SamuelE.GandyMDPhD

PubMed

• Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD ...
  Matthew G Engel, Sushma Narayan, Min-Hui Cui, Craig A Branch, Xusheng Zhang
  Journal of Alzheimer's Disease. 2024-11-29
• 10 citations
  The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
  Karan Sud, Navneet Narula, Elena Aikawa, Eloisa Arbustini, Philippe Pibarot
  Nature Reviews. Cardiology. 2023-06-01
• 25 citations
  Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
  Emilie L Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V Ramirez Jimenez, B Wade Hamilton
  Alzheimer's & Dementia. 2023-06-01

Journal Articles

• Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women  
  Bates KA, Sohrabi HR, Rainey-Smith SR, Weinborn M, Bucks RS, Rodrigues M, Beilby J, Howard M, Taddei K, Martins G, Paton A, Shah T, Dhaliwal SS, Foster JK, Martins IJ,..., Int J Neurosci, 1/1/2017
• Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCA...  
  Ruiz HH, Chi T, Shin AC, Lindtner C, Hsieh W, Ehrlich M, Gandy S, Buettner C, Alzheimers Dement, 1/1/2016
• Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer'srelated Sorcs1  
  Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S, Acta Neuropathol Commun, 1/1/2016
• Effective antiAlzheimer Abeta therapy involves depletion of specific Abeta oligomer subtypes  
  Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW, Neurology Neuroimmunol Neuroinflamm, 1/1/2016
• Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bo...  
  Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S, Mol Psychiatry, 1/1/2015
• Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis  
  Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D, Proc Natl Acad Sci USA, 1/1/2015
• Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-beta peptide  
  Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S, J Neurosci, 1/1/2013
• Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes  
  Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S, J Neurosci, 1/1/2012
• Retromer-mediated Golgi retrieval of the Alzheimer’s amyloid Precursor protein is S655 phosphorylation state-dependent  
  Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah JJ, Lane R, Small SA, Gandy S, da Cruz e Silva OAB, Molecular Neurodegeneration, 1/1/2010
• Profiling brain and plasma lipids in human APOE epsilon 2, epsilon 3 and epsilon 4 knock in mice using electrospray ionization mass spectrometry  
  Sharman MJ, Guanghou S, Fernandis AZ, Lim, WLF, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum J, Gandy S, Wenk M, Martins RN, Journal of Alzheimer's Disease, 1/1/2010
• Alcadein cleavages by APP {alpha}-and {gamma}-secretases generate small peptides p3-Alcs indicating Alzheimer diseaserelated {gamma}-secretase dysfunction  
  Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Ya..., J Biol Chem, 1/28/2009
• X11 proteins regulate the translocation of APP into detergent resistant membrane and suppress the amyloidogenic cleavage of APP by BACE in brain  
  Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T, J Biol Chem, 1/9/2009
• Association of Cardiovascular Factors and Alzheimer’s Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers  
  Bates KA, Sohrabi HR, Rodrigues M, Beilby J, Dhaliwal SS, Taddei K, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager N..., J Alzheimers Dis, 1/6/2009
• Phosphorylation of the amino terminal region of X11L regulates its interaction with APP  
  Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Nairn AC, Nakaya T, Yamamoto T, Suzuki T, J Neurochem, 1/1/2009
• Novel pentameric thiopene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses  
  Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein D, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Ju..., ACS Chemical Biology, 1/1/2009
• nELAV proteins alteration in Alzheimer’s disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing  
  Amadio M, Pascale A, Wang J, Ho L, Quattrone A, Gandy S, Haroutunian V, Racchi M, Pasinetti GM, J Alzheimers Dis, 1/1/2009
• Formation and maintenance of Alzheimer's disease betaamyloid plaques in the absence of microglia  
  Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H,Heppner FL, ..., Nat Neurosci, 1/1/2009
• Novel cerebrovascular pathology in mice fed a high cholesterol diet  
  Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA, Mol Neurodegen, 1/1/2009
• Dietary Composition modulates brain mass and amyloid beta levels in a mouse model of aggressive Alzheimer’s amyloid pathology  
  Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, St George Hyslop P, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME,..., Mol Neurodegener, 1/1/2009
• Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer’s mouse model  
  Karuppagounder SS, Xu H, Qingli S, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE, Neurobiol Aging, 1/9/2008
• Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease  
  Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, Miklossy J..., J Neuroinflam, 1/1/2008
• Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial...  
  Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S, Pasinetti GM, Ann NY Acad Sci, 1/1/2008
• Insulin together with other diabetes medication is associated with less Alzheimer neuropathology  
  Beeri MS, Schmeidler J, Silverman JM, Gandy SE, Wysocki M, Hannigan CM, Purohit DP, Lesser G, Grossman HT, Haroutunian V, Neurology, 1/1/2008
• Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo  
  Gandy S, Zhang Y-w, Ikin A, Schmidt SD, Levy E, Sheffield R, Nixon RA, Liao F-F, Mathews PM, Xu H, Ehrlich ME, J Neurochemistry, 1/1/2007
• Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phosphor-state-sensitive modul...  
  Ikin A, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashivama S, Mustelin T, Burgoyne RD, Gandy S, Mol Neurodegener, 1/1/2007
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Books/Book Chapters

• Intracellular Traffic and Neurodegenerative Disorders, Research and Perspectives in Alzheimer’s Disease. 
  Chapter: Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms. 
  Page 1 - 9Gandy S, da Cruz e Silva O, da Cruz e Silva E, Suzuki T, Ehrlich M, Small SEditors: P. St. George-Hyslop, W.C. Mobley, Y. Christen.Springer-Verlag, Berlin Heidelberg2009
• The World Book Encyclopedia. 
  Chapter: Alzheimer’s disease. 
  Gandy S2004
• Molecular Mechanisms of Membrane Traffic 
  Chapter: Protein phosphorylation regulates the cellular trafficking and processing of the Alzheimer beta/A4 amyloid precursor protein. 
  Page 201 - 202Caporaso, G.L., Gandy, S.E., Buxbaum, J.D., Suzuki, T., Nordstedt, C., Iverfeldt, K., Ramabhadran, T.V., Czernik, A.J., Nairn, A.C., and Greengard, PEditors: K. Howell, D. Morre, J. Bergeron.Springer-Verlag, New York, NY1993
• Alzheimer's disease and related disorders. 
  Chapter: APP intra-amyloid secretory cleavage activity: Phylogenetic conservation. 
  Page 205 - 206Ramabhadran, T.V., Gandy, S.E., Greengard, P.Editors: M. Nicolini, P. Zatta, B. Corain.Pergamon, New York, NY1993
• Cardiovascular Drug Reviews. 
  Chapter: Identification of intercellular signals which regulate processing of the beta/A4 amyloid protein precursor. 
  Page 201 - 209Buxbaum, J., Gandy, S.E., Oishi, M., Chen, H., Iverfeldt, K., and Greengard, PEditors: A.Scriabine.Neva Press, Branford, CT1993
• Principles of Geriatric Medicine and Gerontology. 
  Chapter: Other degenerative disorders of the nervous system. 
  Page 2022 - 2037Gandy, SEditors: W. Hazzard, E. Bierman, J. Blass, W. Ettinger, J. Halter, R. Andres.McGraw-Hill, New York, NY1993
• Heterogeneity of Alzheimer's Disease 
  Chapter: Protein phosphorylation regulates processing of the Alzheimer beta/A4 amyloid precursor protein. 
  Page 130 - 143Gandy, S.E., Caporaso, G.L., Ramabhadran, T.V., Buxbaum, J.D., Suzuki, T., Nordstedt, C., Iverfeldt, K.,Czernik, A.J., Nairn, A.C., and Greengard, P.Editors: F. Boller, Z. Khachaturian, F. Forette, M. Poncet, Y.Christen.Springer-Verlag, Heidelberg1992
• Alzheimer's Disease: New Treatment Strategies 
  Chapter: A Cell Biological Approach to the Therapy of Alzheimer-type Cerebral beta/A4 Amyloidosis. 
  Page 175 - 192Gandy, S.E., Buxbaum, J.D. and Greengard, P.Editors: Z. Khachaturian and J. Blass.Marcel Dekker, New York, NY1992
• Proteases and Proteolysis in Alzheimer's Disease 
  Chapter: Characterization of alternative routes for processing of the Alzheimer beta/A4 amyloid precursor protein: Differential effects of phorbol esters and chloroquine. 
  Page 203 - 217Gandy, S.E., Caporaso, G.L., Ramabhadran, T.V., Buxbaum, J.D., Suzuki, T., Nordstedt, C., Iverfeldt, K., Czernik, A.J., Nairn, A.C., and Greengard, P.Editors: R. Nixon, C. Banner.Ann NY Acad Sci1992
• Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies 
  Chapter: Signal Transduction and the Pathobiology of Alzheimer's Disease. 
  Page 155 - 172Gandy, S.E., Buxbaum, J.D. and Greengard, P.Editors: K. Iqbal, D.Crapper- McLachlan, B. Winblad, H.M. Wisniewski.John Wiley, New York, NY1991
• Advances in Contemporary Neurology 
  Chapter: Tuberculosis of the central nervous system: Recent experience and reappraisal. 
  Page 153 - 184Gandy, S.E.Editors: F. Plum.F.A. Davis, New York, NY1988
• Oxy Radicals and Their Scavenger Systems Volume II: Cellular and Medical Aspects 
  Chapter: Localization of SOD in the cornea and pancreas by light and electron microscopy. 
  Page 11 - 16Crouch, R.K., Redmond, R.M., Gandy, S.E., Coles, W.H., Buse, M.G. and Simson, J.A.Editors: G. Cohen and R. Greenwald.Elsevier Science Publishing, New York, NY1983
• Oxy Radicals and Their Scavenger Systems, Volume II: Cellular and Medical Aspects 
  Chapter: SOD protects B-cells against the diabetogenic drug streptozotocin in rats and in isolated canine islets. 
  Page 119 - 124Buse, M.G., Gandy, S.E. and Crouch, R.K.Editors: G. Cohen and R. Greenwald.Elsevier Science Publishing, New York, NY1983
• Oxy Radicals and Their Scavenger Systems, Volume II: Cellular and Medical Aspects 
  Chapter: Alloxan produces H202-mediated inhibition of SOD in intact canine islets of Langerhans. 
  Page 309 - 312Gandy, S.E., Buse, M.G. and Crouch, R.K.Editors: G.Cohen and R. Greenwald.Elsevier Science Publishing, New York, NY1983
• Oxy Radicals and Their Scavenger Systems, Volume I: Molecular Aspects 
  Chapter: Copper-(II)-3,5(diisopropylsalicylate)2 attenuates streptozotocin-induced diabetes. 
  Page 372 - 375Sorenson, J.R.J., Gandy, S.E., Buse, M.G. and Crouch R.K.Editors: G. Cohen and R. Greenwald.Elsevier Science Publishing, New York, NY1983
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Lectures

• Scientific Foundations of Clinical Medicine, Dementia Module 
  1/1/2007
• Molecular Basis of Neurological Disease 
  1/1/2006