Dr. Mallal is on Doximity
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Office
1161 21st Ave Medical Center Nort S
# S2105
Nashville, TN 37232Phone+1 615-322-2035Fax+1 615-343-6160
Summary
- Dr. Mallal completed his training in Internal Medicine and Clinical Immunology and training in Pathology in Western Australia before undertaking a post-doctoral fellowship in Infectious Diseases at Johns Hopkins Medical School. He has undertaken clinical practice management altering research throughout his career that has informed and directed his basic science research. This has had impacts over time in the domains of: reproductive endocrinology (1978 – 82), genetic disease association studies (1987 – present), immune restoration disease in HIV (1994 onwards), improved efficacy of antiretroviral therapy (1988 onwards), mitochondrial toxicity and metabolic complications of antiretroviral therapy (1997 on), use of pharmacogenetic tests to avoid drug hypersensitivity (2002 on) and HIV and Hepatitis C adaptation to HLA restricted immune responses to support vaccine immunogen design and potential eradication approaches. He is best known for championing the discovery and successful translation of HLA-B*5701 screening to prevent abacavir hypersensitivity. The impact on clinical and healthcare practice and policy in these domains has been important, as has the development of new multidisciplinary capacity and approaches to translational medicine. This culminated in the establishment of a purpose-built translational medicine Institute that he leads. He has authored over 200 articles and book chapters and given over 215 presentations at scientific meetings. He serves on several international scientific committees and advisory boards and received the Western Australian Premiers Science Award in 2006. He is a Fellow of the American Association for the Advancement of Science and a member of the Association of American Physicians.
Education & Training
- OtherClass of 1984
- University of Western AustraliaBachelor's, Medical Science, With honors, 1981
Certifications & Licensure
- TN State Medical License 2014 - 2026
Awards, Honors, & Recognition
- Fellow American Association for the Advancement of Science (AAAS), 2014
- Finalist in the Western Australian Citizen of the Year Award 2009
- Health Services Award, World AIDS Day Award West Australian AIDS Council, 2008
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Publications & Presentations
PubMed
- 124 citationsT cells specific for α-myosin drive immunotherapy-related myocarditis.Margaret L Axelrod, Wouter C Meijers, Elles M Screever, Juan Qin, Mary Grace Carroll
Nature. 2022-11-01 - 118 citationsA case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitisDouglas B. Johnson, Wyatt J. McDonnell, Paula I. Gonzalez-Ericsson, Rami N. Al-Rohil, Bret C. Mobley
Nature Medicine. 2019-07-22 - 266 citationsInfluence of HLA-C Expression Level on HIV ControlRichard Apps, Ying Qi, Jonathan M. Carlson, Haoyan Chen, Xiaojiang Gao
Science. 2013-04-05
Journal Articles
- High CD8 T Cell Receptor Clonality and Altered CDR3 Properties Are Associated with Elevated Isolevuglandins in Adipose Tissue During Diet-Induced ObesitySimon Mallal, MD, Diabetes Care
- Short Population Report Sequence-Based HLA-A, B, C, DP, DQ, and DR Typing of 714 Adults from Colombo, Sri LankaSimon Mallal, MD, ScienceDirect
- Human CD4+ T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection, in magnitude, HLA restriction and antigen specificityAngelo MA, Grifoni A, O'Rourke PH, Sidney J, Paul S, Peters B, de Silva AD, Phillips E, Mallal S, Diehl SA, Kirkpatrick BD, Whitehead SS, Durbin AP, Sette A, Weiskopf D, J Virol, 1/14/2016
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Books/Book Chapters
Abstracts/Posters
- Characterization of TCR repertoire diversity and tissue distribution of drug-specific T cells in DRESSWhite KD, Konvinse K, Pilkinton M, Barnett L, Gangula R, Redwood A, Pavlos R, Chopra A, Mallal S, Phillips E, 16th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS), Boston, MA, 1/22/2016
- Specific Binding Characteristics Of HLA Alleles Associated With Nevirapine HypersensitivityPavlos R, McKinnon E, Ostrov D, Peters B, Buus S, Koelle D, Chopra A, Rive C, Redwood A, Restrepo S, Bracey A, Yuan J, Gaudieri S, Carrington M, Haas D, Mallal S, Phil..., 7th Drug Hypersensitivity Meeting, Malaga, Spain, 1/21/2016
- Variation in ERAP influences risk for HLA-B*57:01 abacavir hypersensitivityPavlos R, Strautins K, James I, Mallal S, Redwood A, Phillips E, 23rd Conference on Retroviruses and Opportunistic Infections (CROI); 7th Drug Hypersensitivity Meeting, Boston, MA, 2015; Malaga, Spain, 2016, 1/21/2016
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Lectures
- Putting together core technologies to your AdVANTAGEVanderbilt University, Nashville, TN - 1/30/2016
- Role of Heterologous Immunity in Transplant Rejection and Other Experiments of ManVanderbilt University, Nashville, TN - 1/30/2016
- T Cells Behaving Badly: Evolution to Population to Single CellsVanderbilt University, Nashville, TN - 1/10/2016
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Other
- Abacavir hypersensitivityPhillips E, Mallal S, UpToDate
1/1/2008 - Monograph: Structuring therapy for successful long-term outcomes
1/1/2002 - Long-term complications: An Interactive WebcastDr H Kessler, Dr W Powderly, Dr SA Mallal
www.hivline.com
1/14/2000 - Join now to see all
Press Mentions
- Functional Conservation of Mitochondrial RNA Levels Despite Divergent mtDNA OrganizationJuly 11th, 2020
- Fighting HIV with Anti-Spam ToolsMay 25th, 2005
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