StavrosManolagasMDPhD

PubMed

• 496 citations
  Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids
  Maria Almeida, Li Han, Marta Martin-Millan, Lilian I. Plotkin, Scott A. Stewart
  The Journal of Biological Chemistry. 2007-09-14
• 106 citations
  Effects of Sex Steroids on Bones and Muscles: Similarities, Parallels, and Putative Interactions in Health and Disease
  James A. Carson, Stavros C. Manolagas
  Bone. 2015-11-01
• 472 citations
  Estrogens and Androgens in Skeletal Physiology and Pathophysiology.
  Maria Almeida, Michaël R. Laurent, Vanessa Dubois, Frank Claessens, Charles A. O'Brien
  Physiological Reviews. 2017-01-01

Journal Articles

• The study of skeletal aging is coming of age: a forum on aging and skeletal health  
  Manolagas SC, Jilka RL, IBMS BoneKEy, 1/1/2011
• Oxidative Stress Stimulates Apoptosis and Activates NF-{kappa} B in Osteoblastic Cells via a PKC{beta}/p66shc Signaling Cascade: Counter Regulation by Estrogens or And...  
  Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC, Mol. Endocrinology, 1/1/2010
• Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone  
  Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC, Aging Cell, 1/1/2010
• Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and �independent mechanisms  
  Jilka RL, O�Brien CA, Bartell SM, Weinstein RS, Manolagas SC, J Bone Miner Res, 1/1/2010
• What Old Means to Bone  
  Manolagas SC and Parfitt AM, Trends Endocrinol Metab, 1/1/2010
• From Estrogen-centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis  
  Manolagas SC, Endocrine Reviews, 1/1/2010
• Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in 21-month-old mice  
  Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O�Brien C, Thostenson J, Roberson P, Boskey A, Clemens T, Manolagas SC, Aging Cell, 1/1/2010
•  
  Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O�Brien C, Manolagas SC, Mol. Endocrinology, 1/1/2010
• Estrogens Attenuate Oxidative Stress and the Differentiation and Apoptosis of Osteoblasts by DNA Binding-Independent Actions of the ERalpha  
  Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC, J Bone Miner Res, 1/1/2010
• Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling i...  
  Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL, Journal of Biological Chemistry, 1/1/2009
• Commitment to the osteoblast lineage is not required for RANKL gene expression  
  Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA, Journal of Biological Chemistry, 1/1/2009
• Giant osteoclast formation and long-term oral bisphosphonate therapy  
  Weinstein RS, Roberson PK, Manolagas SC, New England Journal of Medicine, 1/1/2009
• Targeted deletion of a distant transcriptional enhancer of the RANKL gene reduces bone remodeling and increases bone mass  
  Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA, Endocrinology, 1/1/2008
• Extracellular matrix made by bone marrow stromal cells provides a niche for the preservation of stemness in mesenchymal cell cultures  
  Chen X-D, Dusevich V, Feng JQ, Manolagas SC, and Jilka RL., J Bone Miner Res, 1/1/2007
• Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival: evidence for inside-out signaling leading to anoikis  
  Plotkin LI, Manolagas SC, Bellido TJ, J Biol Chem, 1/1/2007
• A novel ligand-independent function of the estroen receptor is essential for osteocyte and osteoblast mechanotransduction  
  Aguirre JI, Plotkin LI, Gortazar AR, O�Brien CA, Manolagas SC, Bellido T, J Biol Chem, 1/1/2007
•  
  Almeida M, Han L, Martin-Millan M, O�Brien CA, Manolagas SC, J Biol Chem, 1/1/2007
• Gone with the Wnts: Beta-catenin, TCF, FOXO, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism  
  Manolagas SC, Almeida M, Molecular Endocrinology, 1/1/2007
• novel locus on the X chromosome regulates post-maturity bone density changes in mice  
  Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ, Bone, 1/1/2007
• Glucocorticoids Act Directly on Osteoclasts to Increase Their Lifespan and Reduce Bone Density  
  Jia D, O�Brien CA, Stewart SA, Manolagas SC, Weinstein RS, Endocrinology, 1/1/2006
• Let us not toss out the baby with the bath water Online Response to Windahl et al  
  Manolagas S, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L, J Clin Invest, 1/1/2006
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  Fu Q, Manolagas SC, O�Brien CA, Molecular and Cellular Biology, 1/1/2006
• Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss  
  Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido TM, J Bone and Miner Res, 1/1/2006
• Classical Genotropic versus Nongenotropic (Kinase-Initiated) Regulation of Gene Transcription by the Estrogen Receptor  
  Almeida M, Han L, O�Brien CA, Kousteni S, Manolagas SC, Endocrinology, 1/1/2006
• Chronic Elevation of PTH in Mice Reduces Expression of Sclerostin by Osteocytes: a Novel Mechanism for Hormonal Control of Osteoblastogenesis  
  Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'brien CA, Manolagas SC, Jilka RL, Endocrinology, 1/1/2005
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Books/Book Chapters

• Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 
  Chapter: Gonadal Steroids 
  Manolagas SC, Almeida M, and Jilka RLEditors: Clifford J. Rosen.Wiley-Blackwell, Iowa, IAEdition 8th,2013
• UpToDate 
  Chapter: Normal skeletal development and regulation of bone formation and resorption 
  Manolagas SCEditors: Basow DS.UpToDate, Waltham, MA2012
• UpToDate 
  Chapter: Pathogenesis of osteoporosis 
  Manolagas SCEditors: Basow DS.UpToDate, Waltham, MA2011
• Principles of Bone Biology 
  Chapter: Apoptosis of Bone Cells 
  Page 237 - 261Jilka RL, Bellido T, Almeida M, Plotkin LI, O�Brien CA. Weinstein, RS, Manolagas, SCEditors: John Bilezikian, Lawrence Raisz, T. John Martin.Elsevier, New York, NY2008
• The World of Hormones: Molecular and Physiological Insights. The Biomedical & Life Sciences Collection 
  Chapter: Hormonal influence on bone remodeling and its implications for the pathophysiology of osteoporosis 
  Manolagas SCEditors: Henry, H. and Norman, A..Henry Stewart Talks Ltd, London, United Kingdom2007
• Treatment and prevention of osteoporosis 
  Chapter: Pathogenesis of fractures in glucocorticoid-induced osteoporosis 
  Page 4 - 13Manolagas SCEditors: Straub, N..Excerpta Medica, New Jersey, NJ2005
• Current Osteoporosis Reports 
  Chapter: Epidemiology and Pathophysiology 
  Sambrook P, Manolagas SCEditors: Thomas J. Schnitzer.Current Science, Inc., Philadelphia, PA2004
• The Senescence Accelerated Mouse (SAM): An Animal Model of Senescence 
  Chapter: Age-related bone loss: lessons from the osteoporotic SAMP6 mouse model 
  Page 55 - 60Jilka RL, Shmookler Reis RJ, Manolagas SCEditors: Nomura Y, Takeda T, and Okuma Y.Elsevier, New York, NY2003
• Principles of Bone Biology 
  Chapter: Apoptosis in Bone Cells 
  Page 151 - 168Boyce BF, Xing L, Jilka RL, Bellido T, Weinstein RS, Parfitt AM, Manolagas SCEditors: Bilezikian, Raisz, and Rodan.Bilezikian, Raisz, and Rodan2001
• Principles of Molecular Rheumatology, in the series of Molecular Medicine 
  Chapter: Osteoporosis 
  Page 413 - 422Manolagas SCEditors: George Tsokos.The Humana Press. Inc.2000
• Principles of Molecular Rheumatology, in the series of Molecular Medicine 
  Chapter: Osteoblasts and osteoclasts 
  Page 279 - 291Manolagas SCEditors: George Tsokos.The Humana Press. Inc.2000
• The Merck Manual of Geriatrics 
  Chapter: Aging and the musculoskeletal system 
  Page 467 - 472Manolagas SCEditors: MH Beers and R Berkow.Merck Research Laboratories, Whitehouse Station, NJ2000
• Biology of Menopause 
  Chapter: Cellular and Molecular Mechanisms of Postmenopausal Osteoporosis 
  Page 134 - 146Manolagas SCEditors: Francis L. Bellino.Springer-Verlag, New York, NY2000
• Tumor Bone Diseases and Osteoporosis in Cancer Patients 
  Chapter: Basic Principles of Bone Physiology 
  Page 1 - 22Manolagas SC, Weinstein RS and Jilka RLEditors: JJ Body.Marcel Dekker, Inc.1999
• Neuroimmunomodulation: Molecular Aspects, Integrative Systems, and Clinical Advances. Annals New York Acad. Sci. 
  Chapter: The role of IL-6 type cytokines and their receptors in bone 
  Page 194 - 204Manolagas SCEditors: SM McCann, JM Lipton, EM Sternberg, GP Chrousos, PW Gold, and CC Smith.1998
• Hematology/Oncology Clinics of North America 
  Chapter: Pathogenesis and Management of Bone Lesions in Multiple Myeloma 
  Page 349 - 361Bataille, R, Manolagas, SC, Berenson, JRW.B.Saunders Company, Philadelphia, PA1997
• Principles of Bone Biology 
  Chapter: Interleukin-6 type cytokines and their receptors 
  Page 701 - 713Manolagas SC, RL Jilka, T Bellido, CA O'Brien, and AM ParfittEditors: JP Bilezikian, LG Raisz, GA Rodan.Academic Press, San Diego, CA1996
• Proceedings of the Ciba Foundation Symposium on Non-reproductive Actions of Sex Steroids 
  Chapter: Sex steroids, cytokines, and the bone marrow: new concepts on the pathogenesis of osteoporosis 
  Page 187 - 202Manolagas SC, T Bellido, and RL Jilka1995
• Vitamin D: Pluripotent Steroid Hormone, Structural Studies, Molecular Endocrinology and Clinical Applications 
  Chapter: The role of vitamin D in bone marrow cell differentiation 
  Page 675 - 683Manolagas SC, XP Yu, T Bellido, H Mocharla, RL Jilka, and E AbeEditors: A.W. Norman, R. Bouillon, M. Thomasset.Walter de Gruyter, Berlin, Germany1994
• Osteoporosis 
  Chapter: The cellular and biochemical basis of bone remodeling 
  Page 17 - 48Jilka RL, and Manolagas SCEditors: R. Marcus.Blackwell Scientific Publications, Inc., Boston, MA1994
• Sex Steroids and Bone 
  Chapter: Estrogens, cytokines and bone metabolism 
  Page 95 - 118Manolagas SCEditors: Ziegler R, Pfeilschifter J, Brautigam M.Springer-Verlag, Berlin, Germany1993
• Progress in Endocrinology. The Proceedings of the Ninth International Congress of Endocrinology, Nice 1992 
  Chapter: The role of vitamin D in the immune system and in osteoclastogenesis 
  Page 387 - 390Manolagas SC, T Bellido, XP Yu, G Girasole, H Mocharla, G Passeri, N Rice, D Crabb, and R JilkaEditors: Mornex R, C Jaffiol, and J Leclere.The Parthenon Publishing Group, New York, NY1993
• Progress in Endocrinology. The Proceedings of the Ninth International Congress of Endocrinology, Nice 1992 
  Chapter: Estrogen loss, cytokines and osteoclast development 
  Page 364 - 366Manolagas SC, G Girasole, G Passeri, T Bellido, D Crabb, H Broxmeyer, and RL JilkaEditors: Mornex R, C Jaffiol, and J Leclere.The Parthenon Publishing Group, New York, NY1993
• Calcium Regulating Hormones and Bone Metabolism 
  Chapter: Interleukin-6 neutralizing antibody administration prevents the osteoclastogenic response to ovariectomy in the mouse 
  Page 271 - 274Jilka RL, G Girasole, G Passeri, D Williams, J Abrams, and Manolagas SCEditors: Cohn DV, C Gennari, and AH Tashijian, Jr..Elsevier Science Publishers, Amsterdam, The Netherlands1992
• Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application 
  Chapter: 1,25(OH)2D3 Receptor Levels in Peripheral Blood Mononuclear Cells of Patients with Postmenopausal Osteoporosis 
  Page 840 - 841Yu XP, Hustmyer FG, Benninger L, Peacock M, and Manolagas SCEditors: Norman, A.W., Bouillon, R., Thomasset, M..Walter de Gruyter1991
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Abstracts/Posters

• Age-related Loss of Bone Strength in the Spine and Hindlimb of Mice Independently of BMD
  Parfitt AM, Weinstein R, Bellido T, Jilka R, O�Brien C, Kousteni S, Stewart S, Roberson P, Manolagas SC, J Bone Min Res, 1/1/2018
• Cellular and molecular mechanisms of osteoporosis: how far we have come how much further we need to go
  Manolagas SC, Louis V. Avioli plenary ASBMR lecture; VARI Seminar Series, Denver, CO, 2017; Van Andel Research Institute, Grand Rapids, MI, 2018, 1/1/2018
• Culture of marrow derived mesenchymal stem cells in 3-dimensional matrices made by marrow stromal cells promotes retention of the stem cell phenotype
  Chen X, Manolagas SC, Jilka RL, J Bone Min Res, 1/1/2017
• Almeida M, Iyer S, Kim HN, Han L, Johnson M, Zhao H, O�Brien CA, Manolagas SC, The Endocrine Society�s 99th Annual Meeting, Orlando, FL, 1/1/2017
• The NAD+ Precursor Nicotinamide Roboside Reverses the Age-dependent Decline of NAD+ and Osteoprogenitor Differentiation
  Kim HN, Han L, Iyer S, Warren A, Manolagas SC, Almeida M, J Bone Miner Res, 1/1/2017
• The Senolytic ABT263 Eliminates Senescent Osteoprogenitors in Old Mice
  Kim HN, Iyer S, Chang J, Han L, Warren A, Manolagas SC, Jilka RL, O�Brien CA, Zhou D, Almeida M, J Bone Miner Res, 1/1/2017
• Deletion of the transferrin receptor 1 gene in murine osteoclasts attenuates mitochondria metabolism and cytoskeletal organization and increases trabecular bone mass
  Wang L, Fujiwara T, Fang B, Aykin-burns N, Zhang Z, Li X, Jennings M, Manolagas SC, Zhou J, Zhao H, J Bone Miner Res, 1/1/2017
• Estrogens decrease osteoclastogenesis in vitro by stimulating BakBax-dependent apoptosis of early progenitors
  Kim HN, Han L, Warren A, Manolagas SC, Almeida M, Jilka RL, J Bone Miner Res, 1/1/2017
• Increasing intracellular iron by Ferroportin deletion in murine myeloid precursors stimulates mitochondria metabolism and osteoclastogenesis and decreases trabecular b...
  Wang L, Fujiwara T, Fang B, Aykin-burns N, Zhang Z, Li X, Manolagas SC, Jennings M, Zhou J, Zhao H, J Bone Miner Res, 1/1/2017
• Innate IgM natural antibodies against oxidized phospholipids decline with age in mice: a putative contributor to the declining bone formation and a novel target for bo...
  Ambrogini A, Palmieri M, Han L, Berryhill S, Que X, Tsimikas S, Manolagas SC, Witztum J, Jilka RL, J Bone Miner Res, 1/1/2017
• The unfolded protein response plays an important role in osteoblastogenesis and its aberrations adversely affect skeletal homeostasis
  Iyer S, Vyas K, Deloose A, Palmieri M, Kim HN, Piemontese M, Almeida M, O�Brien CA, Manolagas SC, Jilka RL, J Bone Miner Res, 1/1/2017
• The quest of estrogen target genes in bone: an update
  Manolagas SC, Bones & Teeth Gordon Research Conference, Galveston, TX, 1/15/2016
• The role of sex steroids in skeletal health and disease
  Manolagas SC, 9th Annual Pioneers in Endocrinology Workshop, Rutgers University, New Brunswick, NJ, 1/13/2016
• Evidence that the Cellular Mechanisms Responsible for the Anabolic Effect of Intermittent PTH are Different in Murine Cancellous and Periosteal Bone
  Ali AA, O'Brien CA, Gubrij I, Wynne RA, Parfitt AP, Weinstein RS, Manolagas SC, Jilka RL, J Bone Min Res, 1/1/2016
• Natural Antibodies Against Oxidized LDL Cause Bone Anabolism
  Ambrogini E, Que X, Wang S, Yamaguchi F, Deloose A, Palmieri M, Berryhill S, Weinstein RS, Tsimikas S, Manolagas SC, Witztum J, Jilka RL, J Bone Miner Res, 1/1/2016
• From conditional ERa deletion mouse models to novel gene targets of the anti-resorptive effects of estrogens
  Iyer S, Kim HN, Ucer S, Han L, Warren A, Crawford J, DeCabo R, Zhao H, Almeida M, Manolagas SC, J Bone Miner Res, 1/1/2016
• DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decline in number with age
  Kim HN, Chang J, Shao L, Han L, Iyer S, Warren A, Manolagas SC, Jilka RL, O�Brien CA, Zhou D, Almeida M, J Bone Miner Res, 1/1/2016
• Temporal Sequence of Molecular, Cellular, Vascular and Anatomical Changes Leading to Glucocorticoid-induced Osteonecrosis of the Femoral Head in Mice
  Weinstein RS, Hogan EA, Piemontese M, Borrelli MJ, Liachenko S, O�Brien CA, Manolagas SC, J Bone Miner Res, 1/1/2016
• The effects of aging and sex steroid deficiency on the murine skeleton are independent and mechanistically distinct
  Ucer S, Iyer S, Kim HN, Han L, Thostenson JD, Rutlen C Allison K, Jilka RL, O�Brien CA, Almeida M, Manolagas SC, J Bone Miner Res, 1/1/2016
• For whom the bell tolls: the quest for who will fracture and why
  Manolagas SC, Internal Medicine Grand Rounds, University of California at San Diego, San Diego, CA, 1/13/2015
• What Old Means to Bone
  Manolagas SC, Endocrinology Grand Rounds, University of California at San Diego, San Diego, CA, 1/13/2015
• Scientific Integrity � Enhancing the Reproducibility of Results in Preclinical Studies
  Manolagas SC, Perspective from the Research Community, ASBMR, Seattle, WA, 1/11/2015
• RUNX2 potentiates, but is not required for, RANKL expression in mesenchymal cells
  Fu Q, Wang W, Olsen BR, Manolagas SC, O'Brien CA, J Bone Min Res, 1/1/2015
• Decreased cancellous bone mass in a murine model of type 1 diabetes is caused by cell autonomous effects of FoxOs in committed osteoblast precursors and their descendants
  Iyer S, Han L, Ucer SS, Kim H, Warren W, Crawford J, Fowlkes J, Manolagas SC, Almeida M, J Bone Miner Res, 1/1/2015
• H2O2 generated in the mitochondria of osteoclasts is required for the loss of cortical bone mass caused by estrogen or androgen deficiency, but not aging
  Ucer SS, Iyer S, Han L, Bartell SM, Warren A, Crawford J, Rutlen C, Jilka RL, Almeida M, Manolagas SC, J Bone Miner Res, 1/1/2015
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Lectures

• The Vitamin D Endocrine System 
  University of California-San Diego, San Diego, CA - 1/1/1981

Other

• Perspective: Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling 
  Manolagas SC, BoneKEy-Osteovision
  http://www.bonekey-ibms.org/cgi/content/full/ibmske;3/1/5
  1/1/2006
• Estrogen loss, cytokines, macrophages, lymphocytes, osteoclasts and bone loss: six characters in search of an author or an endocrine-immune system relay causing osteop... 
  Manolagas SC, BoneKEy-Osteovision, News & Reviews, Commentaries Archive, Manolagas
  http://www.bonekey-ibms.org/cgi/content/full/ibmske
  1/1/2002
• Advances in the treatment of osteoporosis 
  Manolagas SC, Medscape
  1/1/1999
• Effect of Steroids on Bone 
  Manolagas SC, Faculty of Medicine, University of Manchester
  Manchester, United Kingdom - 1/1/1979
• Pathogenesis of osteoporosis 
  Manolagas SC
  http://www.uptodate.com/contents/pathogenesis-of-osteoporosis
  UpToDate, Wolters Kluwer Health - 2012-09-27
• Normal skeletal development and regulation of bone formation and resorption 
  Manolagas SC
  http://www.uptodate.com/contents/normal-skeletal-development-and-regulation-of-bone-formation-and-re
  UpToDate, Wolters Kluwer Health - 2012-09-27
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