SohailZHusainMD

PubMed

• 45 citations
  Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.
  Sohail Z. Husain, Wayne M. Grant, Fred S. Gorelick, Michael H. Nathanson, Ahsan U. Shah
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 2007-06-01
• 211 citations
  TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis
  Rafaz Hoque, Muhammad A. Sohail, Ahsan F. Malik, Sherhayar Sarwar, Yuhuan Luo
  Gastroenterology. 2011-07-01
• 56 citations
  Protease activation during in vivo pancreatitis is dependent on calcineurin activation
  Ahsan U. Shah, Amna Sarwar, Abrahim I. Orabi, Samir Gautam, Wayne M. Grant
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 2009-11-01

Journal Articles

• Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles  
  Boggs K, Wang T, Orabi AI, Mukherjee A, Eisses JF, Sun T, Wen L, Javed TA, Esni F, Chen W, Husain SZ, Scientific Reports, 1/1/2018
• The Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report from the NASPGHAN Pancreas Committee  
  Abu-El-Haija M, Kumar S, Quiros JA, Balakrishnan K, Barth B, Bitton S, Eisses JF, Foglio EJ, Fox V, Francis D, Freeman AJ, Gonska T, Grover AS, Husain SZ, Kumar R, Lap..., J Pediatr Gastroenterol Nutr, 1/23/2017
• Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational S...  
  Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kum..., Pancreas, 1/1/2017
• The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group  
  Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Sc..., J Pediatr Gastroenterol Nutr, 1/25/2016
• Experimental acute pancreatitis: In vitro models  
  Mareninova OA, Orabi AI, Husain SZ, The Pancreapedia: Exocrine Pancreas Knowledge Base, 1/1/2015
• The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury  
  Lewarchik CM, Orabi AI, Jin S, Wang D, Muili KA, Shah AU, Eisses JF, Malik A, Jayaraman T, Husain SZ, Am J Physiol Gastrointest Liver Physiol, 1/1/2014
• Design and Implementation of Insppire (International Study Group of Pediatric Pancreatitis: in Search for a Cure)  
  Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, Durie PR, Finley B, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain ..., J Pediatr Gastroenterol Nutr, 1/1/2014
• Low pH enhances connexin32 degradation in the pancreatic acinar cell  
  Reed A, Kolodecik TR, Husain SZ, Gorelick FS, Am J Physiol Gastrointest Liver Physiol, 1/1/2014
• Ryanodine Receptor  
  Orabi AI, Lewarchik CM, Jin S, Jayaraman T, Husain SZ, The Pancreapedia: Exocrine Pancreas Knowledge Base, 1/1/2014
• Cluster of differentiation 38 (CD38) mediates bile-acid induced acinar cell injury and pancreatitis through cyclic ADP ribose and intracellular calcium release  
  Orabi AI, Muili KA, Javed TA, Jin S, Jayaraman T, Lund FE, Husain SZ, J Biol Chem, 1/20/2013
• Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium  
  Mishra V, Cline R, Noel P, Karlsson J, Baty CJ, Orlichenko L, Patel K, Trivedi RN, Husain SZ, Acharya C, Durgampudi C, Stolz DB, Navina S, Singh VP, PLoS One, 1/18/2013
• Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice  
  Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G, Am J Physiol Gastrointest Liver Physiol, 1/15/2012
• IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules  
  Orabi AI, Yuhuan L, Ahmad MU, Shah AU, Mannan ZM, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower EC, Chen J, Husain SZ, PLoS One, 1/1/2012
• Definitions of Pediatric Pancreatitis And Survey Of Current Clinical Practices: Report From Insppire (International Study Group Of Pediatric Pancreatitis: In Search Fo...  
  Morinville VD, Husain SZ, Bai H, Barth B, Alhosh R, Durie PR, Freedman SD, Himes R, Lowe ME, Pohl J, Werlin S, Wilschanski M, Uc A; on behalf of the INSPPIRE Group, Journal of Pediatric Gastroenterology & Nutrition, 1/1/2012
• Risk Factors Associated with Biliary Pancreatitis in Children  
  Ma MH, Bai X, Park AJ, Latif SU, Mistry PK, Pashankar D, Northrup VS, Bhandari V, Husain SZ, Journal of Pediatric Gastroenterology & Nutrition, 1/1/2012
• Ethanol accelerates the speed of pancreatic acinar cell calcium waves and predisposes to pathologic protease activation  
  Orabi AI, Shah AU, Muili K, Sarwar S, Luo Y, Mahmood M, Ahmad A, Husain SZ, J Biol Chem, 1/22/2011
• Calcineurin  
  Muili KA, Husain SZ, The Pancreapedia: Exocrine Pancreas Knowledge Base, 1/1/2011
• Novel Characterization of Drug-Associated Pancreatitis in Children  
  Bai HX, Ma M, Orabi AI, Park A, Latif SU, Bhandari V, Husain SZ, Journal of Pediatric Gastroenterology & Nutrition, 1/1/2011
• Measuring Calcium dynamics in pancreatic acini using confocal microscopy  
  Orabi AI, Nathanson MH, Husain SZ, The Pancreapedia: Exocrine Pancreas Knowledge Base, 1/1/2011
• What have we learned about acute pancreatitis in children?  
  Bai HX, Lowe ME, Husain SZ, Journal of Pediatric Gastroenterology & Nutrition, 1/1/2011
• Dantrolene Mitigates Caerulein-Induced Pancreatitis in vivo in Mice  
  Orabi AI, Shah AU, Ahmad MU, Choo-Wing R, Parness J, Jain D, Bhandari V, Husain SZ, Am J Physiology, 1/1/2010
• Molecular and cellular mechanisms of pancreatic injury  
  Thrower EC, Gorelick FS, Husain SZ, Curr Opinions in Gastroenterology, 1/1/2010
• A Comparison of Presentation and Management Trends in Acute Pancreatitis Between Infants/Toddlers and Older Children  
  Park AJ, Latif SU, Ahmad MU, Bultron G, Orabi AI, Bhandari V, Husain SZ, Journal of Pediatric Gastroenterology & Nutrition, 1/1/2010
• Characterization of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum  
  Fairfax KC, Vermeire JJ, Harrison LM, Bungiro RD, Grant WM, Husain SZ, Cappello M, International Journal for Parasitology, 1/1/2009
• Protease Activation during in vivo Pancreatitis is Dependent upon Calcineurin Activation  
  Shah AU, Sarwar A, Orabi AI, Grant WM, Park AJ, Shah AU, Liu J, Mistry PK, Jain D, Husain SZ, Am J Physiology, 1/1/2009
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Books/Book Chapters

• The Pancreas 
  Chapter: Molecular understanding of chronic pancreatitis. 
  Eisses JF, Husain SZEditors: Beger, Hans.Wiley-Blackwell, Ulm, GermanyEdition 3rd,2016
• Gastroenterology: A Color Handbook 
  Chapter: Congenital Abnormalities of the Pancreas 
  Page 259 - 266Chen K, Husain SZEditors: Pohl J, Jolley C, Gelfond D.CRC Press Taylor and Francis Group, Boca Raton, FL2014
• Pediatric Gastroenterology: A Color Handbook 
  Chapter: Other Pancreatic Disorders-Trauma and Neoplasm 
  Page 291 - 296Chen K, Husain SZEditors: Pohl J, Jolley C, Gelfond D.CRC Press Taylor and Francis Group, Boca Raton, FL2014
• Sleisenger and Fordtran's Gastrointestinal and Liver Disease 
  Chapter: Anatomy, histology, and developmental anomalies of the pancreas. 
  Barth B, Husain SZEditors: Feldman M, Freidman LS, Brandt LJ.Saunders Elsevier, Philadelphia, PAEdition 9th,2014
• Curbside Consultation in Pediatric GI 
  Chapter: Non-CF Pancreatic Insufficiency in Children 
  Page 129 - 134Chen K, Husain SZEditors: Rosh J and Bousvaros A.SLACK Inc., Thorofare, NJ2013
• Pediatric Gastrointestinal and Liver Disease 
  Chapter: Pancreatic development. 
  Page 878 - 889Turkish A, Husain SZEditors: Wyllie R, Hyams JS, Kay M.Elsevier Saunders, Philadelphia, PAEdition 4th,2011
• Clinical Decision Support: Pediatrics 
  Chapter: Acute and Chronic Pancreatitis in Children 
  Chen K, Husain SZDecision Support in Medicine, LLC, Wilmington, DE2011
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Abstracts/Posters

• Novel calcineurin inhibitor strategies to prevent radiocontrast-induced organ injury, using the pancreas as a prototypic organ.
  Wen L, Javed TA, Orabi AI, Husain SZ, Annual Meeting of American Pancreatic Association, San Diego, CA, 1/1/2017
• Pancreatic Gene Expression During Recovery After Pancreatitis Reveals Unique Transcriptome Profiles.
  Boggs K, Wang T, Orabi AI, Javed AI, Sun T, Eisses JF, Esni F, Chen W, Husain SZ, Annual Meeting of American Pancreatic Association, San Diego, CA, 1/1/2017
• A role for pancreatic NFAT in pancreatitis.
  Wen L, Javed TA, Orabi AI, Husain SZ, Annual Meeting of American Pancreatic Association, San Diego, CA, 1/1/2017
• Pancreatic epithelial cell, but not immune cell, calcineurin mediates acute pancreatitis.
  Wen L, Javed TA, Brown R, Byersdorfer C, Husain SZ, NASPGHAN (North American Society for Pediatric Gastroenterology, Hepatology and Nutrition) Annual Meeting, Las Vegas, NV, 1/1/2017
• Pancreatic epithelial cell, but not immune cell calcineurin mediates acute pancreatitis.
  Wen L, Javed TA, Brown R, Byersdorfer C, Husain SZ, Gastroenterology, DDW (Digestive Disease Week), 1/1/2017
• Risk Factors for Asparaginase Associated Pancreatitis: A Systematic Review.
  Rose FT, Oparaji JA, Orabi AI, Howard AS, Okafor DC, Turner R, Lowe ME, Ritchey KA, Husain SZ, Pancreas, 47th Annual Meeting of American Pancreatic Association, Boston, MA, 1/1/2016
• NF-kB Activation with Radiocontrast Exposure During Post-ERCP Pancreatitis is Dependent on BCl10 in the Scaffolding CBM Complex.
  Sanker S, Orabi AI, Hu D, McAllister-Lucas LM, Lucas PC, Husain SZ, Pancreas, 47th Annual Meeting of American Pancreatic Association, Boston, MA, 1/1/2016
• Radiocontrast induces pancreatic mitochondrial dysfunction in pancreatic acinar cells and mitophagy in a mouse model of post-ERCP pancreatitis through the dephosphoryl...
  Wen L, Shalbueva N, Mareninova OA, Orabi AI, Javed TA, Gukovkaya AS, Husain SZ, 47th Annual Meeting of American Pancreatic Association, Boston, MA, 1/1/2016
• Epithelial cell-specific calcineurin signaling mediates inflammation in the context of pancreatitis.
  Wen L, Orabi AI, Javed TA, Sanker S, Boggs K, Eisses JF, Husain SZ, 47th Annual Meeting of American Pancreatic Association, Boston, MA, 1/1/2016
• Targeted inhibition of pancreatic acinar cell calcineurin prevents post-ERCP pancreatitis in mice.
  Wen L, Orabi AI, Javed TA, Sanker S, Husain SZ, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada, 1/1/2016
• Using Intra-Ductal AAV Gene Transfer to Study Pancreatic Cell Specific Contributions of Calcineurin to Post-ERCP Pancreatitis.
  Orabi AI, Javed TA, Jin S, Guo P, Gittes GK, Husain SZ, Gastroenterology, 1/1/2016
• Histone Deacetylases Act as a Molecular Switches to Promote Pancreatic Regeneration Following Pancreatitis.
  Eisses JF, Criscimana A, Dionise ZR, Javed TA, Ozolek JA, Davis A, Orabi AI, Sarwar A, Jin S, Monga SPS, Esni F, Husain SZ, Pancreas, 1/1/2015
• A Novel Mechanism for Radiocontrast-Induced Pancreatic NF-KappaB translocation and Injury through Triggering Calcium and Calcineurin Activation.
  Jin S, Orabi AI, Le T, Sah S, Bottino R, Eisses JF, Husain SZ, Gastroenterology, 1/1/2015
• Live, Dynamic Bioluminescent Imaging of Pancreatic NF-KappaB Activation in Mice using Novel Gene Delivery via Intraductal Infusion of an Adeno-Associated Viral Reporter.
  Sah S, Jin S, Javed T, Lemon K, Orabi AI, Xaio X, Guo P, Gittes GK, Husain SZ, Gastroenterology, 1/1/2015
• Targetting Pancreatic Calcineurin to Prevent Post-ERCP Pancreatitis.
  Jin S, Orabi AI, Javed TA, Sah S, Eisses JF, Husain SZ, Pancreas, 1/1/2015
• Valproic Acid Causes Pancreatitis by Inhibiting Histone Deacetylases and Provoking an Imbalance in Pancreatic Recovery.
  Eisses JF, Dionise ZR, Sah S, Sarwar S, Criscimana A, Orabi AI, Esni F, Husain SZ, Pancreas, 1/1/2014
• Radiocontrast Exposure Provokes Post-ERCP Pancreatitis by Selectively Triggering Aberrant Calcium Signals and Activating Calcineurin.
  Jin S, Orabi AI, Le T, Eisses JF, Sah S, Husain SZ, Pancreas, 1/1/2014
• Syntaxin 2 Deficiency Predisposes to Pancreatitis by Enhancing Basolateral Exocytosis and Autophagy.
  Dolai S, Orabi AI, Liang T, Javed TA, Lam PL, Rubin DC, Husain SZ, Gaisano HY, Gastroenterology, 1/1/2014
• The Ryanodine Receptor is Expressed in Mouse and Human Pancreatic Acinar Cells and Contributes to Acinar Cell Injury.
  Lewarchik CM, Jin S, Wang D, Orabi AI, Muili KA, Shah AU, Eisses JF, Jayaraman T, Husain SZ, Gastroenterology, 1/1/2014
• ERCP Contrast Induces NF-kB Activation through Calcineurin and ER Stress in a Pancreatic AR42J Cell Line.
  Jin SQ, Le T, Orabi AI, Sah S, Husain SZ, Gastroenterology, 1/1/2014
• A Non-Invasive Method of Quantifying Pancreatic Volume in Murine Models Using Micro-MRI.
  Paredes JL, Orabi AI, Ahmad T, Benbourenane I, Sah S, Lemon K, Tobita K, Tadros S, Bae T, Husain SZ, Pancreas, 1/1/2013
• Munc18c Mediates Caerulein-induced Pancreatitis and Basolateral SNARE Complex Assembly.
  Dolai S, Orabi AI, Javed TA, Liang T, Thurmond DC, Husain SZ, Gaisano HY, Gastroenterology, 1/1/2013
• CD38/ADP Ribosyl Cyclase Mediates Bile Acid-induced Calcium Signals and Acinar Cell Injury.
  Muili KA, Orabi AI, Jin S, Javed TA, Eisses JF, Le T, Husain SZ, Gastroenterology, 1/1/2013
• Bile Acids Cause Pancreatic Acinar Cell NF-KappaB Activation and Injury through an Interplay of PKC and Calcineurin.
  Muili KA, Jin S, Orabi AI, Wang D, Javed TA, Eisses JF, Le T, Husain SZ, Gastroenterology, 1/1/2013
• Performing functional assays from a pancreas slice to examine early features of acute pancreatitis.
  Orabi AI, Dolai S, Liang T, Husain SZ, Gaisano HY, American Pancreatic Association Annual Meeting, 1/1/2012
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Lectures

• "Translating molecular calcium signals in acute pancreatitis to the bedside." 
  University of Texas Southwestern Medical Center, Dallas, TX - 1/1/2018
• "Why do some drugs cause pancreatitis?" 
  Las Vegas, NV - 1/1/2017
• "Turning investigational therapies into clinical reality: Pancreatitis in the spotlight." 
  University at Buffalo, Buffalo, NY - 1/1/2017
• "Epithelial Cell Calcineurin Signaling in Pancreatitis." 
  Mayo Clinic, Jacksonville, FL - 1/1/2017
• "Pancreatitis." 
  Scottsdale, AZ - 1/1/2017
• "Pancreatic anatomy and anomalies." 
  Scottsdale, AZ - 1/1/2017
• "Hereditary disorders of the pancreas." 
  Scottsdale, AZ - 1/1/2017
• "Manuscript writing made easy." 
  Children's Hospital of Pittsburgh - 1/1/2017
• "A Mock Study Section in Action." 
  Children's Hospital of Pittsburgh - 1/1/2017
• Toxic-Metabolic Risk Factors Are Uncommon in Pediatric Chronic Pancreatitis. 
  1/1/2016
• "Advances in Preventing Radiocontrast-Induced ERCP Pancreatitis by Targeting Calcium and Calcineurin." 
  Children's Hospital of Pittsburgh, Pittsburgh, PA - 1/1/2016
• "Preventing Post-ERCP Pancreatitis by Targeting Calcineurin." 
  1/1/2016
• "Getting published." 
  Children's Hospital of Pittsburgh - 1/1/2016
• "The conundrum of pancreatitis in children: New light on a hidden organ." 
  University of Florida, Gainsville, FL - 1/1/2016
• "Targetting calcineurin to prevent post-ERCP pancreatitis." 
  Cincinnati, OH - 1/1/2016
• "Preventing Post-ERCP Pancreatitis." 
  University of Iowa, Iowa City, IA - 1/1/2016
• "Deciphering Mechanisms for Post-ERCP Pancreatitis." 
  Pittsburgh, PA - 1/1/2016
• "Probing the Association of Pancreatitis with IBD: Perspectives of the Pediatric Pancreatologist." 
  Cornell University, New York, NY - 1/1/2016
• "Inflammatory responses and healing in pancreatic injury." 
  Montreal, Canada - 1/1/2016
• "Mechanistic insights into acute pancreatitis in the pediatric population." 
  Chengdu, China - 1/1/2016
• "Calcineurin mediates acinar cell events required for post-ERCP pancreatitis." 
  Boston, MA - 1/1/2016
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  Boston, MA - 1/1/2016
• "Chronic pancreatitis in children." 
  1/1/2015
• "The alphabet soup of the NIH and other grants." 
  Children's Hospital of Pittsburgh - 1/1/2015
• "Writing an outstanding grant." 
  Children's Hospital of Pittsburgh - 1/1/2015
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