ShellyLuMD

PubMed

• 1409 citations
  REGULATION OF GLUTATHIONE SYNTHESIS
  Shelly C. Lu
  Molecular Aspects of Medicine. 2009-02-01
• 97 citations
  Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
  Yoon Mee Yang, Mazen Noureddin, Cheng Liu, Koichiro Ohashi, So Yeon Kim
  Science Translational Medicine. 2019-06-12
• 13 citations
  Nonalcoholic fatty liver disease prevalence and severity in Asian Americans from the national health and nutrition examination surveys 2017-2018.
  Emily Truong, Yee Hui Yeo, Galen Cook-Wiens, Mark Muthiah, Ju Dong Yang
  Hepatology Communications. 2022-09-01

Journal Articles

• NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications for Liver Transplant and Ethnic and Gender Variances  
  Tsuyoshi Todo, Walid S Ayoub, Naim Alkhouri, Nicholas N Nissen, Vinay Sundaram, Shelly C Lu, Mazen Noureddin, Aarshi Vipani, Tram Tran, Andrew S Klein, Nature
• Sex and racial/ethnic differences in the association of obesity with risk of hepatocellular carcinoma  
  Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Henderson BE, Le Marchand L, Clin Gastroenterology Hepatol, 1/1/2016
• Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis  
  Zubiete-Franco I, García-Rodríguez JL, Martínez-Uña M, Matínez-Lopez N, Woodhoo A, Gutiérrez-De JV, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldámiz-Echevarrí..., J Hepatol, 1/1/2016
• Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes  
  Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain S, Rojas AL, PNAS, 1/1/2016
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  Yang HP, Liu T, Wang J, Li TWH, Fan W, Peng H, Krishnan A, Gores GJ, Mato JM, and Lu SC, Hepatology, 1/1/2016
• Prohibitin 1 regulates the H19-Igf2 axis and proliferation in hepatocytes  
  Ramani K, Mavila N, Ko KS, Mato JM, Lu SC, J. Biol. Chem., 1/1/2016
• Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis  
  Lu SC, Hepatology, 1/1/2016
• S-adenosylmethionine and methylthioadenosine inhibit beta catenin signaling by multiple mechanisms in liver and colon cancer  
  Li TWH, Peng H, Yang HP, Kuriniawidjaja S, Panthaki P, Zheng Y, Mato JM, and Lu SC, Mol. Pharmacol., 1/1/2015
• Activation of a novel c-Myc-miR27-Prohibitin 1 circuitry in cholestatic liver injury inhibits GSH synthesis in mice  
  Yang HP, Li TWH, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, and Lu SC, Antioxidant & Redox Signaling, 1/1/2015
• Coffee intake, chronic liver diseases and hepatocellular carcinoma: the Multiethnic Cohort  
  Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE, Gastroenterology, 1/1/2015
• TRAIL-producing NK cells contribute to fibrogenesis in the context of GNMT deficiency  
  Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, and Beraza N, Lab Invest., 1/1/2015
• S-adenosylmethionine regulates very-low density lipoprotein assembly, features and plasma metabolism in nonalcoholic fatty liver disease  
  Martínez-Uña M, Varela M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, Ga..., J Hepatol., 1/1/2015
• HDAC4 promotes cholestatic liver injury in the absence of prohibitin-1  
  Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales ..., Hepatology, 1/1/2015
• Methionine adenosyltransferase a2 positively regulates B-cell CLL/lymphoma 2 expression in a sumoylation-dependent manner  
  Tomasi ML, Ryoo M, Tomasi I, Giordano P, Mato JM, and Lu SC, Oncotarget, 1/1/2015
• Nutritional status and infection risk in cirrhosis: examining both ends of the spectrum  
  Sundaram V, Kaung A, Rajaram A, Lu SC, Tran TT, Klein AS, Jalan R, Charlton MR, Jeon CY, Alimentary Pharmacology & Therapeutics, 1/1/2015
• Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine  
  Noureddin M, Mato JM, and Lu SC, Exp. Biol Med, 1/1/2015
• Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice  
  Tomasi ML, Ryoo M, Yang HP, Iglesia Ara A, Ko K, and Lu SC, Free Radical Biology & Medicine, 1/1/2014
• Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveal candidate markers for liver toxicity  
  Rodríguez-Suárez E, González E, Hughes C, Conde-Vancells J, Rudella A, Royo F, Palomo L, Elortza F, Lu SC, Mato JM, Vissers JPC, and Falcón-Pérez JM, J. Proteomics, 1/1/2014
• Diabetes and racial/ethnic differences in hepatocellular carcinoma risk: the multiethnic cohort  
  Setiawan VW, Hernandez B, Lu SC, Stram DO, Wilkens LR, Marchand LL, Henderson BE, J Nat Cancer Inst., 1/1/2014
• Systems biology for hepatologists  
  Mato JM, Martínez-Chantar ML, and Lu SC, Hepatology, 1/1/2014
• MiRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma  
  Yang HP, Cho ME, Li TWH, Peng H, Ko KS, Mato JM, and Lu SC, J. Clin. Invest., 1/1/2013
• MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer  
  Peng H, Dara L, Li TWH, Zheng Y, Yang HP, Tomasi ML, Tomasi I, Giordano P, Mato JM, and Lu SC, Hepatology, 1/1/2013
• Methionine Adenosyltransferase 2B, HuR and Sirtuin 1 Crosstalk Impacts on Resveratrol’s Effect on Apoptosis and Growth in Liver Cancer Cells  
  Yang HP, Zheng Y, Li TWH, Peng H, Ramos DF, Martínez-Chantar ML, Rojas AL, Mato JM, and Lu SC, J. Biol. Chem., 1/1/2013
• Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis  
  Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C..., Hepatology, 1/1/2013
• S-adenosylmethionine metabolism and liver disease  
  Mato JM, Martínez-Chantar ML, and Lu SC, Annals Hepatology, 1/1/2013
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Books/Book Chapters

• Liver Metabolism and Fatty Liver Disease 
  Chapter: Chapter 6: Oxidative Stress and Disease: Methionine adenosyltransferase genes in liver health and disease 
  Ramani K, Lu SCEditors: Oren Tirosh.Taylor & Francis Group / CRC Press2014
• Amino Acids in Human Nutrition and Health 
  Chapter: Methionine metabolism 
  Mato JM, Martínez-Chantar ML, Lu SCEditors: D’Mello F.CABI, Oxfordshire, UK2011
• Atlas of Gastroenterology 
  Chapter: Cystic diseases of the liver and biliary tree 
  Chang AJ, Suh JW, Lu SCEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 4th,2009
• Textbook of Gastroenterology 
  Chapter: Cystic diseases of the liver and biliary tree 
  Suh JW, Chang AJ, Lu SCEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 5th,2009
• Alcohol, Tobacco and Cancer 
  Chapter: Role of S-adenosyl-L-methionine in alcohol-associated liver cancer 
  Lu SC, Mato JMEditors: Cho CH, Purohit V.Karger AG, Basel, SwitzerlandEdition 1st,2006
• Liver Diseases: Biochemical Mechanisms and New Therapeutic Insights 
  Chapter: Methionine adenosyltransferase and S-adenosylmethionine in liver health and disease 
  Lu SC, Mato JMEditors: Shakir A, Friedman SL, Mann D.M/s Sc Pub, Inc., Chicago, ILEdition 1st,2006
• Nutrient-Gene Interactions in Cancer 
  Chapter: S-adenosylmethionine and methionine adenosyltransferase genes 
  Mato JM, Martínez-Chantar ML, Lu SCEditors: Choi SW, Friso S.CRC Press LLC, Boca Raton, FLEdition 1st,2006
• Encyclopedia of Dietary Supplements 
  Chapter: S-adenosylmethionine 
  Mato JM, Lu SCEditors: Coates PM, Blackman MR, Levine M, Moss J, White JD.Marcel Dekker, New York, NYEdition 1st,2005
• Textbook of Gastroenterology 
  Chapter: Cystic diseases of the biliary tree 
  Lu SC, Debian KEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 4th,2003
• Atlas of Gastroenterology 
  Chapter: Cystic diseases of the biliary tree 
  Lu SC, Debian KEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 3rrd,2003
• FALK Symposium 113: Cytokines and Cell Homeostasis in the Gastrointestinal Tract 
  Chapter: Glutathione homeostasis in liver regeneration 
  Lu SCEditors: Andus T, Rogler G, Schlottmann K, Frick E, Adler G, Zeitz M, Schmiegel W, Schölmerich J.Kluwer Academic, Dordrecht, NetherlandsEdition 4th,2000
• Kelley's Textbook of Internal Medicine 
  Chapter: Drug-induced hepatic injury 
  Lu SC, Maldonado LEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 3rd,1996
• Biothiols 
  Chapter: Sinusoidal efflux of hepatic GSH: significance, physiology and regulation 
  Kaplowitz N, Oohktens M, Lu SCEditors: Packer L, Cadenas E.Kluwer Academic, Lancaster, United KingdomEdition 2nd,1995
• Hepatic anion transport and bile secretion: physiology and pathophysiology 
  Chapter: The regulation of hepatic glutathione 
  Fernandez-Checa J, Lu SC, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saiki H, Kannan R, Garcia-Ruiz C, Kuhlenkamp JF, Kaplowitz NEditors: Tavoloni N, Berk PD.Raven Press, New York, NYEdition 2nd,1993
• Methionine Metabolism: Molecular Mechanism and Clinical Implications 
  Chapter: Regulation of hepatic GSH synthesis and efflux 
  Kaplowitz N, Lu SC, Ookhtens M, Fernandez-Checa J, Garcia-Ruiz C, Saiki HEditors: Mato J, et al.Edition 3rd,1992
• Liver and Biliary Diseases 
  Chapter: Cystic diseases and strictures 
  Lu SCEditors: Kaplowitz N.Williams & Wilkins, Baltimore, MAEdition 9th,1992
• Atlas of Gastroenterology 
  Chapter: Diseases of the biliary tract 
  Lu SC, Kaplowitz N, Hamlin AEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 1st,1992
• Textbook of Gastroenterology 
  Chapter: Diseases of the biliary tract 
  Lu SC, Kaplowitz NEditors: Yamada T.JB Lippincott, Philadelphia, PAEdition 1st,1991
• Gastrointestinal Emergencies 
  Chapter: Acetaminophen toxicity 
  Lu SC, Kaplowitz NEditors: Taylor MB, Gollan JL, Peppercorn MA, Steer ML, Wolfe MM.Williams & Wilkins, Baltimore, MAEdition 1st,1991
• Current Hepatology 
  Chapter: Drug-induced hepatotoxicity 
  Lu SC, Kaplowitz NEditors: Gitnick G.Year Book Medical, Chicago, ILEdition 9th,1989
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Abstracts/Posters

• Metabolomic classification of murine and human nonalcoholic fatty liver disease
  Alonso C, Lavin JL, Iruarrizaga-Lejarreta M, Fernández-Ramos D, van-Liempd S, delaCruz-Villar L, Navasa N, Martínez-Arranz I, Aurrekoetxea I, Buqué X, Varela M, Falcón..., Hepatology, 1/1/2016
• Prohibitin 1 represses c-Myc-driven E-box gene expression and acts as a tumor suppressor in liver cancers in mice and humans
  Fan W, Yang HP, Wang J, Li TWH, Alagappan A, Mato JM, Lu SC, Hepatology, 1/1/2016
• Prohibitin-1 regulates cellular proliferation by controlling the H19-Igf2 axis in the liver
  Ramani K, Mavila N, Lu SC, Hepatology, 1/1/2016
• Subtyping nonalcoholic steatohepatitis for the development of effective treatments
  Martinez-Arranz I, Alonso C, Fernandez D, Mayo R, Varela M, Noureddin M, Martinez-Chantar ML, Lu SC, Castro A, Mato JM, Hepatology, 1/1/2015
• Yang HP, Liu T, Wang J, Li TWH, Mato JM, Lu SC, Hepatology, 1/1/2015
• S-Adenosylmethionine treatment corrects deregulated lipid metabolic pathways and prevents progression of non-alcoholic steatohepatitis in methionine adenosyltransferas...
  Fernandez D, Alonso C, van Liempd S, Varela M, Navasa N, Martinez-Arranz I, Aspichueta P, Aransay AM, Anguita J, Falcon-Perez JM, Martinez-Chantar ML, Lu SC, Mato JM, Hepatology, 1/1/2015
• Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice
  Tomasi ML, Ryoo M, Lu SC, Hepatology, 1/1/2013
• Role of sumoylation in alcoholic liver disease
  Tomasi ML, Ryoo M, Lu SC, Hepatology, 1/1/2013
• Polyamine and methionine adenosyltransferase 2A crosstalk in human colon cancer
  Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC, Gastroenterology, 1/1/2013
• Dysregulation of phospho-receptor tyrosine kinase protein levels and microRNAs in methionine adenosyltransferase 1A knockout mice
  Tomasi ML, Ryoo M, Mato JM, Lu SC, Hepatology, 1/1/2012
• Ubiquitin-conjugating enzyme 9-methionine adenosyltransferase 2A-Bcl2 axis regulates apoptosis in liver and colon cancer cells
  Tomasi ML, Skay A, Tomasi I, Giordano P, Lu SC, Gastroenterology, 1/1/2012
• Involvement of miRNAs in the regulation of methionine adenosyltransferase 1A expression and tumorigencity in hepatocellular carcinoma
  Yang H, Cho M, Ko K, Li T, Peng H, Mato JM, Lu SC, Gastroenterology, 1/1/2012
• Methionine Adenosyltransferase 2B interacts with G-protein-coupled receptor kinase-interacting protein 1 to activate ERK and induce growth
  Peng H, Dara L, Li TW, Mato JM, Lu SC, Hepatology, 1/1/2012
• Sumoylation of nuclear factor erythroid 2-related factor 2 and MafG protein is essential for glutamate-cysteine ligase catalystic subunit expression in hepatic stellat...
  Ramani K, Tomasi ML, Yang H, Lu SC, Hepatology, 1/1/2012
• The flow from phosphatidylethanolamine to phos-phatidylcholine regulates hepatic lipid homeostasis
  Martínez-Uña M, Varela-Rey M, Fernandez-Ares L, Beraza N, Buqué X, Aurrekoetxea I, Lu SC, Martinez-Chantar ML, Aspichueta P, Mato JM, Hepatology, 1/1/2012
• S-Adenosylmethionine regulates ubiquitin conjugating enzyme 9 expression and sumoylation:Molecular mechanism and implication in hepatocarcinogenesis
  Tomasi ML, Ramani K, Li TW, Xu J, Mato JM, Lu SC, Hepatology, 1/1/2011
• Obesity Dependent Metabolic signatures associated with nonalcoholic fatty liver disease progression
  Barr J, Caballeria J, Martinez Arranz, I, Dominguez-Diez A, Alonso C, Muntane J, Perez-Cormenzana M, Garcia-Monzon C, Mayo R, Martin-Duce, A, Romero-Gomez M, Lo locono..., Hepatology, 1/1/2011
• Expression of glutathione synthetic enzymes during hepatic stellate cell activation and differentiation
  Ramani K, Yang H, Tomasi ML, Ko K, Lu SC, Hepatology, 1/1/2010
• S-adenosylmethionine regulates ubiquitin-conjugating enzyme 9 protein level and sumoylation
  Tomasi ML, Ramani K, Li TW, Xu J, Mato JM, Lu SC, Hepatology, 1/1/2010
• Serum metabolic profiling reveals novel biomarkers associated with liver injury
  Barr J, Alonso C. Suero R, Castro A, Gonzalez E, Conde-Vancells J, Lu SC, Mato JM, Falcon-Perez JM, Hepatology, 1/1/2009
• Forced expression of methionine adenosyltransferase 1A (MAT1A) in human hepatoma cells suppresses in vivo tumorigenicity by reducing proliferation and angiogenesis whi...
  Li J, Ramani K, Sun Z, Zee C, Grant EG, Yang H, Xia M, Oh P, Ko K, Mato JM, Lu SC, Hepatology, 1/1/2009
• Proliferative role of LKB1 in the development of hepatocellular varcinoma associated to nonalcohlic steatohepatitis
  Martinez N, Varela-Rey M, Fernandez D, Vasquez M, Embade N, Woodhoo A, Espinosa-Hevia L, Parada LA, Rodriguez MS, Lu SC, Hepatology, 1/1/2009
• S-Adenosylmethionine stablizes dual-specificity MAPK phosphatase protein (DUSP1) by inhibiting protesomal activity: Implication in the pathogenesis and chemoprevention...
  Tomasi ML, Ramani K, Iglesias-Ara A, Li TWH, Bardag-Gorce F, Feo F, Pascale RM, Mato JM, Lu SC, Hepatology, 1/1/2009
• Evidence for an LKB1/AMPK/eNOS Cascade Regulated by HGF, S-Adenosylmethionine and NO in Hepatocyte Proliferation
  Vázquez M, Ariz U, Varela-Rey M, Embade N, Martínez N, Fernández D, Gómez L, Lamas S, Lu SC, Martínez-Chantar ML, and Mato JM, Hepatology, 1/1/2008
• Methionine adenosyltransferase genes as therapeutic targets for liver fibrosis
  Ramani K, Yang HP, Kuhlenkamp JF, Tomasi ML, Tsukamoto H and Lu SC, Hepatology, 1/1/2008
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