SonataJodeleMD

Summary

• I am a Research Professor in the Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children's Hospital Medical Center (CCHMC). The overall focus of my research is to reduce organ toxicity in children and young adults undergoing a hematopoietic stem cell transplant (HCT). My primary research interest is transplant-associated thrombotic microangiopathy (TMA). TMA is systemic vascular endothelial injury that occurs during HCT. TMA can result in multi-organ injury and effects overall outcomes. My research effort is targeted towards understanding the pathogenesis of organ injury after HCT, developing screening and early diagnostic tools and investigating novel therapeutic interventions. I have national and international collaborations with colleagues in Nephrology, Cardiology, Critical Care, Genetics, Pharmacology, Bioinformatics. Our collaborative research on TMA has resulted in significant changes to the clinical care of transplant patients, publications, presentations at national and international scientific meetings, working committees and NIH funded research projects.