SamanthaEMeltzer-BrodyMD

Executive Dean, UNC School of Medicine Assad Meymandi Distinguished Professor and Chair, UNC Department of Psychiatry, Director UNC Center for Women's Mood Disorders

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Office
CB 7160
Chapel Hill, NC 27599
Phone+1 919-966-5217

Summary

Samantha Meltzer-Brody, MD, MPH is a psychiatry specialist based in Chapel Hill, NC, who became the Executive Dean of the UNC School of Medicine in 2025. She served as the Assad Meymandi Distinguished Professor and Chair of the Department of Psychiatry at University of North Carolina Hospitals from October 2019-March 2025. Dr. Meltzer-Brody completed her medical education at Northwestern University The Feinberg School of Medicine in 1996 and her psychiatry residency at Duke University Hospital in 2000. Dr. Meltzer-Brody's expertise covers women's health, depressive disorders, post-partum depression, and women's reproductive mood disorders. She has published widely and has been involved in several pivotal clinical trials focused on postpartum depression.

Education & Training

Duke University HospitalResidency, Psychiatry, 1996 - 2000
Northwestern University The Feinberg School of MedicineClass of 1996

Certifications & Licensure

AZ State Medical License 2023 - 2026
CA State Medical License 2024 - 2026
GA State Medical License 2023 - 2026
IL State Medical License 2022 - 2026
MA State Medical License 2022 - 2026
NE State Medical License 2022 - 2026
NY State Medical License 2023 - 2026
CO State Medical License 2022 - 2025
IN State Medical License 2022 - 2025
KS State Medical License 2023 - 2025
MI State Medical License 2022 - 2025
NC State Medical License 1997 - 2025
NJ State Medical License 2023 - 2025
NV State Medical License 2023 - 2025
WV State Medical License 2023 - 2025
American Board of Psychiatry and Neurology Psychiatry
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Awards, Honors, & Recognition

Sanders Clinician Scholar UNC, 2012

Clinical Trials

Partner-Assisted Interpersonal Psychotherapy or Antidepressant Medication for Antenatal Depression Start of enrollment: 2012 Nov 01
Terminated
Phase 1, Phase 2
Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition Start of enrollment: 2013 Aug 01
Completed
Not Applicable
Study of Exposure to Stress, Postpartum Mood, Adverse Life Events, and Hormonal Function Among Latinas (SEPAH Latina) Start of enrollment: 2013 Aug 01
Completed
Feasibility of Heart Rate Variability Biofeedback With In-patient Pregnant Women Start of enrollment: 2014 May 01
Terminated
Not Applicable
A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression Start of enrollment: 2015 Dec 15
Completed
Phase 2
A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B) Start of enrollment: 2016 Aug 01
Completed
Phase 3
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C) Start of enrollment: 2016 Jul 01
Completed
Phase 3
Scaling Up Maternal Mental Healthcare by Increasing Access to Treatment (SUMMIT) Start of enrollment: 2020 Jan 06
COMPLETED
NA
Personalized Integrated Chronotherapy for Perinatal Depression Start of enrollment: 2020 Nov 02
ACTIVE_NOT_RECRUITING
NA
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Publications & Presentations

PubMed

Zuranolone for Postpartum Depression After Highly Lethal Suicide Attempt: Two Case Illustrations and a Narrative Literature Review.
Anne Ruminjo, Parisa R Kaliush, Emily M Pisetsky, Crystal E Schiller, Samantha Meltzer-Brody
Journal of the Academy of Consultation-Liaison Psychiatry. 2025-03-04
Task-sharing and telemedicine delivery of psychotherapy to treat perinatal depression: a pragmatic, noninferiority randomized trial.
Daisy R Singla, Richard K Silver, Simone N Vigod, Nour Schoueri-Mychasiw, J Jo Kim
Nature Medicine. 2025-03-03
HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents.
Katharine E Bruce, Kathryn Wouk, Karen M Grewen, Brenda Pearson, Samantha Meltzer-Brody
Psychoneuroendocrinology. 2025-02-01

Authored Content

F124. PPD ACT, an App-Based Postpartum Depression Genetic StudyApril 2018
F124. PPD ACT, an App-Based Postpartum Depression Genetic StudyApril 2018
S100. Efficacy and Safety of Brexanolone IV Across Phase 2/3 Studies: A First-in-Class GABAA Receptor Positive Allosteric Modulator for Postpartum DepressionApril 2018

Press Mentions

Global Psychotherapy Trial to Impact Maternal Mental CareMarch 3rd, 2025
FDA Approves Zuranolone for Postpartum DepressionAugust 7th, 2023
How to Treat Postpartum Depression in Women: From Group Therapy to MedicationMay 18th, 2023
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