Sarah E. Leary MD

Clinical Trials

• Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System Start of enrollment: 2009 Feb 25

  Completed

  Phase 1

• Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) Start of enrollment: 2011 Sep 01

  Terminated

  Phase 2

• Trebananib in Treating Younger Patients With Relapsed or Refractory Solid Tumors, Including Central Nervous System Tumors Start of enrollment: 2012 Feb 01

  Completed

  Phase 1

• Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27

  COMPLETED

  PHASE2

• A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB) Start of enrollment: 2013 May 06

  Completed

  Phase 2

• PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Start of enrollment: 2012 Dec 13

  COMPLETED

  PHASE2

• Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas Start of enrollment: 2014 Apr 29

  ACTIVE_NOT_RECRUITING

  EARLY_PHASE1

• Selecting Patient-Specific Biologically Targeted Therapy for Pediatric Patients With Refractory Or Recurrent Brain Tumors Start of enrollment: 2013 Dec 01

  Unknown status

  Not Applicable

• Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma Start of enrollment: 2017 Apr 04

  Terminated

  Early Phase 1

• Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Start of enrollment: 2014 Dec 08

  Terminated

  Phase 1

• Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer Start of enrollment: 2017 Nov 29

  ACTIVE_NOT_RECRUITING

  PHASE3

• REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma Start of enrollment: 2018 Sep 24

  TERMINATED

  PHASE1, PHASE2

• Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08

  ACTIVE_NOT_RECRUITING

  PHASE2

• A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Start of enrollment: 2019 Jul 03

  ACTIVE_NOT_RECRUITING

  PHASE3

• A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma with NTRK Fusion Start of enrollment: 2021 Apr 08

  RECRUITING

  EARLY_PHASE1

  Roles: Contact

• ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2022 Dec 16

  RECRUITING

  PHASE2

  Roles: Contact

• Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT Start of enrollment: 2017 Feb 22

  Completed

  Phase 1

  Roles: Contact

• Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06

  ACTIVE_NOT_RECRUITING

  PHASE1, PHASE2

  Roles: Principal Investigator, Contact

• A Phase 1b Study of PTC596 in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma Start of enrollment: 2018 Aug 01

  ACTIVE_NOT_RECRUITING

  PHASE1

  Roles: Principal Investigator, Contact

• Fimepinostat in Treating Brain Tumors in Children and Young Adults Start of enrollment: 2019 Aug 07

  ACTIVE_NOT_RECRUITING

  EARLY_PHASE1

  Roles: Contact

• PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma Start of enrollment: 2024 Jul 18

  RECRUITING

  PHASE2

  Roles: Contact, Principal Investigator

• MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2023 Apr 10

  RECRUITING

  PHASE2

  Roles: Contact

• Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors Start of enrollment: 2022 Nov 21

  RECRUITING

  PHASE1, PHASE2

  Roles: Contact

• Targeted Pediatric High-Grade Glioma Therapy Start of enrollment: 2024 Aug 02

  RECRUITING

  Roles: Contact

• Study of Ribociclib and Everolimus in HGG and DIPG Start of enrollment: 2024 Aug 22

  RECRUITING

  PHASE2

  Roles: Contact

• Study of Olutasidenib and Temozolomide in HGG

  RECRUITING

  PHASE2

  Roles: Contact

• Lorlatinib for Newly-Diagnosed High-Grade Glioma with ROS or ALK Fusion Start of enrollment: 2025 Jun 01

  NOT_YET_RECRUITING

  EARLY_PHASE1

  Roles: Contact

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