RyanAlanBrownMD

Research History

• Sub-InvestigatorPARTNER: Placement of Aortic Transcatheter Valve Trial2009 - 2010
• Sub-InvestigatorSEASIDE: Scripps Evaluation of Antiplatelet Therapies for Intermediate Duration with the Endeavor Stent2008 - 2009
• Sub-InvestigatorHemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients: HOMEOSTASIS II2008 - 2009
• Sub-InvestigatorA randomized, un-blinded, multicenter Optical Coherence Tomography (OCT) imaging study in patients scheduled for either coronary diagnostic catheterization or intervention. The VOILA Trial.2008 - 2009
• Sub-InvestigatorAn Unblinded, Multicenter, First-in-Man Imaging Study Comparing the REVO IQ System and Catheter with the Revolution and Atlantis IVUS Imaging Catheters in Subjects Scheduled for Stent Placement. The REVO-IQ Trial2008 - 2009
• Sub-InvestigatorPREDICT: Scripps Pilot Study on the Effect of High clopidogrel Maintenance Dosing and its Relationship to Cytochrome P450 2C19 Polymorphism Status [STSI/CTSA]2008 - 2009
• Sub-InvestigatorHuman Recombinant Fibroblast Growth Factor-1 (FGF-1141) for the Treatment of Subjects with Severe Coronary Heart Disease, a Double-blind, Placebo-controlled, Dose-varying study. The FGF Study.2008 - 2009
• Sub-InvestigatorA 12-month follow up Study to Protocol No. 24779. A Double-Blind, Prospective, Randomized, Placebo-Controlled Study to Determine the Tolerability, Efficacy, Safety, and Dose Range of Intramyocardial Injections of G-CSF Mobilized Auto-CD34+ Cells for Reduction of Angina Episodes in Patients with Ref2008 - 2009
• Sub-InvestigatorA Double-Blind, Prospective, Randomized, Placebo-Controlled Study to Determine the Tolerability, Efficacy, Safety, and Dose Range of Intramyocardial Injections of G-CSF Mobilized Auto-CD34+ Cells for Reduction of Angina Episodes in Patients with Refractory Chronic Myocardial Ischemia (ACT 34-CMI).2008 - 2009
• Sub-InvestigatorA Phase II/III, Double-Blind, Randomized, Controlled, Multicenter Study to Assess the Safety and Cardiovascular Effects of Myocell™ Implantation by a Catheter Delivery System in Congestive Heart Failure Patients Post Myocardial Infarction(s). The MARVEL Study2008 - 2009
• Sub-InvestigatorMaintenance of platelet inhibition with cangrelor after discontinuation of thienopyridines in patients undergoing surgery. The BRIDGE Study.2008 - 2009
• Sub-InvestigatorA Randomized, Double-Blind, Active- Controlled Trial to Evaluate Intravenous and Oral PRT060128, A Selective and Reversible P2Y12-Receptor Inhibitor, vs. Clopidogrel, as a Novel Antiplatelet Therapy in Patients Undergoing Non-Urgent Percutaneous Coronary Interventions. The INNOVATE-PCI Study2008 - 2009
• Sub-InvestigatorA Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Element™) for the Treatment of up to two De Novo Coronary Artery Lesions. The PLATINUM Trial2008 - 2009
• Sub-InvestigatorA Clinical Evaluation of the Medtronic Endeavor® Resolute Zotarolimus-Eluting Coronary Stent System in the Treatment of De Novo Lesions in Native Coronary Arteries with a Reference Vessel Diameter of 2.25 mm to 4.2 mm. The Medtronic RESOLUTE US Clinical Trial.2008 - 2009
• Sub-InvestigatorA Prospective Evaluation in a non-Randomized Trial of the Safety and Efficacy of the Use of the TAXUS ® Element ™ Paclitaxel-Eluting Coronary Stent System for the Treatment of De Novo coronary Artery Lesions in Small Vessels. The PERSEUS Trial: Small Vessel2008 - 2009
• Sub-InvestigatorA Prospective Evaluation in a Randomized Trial of the Safety and Efficacy of the Use of the TAXUS® Element™ Paclitaxel-Eluting Coronary Stent System for the Treatment of DeNovo Coronary Artery Lesions. The PERSEUS Trial2008 - 2009
• Sub-InvestigatorPost-Market Observation Study of Intra-renal Drug Delivery. Short Title: The PROVIDE Study2008 - 2009
• Sub-InvestigatorGauging Responsiveness with a VerifyNow Assay- Impact on Thrombosis and Safety: GRAVITAS2008 - 2009
• Sub-InvestigatorIntracoronary Brachytherapy for Recurrent Restenosis after Multiple Drug-Eluting Stents. Short Title: SCRIPPS V2008 - 2009
• Sub-InvestigatorCarotid Stenting for High Surgical-Risk Patients; Evaluating Outcomes Through the Collection of Clinical Evidence. The CHOICE study2008 - 2009
• Sub-InvestigatorA Prospective, multi-center randomized controlled trial of the IMPELLA® RECOVER ® LP 2.5 System versus Intra Aortic Balloon Pump (IABP) in Patients Undergoing Non-Emergent High Risk PCI. The PROTECT II Trial2008 - 2009
• Sub-InvestigatorThe effect of cangrelor on the pharmacodynamics of Clopidogrel. A clinical trial comparing cangrelor to Clopidogrel in subjects who require percutaneous coronary intervention. A substudy to Protocol No. TMC-CAN-05-022008 - 2009
• Sub-InvestigatorA Clinical Trial Comparing Cangrelor to Clopidogrel in Subjects Who Require Percutaneous Coronary Intervention. Protocol No. TMC-CAN-05-02. CHAMPION PCI.2008 - 2009
• Sub-InvestigatorSCRIPPS DES REAL WORLD REGISTRY: A Prospective Registry for the Use of Cypher™ Sirolimus-Eluting Stent in Patients with Coronary Artery Disease treated with Percutaneous Coronary Interventions at Scripps Clinic2008 - 2009
• Sub-InvestigatorProspective, Multi-Center, Single-Blind, Two-Arm, Randomized Controlled Trial of the Conor Costar Paclitaxel-Eluting Coronary Stent System Versus the Taxus Drug-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries: Short Title: COSTAR II2008 - 2009
• Sub-InvestigatorA Multicenter, Randomized Study of the Sirolimus-Eluting Bx Velocity® Balloon- Expandable Stent vs Intravascular Brachytherapy in the Treatment of Patients with In-Stent Restenotic Coronary Artery Lesions. Short Title: The SISR Study2008 - 2009
• Sub-InvestigatorA Multicenter, Non-Randomized Study of the 2.25mm Sirolimus-Eluting Bx VelocityTM Balloon-Expandable Stent in the Treatment of Patients With DeNovo Native Coronary Artery Lesions (Protocol P03-6320) (SIRIUS 2.25mm)2008 - 2009