ScottBrianSnapperMDPhD

Inflammatory Bowel Disease

Chief, Division of GI, Hepatology, & Nutrition; Wolpow Family Chair in IBD Treatment and Research, Boston Children's Hospital; Egan Family Professor of Pediatrics in the Field of Transitional Medicine and Professor of Medicine, Harvard Medical School

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Office
300 Longwood Ave
Boston, MA 02115
Phone+1 617-919-4973

Education & Training

Massachusetts General HospitalFellowship, Gastroenterology, 1993 - 1997
Brigham and Women's HospitalResidency, Internal Medicine, 1990 - 1993
Albert Einstein College of MedicineClass of 1990

Certifications & Licensure

MA State Medical License 1992 - 2026
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2007

Clinical Trials

Oral OKT3 for the Treatment of Active Ulcerative Colitis Start of enrollment: 2011 Apr 07
Completed
Phase 1, Phase 2
Low Dose IL-2 for Ulcerative Colitis Start of enrollment: 2015 Feb 01
Completed
Phase 1
Low Dose IL-2 for the Treatment of Crohn's Disease Start of enrollment: 2021 Mar 11
Recruiting
Phase 1, Phase 2

Publications & Presentations

PubMed

Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort.
Sek Won Kong, In-Hee Lee, Lauren V Collen, Michael Field, Arjun K Manrai
NPJ Genomic Medicine. 2025-02-28
Human colon stem cells are the principal epithelial responders to bacterial antigens.
Maaike H de Vries, Claartje A Meddens, Hemme J Hijma, Anne-Claire Berrens, Suze A Jansen
Biorxiv. 2025-02-08
Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease.
Sun-Ho Lee, Maham Bushra, Lanhui Qiu, Anne M Griffiths, Williams Turpin
Gastroenterology. 2025-02-01

Journal Articles

Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte–Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease
Lee A Denson, Bruce J Aronow, Barbara S Kirschner, Joshua D Noe, Melvin B Heyman, Ramnik J Xavier, Robert N Baldassano, Jeffrey S Hyams, Subra Kugathasan, Wallace V Cr..., Inflammatory Bowel Diseases
Mucosal Gene Expression in Pediatric and Adult Patients with Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis
Athos Bousvaros, Scott B Snapper, Jodie Ouahed, Inflammatory Bowel Diseases
The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies
Scott Snapper, MD, Journal of Clinical Immunology

Other

Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers
Scott Snapper, MD, Frontiers in Neurology
https://www.doximity.com/articles/50e86467-0edf-46ac-a42c-04b98941286b
UpToDate, Wolters Kluwer Health - 2011-04-29
Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers
Scott Snapper, MD, Frontiers in Neurology
https://www.doximity.com/articles/50e86467-0edf-46ac-a42c-04b98941286b
UpToDate, Wolters Kluwer Health - 2012-01-09

Authored Content

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and ThrombosisJune 2017

Press Mentions

Health Rounds: Roche/BioNTech Experimental Vaccine Shows Early Promise in Pancreatic CancerMarch 5th, 2025
A Surprising Link Between Epstein-Barr Virus & Crohn's Is RevealedMarch 5th, 2025
Epstein-Barr Virus Infection Predisposes People to Develop Crohn's DiseaseMarch 2nd, 2025
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Grant Support

Training in Pediatric Gastroenterology, Hepatology, and NutritionBOSTON CHILDREN'S HOSPITAL1983–2029
Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2011–2012
Deciphering The Role Of WASP Family Proteins In T Cell FunctionNational Heart, Lung, And Blood Institute2010–2011
Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2009–2010
Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2008
Cytoskeletal-Pathogen Interactions In Shigella InfectionNational Institute Of Allergy And Infectious Diseases2003–2007
The Pathogenesis Of Colitis In A Novel TH2 Model Of IBDNational Institute Of Allergy And Infectious Diseases2002–2004
Molecular And Genetic Analysis Of A Blood Cell DiseaseNational Heart, Lung, And Blood Institute1997–2001