Stephan A Grupp MD PhD

PubMed

• Impact of Different Definitions of Vaso-Occlusion on Efficacy Assessments in Sickle Cell Disease Clinical Trials.
  Haydar Frangoul, Franco Locatelli, Michael J Eckrich, Suzan Imren, Nanxin Li
  Advances in Therapy. 2025-03-27
• 1 citations
  Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy.
  Barbara D Friedes, Amanda M DiNofia, Emma Iannone, Yimei Li, Susan R Rheingold
  Blood Advances. 2025-01-28
• 3 citations
  Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies.
  Julie K Jadlowsky, Elizabeth O Hexner, Amy Marshall, Stephan A Grupp, Noelle V Frey
  Nature Medicine. 2025-01-20

Journal Articles

• CRISPR-Cas9 Gene Editing for Sickle Cell Disease and Β-thalassemia  
  Haydar Frangoul, Jennifer Domm, Stephan Grupp, Rupert Handgretinger, The New England Journal of Medicine
• Induction of Resistance to Chimeric Antigen Receptor T Cell Therapy by Transduction of a Single Leukemic B Cell  
  Vijay G Bhoj, David M Barrett, Carl H June, Stephan A Grupp, David E Ambrose, Saar I Gill, Marco Ruella, Bruce L Levine, Shannon L Maude, Nature
• Genetic Mechanisms of Target Antigen Loss in CAR19 Therapy of Acute Lymphoblastic Leukemia  
  John E Levine, Muna Qayed, Stephan A Grupp, Eneida R Nemecek, Stella M Davies, Michael R Verneris, Michael Boyer, Jeffrey A Engelman, Nature
• Veno-Occlusive Disease After High-Dose Busulfan–Melphalan in Neuroblastoma  
  Gregory Yanik, Morris Kletzel, Stephan Grupp, David Jacobsohn, Christopher C Dvorak, Alix E Seif, Mark Ranalli, Haydar Frangoul, Nature
• CAR-T in the Clinic: Drive with Care  
  Stephan Grupp, MD, Nature
• Non-Viral RNA Chimeric Antigen Receptor Modified T Cells in Patients with Hodgkin Lymphoma  
  Stephan A Grupp, Sunita Dwivedy Nasta, Susan R Rheingold, Daniel J Landsburg, Carl H June, Jakub Svoboda, Stephen J Schuster, Saar I Gill, David L Porter, Bruce L Levine, Blood
• High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model  
  Stephan A Grupp, Zissimos Mourelatos, Michael C Milone, David M Barrett, Sarah A Richman, Clinical Cancer Research
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Abstracts/Posters

• Trends in Inpatient and Intensive Care Resource Utilization after Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia from 2012-2019
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The MAGIC Algorithm Probability (MAP): A Novel Laboratory Biomarker for the Response to Treatment of Acute Graft-Versus-Host Disease
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Cytogenetic Characteristics and Outcomes of Patients Receiving CTL019 CAR T Cell Therapy
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Prediction of Patients at Risk of CD19Neg Relapse Following CD19-Directed CAR T Cell Therapy in B Cell Precursor Acute Lymphoblastic Leukemia
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors
  Stephan Grupp, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

• Medical Crossfire¬: Case Studies in AYA and Adult Acute Lymphoblastic Leukemia _ How the Experts Think and Treat 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World E... 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• High Vs. Low-Intensity Bridging Chemotherapy in Children with Acute Lymphoblastic Leukemia Awaiting Chimeric Antigen Receptor T-Cell Therapy: A Population-Based Study ... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• CD19-Directed CAR T-Cell (CTL019) Product Viability and Clinical Outcomes in Non-Hodgkin Lymphomas and B-Cell Acute Lymphoblastic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphobl... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• How the Experts Treat Acute Lymphocytic Leukemia: Case Discussions From Adolescent to Adult 
  60th American Society of Hematology Annual Meeting - 11/30/2018
• CAR T Cells: How and How Well They Work in Acute Lymphoblastic Leukemia 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
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