Sanjay Kumar Jain MD

Pediatric Infectious Disease•Baltimore, MD

Professor of Pediatrics, Radiology & Radiological Science and International Health Vice Chair for Basic & Translational Research, Department of Pediatrics Director, Center for Infection and Inflammation Imaging Research

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200 North Wolfe StreetRubenstein BLDG Lower LevelBaltimore, MD 21287
Phone+1 443-997-5437
Fax+1 410-955-1491

Summary

Sanjay K Jain, M.D. is Professor of Pediatrics, Radiology & Radiological Sciences and International Health at the Johns Hopkins University. He directs the Center for Infection and Inflammation Imaging Research and is a member of the Center for TB Research at Johns Hopkins. Dr. Jain is also the Vice Chair for Basic & Translational Research in the Department of Pediatrics. His primary research interests include the development of novel molecular imaging technologies for bacterial infections, pediatric tuberculosis (TB), and TB meningitis. Dr. Jain’s laboratory conducts animal and human studies to develop and evaluate novel radiopharmaceutical imaging methods (CT, PET, SPECT, MRI) to understand disease pathogenesis (e.g. study antimicrobial pharmacokinetics at infection sites) and pathogen-specific imaging diagnostics. Several novel tracers developed in his laboratory are now being tested in first-in-human studies. For example, they have performed first-in-human studies using a radiolabeled version of rifampin and pretomanid (important antibiotics) in humans with TB or S. aureus infections to test whether these antibiotics achieves adequate levels at the infection sites. Similarly, his group is evaluating novel pathogen-specific PET tracers to noninvasively detect invasive bacterial and fungal infections in patients. Dr. Jain is funded though several grants. Notably, he is also the recipient of the prestigious NIH Director’s New Innovator Award (2009) and the NIH Director’s Transformative Research Award (2014). Dr. Jain is the past chair (2014-2021) and a founding member of the Infectious Diseases subgroup and current board member and Executive committee member of the World Molecular Imaging Society. He serves as a reviewer for multiple scientific journals and NIH study panels.

Education & Training

Johns Hopkins UniversityFellowship, Pediatric Infectious Diseases, 2002 - 2005
Tufts Medical CenterResidency, Pediatrics, 2000 - 2002
Penn State Milton S Hershey Medical CenterInternship, Pediatrics, 1999 - 2000
All India Institute of Medical SciencesClass of 1999

Certifications & Licensure

MD State Medical License 2005 - 2026
PA State Medical License 1999 - 2000
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Infectious Diseases

Awards, Honors, & Recognition

NIH Director's Transformative Research Award National Institutes of Health, 2014
NIH Director's New Innovator Award National Institutes of Health, 2009
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America’s Best and the Brightest in the Arts, Sciences and Social change Esquire Magazine, 2007
Program Choice Award at the IDSA 2005
Bill and Melinda Gates' Foundation Education scholarship 2005
Pediatric Infectious Diseases Society Award at the IDSA 2005
IDSA Special citation for fellow-in-training 2005
Fellows Travel Award at the IDSA 2005
Young Investigator’s Travel Award American Pediatric Society & Society for Pediatric Research, 2005
Clinician Scientist Award Johns Hopkins University, 2005
Adarsh A Kumar Award for best oral presentation 2001
Sir Dorabji Tata Prize for the best student in Biochemistry 1994
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Clinical Trials

Timeliness of Immunization and Compliance Assessment Study Start of enrollment: 2018 Apr 25
Completed
Not Applicable
Biodistribution and Pharmacokinetics of Pretomanid in Tuberculosis Patients Using 18F-Pretomanid PET Start of enrollment: 2023 May 22
RECRUITING
Roles: Contact, Principal Investigator

Publications & Presentations

PubMed

DynamicC-PABA PET/CT for Visualizing PulmonaryInfections.
Yuderleys Masias-Leon, Carlos E Ruiz-Gonzalez, Oscar J Nino-Meza, Medha Singh, Mona O Sarhan
American Journal of Respiratory and Critical Care Medicine. 2025-03-28
Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis.
Medha Singh, Mona O Sarhan, Nerketa N L Damiba, Alok K Singh, Andres Villabona-Rueda
Nature Communications. 2025-03-27
3 citations
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.
Xueyi Chen, Bhavatharini Arun, Oscar J Nino-Meza, Mona O Sarhan, Medha Singh
Nature Communications. 2024-08-14

Journal Articles

Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo
Ashbaugh AG, Jiang X, Zheng J, Tsai AS, Kim WS, Thompson JM, Miller RJ, Shahbazian JH, Wang Y, Ordonez AA, Chang YS, Jain SK, Jones LC, Sterling RS, Mao HQ, Miller LS, Proc Natl Acad Sci U S A, 1/24/2016
A Systematic Approach for Developing Bacteria-Specific Imaging Tracers
Ordonez AA, Weinstein EA, Bambarger LE, Saini V, Chang YS, DeMarco VP, Klunk M, Urbanowski ME, Moulton KL, Murawski AM, Pokkali S, Kalinda AS, Jain SK, J Nucl Med, 1/15/2016
The anti-fibrotic drug pirfenidone promotes pulmonary cavitation and drug resistance in a mouse model of chronic tuberculosis
Ahidjo BA, Maiga MC, Ihms EA, Maiga M, Ordonez AA, Cheung LS, Beck S, Andrade BB, Jain SK, Bishai WR, JCI Insight, 1/1/2016
Design of selective substrates and activity-based probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis
Lentz CS, Ordonez AA, Kasperkiewicz P, Greca FL, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M, ACS Infect. Dis., 1/1/2016
Mouse Model of Pulmonary Cavitary Tuberculosis and Expression of Matrix Metalloproteinase-9
Ordonez AA, Tasneen R, Pokkali S, Xu Z, Converse PJ, Klunk MH, Mollura DJ, Nuermberger EL, Jain SK, Dis Model Mech, 1/1/2016
Determination of 11C-Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice Using Dynamic Positron Emission Tomography Bioimaging
DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, Tonge PJ, Dannals RF, Holt DP, Lee CK, Weinstein EA, Dartois V, Dooley KE, Jain SK, Antimicrob Agents Chemother, 1/1/2015
Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function
Rajeshkumar NV, Dutta P, Yabuuchi S, de Wilde RF, Matrinez GV, Le A, Kamphorst JJ, Rabinowitz JD, Jain SK, Hidalgo M, Dang CV, Gillies RJ, Maitra AM, Cancer Res, 1/1/2015
Computer-aided pulmonary image analysis in small animal models
Xu Z, Bagci U, Mansoor A, Marek GK, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ, Med Phys, 1/1/2015
Imaging Chronic Tuberculous Lesions using Sodium [18F]Fluoride Positron Emission Tomography in Mice
Ordonez AA, DeMarco VP, Klunk MH, Pokkali S, Jain SK, Mol Imaging Biol, 1/1/2015
Radioiodo-DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice
Ordonez AA, Pokkali S, DeMarco VP, Klunk M, Mease RC, Foss CA, Pomper MG, Jain SK, Antimicrob Agents Chemother, 1/1/2015
In vivo Prediction of Tuberculosis Cavity Formation in Rabbits
Luna B, Kubler A, Larsson C, Foster B, Bagci U, Mollura DJ, Jain S, Bishai WR, J Infect Dis, 1/1/2015
Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography
Weinstein EA, Ordonez AA, DeMarco VP, Murawski AM, Pokkali S, MacDonald EM, Klunk M, Mease RC, Pomper MG, Jain SK, Sci Transl Med, 1/22/2014
Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation
Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Molura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain..., J Pathol, 1/4/2014
Nuclear Imaging: A Powerful Novel Approach for Tuberculosis
Johnson D, Via L, Kim P, Laddy D, Lau CY, Weinstein E, Jain SK, Nucl Med Biol, 1/4/2014
Accurate and Efficient Separation of Left and Right Lungs from 3D CT Scans: A Generic Hysteresis Approach
Ziyue Xu, Bagci U, Jonsson C, Jain S, Mollura DJ, Conf Proc IEEE Eng Med Biol Soc, 1/1/2014
Efficient ribcage segmentation from CT scans using shape features
Xu Z, Bagci U, Jonsson C, Jain S, Mollura DJ, Conf Proc IEEE Eng Med Biol Soc, 1/1/2014
Imaging the Evolution of Reactivation Pulmonary Tuberculosis in Mice Using 18F-FDG PET
Murawski AM, Gurbani S, Harper JS, Younes L, Jain SK*, Jedynak B, J Nucl Med, 1/1/2014
Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice
Dutta NK, Illei PB, Jain SK, Karakousis PC, Am J Pathol, 1/1/2014
Modifiable risk factors associated with tuberculosis disease in children in Pune, India
Jubulis J, Kinikar A, Ithape M, Khandave M, Dixit S, Hatolkar S, Kulkarni V, Mave V, Gupte N, Kagal A, Jain S, Bharadwaj R, Gupta A, Int J Tuberc Lung Dis, 1/1/2014
Novel Adjunctive Therapies for the Treatment of Tuberculosis
Ordonez AA, Maiga M, Gupta S, Weinstein EA, Bishai WR, Jain SK, Curr Mol Med, 1/17/2013
Segmentation of PET images for Computer-aided functional quantification of Tuberculosis in Small Animal Models
Foster B, Bagci U, Zu Z, Dey B, Luna B, Bishai W, Jain S, Mollura DJ, IEEE Trans Biomed Eng, 1/5/2013
Pediatric Tuberculosis in Young Children in India: A Prospective Study
Jain SK, Ordonez A, Gupte N, Kinikar A, Thakar M, Mave V, Jubulis J, Hatolkar S, Lalvani A, Kagal A, Gupta A, Bharadwaj R, Biomed Res Int, 1/1/2013
Non-Invasive Molecular Imaging of Tuberculosis-Associated Inflammation with Radioiodinated DPA-713
Foss CA, Harper JS, Wang H, Pomper MG, Jain SK, J Infect Dis, 1/1/2013
Xu Z, Bagci U, Kubler A, Luna B, Jain S, Bishai WR, Mollura, DJ, Med Phys, 1/1/2013
A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging
Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ, EJNMMI Res, 1/1/2013
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Books/Book Chapters

Radiology in Global Health: Strategies, Implementation, and Applications
Chapter: Infectious Disease Imaging
Lungren MP, Peper JPC, Ordoñez AA, Jain SKEditors: D.J. Mollura and M.P. Lungren.Springer Science, Business Media, LLC2014
Clinical Decision Support in Infectious Diseases
Chapter: Extra-Pulmonary Tuberculosis
Hiruy H and Jain SKEditors: A. Karchmer, F. Southwick, R. Wenzel and I. Frank.Decision Support in Medicine, LLC2013
Clinical Decision Support in Infectious Diseases
Chapter: Tuberculous meningitis
Jubulis J and Jain SKEditors: J. McMillan, D. Barrett, C. Boney, and D. Jones.Decision Support in Medicine, LLC2013
Hidden Beauty: Exploring the Aesthetics of Medical Science
Chapter: Tuberculosis
Jain SKEditors: N. Barker, and C. Iacobuzio-Donahue.Schiffer Books2013
Tuberculosis: The Essentials
Chapter: Pathogenesis of Tuberculosis: New Insights
Be NA, Bishai WR, Jain SKEditors: Raviglione, MC.Informa Healthcare2009
The Harriet Lane Handbook of Pediatric Antimicrobial Therapy
Chapter: Recommended Empiric Antimicrobial Therapy for Selected Clinical Syndromes
George-Agwu A, Milstone A, Jain SKEditors: J.A. McMillan, C.K. Lee, G.K. Siberry, and J.D. Dick.Mosby-Elsevier2008
Antimicrobial Resistance: Modern Principles and Management Strategies
Chapter: Streptococcus pneumoniae: Resistance Update and Treatment Options
Akar N, Bishai WR, Jain SKEditors: R Owens, E Lautenbach.Marcel Dekker, Inc., NY2007
Antimicrobial Pharmacodynamics in Theory and Clinical Practice: Second Edition, Revised and Expanded
Chapter: Macrolide, Azalide and Ketolides
Jain SK, Bishai W and Nightingale CEditors: C.H. Nightingale, G. Drusano, P.G. Ambrose and T. Murakawa.Marcel Dekker, Inc., NY2007
First Aid for the Pediatric Boards
Chapter: Infectious Diseases
George AL, Jain SKEditors: T. Le, W. Lam, S. Rabizadeh, A. Schroeder, K. Vera.McGraw-Hill2006
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Lectures

Enhancing Health Care Access with Cellular Technology
National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD - 1/1/2016
Imaging pulmonary infections
Stevenage, UK - 1/1/2016
Workshop: Development milestone: A road for competence
Abu Dhabi, UAE - 1/1/2016
Pediatric Tuberculosis: Overview and Challenges
Abu Dhabi, UAE - 1/1/2016
Novel Imaging techniques: Focus on Tuberculosis
AERAS, Rockville, MD - 1/1/2016
Bacteria Specific Agents
San Diego, CA - 1/1/2016
Macrophage-associated Inflammation
San Diego, CA - 1/1/2016
Bugs, Drugs and Star Trek
San Diego, CA - 1/1/2016
Molecular Imaging of Bacterial Infections
New York, NY - 1/1/2016
Introduction
New York, NY - 1/1/2016
Imaging Bacteria using 18F-Fluorodeoxysorbitol PET
New York, NY - 1/1/2016
A Rational Approach for Developing Bacteria-Specific Imaging Tracers
New York, NY - 1/1/2016
In vivo Imaging of Bacterial Infections
Vanderbilt University Institute of Imaging Science, Nashville, TN - 1/1/2016
Clinical Imaging Applications – Case Studies
Moran, Teton County, WY - 1/1/2016
Molecular Imaging for Macrophage-Associated Pulmonary Inflammation
Denver, CO - 1/1/2015
Challenges in Infectious Disease: Need for Imaging
1/1/2015
Tuberculosis - What you need to Know?
Johns Hopkins University, Baltimore, MD - 1/1/2015
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection
Rutgers University, Newark, NJ - 1/1/2015
Molecular Imaging of Mycobacterial Infections
Baltimore, MD - 1/1/2015
Novel Imaging Approaches for TB in Children
Arlington, VA - 1/1/2015
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infections
Honolulu, HI - 1/1/2015
Update on Infectious Diseases Imaging
NIH, Bethesda, MD - 1/1/2015
Bugs, Drugs and Star Trek!
NIH, Bethesda, MD - 1/1/2015
Meet-the-Professor session: Current and Novel Imaging Techniques for Pulmonary Infections
Philadelphia, PA - 1/8/2014
Infection Imaging
Antwerp, Belgium - 1/1/2014
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