Sara Isabel Pai MD PhD
Head & Neck Oncologic Surgery
Massachusetts General Hospital, Harvard Medical School/ Director, Translational Head and Neck Cancer Research
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35 Park StSmilow Cancer Hospital at Yale New HavenNew Haven, CT 06510
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Education & Training
Johns Hopkins UniversityResidency, Otolaryngology - Head and Neck Surgery, 2003 - 2007- Johns Hopkins UniversityInternship, Surgery, 2002 - 2003
- Johns Hopkins UniversityInternship, Otolaryngology - Head and Neck Surgery, 2002 - 2003
- Johns Hopkins University School of MedicineClass of 2002
Certifications & Licensure
MA State Medical License 2014 - 2026
CT State Medical License 2023 - 2025
MD State Medical License 2007 - 2025
ME State Medical License 2020 - 2021
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
- Fellow (FACS) American College of Surgeons
- Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
Clinical Trials
Publications & Presentations
PubMed
- Epigenetic therapy sensitizes anti-PD-1 refractory head and neck cancers to immunotherapy rechallenge.Tingting Qin, Austin K Mattox, Jean S Campbell, Jong Chul Park, Kee-Young Shin
The Journal of Clinical Investigation. 2025-03-17 - 2 citationsQuantifying cell divisions along evolutionary lineages in cancer.Martin Blohmer, David M Cheek, Wei-Ting Hung, Maria Kessler, Foivos Chatzidimitriou
Nature Genetics. 2025-03-01 - 7 citationsRodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes.Henrique Hadad, Henrique R Matheus, Sara I Pai, Francisley A Souza, Fernando P S Guastaldi
Archives of Oral Biology. 2024-03-01
Lectures
- A phase II study of pembrolizumab for HPV-associated papilloma patients with laryngeal, tracheal, and/or pulmonary involvement.2019 ASCO Annual Meeting - 6/1/2019
- ICR gene signature to identify differential immune landscapes in anatomic subsites of head and neck squamous cell carcinomas and implications in personalized medicine.2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
Press Mentions
Yale Surgeon-Scientist Secures FDA Orphan Drug Designation for Pembrolizumab in Rare Respiratory DiseaseJanuary 7th, 2025
Grant Support
- Cue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck CancersYALE UNIVERSITY2024–2029
- Early detection and risk of head and neck cancer through immune based spatial omicsYALE UNIVERSITY2024–2028
- FAST-FNA immune cell profiling in HNSCCMASSACHUSETTS GENERAL HOSPITAL2021–2025
- Strategies to Overcome Immune Resistance in Head and Neck CancersYALE UNIVERSITY2019–2025
- HPV Vaccine Therapy And Correlates Of Response In Head And Neck Squamous CellNational Institute Of Dental &Craniofacial Research2007–2011
Professional Memberships
- Fellow
- Member
- Member
- Member
Other Languages
- Spanish, Korean
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