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Office
75 Francis St
Boston, MA 02115Phone+1 617-525-7437Fax+1 617-264-5169
Summary
- Sabina Signoretti, MD, is based in Boston, MA, and specializes in Medical Genetics with a focus on Clinical Molecular Genetics. She is a Professor at Brigham and Women's Hospital. Dr. Signoretti graduated in 1988 from Sapienza University of Rome. Her recent publications include research on immunogenomic predictors of outcomes in renal cell carcinoma, spatial multi-omics integration linked to response to immunotherapy, and predictive biomarkers for targeted therapies in renal cell carcinoma. Her work often appears in esteemed journals such as Nature Cancer, Clinical Cancer Research and Nature Medicine among others.
Education & Training
Sapienza University of RomeClass of 1988
Certifications & Licensure
MA State Medical License 2017 - 2025
American Board of Medical Genetics and Genomics Clinical Molecular Genetics and Genomics
Publications & Presentations
PubMed
- 2 citationsA neoantigen vaccine generates antitumour immunity in renal cell carcinoma.David A Braun, Giorgia Moranzoni, Vipheaviny Chea, Bradley A McGregor, Eryn Blass
Nature. 2025-03-01 - 1 citationsOncogenic TFE3 fusions drive OXPHOS and confer metabolic vulnerabilities in translocation renal cell carcinoma.Jiao Li, Kaimeng Huang, Meha Thakur, Fiona McBride, Ananthan Sadagopan
Nature Metabolism. 2025-03-01 - Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma.Miya B Hugaboom, Lena V Wirth, Kelly Street, Neil Ruthen, Opeyemi A Jegede
Cancer Discovery. 2025-02-24
Journal Articles
- Genomic Correlates of Response to Immune Checkpoint Blockade in Microsatellite-Stable Solid TumorsJeffrey A Engelman, David A Barbie, Nicole G Chau, Glenn J Hanna, Natalie I Vokes, Sabina Signoretti, Pasi A Janne, Robert I Haddad, Lynette M Sholl, Rizwan Haq, Peter..., Nature
Press Mentions
Study Reveals Factors Influencing Outcomes in Kidney Cancer Treated with ImmunotherapyMay 29th, 2020
Grant Support
- Tissue-based biomarkers of anti-PD-1-based therapy in metastatic renal cell carcinomaDANA-FARBER CANCER INST2022–2027
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