SamuelAMcLeanMDFACEP
Emergency Medicine • Chapel Hill, NCJeffrey Houpt Distinguished Investigator and Professor of Emergency Medicine, Psychiatry, and Anesthesiology, University of North Carolina at Chapel Hill School of Medicine
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Office
101 Manning Dr
Chapel Hill, NC 27514Phone+1 919-966-4131
Education & Training
Boston University Medical CenterResidency, Emergency Medicine, 1998 - 2001
Massachusetts General HospitalResidency, Internal Medicine, 1995 - 1998
University of Michigan Medical SchoolClass of 1995
Certifications & Licensure
NC State Medical License 2007 - 2025
MI State Medical License 2001 - 2008
MA State Medical License 1997 - 2002
American Board of Emergency Medicine Emergency Medicine
Awards, Honors, & Recognition
- Fellow (FACEP) American College of Emergency Physicians
Clinical Trials
- Burn Healing and Analgesia With Propranolol Start of enrollment: 2009 Jul 01
- TRAUMA HELP: Healing and Analgesia With Propranolol Start of enrollment: 2009 Oct 01
- Healing With Venlafaxine After Injury (HELP) Start of enrollment: 2012 Oct 01
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Publications & Presentations
PubMed
- Further evidence that peritraumatic 17β-estradiol levels influence chronic posttraumatic pain outcomes in women, data from both humans and animals.Esther Son, Rachel Gaither, Jarred Lobo, Ying Zhao, Lauren A McKibben
Pain. 2025-04-01 - Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.Robyn A Ellis, Theresa K Webber, Natalie C Noble, Sarah D Linnstaedt, Rebecca Hinrichs
Stress and Health. 2025-04-01 - Reward Neurocircuitry Predicts Longitudinal Changes in Alcohol Use Following Trauma Exposure.Cecilia A Hinojosa, Sanne J H van Rooij, Negar Fani, Robyn A Ellis, Nathaniel G Harnett
Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2025-03-01
Journal Articles
- Nausea in the Peri-Traumatic Period Is Associated with Prospective Risk for PTSD Symptom DevelopmentElizabeth I Roger, Samuel A McLean, Ian M Kronish, Kerry J Ressler, Barbara O Rothbaum, Lauren Hudak, Charles F Gillespie, Jennifer A Sumner, Nature
- Archival Report Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms over Early Posttrauma PeriodsSamuel A McLean, Israel Liberzon, Kristopher R Brickman, Marijo B Tamburrino, ScienceDirect
- A Functional riboSNitch in the 3′UTR of FKBP5 Alters microRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Posttraumatic PainClaire Pearson, Phyllis L Hendry, Robert Domeier, Samuel A McLean, Michael C Kurz, Elizabeth Datner, Christopher Lewandowski, The Journal of Neuroscience
Press Mentions
Health News | Feeling of Detachment After Trauma Has Worse Impact on Mental Health, Reveals StudyJune 22nd, 2022- App Measures Mental Wellness of Front Line Workers, RespondersJuly 24th, 2020
- UNC Helps Launch COVID-19 Mental Health App for Health WorkersJuly 22nd, 2020
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Grant Support
- FKBP51 antagonism to prevent chronic pain: optimizing efficacy & evaluating safety and mechanismsUNIV OF NORTH CAROLINA CHAPEL HILL2020–2025
- Applying Biopsychosocial Model To Post-Mvc Pain Development In African AmericansNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
- Genetic Predictors Of Acute And Chronic Musculoskeletal Pain After Minor MVCNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008–2011
- Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2008
- Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2006–2007
- Outcome Of PTS Treated In Emergency Department After Motor Vehicle CollisionNational Center For Research Resources2005–2006
Professional Memberships
- Fellow
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