SamuelJacobKlempnerMD

PubMed

• 59 citations
  Combined PD-1, BRAF and MEK inhibition in BRAFcolorectal cancer: a phase 2 trial.
  Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis
  Nature Medicine. 2023-02-01
• 670 citations
  Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
  Jaffer A Ajani, Thomas A D'Amico, David J Bentrem, Joseph Chao, David Cooke
  Journal of the National Comprehensive Cancer Network. 2022-02-01
• 17 citations
  Association Between Liquid Biopsy and Prognosis of Gastric Cancer Patients: A Systematic Review and Meta-Analysis.
  Yunhe Gao, Hongqing Xi, Bo Wei, Jianxin Cui, Kecheng Zhang
  Frontiers in Oncology. 2019-11-26

Journal Articles

• PD-1 as an emerging target in gastric cancer: current evidence  
  Tran PN, Sarkissian S, Chao J, Klempner SJ, Gastrointestinal Cancer: Targets and Therapy, 1/1/2017
• Moving Molecular Subtypes to the Clinic in Gastric Cancer  
  Chao J, Lee J, Klempner SJ, Transl Cancer Res, 1/1/2016
• ROS1 (c-ros oncogene 1)  
  Klempner SJ, Ou, SH, Atlas Genet Cytogenet Oncol Haematol, 1/1/2014

Books/Book Chapters

• Targeted Therapy in Cancer 
  Chapter: The Phosphatidylinositol 3-kinase Pathway in Human Malignancy. 
  Klempner SJ, Vo T, Myers AP, Cantley LCEditors: Kurzrock R, Anderson KC and Tsimberidou AM.Wiley, New York, NY2015
• The PI3K Pathway in Colorectal Cancer. 
  Chapter: Molecular Pathogenesis of Colorectal Cancer. 
  Yun J, Poulogiannis G, Brown E, Klempner S, Cantley LCEditors: K.M. Haigis.Springer, New York, NY2013

Abstracts/Posters

• Neoadjuvant Chemotherapy Improves Survival In Patients With Clinical T4b Colon Cancer.
  Dehal A, Graff-Baker AN, Voung B, Fischer T, Klempner SJ, et al, Digestive Disease Week, Chicago, IL, 1/6/2017
• Genomic profiling of circulating tumor DNA (ctDNA) from patients with advanced cancers of the GI tract and anus.
  Schrock AB, Young L, Klempner SJ, Bordoni R, Ross JS, et al, GI ASCO, 1/1/2017
• Comprehensive genomic profiling (CGP) of esophageal and tubular GI tumors identifies differing frequencies of ErbB family member amplifications with therapeutic implic...
  Bailey M, Ali SM, Schrock AB, Klempner SJ, George B, Lipson D, et al, GI ASCO, 1/1/2017
• A Phase 1 Study of LY3022855 (A Colony-Stimulating Factor-1 receptor [CSF-1R] inhibitor) in Patients (pts) With Advanced Solid Tumors
  Dowlati A, Rugo HS, et al, ASCO, 1/1/2017
• Advanced Acinic Cell Carcinomas Harbor Recurrent BRAF Kinase Domain Duplications, NTRK3 fusions and Genomic Alterations Hyperactivating the mTOR Pathway.
  Ali SM, Fedorchak K, Schrock AB, Johnson J, Gowen K, Elvin JA, Vergilio J, Klempner SJ, Mehra R, Ho A, Pavlick D, Suh JH, Bordoni R, Jung DH, Stephens PJ, Chung C, Ros..., ESMO, 1/1/2016
• Comprehensive genomic profiling of advanced colorectal carcinoma in the course of clinical care identifies KRAS insertions not detected by focused molecular testing.
  Rankin A, Schrock AB, Elvin JA, Chmielecki J, Erlich R, Morosini D, Frampton GM, Grothey A, Rosenblum A, Bufill JA, Helton DA, Sequeria J, George TJ, Klempner SJ, Ross..., J Clin Oncol, 1/1/2016
• Comprehensive Genomic Profiling Assesses Mutational Load in Gastric and Esophageal Adenocarcinomas: Implications for Immunotherapies.
  Frampton GM, Schrock A, Chalmers Z, Sun J, Gowen K, Beg M, Rubinson D, Stephens PJ, Miller VA, Ross JS, Ali SM, Klempner SJ, J Clin Oncol, 1/1/2016
• Small cell lung carcinoma harbors targetable alterations including MYCL1 fusions responding to Aurora kinase inhibitor.
  Ali SM, Khollar B, Bailey M, Schrock AB, Frampton G, Fabrizio D, Ou SH, Klempner SJ, He J, Suh JH, Ross JS, Stephens PJ, Miller VA, Patel M, ESMO Congress, 1/1/2016
• Broad detection of alterations predicted to confer lack of benefit from EGFR antibodies or sensitivity to targeted therapy in advanced colorectal cancer.
  Klempner SJ, Rankin A, Erlich RA, Sun J, Grothey A, Fakih M, George TJ, Lee J, Ross JS, Stephens PJ, Miller VA, Ali SM, Schrock AB, ESMO, 1/1/2016
• HER2 V659 and G660 transmembrane mutations that stabilize homo- and hetero-dimerization are rare oncogenic drivers in lung adenocarcinoma that are clinically responsiv...
  Ali SM, Khollar B, Bailey M, Schrock AB, Frampton G, Fabrizio D, Ou SH, Klempner SJ, He J, Suh JH, Ross JS, Stephens PJ, Miller VA, Patel M, ESMO, 1/1/2016
• The impact of sex, race, and socioeconomic status (SES) on outcomes in 6,870 patients with esophageal cancer.
  Tran P, Taylor TH, Klempner SJ, Zell J, ASCO Annual Meeting, 1/1/2016
• Mutational load as a potential biomarker for PD1/PD-L1 therapy in colorectal cancer.
  George TA, Frampton GM, Sun J, Gowen K, Kennedy M, Greenbowe JR, Schrock AB, Ali SM, Klempner SJ, Hezel AF, Ross JS, Stephens P, Miller VA, Fabrizio D, ASCO Annual Meeting, 1/1/2016
• Bone Mineral Density Loss in Thoracic and Lumber Vertebrae Following Radiation for Abdominal Cancers.
  Jung BC, Wei RL, Manzano W, Seghal V, Lee S, Klempner SJ, Ramsinghani N, Lall C, ASTRO, Boston, MA, 1/1/2016
• Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors.
  Klempner SJ, Myers AP, Li J, Mills G, Cantley L, Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; ; AACR Annual Meeting, Washington, DC, 1/1/2013
• PTEN loss is a context dependent determinant of patient outcomes in obese and non-obese endometrioid endometrial cancer patients.
  Ju Z, Westin S, Broaddus R, Li J, Pal N, Lu K, Coleman RL, Klempner SJ, Cantley LC, Mills GB, Myers AP, J Clin Oncol; ASCO Annual Meeting, Chicago, IL, 1/1/2013
• Apoptosis precedes removal of avian thyroglossal duct and suggests cell culling in early bilobed thyroid.
  Miller SA, Campbell C, Ransom E, Klempner SJ, Experimental Biology, FASEB late-breaking abstracts program, Washington, DC, 1/21/2004
• Apoptosis plays a role in removal of the first and second aortic arch arteries, in remodeling of the thyroid rudiment and in rupture of closing plates in chick embryos.
  Klempner SJ, Miller SA, 62nd Annual Society of Developmental Biology Meeting, Developmental Biology, Boston, MA, 1/1/2003
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Lectures

• Early Is Better: The Roles of Prevention, Screening, and Early Detection 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• DKN-01 in combination with pembrolizumab in patients with advanced gastroesophageal adenocarcinoma (GEA): Tumoral DKK1 expression as a predictor of response and survival. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/23/2020
• Help From Within: DNA to Personalized Therapy for Gastric Cancer 
  1/18/2017
• Considerations for Implementation of Cancer Molecular Diagnostics into Clinical Care 
  1/1/2017
• Genomics in Cancer 
  Long Beach, CA - 1/29/2016
• ASCO Highlights, Gastrointestinal 
  Long Beach, CA - 1/16/2016
• Cancer Epidemiology – Lecture on Lung Cancer Epidemiology 
  UCI - 1/27/2015
• Molecular Testing in NSCLC 
  Fountain Valley Hospital - 1/25/2015
• Gastric and Esophageal Cancer 
  UCI - 1/19/2015
• Esophageal Cancer 
  Huntington Beach Hospital, 2014; Fountain Valley Hospital, 2015 - 1/17/2015
• ASCO Highlights 
  Long Beach, CA - 1/16/2015
• Gastric Cancer 
  Anaheim Regional Medical Center - 1/13/2015
• Clinical Cancer for Basic Scientists 
  UCI - 1/1/2015
• Lung Cancer Update 
  Los Alamitos Medical Center - 1/23/2014
• Lung Cancer 
  Fountain Valley Hospital - 1/21/2014
• New Concept in Molecular Medicine 
  Temple Community Hospital - 1/21/2014
• New Paradigms in the Treatment of Esophageal and Gastric Cancer 
  Disney Grand Hotel, Anaheim, CA - 1/21/2014
• Updates in Lung Cancer 
  La Palma Hospital - 1/10/2014
• Lung Cancer: A Review and What's New 
  Desert Valley Hospital, Victorville, CA - 1/27/2013
• Updates in Lung Cancer. 
  UCI - 1/26/2013
• Gastric and Esophageal Cancer: ABIM 101. 
  Long Beach VA Medical Center - 1/21/2013
• Cool Toys, Few Joys: Capitalizing on Personalized Medicine 
  UCI - 1/20/2013
• Mechanisms of Resistance to compounds targeting the PI3-kinase pathway in Endometrial Cancer 
  Beth Israel Deaconess Medical Center - 1/19/2013
• Gastric and Esophageal Cancer: ABIM 101 
  UCI - 1/9/2013
• Signaling Changes During Chronic PI3K Pathway Inhibition in Endometrial Cancer 
  Boston, MA - 1/8/2013
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Other

• Navigating the complexity of cancer with tumor mutational burden (TMB). 
  Klempner SJ, Oncology Times
  1/1/2017
• Advancing precision medicine in colorectal cancer. 
  Klempner SJ, Pharma Letter
  1/1/2017