ShahinRafiiMD

Hematologic Oncology, Myeloproliferative Disorder Hematology-Oncology, Sickle Cell & Other Anemias

Arthur B Belfer Professor of Genetic Medicine, Division Chief of Regenerative Medicine, Department of Medicine, Director Ansary Stem Cell Institute; Professor of Reproductive Medicine, Weill Cornell Medicine, New York, NY, Founder: Angiocrine Bioscience, San Diego, CA

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Office
1300 York Ave
Weill Cornell Medical College, Room A-863
New York, NY 10065
Phone+1 917-287-3801

Fax+1 212-746-8481

Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Hematology and Medical Oncology, 1989 - 1992
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 1986 - 1988
Albert Einstein College of MedicineClass of 1986

Certifications & Licensure

NY State Medical License 1987 - 2015

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2001
Investigator Howard Hughes Medical Institute

Publications & Presentations

PubMed

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature.
Charlie J Childs, Holly M Poling, Kevin Chen, Yu-Hwai Tsai, Angeline Wu
Cell Stem Cell. 2025-03-04
Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing.
Tomer Itkin, Sean Houghton, Ryan Schreiner, Yang Lin, Chaitanya R Badwe
Nature Immunology. 2025-03-01
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes.
Rebecca Craig-Schapiro, Ge Li, Kevin Chen, Jesus M Gomez-Salinero, Ryan Nachman
Nature Communications. 2025-02-06

Journal Articles

Catheter-Directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis
Kyungmouk Steve Lee, Shahin Rafii, David C. Madoff, David Li, Radiology

Abstracts/Posters

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo
Shahin Rafii, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo
Shahin Rafii, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells
Shahin Rafii, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

Reprogrammed Adult Human Endothelium into Hematopoietic Stem Cells Yields Functional T Cells In Vivo
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

‘Flipping’ Switch Boosts Stem Cell Numbers for TherapiesMarch 12th, 2025
FLIpping the Switch: Boosting Stem Cell Numbers for TherapiesMarch 10th, 2025
Revolutionizing Type 1 Diabetes: Breakthrough in Islet Transplantation with Blood Vessel Cells Offers New HopeFebruary 22nd, 2025
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Grant Support

Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Molecular Determinants of liver sinusoidal endothelial cells for hepatic regenerationWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progressionWEILL MEDICAL COLL OF CORNELL UNIV2023–2028
Adaptable tissue-specific endothelial cells for organ regenerationWEILL MEDICAL COLL OF CORNELL UNIV2020–2027
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Derivation of pancreatic islet-like organoids from human gastric stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyWEILL MEDICAL COLL OF CORNELL UNIV2022–2026
Negative feedback regulation of growth factor signaling in adult spermatogonial stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2026
Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2023–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Investigating a master regulator of large intestine stem cellsWEILL MEDICAL COLL OF CORNELL UNIV2021–2025
Endothelial cell transplantation for multi-organ repair to counter radiation injuryWEILL MEDICAL COLL OF CORNELL UNIV2018–2025
Endothelial cell transplantation for multi-organ repair to counter radiation injuryWEILL MEDICAL COLL OF CORNELL UNIV2018–2025
Identification Of Vascular Inductive Signals In Liver RegenerationNational Institute Of Diabetes And Digestive And Kidney Diseases2012
Contribution Of The Vascular Niche To The Hematopoietic Reconstitution.National Heart, Lung, And Blood Institute2009–2011
Contribution Of Cxcr4+Vegfr1+ Hemangiogenic Progenitors To Lung RevascularizationNational Heart, Lung, And Blood Institute2007–2011
Dynamic Regulation Of The Epigenome During Hematopoietic DifferntiationNational Heart, Lung, And Blood Institute2009–2010
Reconstitution Of Thrombopoiesis By Angiogenic FactorsNational Institute Of Allergy And Infectious Diseases2009
Therapy Of Thrombocytopenic Disorders By ChemokinesNational Heart, Lung, And Blood Institute2006–2007
Vascular Heterogeneity Determination By Marrow Progenit*National Heart, Lung, And Blood Institute2004–2006
Regulation Of Hemangiogenesis By Adenoviral E4 GenesNational Heart, Lung, And Blood Institute2002–2006
Postnatal Angiogenesis And Marrow Derived Precursor CellNational Heart, Lung, And Blood Institute2001–2005
Vascular Heterogeneity Determination /Marrow ProgenitorsNational Heart, Lung, And Blood Institute2003
Bone Marrow Totipotent Stem Cells &Adenoviral VectorsNational Heart, Lung, And Blood Institute2000–2002
Chemokine Receptors And ITP And HIV ThrombocytopeNational Heart, Lung, And Blood Institute1998–2002
Endothelium Regulation Of Stem Cell Homing/ProliferationNational Heart, Lung, And Blood Institute1997–2000
Regulation Of Thrombopoiesis By Bone Marrow EndotheliumNational Heart, Lung, And Blood Institute1994–1996