC, American Association of Cancer Research Annual Meeting, Washington, DC, 1/1/2010
• Emergent properties of EWS/FLI regulation via GGAA-microsatellites in Ewing's sarcoma.
  Gangwal K, Enriquez CA, Close D, Hill CP, and Lessnick SL, American Association of Cancer Research Annual Meeting, Washington, DC, 1/1/2010
• Emergent properties of EWS/FLI regulation via GGAA microsatellites in Ewing's sarcoma.
  Gangwal K and Lessnick SL, Connective Tissue Oncology Society annual meeting, Miami, FL, 1/1/2009
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Lectures

• Targeting Translocations in Pediatric Leukemias and Sarcomas 
  Rockville, MD - 1/1/2015
• Topical Advances and Applications in Bone Pathology 
  San Diego, CA - 1/1/2014
• Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence 
  Pultusk, Poland - 1/1/2012
• RNA Interference - Target Validation & Potential Therapeutic Applications for Childhood Cancer 
  Bethesda, MD - 1/1/2004
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Other

• Epidemiology, pathology, and molecular genetics of the Ewing sarcoma family of tumors. 
  Delaney, T, Hornicek, F, Lessnick, SL, and Mankin H; Basow, DS (Ed), UpToDate
  Waltham, MA - 1/1/2010
• Epidemiology, pathology, and molecular genetics of the Ewing sarcoma family of tumors 
  Lessnick SL, Hornicek FJ, Mankin HJ, DeLaney TF
  http://www.uptodate.com/contents/epidemiology-pathology-and-molecular-genetics-of-the-ewing-sarcoma-
  UpToDate, Wolters Kluwer Health - 2012-04-23