Scott Brian Snapper MD PhD
Inflammatory Bowel Disease
Chief, Division of GI, Hepatology, & Nutrition; Wolpow Family Chair in IBD Treatment and Research, Boston Children's Hospital; Egan Family Professor of Pediatrics in the Field of Transitional Medicine and Professor of Medicine, Harvard Medical School
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300 Longwood AveBoston, MA 02115
Phone+1 617-919-4973
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Education & Training
Mass General Brigham/Massachusetts General HospitalFellowship, Gastroenterology, 1993 - 1997
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1990 - 1993
Albert Einstein College of MedicineClass of 1990
Certifications & Licensure
MA State Medical License 1992 - 2026
American Board of Internal Medicine Gastroenterology
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 2007
Clinical Trials
- Oral OKT3 for the Treatment of Active Ulcerative Colitis Start of enrollment: 2011 Apr 07
- Low Dose IL-2 for Ulcerative Colitis Start of enrollment: 2015 Feb 01
- Low Dose IL-2 for the Treatment of Crohn's Disease Start of enrollment: 2021 Mar 11
Publications & Presentations
PubMed
- Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort.Sek Won Kong, In-Hee Lee, Lauren V Collen, Michael Field, Arjun K Manrai
NPJ Genomic Medicine. 2025-02-28 - Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development.Anubhab Nandy, Francesca Petralia, Chad Porter, Stephen Elledge,
Gastroenterology. 2025-02-24 - Human colon stem cells are the principal epithelial responders to bacterial antigens.Maaike H de Vries, Claartje A Meddens, Hemme J Hijma, Anne-Claire Berrens, Suze A Jansen
Biorxiv. 2025-02-08
Journal Articles
- Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte–Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s DiseaseLee A Denson, Bruce J Aronow, Barbara S Kirschner, Joshua D Noe, Melvin B Heyman, Ramnik J Xavier, Robert N Baldassano, Jeffrey S Hyams, Subra Kugathasan, Wallace V Cr..., Inflammatory Bowel Diseases
- Mucosal Gene Expression in Pediatric and Adult Patients with Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic AnalysisAthos Bousvaros, Scott B Snapper, Jodie Ouahed, Inflammatory Bowel Diseases
- The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary ImmunodeficienciesScott Snapper, MD, Journal of Clinical Immunology
Other
- Increased Risk for Malignancies in 131 Affected CTLA4 Mutation CarriersScott Snapper, MD, Frontiers in Neurology
https://www.doximity.com/articles/50e86467-0edf-46ac-a42c-04b98941286b
UpToDate, Wolters Kluwer Health - 2011-04-29 - Increased Risk for Malignancies in 131 Affected CTLA4 Mutation CarriersScott Snapper, MD, Frontiers in Neurology
https://www.doximity.com/articles/50e86467-0edf-46ac-a42c-04b98941286b
UpToDate, Wolters Kluwer Health - 2012-01-09
Authored Content
- CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and ThrombosisJune 2017
Press Mentions
Health Rounds: Roche/BioNTech Experimental Vaccine Shows Early Promise in Pancreatic CancerMarch 5th, 2025- A Surprising Link Between Epstein-Barr Virus & Crohn's Is RevealedMarch 5th, 2025
- Epstein-Barr Virus Infection Predisposes People to Develop Crohn's DiseaseMarch 2nd, 2025
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Grant Support
- Training in Pediatric Gastroenterology, Hepatology, and NutritionBOSTON CHILDREN'S HOSPITAL1983–2029
- Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
- Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
- Type III interferon Control of Mucosal ImmunityBOSTON CHILDREN'S HOSPITAL2017–2026
- Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs DiseaseBOSTON CHILDREN'S HOSPITAL2020–2025
- Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2011–2012
- Deciphering The Role Of WASP Family Proteins In T Cell FunctionNational Heart, Lung, And Blood Institute2010–2011
- Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2009–2010
- Exploring Regulatory T Cell Dysfunction In A Murine Model Of ColitisNational Institute Of Allergy And Infectious Diseases2008
- Cytoskeletal-Pathogen Interactions In Shigella InfectionNational Institute Of Allergy And Infectious Diseases2003–2007
- The Pathogenesis Of Colitis In A Novel TH2 Model Of IBDNational Institute Of Allergy And Infectious Diseases2002–2004
- Molecular And Genetic Analysis Of A Blood Cell DiseaseNational Heart, Lung, And Blood Institute1997–2001
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