SaulJosephKarpenMDPh.D.

Pediatric Gastroenterology • Atlanta, GA

Pediatric Hepatology and Liver Transplantation

Professor, Pediatrics, Emory Univ Sch of Med

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Office
2015 Uppergate Dr Ne
Suite 208b
Atlanta, GA 30322
Phone+1 404-785-1832

Fax+1 832-825-4131

Education & Training

Yale-New Haven Medical CenterFellowship, Pediatric Gastroenterology, 1991 - 1994
Yale-New Haven Medical CenterResidency, Pediatrics, 1989 - 1991
Icahn School of Medicine at Mount SinaiClass of 1989

Certifications & Licensure

VA State Medical License 2023 - 2026
GA State Medical License 2011 - 2024
TX State Medical License 2000 - 2012
CT State Medical License 1991 - 2000
American Board of Pediatrics Pediatric Gastroenterology
American Board of Pediatrics Pediatric Transplant Hepatology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com
Top MD Consumers Checkbook

Clinical Trials

A Prospective Database of Infants With Cholestasis Start of enrollment: 2004 Apr 21
Recruiting
Biliary Atresia Study in Infants and Children Start of enrollment: 2006 May 16
Recruiting
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) Start of enrollment: 2007 Nov 30
Suspended
NAFLD Pediatric Database 2 Start of enrollment: 2010 Jan 20
Completed
Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Start of enrollment: 2010 Oct 01
Completed
Phase 1
Longitudinal Study of Mitochondrial Hepatopathies Start of enrollment: 2010 Aug 18
Suspended
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome Start of enrollment: 2014 Nov 24
Completed
Phase 2
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Publications & Presentations

PubMed

Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response inknockout mice with a humanized bile acid composition.
Caroline Klindt, Jennifer K Truong, Ashley L Bennett, Kimberly J Pachura, Diran Herebian
American Journal of Physiology. Gastrointestinal and Liver Physiology. 2024-12-01
2 citations
Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.
Sindhu Pandurangi, Reena Mourya, Shreya Nalluri, Lin Fei, Shun Dong
Hepatology. 2024-07-01
1 citations
BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.
Dominick J Hellen, Meredith E Fay, David H Lee, Caroline Klindt-Morgan, Ashley Bennett
American Journal of Physiology. Gastrointestinal and Liver Physiology. 2024-07-01

Journal Articles

A Randomized, Controlled, Crossover Pilot Study of Losartan for Pediatric Nonalcoholic Fatty Liver Disease
Saul Karpen, Jennifer K Frediani, Miriam B Vos, BioMed Central

Press Mentions

Mystery Hepatitis Cases in Kids Linked to Unexpected Viral SuspectJuly 25th, 2022
Link Between Pediatric Hepatitis and Adenovirus 41 Still UnclearJuly 15th, 2022
Adenovirus Common in Kids with Unexplained Acute Hepatitis, Studies ShowJuly 14th, 2022
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Grant Support

The Childhood Liver Disease Research And Education Network (CHILDREN)National Institute Of Diabetes And Digestive And Kidney Diseases2011
Cholestatic Liver Disease Consortium (Clic): Longitudinal Study Of Genetic CauseNational Center For Research Resources2010–2011
The Childhood Liver Disease Research And Education Network (CHILDREN)National Institute Of Diabetes And Digestive And Kidney Diseases2009–2011
A Randomized, Double-Blinded, Placebo-Controlled Trial Of Corticosteroid TherapyNational Center For Research Resources2009–2011
Barc: Billiary Atresia Study In Infants And Children (BASIC)National Center For Research Resources2008–2011
Biliary Atresia Research Consortium (Barc): A Prospective Database Of InfantNational Center For Research Resources2007–2011
Molecular Regulation Of Hepatic TransportersNational Institute Of Diabetes And Digestive And Kidney Diseases2010
Genome-Wide Analysis Of Rxr-Alpha Binding In Mouse Liver Chromatin With Chip-SeqNational Institute Of Diabetes And Digestive And Kidney Diseases2010
Genome-Wide Analysis Of Rxr-Alpha Binding In Mouse Liver Chromatin With Chip-SeqNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
Molecular Regulation Of Hepatic TransportersNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2010
Cholestatic Liver Disease Consortium Longitudinal StudyNational Center For Research Resources2009
Biliary Atresia Clinical Research ConsortiumNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2008
Molecular Regulation Of Hepatic TransportersNational Institute Of Diabetes And Digestive And Kidney Diseases1999
Transcriptional Regulation Of Bile Acid TransportNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1998