SarahESartainMD

Pediatric Hematology & Oncology • Houston, TX

Pediatric Coagulation Disorder Hematology

Associate Professor of Pediatrics, Texas Children's Hospital, Baylor College of Medicine Director, Hemostasis and Thrombosis Program

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Office
6701 Fannin St
Suite 1580
Houston, TX 77030
Phone+1 832-822-1309

Summary

I am a physician-scientist with a growing knowledge base in endothelial dysfunction and a particular interest in microvascular thrombosis. As an Assistant Professor at Baylor College of Medicine (BCM), I am dedicated to delineating disease mechanisms and discovering new treatments for thrombotic microangiopathy and other thromboinflammatory disorders in a basic science laboratory. As a pediatric hematologist at Texas Children’s Hospital, I treat patients with bleeding and clotting disorders and focus on those involving catastrophic microvascular thrombosis caused by inflammation and alternative complement pathway overactivation. The alternative complement pathway is one of three pathways within the innate immune system responsible for ridding the body of unwanted or foreign invaders, but overactivation may lead to human disease. My patients’ experiences have inspired my specific laboratory investigations, and because I know firsthand how breakthroughs in this area would improve patient morbidity and mortality, I want to pinpoint mechanisms of alternative complement pathway activation, endothelial injury, and microvascular thrombosis in thromboinflammation. I have gained technical fluency in endothelial cell functional studies in the laboratory, and with these competencies, I have elucidated mechanisms for cytokine-mediated alternative complement pathway activation by endothelial cells, detected differences in complement regulation amongst varying types of microvascular endothelial cells, discovered that patients with transplantation-associated thrombotic microangiopathy have elevated plasma levels of the alternative complement pathway activation product Ba, and linked von Willebrand factor (VWF) to the activation of the alternative complement pathway in thromboinflammation in vivo.

Education & Training

Baylor College of MedicineFellowship, Pediatric Hematology/Oncology, 2012 - 2015
Boston Children’s Hospital/Boston Medical CenterResidency, Pediatrics, 2009 - 2012
Tulane University School of MedicineClass of 2009

Certifications & Licensure

TX State Medical License 2012 - 2026
MA State Medical License 2009 - 2012
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Best Poster Presentation, “Von Willebrand Factor Activates the Alternative Complement Pathway in vivo in Murine Thromboinflammation.” Texas Children’s Cancer and Hematology Centers 17th Annual Research Symposium, 2021
Best Oral Presentation, “Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C.” Texas Children’s Cancer and Hematology Centers 17th Annual Research Symposium, 2021
Fellows’ Annual Award for Most Outstanding Foundations in Pediatric Hematology/Oncology Lecture, “Thrombosis.” Texas Children’s Cancer and Hematology Center, 2021
Faculty Education Award, established to recognize a significant contribution to the educational objectives of the Texas Children’s Cancer and Hematology Centers by members of the faculty Texas Children’s Cancer and Hematology Centers, 2021
Power of Professionalism (POP) Award Baylor College of Medicine, 2021
Norton Rose Fulbright Faculty Excellence Award in Teaching and Evaluation Baylor College of Medicine, 2021
Young Investigator Travel Award Thrombosis and Hemostasis Summit of North America, 2018
Travel Award Hemostasis and Thrombosis Research Society, 2017
Trainee Travel Award Thrombosis and Hemostasis Summit of North America, 2016
Abstract Achievement Award American Society of Hematology, 2014
Division of Pediatric Hematology and Oncology Tumor Board Award Texas Children's Hospital, 2013
Victor Tesoriero/Monica Oglesby Award for Outstanding Contribution to Community Pediatrics Boston Medical Center, 2012
Merck Manual Award for Academic Excellence Tulane University School of Medicine, 2009
Alpha Omega Alpha Honor Society 2008
Department of Medicine Award for Outstanding Performance Tulane University School of Medicine, 2008
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Publications & Presentations

PubMed

Transplant-associated TMA: the conundrum of diagnosis and treatment.
Ang Li, Sarah E Sartain
Hematology. American Society of Hematology. Education Program. 2024-12-06
Management of neonatal and infant aortic thrombosis: A single-center case series.
Ajibike Lapite, Mohammad H Abu-Arja, Hyojeong Han, YoungNa Lee-Kim, Sarah E Sartain
Pediatric Blood & Cancer. 2024-11-01
Hospital acquired venous thromboembolism in children with sickle cell disease.
Shreya Agarwal, Kayla L Foster, Shaniqua J Anum, Mary C Shapiro, HyoJeong Han
Pediatric Hematology and Oncology. 2024-10-01

Journal Articles

Downregulation of thrombomodulin-thrombin-activated protein C pathway as a mechanism for SARS-CoV-2 induced endotheliopathy and microvascular thrombosis.
Agarwal S, Cohen CT, Zobeck M, Jacobi PM, Sartain SE., Thrombosis Update, 8/8/2022

Books/Book Chapters

Management of Bleeding Patients
Chapter: Bleeding Associated with Thrombocytopenia
Sartain S, Despotovic JSpringer International PublishingEdition 2,2021
Hematology in the Adolescent Female
Chapter: Thrombotic Microangiopathy
Cohen C, Singleton T, Sartain SEditors: Srivaths, L.Springer NatureEdition 1,2020
Handbook of Benign Hematology
Chapter: Platelet Disorders
Han H, Sartain S.Demos Medical, An Imprint of Springer PublishingEdition 1,2020
Rudolph’s Pediatrics
Chapter: Disorders of Platelets
Sartain S, Despotovic JEditors: Kline MW.McGraw-HillEdition 23,2018
Immune Hematology: Diagnosis and Management of Autoimmune Cytopenias
Chapter: Pathophysiology of Thrombotic Thrombocytopenic Purpura
Sartain SEditors: Despotovic J.SpringerEdition 1,2018
Management of Bleeding Patients
Chapter: Bleeding Associated with Thrombocytopenia
Sartain S, Despotovic JEditors: Teruya, J..Springer International PublishingEdition 1,2016
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Abstracts/Posters

PLASMIC-KID score for pediatric thrombotic thrombocytopenic purpura (TTP)
Rairikar M, Sartain SE, Solomon C, Hui SK, Srivaths P, Hemostasis and Thrombosis Research Society Scientific Symposium, Orlando, FL, 3/12/2023
Complement Activation Is Associated with Endothelial Damage in Hematopoietic Stem Cell Transplant Associated-Thrombotic Microangiopathy
Jacobi P, Coffiel R, Chang C, Kim S, Sartain SE, American Society of Hematology Annual Meeting, New Orleans, LA, 12/11/2022
Exploring the risk factors for venous thromboembolism in children with sickle cell disease
Agarwal S, Foster K, Johnson S, Shapiro M, Han HJ, Scherer ME, Airewele G, Sartain SE, Thrombosis and Hemostasis Summit of North America, Chicago, IL, 8/17/2022
Bleeding outcomes and management of supratherapeutic episodes secondary to warfarin in pediatrics: a single center 11-year experience
Cohen CT, Powers J, Zobek MC, Han H, Sartain SE, Thrombosis and Hemostasis Summit of North America, Chicago, IL, 8/16/2022
Adolescent Thrombotic Thrombocytopenic Purpura is a Serious Disorder Requiring Intense Therapies with Significant Relapse Rate – Analysis of the Pediatric Health Infor...
Cohen CT, Zobeck M, Olmstead T, Sartain SE, Raffini L, Srivaths L, International Society on Thrombosis and Hemostasis Annual Meeting, London, England, 7/10/2022
Neonatal occlusive abdominal aortic thrombosis: a case series of two neonates
Abu Arja M, Sartain SE, Cohen CT, American Society of Pediatric Hematology and Oncology, Pittsburgh, PA, 5/5/2022
Provoked deep vein thrombosis and saddle pulmonary embolism in a pediatric patient with multiple genetic risk factors for venous thromboembolism
Hofstee K, Camacho P, Sartain SE, Shapiro MC, American Society of Pediatric Hematology and Oncology, 5/5/2022
Sars-CoV-2 Induced Endotheliopathy and the Impact on Clinical Outcomes in Critically Ill Pediatric Patients
Agarwal S, Zobeck M, Cohen C, Sartain S, Poster Abstract presented at the 63rd American Society of Hematology Annual Meeting and Exposition, Atlanta, GA, 12/13/2021
Rare variant genetic association study for transplant-associated thrombotic microangiopathy (TA-TMA) via whole exome sequencing
Zhang, Z, Wu Q, Amos CI, Liu Y, Wei H, Cheng C, Tsavachidis S, Bryce A, Sartain S, Martinez C, Afshar-Kharghan V, Dong J, Bhatraju P, Martin PJ, Lee SJ, Makar RS, Bend..., Oral Abstract presented at the 63rd American Society of Hematology Annual Meeting and Exposition, Atlanta, GA, 12/13/2021
Pulmonary Complications after Bone Marrow Transplantation in the Pediatric Population: A Clinicopathologic Study
Cortes-Santiago N, Pogoriler J, Patel K, Sartain SE, Silva-Carmona M, Bhar S, Deutsch G, Oral virtual platform presentation presented at the Pediatric Pathology Fall Meeting, Virtual, 10/8/2021
Von Willebrand Factor Contributes to Alternative Complement Pathway Activation, Microangiopathy, and Renal Dysfunction in Murine Thromboinflammation
Jacobi PM, Sartain SE, Oral abstract presented at the 2021 ISTH Virtual Congress, Philadelphia, PA, 7/21/2021
Utility of Antithrombotic Therapy in Pediatric Portal Vein Thrombosis after Endovascular Procedure
Na KY, Diaz R, Hernandez JA, Justino H, Zobeck M, Cohen CT, Sartain SE, Lee-Kim Y, Poster session presented at the 2021 ISTH Virtual Congress, Philadelphia, PA, 7/18/2021
D-dimer elevation at time of admission is associated with need of ventilator support among pediatric patients with COVID-19 infection
Wilken N, Kotousov V, Bruzdoski K, Sartain SE, Krum K, Hensch L, Teruya J, and Hui, SK, Poster session presented at the 2021 ISTH Virtual Congress, Philadelphia, PA, 7/17/2021
Downregulation of Thrombomodulin-Thrombin-Activated Protein C pathway as a mechanism for SARS-CoV-2 induced endotheliopathy and microvascular thrombosis
Agarwal S, Jacobi PM, Sartain SE, International Society on Thrombosis and Hemostasis Annual Meeting, London, England, 7/12/2021
Von Willebrand Factor Activates the Alternative Complement Pathway in vivo in Murine Thromboinflammation
Jacobi PM, Sartain SE, Poster session presented at the TXCH 17th Annual Research Symposium, Houston, TX, 4/16/2021
Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C
8. Sartain SE, Cohen CT, Diaz R, Srivaths L, Oral abstract presented at the TXCH 17th Annual Research Symposium, Houston, TX, 4/16/2021
Tumor Thrombus – a Single Center Experience with Tumor Thrombus and Role of Anticoagulation.
Agarwal S, Diaz R, Smith V, Foster J, Naik B, Scheurer M, Sartain S, American Society of Hematology Annual Meeting, Chicago, IL (Virtual), 12/7/2020
Catheter Directed Thrombolysis for Pediatric Lower Extremity and Inferior Vena Cava Thrombosis
Cohen CT, Sartain SE, Sagni-Haghpeykar H, Kukreja KU, Desai SB, American Society of Hematology Annual Meeting, Chicago, IL (Virtual), 12/6/2020
von Willebrand Factor Activates the Alternative Complement Pathway In Vivo in a Mouse Model of Complement Thrombotic Microangiopathy
Jacobi PM, Sartain SE, American Society of Hematology Annual Meeting, Chicago, IL (Virtual), 12/5/2020
Pulmonary Hemorrhage as a complication of transplantation-associated thrombotic microangiopathy: an insitutional experience
Sartain S, Shubert S, Martinez C., Thrombosis and Hemostasis Summit of North America, Chicago, 4/23/2020
Patients with transplantation-associated thrombotic microangiopathy demonstrate elevated lvels of Ba Protein that correlate with renal function.
Sartain S, Shubert S, Wu M, Tao W, Martinez C, Transplantation and Cellular Therapy Meetings of ASBMT and CIBMTR, Houston, TX, 2/20/2019
Patients with transplantation-associated thrombotic microangiopathy demonstrate elevated levels of Ba protein
Sartain S, Shubert S, Wu M, Wang T, Martinez C, The 27th International Complement Workshop, Santa Fe, NM, 9/18/2018
Efficient alternative complement pathway regulation decreases C3a and C5a generation in human cerebral vs. renal microvascular endothelial cells
Sartain SE, Turner NA, Moake JL, Thrombosis and Hemostasis Summit of North America, 3/8/2018
Therapeutic plasma exchange does not prevent chronic kidney disease in hematopoietic stem cell transplantation-associated thrombotic microangiopathy: an inistutional e...
Sartain S, Shubert S, Wu M, Srivaths P, Teruya J, Krance R, Martinez C, American Society for Bone Marrow Transplant BMT Tandem Meetings, Salt Lake City, UT, 2/18/2018
Heat-inactivated factor B suppresses alternative complement pathway activation on ultra-large VWF strings
Turner NA, Sartain S, Moake J, HTRS Scientific Symosium, Scottsdale, AZ, 4/7/2017
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