Sharlene Mary Day MD

PubMed

• Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy.
  Qinghong Li, Max Homilius, Erin Achilles, Laura K Massey, Victoria Convey
  ESC Heart Failure. 2025-04-01
• Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
  Joshua K Meisner, Aaron Renberg, Eric D Smith, Yao-Chang Tsan, Brynn Elder
  Circulation. 2025-03-18
• A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets.
  Alexandra Butters, Kate Thomson, Franki Harrington, Natasha Henden, Karen McGuire
  European Heart Journal. 2025-03-05

Journal Articles

• Exercise Hemodynamics in Hypertrophic Cardiomyopathy Identify Risk of Incident Heart Failure but Not Ventricular Arrhythmias or Sudden Cardiac Death☆  
  Sharlene M Day, Sara Saberi, International Journal of Cardiology
• Proinflammatory Effects of Interferon gamma in Mouse Adenovirus Type 1 Myocarditis  
  McCarthy M, Procario MC, Twisselmann N, Wilkinson JE, Archambeau AJ, Michele D, Day SM, Weinberg J, J Virology, 1/1/2015
• Prediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy  
  Captur G, Lopes LR, Mahun TJ, Patel V, Li C, Bassett P, Finocchiaro G, Ferreira VM, Esteban MT, Muthurangu V, Sherrid MV, Day SM, Canter CE, McKenna WJ, Seidman CE, Bl..., J Am Coll Cardiol: Cardiovascular Imagin, 11/1/2014
• Clinical Phenotype and Outcome of Hypertrophic Cardiomyopathy Associated with Sarcomere Thin Filament Gene Mutations  
  Coppini R, Ho C, Ashley E, Day SM, Ferrantini C, Girolami F, Tomberli B, Bardi S, Torricelli F, Cecchi F, Poggesi C, Tardiff J, Olivotto I, J Am Coll Cardiol, 1/1/2014
• Family Communication in a Population at Risk for Hypertrophic Cardiomyopathy  
  Batte B, Sheldon J, Arscott P, Huismann D, Salberg L, Day SM, Yashar B, J Genetic Counseling, 1/1/2014
• Sarcomere Mutation-Specific Expression Patterns in Human Hypertrophic Cardiomyopathy  
  Helms A, Davis FR, Coleman D, Bartolone S, Glazier A, Pagani F, Yob J, Sadayappan S, Pedersen E, Lyons R, Westfall MV, Jones R, Russell M, Day SM, Circulation: Cardiovascular Genetics, 1/1/2014
• Supercomputing for the Parallelization of Whole Genome Analysis  
  Puckelwartz MJ, Pesce L, Dewey F, Nelakuditi V, Dellefave-Castillo L, Golbus JR, Day SM, Cappola T, Ashley E, Dorn, G, Foster I, McNally EM, Bioinformatics, 1/1/2014
• Implanted Defibrillators in Young Hypertrophic Cardiomyopathy Patients: A Multicenter Study  
  Kamp AN, Von Bergen NH, Henrikson CA, Makhoul M, Saarel EV, OaPage MJ, Russell MW, Strieper M, Yu S, Dick M, Day SM, Bradley DJ, Pediatric Cardiology, 1/1/2013
• Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy  
  Reineck E, Rolston B, Bragg-Gresham J, Salberg L, Baty LC, Kumar S, Wheeler M, Ashley E, Saberi S, Day SM, Am J Cardiology, 1/1/2013
• Prevention of Sudden Cardiac Death with the Implantable Cardioverter-Defibrillator in Children and Adolescents with Hypertrophic Cardiomyopathy  
  Maron BJ, Spirito P, Ackerman MJ, Casey SA, Semsarian C, Estes NA Mark, Shannon KM, Ashley EA, Day SM, Pacileo G, Formisano F, Anastasakis A, Bos JM, Woo A, Autore C, ..., J Am Coll Cardiol, 1/1/2013
• Impaired Assembly and Post-translation Regulation of 26S Proteasome in Human End Stage Heart Failure  
  Day SM, Divald A, Wang P, Davis FR, Bartolone S, Jones R, Powell SR, Circ: Heart Failure, 1/1/2013
• The Ubiquitin Proteasome System in Human Cardiomyopathies and Heart Failure  
  Day SM, Am J Physiol: Heart Circ Physiol, 1/1/2013
• Agonist Activated PKCBetaII Translocation and Modulation of Cardiac Myocyte Contractile Function  
  Hwang H, Robinson D, Stevenson T, Rogers J, Kampert S, Sadayappan S, Day SM, Sivaramakrishnan S, Westfall MV, Scientific Reports, 1/1/2013
• Prevalence of aortic dilation in hypertrophic cardiomyopathy  
  Jain R, Helms A, Day SM, Booher AM, Am J Cardiovasc Dis, 1/1/2013
• Coronary Artery Thromboembolism as a Result of Left Ventricular Sump Aneurysm after Congenital Heart Surgery  
  Cotts T, Rogers FJ, Mueller G, Day SM, J Thor Cardiovasc Surgery, 1/1/2012
• A Redox-sensitive Fate Switch Controls Ion Channel Surface Density and Degradation  
  Svoboda LK, Reddie KG, Zhang L, Vesely ED, Williams ES, O'Connell RP, Day SM, Anumonwo JM, Carroll KS, Martens JR, Circ Research, 1/1/2012
• PKCBetaII Modulation of Myocyte Contractile Performance  
  Hwang H, Robinson DA, Stevenson TK, Wu HC, Kampert SE, Pagani FD, Dyke DB, Martin JL, Sadayappan S, Day SM, Westfall MV, J Mol Cell Cardiol, 1/1/2012
• MT-MMP-Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction  
  Koenig GC, Rowe RG, Day SM, Sabeh F, Atkinson JJ, Cooke KR, Weiss SJ, American Journal of Pathology, 1/1/2012
• Anxiety in Patients with ICDs and Arrhythmogenic Right Ventricular Cardiomyopathy (Invited editorial)  
  Day SM, Circulation: Cardiovascular Genetics, 1/1/2012
• A Role for H3K4 Methylation in Stabilizing Gene Expression Patterns and Physiological Functions in Adult Cardiomyocytes  
  Stein AB, Jones TA, Herron TJ, Patel SR, Day SM, Dressler GR, J Clin Invest, 1/1/2011
• Psychological Issues in Cardiovascular Genetic Testing  
  Aatre R, Day SM, Circulation: Cardiovascular Genetics, 1/1/2011
• Cardiac Risks Associated with Marathon Running  
  Day SM, Thompson PD, Sports Health: A Multidisciplinary Approach, 1/1/2011
• Use and Interpretation of Genetic Tests in Cardiovascular Genetics  
  Brown C, Day SM, Rehm HL, Baxter S, Heart, 1/1/2011
• Calcium-independent positive molecular inotropy for failing rabbit and human cardiac muscle by Alpha-myosin motor gene transfer  
  Herron TJ, Devaney E, Mundada L, Arden E, Day SM, Guerrero-Serna G, Turner I, Westfall MW, Metzger JM, FASEB Journal, 1/1/2010
• Cardiovascular Health - Part Two: Sports Participation in Athletes with Cardiovascular Conditions  
  Baman T, Gupta S, Day SM, Sports Health: A Multidisciplinary Approach, 1/1/2010
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Books/Book Chapters

• Psychiatry and Heart Disease: the Mind, Brain, and Heart. 
  Chapter: Hypertrophic Cardiomyopathy. 
  Page 106 - 115Kessler M, Saberi S, Day SM, Gay T, Baty L, Deneke EEditors: Riba M, Wulsin L, Rubenfire M.Wiley-Blackwell, John Wiley & Sons, Ltd., West Sussex, UK2012

Abstracts/Posters

• MYBPC3 Mutations Causative for Hypertrophic Cardiomyopathy Result in Locus-Dependent Alterations in Cellular Localization and Contractility.
  Helms A, Glazier A, Bartolone A, Tang V, Yob J, Westfall MV, Schnell S, Day SM, Circulation, 1/1/2014
• MYBPC3 Mutations Causative for Hypertrophic Cardiomyopathy Result in Altered Protein Folding, Sarcomere Localization and Contractility.
  Helms A, Glazier A, Bartolone S, Tang V, Yob J, Westfall M, Schnell S, Day, SM, Internal Medicine Research Day, University of Michigan, 1/1/2014
• Obstructive Sleep Apnea in Hypertrophic Cardiomyopathy: Comparing Exercise Tolerance, Cardiac Remodeling.
  Ebner B, Kumar S, Bragg- Gresham J, Farrehi P, Day SM, Circulation QCOR, 1/1/2014
• Truncating Mutations in Titin Associated with Left Ventricular Noncompaction in Two Unrelated Families.
  Arscott P, Day SM, Heart Rhythm, 1/1/2014
• Rare Variation in Sarcomeric Genes Accompanies MHY7 Hypertrophic Cardiomyopathy.
  Caliri SJ, Dewey FE, Grove M, Priest J, Shringarpure S, Pan C, Datta S, Puckelwartz M, Snyder M, Bustamante C, Day SM, McNally E, Cappola T, Dorn G, Ashley EA, Circ, 1/1/2013
• Selective Inhibition of the Immunoproteasome Attenuates Adverse Left Ventricular Remodeling, Improves Cardiac Function, and Prevents Heart Failure after Myocardial Inf...
  Day SM, Yob J, Davis FR, Wang P, Converso KL, Wang XJ, Powell SR, Circ, 1/1/2013
• Immunoproteasome Activation during Mouse Adenovirus Type 1 Myocarditis.
  McCarthy MK, Levine RE, Procario MC, Powell SR, Day SM, Weinberg JB, Circ, 1/1/2013
• Identification of the Quality Control Machinery Responsible for Mediating the Proteasomal Degradation of Mutant Myosin Binding Protein C in Hypertrophic Cardiomyopathy.
  Benson M, Glazier A, Day SM, Internal Medicine Research Day, University of Michigan, 1/1/2013
• Genotype-dependent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy.
  Helms A, Alvarado F, Yob J, Tang V, Bartolone S, Pagani F, Russell M, Valdivia H, Day SM, Keystone Symposia, 1/1/2013
• Prevention of Sudden Cardiac Death with the Implantable Cardioverter-Defibrillator in Children and Adolescents with Hypertrophic Cardiomyopathy: An International Multi...
  Maron B, Spirito P, Ackerman M, Casey S, Semsarian C, Estes M, Day SM, Formisano F, Bos JM, Maron M, Circ, 1/1/2012
• Decreased Expression of SERCA Relative to Phospholamban in Cardiac Tissue from Patients with Hypertrophic Cardiomyopathy.
  Douglas K, Predmore J, Bartolone S, Day SM, Internal Medicine Research Day, University of Michigan, 1/1/2012
• Utilizing Illness Representations to Improve Family Communication Within a Population At-Risk for Cardiomyopathy.
  Batte B, Sheldon J, Day SM, Arscott P, Huismann D, Yashar B, National Society for Genetic Counselors National Meeting, 1/1/2012
• Looking Past the Red Herring: A Case of Partial Anomalous Pulmonary Venous Return.
  Ebner B, Helms A, Day SM, Michigan American College of Physicians Annual Meeting, 1/1/2012
• Cardiac Sodium Channel (Scn5a) mRNA Splicing Abnormalities in Hypertrophic Cardiomyopathy.
  Gu L, Gao G, Kasturirangan S, Day SM, Dudley S, Circ, 1/1/2012
• Patients with Hypertrophic Cardiomyopathy are Less Physically Active than the General Population.
  Rolston B, Reineck E, Bragg-Gresham J, Salberg L, Saberi S, Baty LC, Wheeler M, Ashley E, Day SM, Circ, 1/1/2012
• Sarcomere Gene and Protein Expression Studies Suggest Mutation-Specific Disease Mechanisms in Human Hypertrophic Cardiomyopathy.
  Coleman DT, Davis FR, Pagani F, Predmore J, Bartolone S, Sadayappan S, Pedersen E, Lyons R, Jones R, Russell M, Day SM, Circ, 1/1/2011
• Disrupted Sarcomere Stoichiometry and Heterogeneous Expression of Mutant Sarcomere Proteins in Human Hypertrophic Cardiomyopathy.
  Coleman DT, Davis FR, Predmore J, Bartolone S, Pagani F, Sadayappan S, Allen D, Jones R, Russell M, Day SM, Keystone Symposia, 1/1/2011
• Sarcomere Mutant Protein Expression in Human Hypertrophic Cardiomyopathy: Implications for Mechanism and Phenotype Severity.
  Davis FR, Predmore JL, Pagani F, Sadayappan S, Allen D, Jones R, Day SM, Keystone Symposia, 3/1/2010
• Activation of the Ubiquitin Proteasome System After Myocardial Infarction.
  Davis FR, Predmore J, Wang P, Li J, Su H, Converso KL, Allen D, Jones R, Powell SR, Wang XJ, Day SM, Circ, 1/1/2010
• Sarcomere Mutant Protein Expression in Human Hypertrophic Cardiomyopathy: Implications for Mechanism and Phenotype Severity.
  Davis FR, Predmore J, Pagani F, Sadayappan S, Allen D, Jones R, Day SM, Internal Medicine Research Day, University of Michigan, 1/1/2010
• Exercise in Hypertrophic Cardiomyopathy Patients: Perceptions and Practices.
  Reineck E, Baty L, Rolston B, Saberi S, Salberg L, Richardson C, Kolenic G, Sen A, Day SM, Internal Medicine Research Day, University of Michigan, 1/1/2010
• Differential Proteomics Analysis in Ischemic Heart Disease.
  Kim EH, Galchev VI, Day SM, Pagani F, Kim JY, Kim Y, Misek DE, Westfall MV, 58th American Society of Mass Spectroscopy Conference, 1/1/2010
• Dominant Effect of Histidine Modified Troponin to Normalize SR Ca2+ Load and Rescue Ischemia/Reperfusion Deficits in Phospholamban Deficient Hearts.
  Martindale JJ, Herron TJ, Day SM, Palpant NJ, Metzger JM, Keystone Symposia, 4/1/2009
• Histidine modified troponin I molecular switch causes reduced sarcoplasmic reticulum Ca2+ load: implications for myocardial performance during ischemia-reperfusion.
  Day SM, Herron T, Predmore J, Converso KL, Westfall MV, Metzger JM, Keystone Symposia, 1/1/2007
• Histidine substituted cardiac troponin I (A164H) improves survival and protects cardiac contractility during acute hypoxia in the aged murine heart.
  Palpant NJ, Day SM, Converso KL, Metzger JM, Circ, 1/1/2007
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Lectures

• How I Have a Shared Decision Making Discussion 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
• Hypertrophic Cardiomyopathy: More Than Just Myofibrillar Disarray 
  2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
• Dysregulation of Proteostasis in the Cardiomyopathic Heart. 
  1/1/2014
• Hypertrophic Cardiomyopathy: Diagnosis, Management and Genetics. 
  1/1/2014
• Hypertrophic cardiomyopathy today: Diagnosis and Genetic Testing, Current Therapies. 
  Big Sky, MT - 1/1/2014
• Molecular Aspects and Genetics of Hypertrophic Cardiomyopathy. 
  1/1/2014
• How should we screen athletes? 
  Big Sky, MT - 1/1/2014
• How Should We Evaluate Suspected Hypertrophic Cardiomyopathy. 
  Ann Arbor, MI - 1/1/2014
• Overwhelmed, Disassembled and Maladapted: Ubiquitin Proteasome Dysfunction in Cardiomyopathies. 
  Morgantown, WV - 1/1/2014
• Controversies in Athlete Screening. 
  1/1/2014
• Genetics in your Practice: The Revolution is Upon Us. 
  1/1/2014
• Hypertrophic Cardiomyopathy as a Protein Folding Disease. 
  Burlington, VT - 1/1/2014
• Hypertrophic Cardiomyopathy Associated with Mutations in Myosin Binding Protein C: Haploinsufficiency or Poison Peptide? 
  Burlington, VT - 1/1/2014
• Exercise in HCM: How much and how hard?. 
  Chicago, IL - 1/1/2014
• Potential Approaches to Better Understand and Treat Hypertrophic Cardiomyopathy. 
  1/1/2013
• Exercise Training in Patients with Hypertrophic Cardiomyopathy. 
  San Francisco, CA - 1/1/2013
• Risk of Sports-Related Sudden Cardiac Death in Patients with Hypertrophic Cardiomyopathy. 
  Denver, CO - 1/1/2013
• Cardiovascular Genetics. 
  Mackinac Island, MI - 1/1/2013
• The Vagaries of LVH. 
  Mackinac Island, MI - 1/1/2013
• Case Studies of the Cardiomyopathies: HCM, Noncompaction. 
  Mackinac Island, MI - 1/1/2013
• Genetic testing: Interpretation and Counseling. 
  Dallas, TX - 1/1/2013
• Insights into Hypertrophic Cardiomyopathy Using Genetics, Proteomics, and Human Stem Cell-Derived Cardiac Myocytes. 
  1/1/2013
• Sudden Cardiac Death in the Young. 
  1/1/2013
• Epidemiology of Sudden Cardiac Arrest and Inherited Cardiomyopathies. 
  1/1/2012
• How to Approach Genetic Testing for Sudden Cardiac Death/ When and How to Organize DNA Banking for a Family. 
  Boston, MA - 1/1/2012
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