Samuel A McLean MD FACEP

Jeffrey Houpt Distinguished Investigator and Professor of Emergency Medicine, Psychiatry, and Anesthesiology, University of North Carolina at Chapel Hill School of Medicine

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101 Manning DrChapel Hill, NC 27514
Phone+1 919-966-4131

Education & Training

Boston University Medical CenterResidency, Emergency Medicine, 1998 - 2001
Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1995 - 1998
University of Michigan Medical SchoolClass of 1995

Certifications & Licensure

NC State Medical License 2007 - 2025
MI State Medical License 2001 - 2008
MA State Medical License 1997 - 2002
American Board of Emergency Medicine Emergency Medicine

Awards, Honors, & Recognition

Fellow (FACEP) American College of Emergency Physicians

Clinical Trials

Burn Healing and Analgesia With Propranolol Start of enrollment: 2009 Jul 01
Completed
Phase 2
TRAUMA HELP: Healing and Analgesia With Propranolol Start of enrollment: 2009 Oct 01
Withdrawn
Phase 2
Healing With Venlafaxine After Injury (HELP) Start of enrollment: 2012 Oct 01
Completed
Phase 2
Vitamin D to ENhance TraUma REcovery Start of enrollment: 2023 Jan 24
COMPLETED
PHASE2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Further evidence that peritraumatic 17β-estradiol levels influence chronic posttraumatic pain outcomes in women, data from both humans and animals.
Esther Son, Rachel Gaither, Jarred Lobo, Ying Zhao, Lauren A McKibben
Pain. 2025-04-01
Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.
Robyn A Ellis, Theresa K Webber, Natalie C Noble, Sarah D Linnstaedt, Rebecca Hinrichs
Stress and Health. 2025-04-01
Childhood adversity is associated with longitudinal white matter changes after adulthood trauma.
Li Tianyi, Megan E Huibregtse, Timothy D Ely, Sanne J H van Rooij, Lauren A M Lebois
Medrxiv. 2025-03-14

Journal Articles

Nausea in the Peri-Traumatic Period Is Associated with Prospective Risk for PTSD Symptom Development
Elizabeth I Roger, Samuel A McLean, Ian M Kronish, Kerry J Ressler, Barbara O Rothbaum, Lauren Hudak, Charles F Gillespie, Jennifer A Sumner, Nature
Archival Report Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms over Early Posttrauma Periods
Samuel A McLean, Israel Liberzon, Kristopher R Brickman, Marijo B Tamburrino, ScienceDirect
A Functional riboSNitch in the 3′UTR of FKBP5 Alters microRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Posttraumatic Pain
Claire Pearson, Phyllis L Hendry, Robert Domeier, Samuel A McLean, Michael C Kurz, Elizabeth Datner, Christopher Lewandowski, The Journal of Neuroscience

Press Mentions

Health News | Feeling of Detachment After Trauma Has Worse Impact on Mental Health, Reveals StudyJune 22nd, 2022
App Measures Mental Wellness of Front Line Workers, RespondersJuly 24th, 2020
UNC Helps Launch COVID-19 Mental Health App for Health WorkersJuly 22nd, 2020
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Grant Support

FKBP51 antagonism to prevent chronic pain: optimizing efficacy & evaluating safety and mechanismsUNIV OF NORTH CAROLINA CHAPEL HILL2020–2025
Applying Biopsychosocial Model To Post-Mvc Pain Development In African AmericansNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
Genetic Predictors Of Acute And Chronic Musculoskeletal Pain After Minor MVCNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008–2011
Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2008
Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2006–2007
Outcome Of PTS Treated In Emergency Department After Motor Vehicle CollisionNational Center For Research Resources2005–2006

Professional Memberships

American College of Emergency Physicians - ACEP
Fellow